|
|
| PMID |
|
|
| TITLE |
|
| Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. |
|
| ABSTRACT |
|
|
|
| Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research. |
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| DATE PUBLISHED |
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|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| retracted |
2018/08/01 |
| received |
2017/11/06 |
| accepted |
2018/04/30 |
| pubmed |
2018/07/25 06:00 |
| medline |
2019/04/25 06:00 |
| entrez |
2018/07/25 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Lee JJ |
|
Lee |
James J |
JJ |
|
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA. |
| Wedow R |
|
Wedow |
Robbee |
R |
|
Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA. |
| Okbay A |
|
Okbay |
Aysu |
A |
|
Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. a.okbay@vu.nl. |
| Kong E |
|
Kong |
Edward |
E |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
| Maghzian O |
|
Maghzian |
Omeed |
O |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
| Zacher M |
|
Zacher |
Meghan |
M |
|
Department of Sociology, Harvard University, Cambridge, MA, USA. |
| Nguyen-Viet TA |
|
Nguyen-Viet |
Tuan Anh |
TA |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
| Bowers P |
|
Bowers |
Peter |
P |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
| Sidorenko J |
|
Sidorenko |
Julia |
J |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
| Karlsson Linnér R |
|
Karlsson Linnér |
Richard |
R |
|
Institute for Behavior and Biology, Erasmus University Rotterdam, Rotterdam, The Netherlands. |
| Fontana MA |
|
Fontana |
Mark Alan |
MA |
|
Center for the Advancement of Value in Musculoskeletal Care, Hospital for Special Surgery, New York, NY, USA. |
| Kundu T |
|
Kundu |
Tushar |
T |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
| Lee C |
|
Lee |
Chanwook |
C |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
| Li H |
|
Li |
Hui |
H |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
| Li R |
|
Li |
Ruoxi |
R |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
| Royer R |
|
Royer |
Rebecca |
R |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
| Timshel PN |
|
Timshel |
Pascal N |
PN |
|
Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark. |
| Walters RK |
|
Walters |
Raymond K |
RK |
|
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
| Willoughby EA |
|
Willoughby |
Emily A |
EA |
|
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA. |
| Yengo L |
|
Yengo |
Loïc |
L |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
|
23andMe Research Team |
|
|
|
|
|
|
COGENT (Cognitive Genomics Consortium) |
|
|
|
|
|
|
Social Science Genetic Association Consortium |
|
|
|
|
|
| Alver M |
|
Alver |
Maris |
M |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
| Bao Y |
|
Bao |
Yanchun |
Y |
|
Institute for Social and Economic Research, University of Essex, Colchester, UK. |
| Clark DW |
|
Clark |
David W |
DW |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
| Day FR |
|
Day |
Felix R |
FR |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
| Furlotte NA |
|
Furlotte |
Nicholas A |
NA |
|
23andMe, Inc., Mountain View, CA, USA. |
| Joshi PK |
|
Joshi |
Peter K |
PK |
|
Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland. |
| Kemper KE |
|
Kemper |
Kathryn E |
KE |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
| Kleinman A |
|
Kleinman |
Aaron |
A |
|
23andMe, Inc., Mountain View, CA, USA. |
| Langenberg C |
|
Langenberg |
Claudia |
C |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
| Mägi R |
|
Mägi |
Reedik |
R |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
| Trampush JW |
|
Trampush |
Joey W |
JW |
|
Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. |
| Verma SS |
|
Verma |
Shefali Setia |
SS |
|
Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA. |
| Wu Y |
|
Wu |
Yang |
Y |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
| Lam M |
|
Lam |
Max |
M |
|
Genome Institute, Singapore, Singapore. |
| Zhao JH |
|
Zhao |
Jing Hua |
JH |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
| Zheng Z |
|
Zheng |
