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PMID |
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TITLE |
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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. |
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ABSTRACT |
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Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
retracted |
2018/08/01 |
received |
2017/11/06 |
accepted |
2018/04/30 |
pubmed |
2018/07/25 06:00 |
medline |
2019/04/25 06:00 |
entrez |
2018/07/25 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Lee JJ |
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Lee |
James J |
JJ |
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Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA. |
Wedow R |
|
Wedow |
Robbee |
R |
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Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA. |
Okbay A |
|
Okbay |
Aysu |
A |
|
Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. a.okbay@vu.nl. |
Kong E |
|
Kong |
Edward |
E |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
Maghzian O |
|
Maghzian |
Omeed |
O |
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Department of Economics, Harvard University, Cambridge, MA, USA. |
Zacher M |
|
Zacher |
Meghan |
M |
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Department of Sociology, Harvard University, Cambridge, MA, USA. |
Nguyen-Viet TA |
|
Nguyen-Viet |
Tuan Anh |
TA |
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Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
Bowers P |
|
Bowers |
Peter |
P |
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Department of Economics, Harvard University, Cambridge, MA, USA. |
Sidorenko J |
|
Sidorenko |
Julia |
J |
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Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Karlsson Linnér R |
|
Karlsson Linnér |
Richard |
R |
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Institute for Behavior and Biology, Erasmus University Rotterdam, Rotterdam, The Netherlands. |
Fontana MA |
|
Fontana |
Mark Alan |
MA |
|
Center for the Advancement of Value in Musculoskeletal Care, Hospital for Special Surgery, New York, NY, USA. |
Kundu T |
|
Kundu |
Tushar |
T |
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Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
Lee C |
|
Lee |
Chanwook |
C |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
Li H |
|
Li |
Hui |
H |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
Li R |
|
Li |
Ruoxi |
R |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
Royer R |
|
Royer |
Rebecca |
R |
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Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
Timshel PN |
|
Timshel |
Pascal N |
PN |
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Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark. |
Walters RK |
|
Walters |
Raymond K |
RK |
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Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
Willoughby EA |
|
Willoughby |
Emily A |
EA |
|
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA. |
Yengo L |
|
Yengo |
Loïc |
L |
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Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
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23andMe Research Team |
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COGENT (Cognitive Genomics Consortium) |
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Social Science Genetic Association Consortium |
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Alver M |
|
Alver |
Maris |
M |
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Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Bao Y |
|
Bao |
Yanchun |
Y |
|
Institute for Social and Economic Research, University of Essex, Colchester, UK. |
Clark DW |
|
Clark |
David W |
DW |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Day FR |
|
Day |
Felix R |
FR |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
Furlotte NA |
|
Furlotte |
Nicholas A |
NA |
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23andMe, Inc., Mountain View, CA, USA. |
Joshi PK |
|
Joshi |
Peter K |
PK |
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Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland. |
Kemper KE |
|
Kemper |
Kathryn E |
KE |
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Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Kleinman A |
|
Kleinman |
Aaron |
A |
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23andMe, Inc., Mountain View, CA, USA. |
Langenberg C |
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Langenberg |
Claudia |
C |
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MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
Mägi R |
|
Mägi |
Reedik |
R |
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Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Trampush JW |
|
Trampush |
Joey W |
JW |
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Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. |
Verma SS |
|
Verma |
Shefali Setia |
SS |
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Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA. |
Wu Y |
|
Wu |
Yang |
Y |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Lam M |
|
Lam |
Max |
M |
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Genome Institute, Singapore, Singapore. |
Zhao JH |
|
Zhao |
Jing Hua |
JH |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
Zheng Z |
|
Zheng |
Zhili |
Z |
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The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China. |
Boardman JD |
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Boardman |
Jason D |
JD |
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Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA. |
Campbell H |
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Campbell |
Harry |
H |
