Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30223776
TITLE
Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Human perception of bitter substances is partially genetically determined. Previously we discovered a single nucleotide polymorphism (SNP) within the cluster of bitter taste receptor genes on chromosome 12 that accounts for 5.8% of the variance in the perceived intensity rating of quinine, and we strengthened the classic association between TAS2R38 genotype and the bitterness of propylthiouracil (PROP). Here we performed a genome-wide association study (GWAS) using a 40% larger sample (n = 1999) together with a bivariate approach to detect previously unidentified common variants with small effects on bitter perception.
RESULTS NlmCategory: RESULTS
We identified two signals, both with small effects (< 2%), within the bitter taste receptor clusters on chromosomes 7 and 12, which influence the perceived bitterness of denatonium benzoate and sucrose octaacetate respectively. We also provided the first independent replication for an association of caffeine bitterness on chromosome 12. Furthermore, we provided evidence for pleiotropic effects on quinine, caffeine, sucrose octaacetate and denatonium benzoate for the three SNPs on chromosome 12 and the functional importance of the SNPs for denatonium benzoate bitterness.
CONCLUSIONS NlmCategory: CONCLUSIONS
These findings provide new insights into the genetic architecture of bitter taste and offer a useful starting point for determining the biological pathways linking perception of bitter substances.
DATE PUBLISHED
2018 Sep 17
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/01/27
accepted 2018/09/06
entrez 2018/09/19 06:00
pubmed 2018/09/19 06:00
medline 2018/09/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hwang LD Hwang Liang-Dar LD University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, 4102, Australia. d.hwang@uq.edu.au.
Gharahkhani P Gharahkhani Puya P QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Breslin PAS Breslin Paul A S PAS Department of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Zhu G Zhu Gu G QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Reed DR Reed Danielle R DR Monell Chemical Senses Center, Philadelphia, Pennsylvania, 19104, USA.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, 4072, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 19
ISSUE: 1
TITLE: BMC genomics
ISOABBREVIATION: BMC Genomics
YEAR: 2018
MONTH: Sep
DAY: 17
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1471-2164
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: BMC Genomics
COUNTRY: England
ISSNLINKING: 1471-2164
NLMUNIQUEID: 100965258
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 DC002995 NIDCD NIH HHS United States
DC02995 National Institute on Deafness and Other Communication Disorders
DC004698 National Institute on Deafness and Other Communication Disorders
1031119 National Health and Medical Research Council
DP0664638 Australian Research Council
241944 National Health and Medical Research Council
DP1093900 Australian Research Council
R29 DC002995 NIDCD NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Bitter
GWAS
Human
Perception
Receptor
Taste
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's