Zhili |
Z |
|
The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China. |
| Boardman JD |
|
Boardman |
Jason D |
JD |
|
Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA. |
| Campbell H |
|
Campbell |
Harry |
H |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
| Freese J |
|
Freese |
Jeremy |
J |
|
Department of Sociology, Stanford University, Stanford, CA, USA. |
| Harris KM |
|
Harris |
Kathleen Mullan |
KM |
|
Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
| Hayward C |
|
Hayward |
Caroline |
C |
|
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
| Herd P |
|
Herd |
Pamela |
P |
|
La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI, USA. |
| Kumari M |
|
Kumari |
Meena |
M |
|
Institute for Social and Economic Research, University of Essex, Colchester, UK. |
| Lencz T |
|
Lencz |
Todd |
T |
|
Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, CA, USA. |
| Luan J |
|
Luan |
Jian'an |
J |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
| Malhotra AK |
|
Malhotra |
Anil K |
AK |
|
Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, CA, USA. |
| Metspalu A |
|
Metspalu |
Andres |
A |
|
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. |
| Milani L |
|
Milani |
Lili |
L |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
| Ong KK |
|
Ong |
Ken K |
KK |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
| Perry JRB |
|
Perry |
John R B |
JRB |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
| Porteous DJ |
|
Porteous |
David J |
DJ |
|
Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
| Ritchie MD |
|
Ritchie |
Marylyn D |
MD |
|
Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA. |
| Smart MC |
|
Smart |
Melissa C |
MC |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
| Smith BH |
|
Smith |
Blair H |
BH |
|
Medical Research Institute, University of Dundee, Dundee, UK. |
| Tung JY |
|
Tung |
Joyce Y |
JY |
|
23andMe, Inc., Mountain View, CA, USA. |
| Wareham NJ |
|
Wareham |
Nicholas J |
NJ |
|
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. |
| Wilson JF |
|
Wilson |
James F |
JF |
|
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
| Beauchamp JP |
|
Beauchamp |
Jonathan P |
JP |
|
Department of Economics, University of Toronto, Toronto, Ontario, Canada. |
| Conley DC |
|
Conley |
Dalton C |
DC |
|
Department of Sociology, Princeton University, Princeton, NJ, USA. |
| Esko T |
|
Esko |
Tõnu |
T |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
| Lehrer SF |
|
Lehrer |
Steven F |
SF |
|
National Bureau of Economic Research, Cambridge, MA, USA. |
| Magnusson PKE |
|
Magnusson |
Patrik K E |
PKE |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Oskarsson S |
|
Oskarsson |
Sven |
S |
|
Department of Government, Uppsala University, Uppsala, Sweden. |
| Pers TH |
|
Pers |
Tune H |
TH |
|
Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark. |
| Robinson MR |
|
Robinson |
Matthew R |
MR |
|
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. |
| Thom K |
|
Thom |
Kevin |
K |
|
Department of Economics, New York University, New York, NY, USA. |
| Watson C |
|
Watson |
Chelsea |
C |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. |
| Chabris CF |
|
Chabris |
Christopher F |
CF |
|
Autism and Developmental Medicine Institute, Geisinger Health System, Lewisburg, PA, USA. |
| Meyer MN |
|
Meyer |
Michelle N |
MN |
|
Center for Translational Bioethics and Health Care Policy, Geisinger Health System, Danville, PA, USA. |
| Laibson DI |
|
Laibson |
David I |
DI |
|
Department of Economics, Harvard University, Cambridge, MA, USA. |
| Yang J |
|
Yang |
Jian |
J |
|
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
| Johannesson M |
|
Johannesson |
Magnus |
M |
|
Department of Economics, Stockholm School of Economics, Stockholm, Sweden. |
| Koellinger PD |
|
Koellinger |
Philipp D |
PD |
|
Institute for Behavior and Biology, Erasmus University Rotterdam, Rotterdam, The Netherlands. |
| Turley P |
|
Turley |
Patrick |
P |
|
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
| Visscher PM |
|
Visscher |
Peter M |
PM |
|