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Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Freese J |
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Freese |
Jeremy |
J |
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Department of Sociology, Stanford University, Stanford, CA, USA. |
Harris KM |
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Harris |
Kathleen Mullan |
KM |
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Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
Hayward C |
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Hayward |
Caroline |
C |
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MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Herd P |
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Herd |
Pamela |
P |
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La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI, USA. |
Kumari M |
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Kumari |
Meena |
M |
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Institute for Social and Economic Research, University of Essex, Colchester, UK. |
Lencz T |
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Lencz |
Todd |
T |
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Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, CA, USA. |
Luan J |
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Luan |
Jian'an |
J |
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MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
Malhotra AK |
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Malhotra |
Anil K |
AK |
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Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, CA, USA. |
Metspalu A |
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Metspalu |
Andres |
A |
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Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. |
Milani L |
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Milani |
Lili |
L |
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Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Ong KK |
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Ong |
Ken K |
KK |
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MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
Perry JRB |
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Perry |
John R B |
JRB |
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MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
Porteous DJ |
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Porteous |
David J |
DJ |
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Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Ritchie MD |
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Ritchie |
Marylyn D |
MD |
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Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA. |
Smart MC |
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Smart |
Melissa C |
MC |
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Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Smith BH |
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Smith |
Blair H |
BH |
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Medical Research Institute, University of Dundee, Dundee, UK. |
Tung JY |
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Tung |
Joyce Y |
JY |
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23andMe, Inc., Mountain View, CA, USA. |
Wareham NJ |
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Wareham |
Nicholas J |
NJ |
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MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
Wilson JF |
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Wilson |
James F |
JF |
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MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Beauchamp JP |
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Beauchamp |
Jonathan P |
JP |
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Department of Economics, University of Toronto, Toronto, Ontario, Canada. |
Conley DC |
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Conley |
Dalton C |
DC |
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Department of Sociology, Princeton University, Princeton, NJ, USA. |
Esko T |
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Esko |
Tõnu |
T |
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Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Lehrer SF |
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Lehrer |
Steven F |
SF |
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National Bureau of Economic Research, Cambridge, MA, USA. |
Magnusson PKE |
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Magnusson |
Patrik K E |
PKE |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Oskarsson S |
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Oskarsson |
Sven |
S |
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Department of Government, Uppsala University, Uppsala, Sweden. |
Pers TH |
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Pers |
Tune H |
TH |
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Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark. |
Robinson MR |
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Robinson |
Matthew R |
MR |
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Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. |
Thom K |
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Thom |
Kevin |
K |
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Department of Economics, New York University, New York, NY, USA. |
Watson C |
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Watson |
Chelsea |
C |
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Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
Chabris CF |
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Chabris |
Christopher F |
CF |
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Autism and Developmental Medicine Institute, Geisinger Health System, Lewisburg, PA, USA. |
Meyer MN |
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Meyer |
Michelle N |
MN |
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Center for Translational Bioethics and Health Care Policy, Geisinger Health System, Danville, PA, USA. |
Laibson DI |
|
Laibson |
David I |
DI |
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Department of Economics, Harvard University, Cambridge, MA, USA. |
Yang J |
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Yang |
Jian |
J |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Johannesson M |
|
Johannesson |
Magnus |
M |
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Department of Economics, Stockholm School of Economics, Stockholm, Sweden. |
Koellinger PD |
|
Koellinger |
Philipp D |
PD |
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Institute for Behavior and Biology, Erasmus University Rotterdam, Rotterdam, The Netherlands. |
Turley P |
|
Turley |
Patrick |
P |
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Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
Visscher PM |
|
Visscher |
Peter M |
PM |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. peter.visscher@uq.edu.au. |
Benjamin DJ |
|
Benjamin |
Daniel J |
DJ |
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Department of Economics, University of Southern California, Los Angeles, CA, USA. daniel.benjamin@gmail.com. |
Cesarini D |
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Cesarini |
David |
D |
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Center for Experimental Social Science, New York University, New York, NY, USA. |
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INVESTIGATORS |
|
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
Agee |
Michelle |
M |
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Alipanahi |
Babak |
B |
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Auton |
Adam |
A |
|
Bell |
Robert K |
RK |
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Bryc |
Katarzyna |
K |
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Elson |
Sarah L |
SL |
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Fontanillas |
Pierre |
P |
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Hinds |
David A |
DA |
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McCreight |
Jennifer C |
JC |
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Huber |
Karen E |
KE |
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Litterman |
Nadia K |
NK |
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McIntyre |
Matthew H |
MH |
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Mountain |
Joanna L |
JL |
|
Noblin |
Elizabeth S |
ES |
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Northover |
Carrie A M |
CAM |
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Pitts |
Steven J |
SJ |
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Sathirapongsasuti |
J Fah |
JF |
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Sazonova |
Olga V |
OV |
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Shelton |
Janie F |
JF |
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Shringarpure |
Suyash |
S |
|
Tian |
Chao |
C |
|
Vacic |
Vladimir |
V |
|
Wilson |
Catherine H |
CH |
|
Okbay |
Aysu |
A |
|
Beauchamp |
Jonathan P |
JP |
|
Fontana |
Mark Alan |
MA |
|
Lee |
James J |
JJ |
|
Pers |
Tune H |
TH |
|
Rietveld |
Cornelius A |
CA |
|
Turley |
Patrick |
P |
|
Chen |
Guo-Bo |
GB |
|
Emilsson |
Valur |
V |
|
Meddens |
S Fleur W |
SFW |
|
Oskarsson |
Sven |
S |
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Pickrell |
Joseph K |
JK |
|
Thom |
Kevin |
K |
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Timshel |
Pascal |
P |
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Vlaming |
Ronald de |
R |
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Abdellaoui |
Abdel |
A |
|
Ahluwalia |
Tarunveer S |
TS |
|
Bacelis |
Jonas |
J |
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Baumbach |
Clemens |
C |
|
Bjornsdottir |
Gyda |
G |
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Brandsma |
Johannes H |
JH |
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Concas |
Maria Pina |
MP |
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Derringer |
Jaime |
J |
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Furlotte |
Nicholas A |
NA |
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Galesloot |
Tessel E |
TE |
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Girotto |
Giorgia |
G |
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Gupta |
Richa |
R |
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Hall |
Leanne M |
LM |
|
Harris |
Sarah E |
SE |
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Hofer |
Edith |
E |
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Horikoshi |
Momoko |
M |
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Huffman |
Jennifer E |
JE |
|
Kaasik |
Kadri |
K |
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Kalafati |
Ioanna P |
IP |
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Karlsson |
Robert |
R |
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Kong |
Augustine |
A |
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Lahti |
Jari |
J |
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van der Lee |
Sven J |
SJ |
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Leeuw |
Christiaan de |
C |
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Lind |
Penelope A |
PA |
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Lindgren |
Karl-Oskar |
KO |
|
Liu |
Tian |
T |
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Mangino |
Massimo |
M |
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Marten |
Jonathan |
J |
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Mihailov |
Evelin |
E |
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Miller |
Michael B |
MB |
|
van der Most |
Peter J |
PJ |
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Oldmeadow |
Christopher |
C |
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Payton |
Antony |
A |
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Pervjakova |
Natalia |
N |
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Peyrot |
Wouter J |
WJ |
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Qian |
Yong |
Y |
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Raitakari |
Olli |
O |
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Rueedi |
Rico |
R |
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Salvi |
Erika |
E |
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Schmidt |
Börge |
B |
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Schraut |
Katharina E |
KE |
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Shi |
Jianxin |
J |
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Smith |
Albert V |
AV |
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Poot |
Raymond A |
RA |
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St Pourcain |
Beate |
B |
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Teumer |
Alexander |
A |
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Thorleifsson |
Gudmar |
G |
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Verweij |
Niek |
N |
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Vuckovic |
Dragana |
D |
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Wellmann |
Juergen |
J |
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Westra |
Harm-Jan |
HJ |
|
Yang |
Jingyun |
J |
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Zhao |
Wei |
W |
|
Zhu |
Zhihong |
Z |
|
Alizadeh |
Behrooz Z |
BZ |
|
Amin |
Najaf |
N |
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Bakshi |
Andrew |
A |
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Baumeister |
Sebastian E |
SE |
|
Biino |
Ginevra |
G |
|
Bønnelykke |
Klaus |
K |
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Boyle |
Patricia A |
PA |
|
Campbell |
Harry |
H |
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Cappuccio |
Francesco P |
FP |
|
Davies |
Gail |
G |
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De Neve |
Jan-Emmanuel |
JE |
|
Deloukas |
Panos |
P |
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Demuth |
Ilja |
I |
|
Ding |
Jun |
J |
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Eibich |
Peter |
P |
|
Eisele |
Lewin |
L |
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Eklund |
Niina |
N |
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Evans |
David M |
DM |
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Faul |
Jessica D |
JD |
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Feitosa |
Mary F |
MF |
|
Forstner |
Andreas J |
AJ |
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Gandin |
Ilaria |
I |
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Gunnarsson |
Bjarni |
B |
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Halldórsson |
Bjarni V |
BV |
|
Harris |
Tamara B |
TB |
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Heath |
Andrew C |
AC |
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Hocking |
Lynne J |
LJ |
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Holliday |
Elizabeth G |
EG |
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Homuth |
Georg |
G |
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Horan |
Michael A |
MA |
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Hottenga |
Jouke-Jan |
JJ |
|
de Jager |
Philip L |
PL |
|
Joshi |
Peter K |
PK |
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Jugessur |
Astanand |
A |
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Kaakinen |
Marika A |
MA |
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Kähönen |
Mika |
M |
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Kanoni |
Stavroula |
S |
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Keltigangas-Järvinen |
Liisa |
L |
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Kiemeney |
Lambertus A L M |
LALM |
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Kolcic |
Ivana |
I |
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Koskinen |
Seppo |
S |
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Kraja |
Aldi T |
AT |
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Kroh |
Martin |
M |
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Kutalik |
Zoltan |
Z |
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Latvala |
Antti |
A |
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Launer |
Lenore J |
LJ |
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Lebreton |
Maël P |
MP |
|
Levinson |
Douglas F |
DF |
|
Lichtenstein |
Paul |
P |
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Lichtner |
Peter |
P |
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Liewald |
David C M |
DCM |
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Loukola |
LifeLines Cohort Study Anu |
LCSA |
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Madden |
Pamela A |
PA |
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Mägi |
Reedik |
R |
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Mäki-Opas |
Tomi |
T |
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Marioni |
Riccardo E |
RE |
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Marques-Vidal |
Pedro |
P |
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Meddens |
Gerardus A |
GA |
|
McMahon |
George |
G |
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Meisinger |
Christa |
C |
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Meitinger |
Thomas |
T |
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Milaneschi |
Yusplitri |
Y |
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Milani |
Lili |
L |
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Montgomery |
Grant W |
GW |
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Myhre |
Ronny |
R |
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Nelson |
Christopher P |
CP |
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Nyholt |
Dale R |
DR |
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Ollier |
William E R |
WER |
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Palotie |
Aarno |
A |
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Paternoster |
Lavinia |
L |
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Pedersen |
Nancy L |
NL |
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Petrovic |
Katja E |
KE |
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Porteous |
David J |
DJ |
|
Räikkönen |
Katri |
K |
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Ring |
Susan M |
SM |
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Robino |
Antonietta |
A |
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Rostapshova |
Olga |
O |
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Rudan |
Igor |
I |
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Rustichini |
Aldo |
A |
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Salomaa |
Veikko |
V |
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Sanders |
Alan R |
AR |
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Sarin |
Antti-Pekka |
AP |
|
Schmidt |
Helena |
H |
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Scott |
Rodney J |
RJ |
|
Smith |
Blair H |
BH |
|
Smith |
Jennifer A |
JA |
|
Staessen |
Jan A |
JA |
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Steinhagen-Thiessen |
Elisabeth |
E |
|
Strauch |
Konstantin |
K |
|
Terracciano |
Antonio |
A |
|
Tobin |
Martin D |
MD |
|
Ulivi |
Sheila |
S |
|
Vaccargiu |
Simona |
S |
|
Quaye |
Lydia |
L |
|
van Rooij |
Frank J A |
FJA |
|
Venturini |
Cristina |
C |
|
Vinkhuyzen |
Anna A E |
AAE |
|
Völker |
Uwe |
U |
|
Völzke |
Henry |
H |
|
Vonk |
Judith M |
JM |
|
Vozzi |
Diego |
D |
|
Waage |
Johannes |
J |
|
Ware |
Erin B |
EB |
|
Willemsen |
Gonneke |
G |
|
Attia |
John R |
JR |
|
Bennett |
David A |
DA |
|
Berger |
Klaus |
K |
|
Bertram |
Lars |
L |
|
Bisgaard |
Hans |
H |
|
Boomsma |
Dorret I |
DI |
|
Borecki |
Ingrid B |
IB |
|
Bültmann |
Ute |
U |
|
Chabris |
Christopher F |
CF |
|
Cucca |
Francesco |
F |
|
Cusi |
Daniele |
D |
|
Deary |
Ian J |
IJ |
|
Dedoussis |
George V |
GV |
|
van Duijn |
Cornelia M |
CM |
|
Eriksson |
Johan G |
JG |
|
Franke |
Barbara |
B |
|
Franke |
Lude |
L |
|
Gasparini |
Paolo |
P |
|
Gejman |
Pablo V |
PV |
|
Gieger |
Christian |
C |
|
Grabe |
Hans-Jörgen |
HJ |
|
Gratten |
Jacob |
J |
|
Groenen |
Patrick J F |
PJF |
|
Gudnason |
Vilmundur |
V |
|
van der Harst |
Pim |
P |
|
Hayward |
Caroline |
C |
|
Hinds |
David A |
DA |
|
Hoffmann |
Wolfgang |
W |
|
Hyppönen |
Elina |
E |
|
Iacono |
William G |
WG |
|
Jacobsson |
Bo |
B |
|
Järvelin |
Marjo-Riitta |
MR |
|
Jöckel |
Karl-Heinz |
KH |
|
Kaprio |
Jaakko |
J |
|
Kardia |
Sharon L R |
SLR |
|
Lehtimäki |
Terho |
T |
|
Lehrer |
Steven F |
SF |
|
Magnusson |
Patrik K E |
PKE |
|
Martin |
Nicholas G |
NG |
|
McGue |
Matt |
M |
|
Metspalu |
Andres |
A |
|
Pendleton |
Neil |
N |
|
Penninx |
Brenda W J H |
BWJH |
|
Perola |
Markus |
M |
|
Pirastu |
Nicola |
N |
|
Pirastu |
Mario |
M |
|
Polasek |
Ozren |
O |
|
Posthuma |
Danielle |
D |
|
Power |
Christine |
C |
|
Province |
Michael A |
MA |
|
Samani |
Nilesh J |
NJ |
|
Schlessinger |
David |
D |
|
Schmidt |
Reinhold |
R |
|
Sørensen |
Thorkild I A |
TIA |
|
Spector |
Tim D |
TD |
|
Stefansson |
Kari |
K |
|
Thorsteinsdottir |
Unnur |
U |
|
Thurik |
A Roy |
AR |
|
Timpson |
Nicholas J |
NJ |
|
Tiemeier |
Henning |
H |
|
Tung |
Joyce Y |
JY |
|
Uitterlinden |
André G |
AG |
|
Vitart |
Veronique |
V |
|
Vollenweider |
Peter |
P |
|
Weir |
David R |
DR |
|
Wilson |
James F |
JF |
|
Wright |
Alan F |
AF |
|
Conley |
Dalton C |
DC |
|
Krueger |
Robert F |
RF |
|
Smith |
George Davey |
GD |
|
Hofman |
Albert |
A |
|
Laibson |
David I |
DI |
|
Medland |
Sarah E |
SE |
|
Meyer |
Michelle N |
MN |
|
Yang |
Jian |
J |
|
Johannesson |
Magnus |
M |
|
Visscher |
Peter M |
PM |
|
Esko |
Tõnu |
T |
|
Koellinger |
Philipp D |
PD |
|
Cesarini |
David |
D |
|
Benjamin |
Daniel J |
DJ |
|
|
JOURNAL |
|
VOLUME: 50 |
ISSUE: 8 |
TITLE: Nature genetics |
ISOABBREVIATION: Nat Genet |
YEAR: 2018 |
MONTH: 07 |
DAY: 23 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1718 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Meta-Analysis |
Research Support, Non-U.S. Gov't |
|
COMMENTS AND CORRECTIONS |
|
REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
CommentIn |
Nat Rev Genet. 2018 Oct;19(10):592-593 |
30093724 |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
G1001799 |
Medical Research Council |
United Kingdom |
MR/N01104X/2 |
Medical Research Council |
United Kingdom |
R01 HD073342 |
NICHD NIH HHS |
United States |
L30 MH104879 |
NIMH NIH HHS |
United States |
MR/K026992/1 |
Medical Research Council |
United Kingdom |
MC_UU_12015/1 |
Medical Research Council |
United Kingdom |
P30 AG010161 |
NIA NIH HHS |
United States |
R01 AG055406 |
NIA NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
R01 AG015819 |
NIA NIH HHS |
United States |
647648 |
European Research Council |
International |
MC_UU_12015/2 |
Medical Research Council |
United Kingdom |
P2C HD047879 |
NICHD NIH HHS |
United States |
P2C HD066613 |
NICHD NIH HHS |
United States |
BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
P01 AG005842 |
NIA NIH HHS |
United States |
P2C HD050924 |
NICHD NIH HHS |
United States |
G0600237 |
Medical Research Council |
United Kingdom |
G0100594 |
Medical Research Council |
United Kingdom |
P30 AG012810 |
NIA NIH HHS |
United States |
R01 AG042568 |
NIA NIH HHS |
United States |
T32 AG000186 |
NIA NIH HHS |
United States |
BB/F022441/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
G0901461 |
Medical Research Council |
United Kingdom |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
|
Aged |
|
Aged, 80 and over |
|
Cohort Studies |
|
Educational Status |
|
Female |
|
Genome-Wide Association Study |
methods |
Humans |
methods |
Male |
methods |
Middle Aged |
methods |
Multifactorial Inheritance |
methods |
Phenotype |
methods |
Polymorphism, Single Nucleotide |
methods |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
|
OTHER ID's |
|
|
|