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. peter.visscher@uq.edu.au. |
| Benjamin DJ |
|
Benjamin |
Daniel J |
DJ |
|
Department of Economics, University of Southern California, Los Angeles, CA, USA. daniel.benjamin@gmail.com. |
| Cesarini D |
|
Cesarini |
David |
D |
|
Center for Experimental Social Science, New York University, New York, NY, USA. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Agee |
Michelle |
M |
|
| Alipanahi |
Babak |
B |
|
| Auton |
Adam |
A |
|
| Bell |
Robert K |
RK |
|
| Bryc |
Katarzyna |
K |
|
| Elson |
Sarah L |
SL |
|
| Fontanillas |
Pierre |
P |
|
| Hinds |
David A |
DA |
|
| McCreight |
Jennifer C |
JC |
|
| Huber |
Karen E |
KE |
|
| Litterman |
Nadia K |
NK |
|
| McIntyre |
Matthew H |
MH |
|
| Mountain |
Joanna L |
JL |
|
| Noblin |
Elizabeth S |
ES |
|
| Northover |
Carrie A M |
CAM |
|
| Pitts |
Steven J |
SJ |
|
| Sathirapongsasuti |
J Fah |
JF |
|
| Sazonova |
Olga V |
OV |
|
| Shelton |
Janie F |
JF |
|
| Shringarpure |
Suyash |
S |
|
| Tian |
Chao |
C |
|
| Vacic |
Vladimir |
V |
|
| Wilson |
Catherine H |
CH |
|
| Okbay |
Aysu |
A |
|
| Beauchamp |
Jonathan P |
JP |
|
| Fontana |
Mark Alan |
MA |
|
| Lee |
James J |
JJ |
|
| Pers |
Tune H |
TH |
|
| Rietveld |
Cornelius A |
CA |
|
| Turley |
Patrick |
P |
|
| Chen |
Guo-Bo |
GB |
|
| Emilsson |
Valur |
V |
|
| Meddens |
S Fleur W |
SFW |
|
| Oskarsson |
Sven |
S |
|
| Pickrell |
Joseph K |
JK |
|
| Thom |
Kevin |
K |
|
| Timshel |
Pascal |
P |
|
| Vlaming |
Ronald de |
R |
|
| Abdellaoui |
Abdel |
A |
|
| Ahluwalia |
Tarunveer S |
TS |
|
| Bacelis |
Jonas |
J |
|
| Baumbach |
Clemens |
C |
|
| Bjornsdottir |
Gyda |
G |
|
| Brandsma |
Johannes H |
JH |
|
| Concas |
Maria Pina |
MP |
|
| Derringer |
Jaime |
J |
|
| Furlotte |
Nicholas A |
NA |
|
| Galesloot |
Tessel E |
TE |
|
| Girotto |
Giorgia |
G |
|
| Gupta |
Richa |
R |
|
| Hall |
Leanne M |
LM |
|
| Harris |
Sarah E |
SE |
|
| Hofer |
Edith |
E |
|
| Horikoshi |
Momoko |
M |
|
| Huffman |
Jennifer E |
JE |
|
| Kaasik |
Kadri |
K |
|
| Kalafati |
Ioanna P |
IP |
|
| Karlsson |
Robert |
R |
|
| Kong |
Augustine |
A |
|
| Lahti |
Jari |
J |
|
| van der Lee |
Sven J |
SJ |
|
| Leeuw |
Christiaan de |
C |
|
| Lind |
Penelope A |
PA |
|
| Lindgren |
Karl-Oskar |
KO |
|
| Liu |
Tian |
T |
|
| Mangino |
Massimo |
M |
|
| Marten |
Jonathan |
J |
|
| Mihailov |
Evelin |
E |
|
| Miller |
Michael B |
MB |
|
| van der Most |
Peter J |
PJ |
|
| Oldmeadow |
Christopher |
C |
|
| Payton |
Antony |
A |
|
| Pervjakova |
Natalia |
N |
|
| Peyrot |
Wouter J |
WJ |
|
| Qian |
Yong |
Y |
|
| Raitakari |
Olli |
O |
|
| Rueedi |
Rico |
R |
|
| Salvi |
Erika |
E |
|
| Schmidt |
Börge |
B |
|
| Schraut |
Katharina E |
KE |
|
| Shi |
Jianxin |
J |
|
| Smith |
Albert V |
AV |
|
| Poot |
Raymond A |
RA |
|
| St Pourcain |
Beate |
B |
|
| Teumer |
Alexander |
A |
|
| Thorleifsson |
Gudmar |
G |
|
| Verweij |
Niek |
N |
|
| Vuckovic |
Dragana |
D |
|
| Wellmann |
Juergen |
J |
|
| Westra |
Harm-Jan |
HJ |
|
| Yang |
Jingyun |
J |
|
| Zhao |
Wei |
W |
|
| Zhu |
Zhihong |
Z |
|
| Alizadeh |
Behrooz Z |
BZ |
|
| Amin |
Najaf |
N |
|
| Bakshi |
Andrew |
A |
|
| Baumeister |
Sebastian E |
SE |
|
| Biino |
Ginevra |
G |
|
| Bønnelykke |
Klaus |
K |
|
| Boyle |
Patricia A |
PA |
|
| Campbell |
Harry |
H |
|
| Cappuccio |
Francesco P |
FP |
|
| Davies |
Gail |
G |
|
| De Neve |
Jan-Emmanuel |
JE |
|
| Deloukas |
Panos |
P |
|
| Demuth |
Ilja |
I |
|
| Ding |
Jun |
J |
|
| Eibich |
Peter |
P |
|
| Eisele |
Lewin |
L |
|
| Eklund |
Niina |
N |
|
| Evans |
David M |
DM |
|
| Faul |
Jessica D |
JD |
|
| Feitosa |
Mary F |
MF |
|
| Forstner |
Andreas J |
AJ |
|
| Gandin |
Ilaria |
I |
|
| Gunnarsson |
Bjarni |
B |
|
| Halldórsson |
Bjarni V |
BV |
|
| Harris |
Tamara B |
TB |
|
| Heath |
Andrew C |
AC |
|
| Hocking |
Lynne J |
LJ |
|
| Holliday |
Elizabeth G |
EG |
|
| Homuth |
Georg |
G |
|
| Horan |
Michael A |
MA |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| de Jager |
Philip L |
PL |
|
| Joshi |
Peter K |
PK |
|
| Jugessur |
Astanand |
A |
|
| Kaakinen |
Marika A |
MA |
|
| Kähönen |
Mika |
M |
|
| Kanoni |
Stavroula |
S |
|
| Keltigangas-Järvinen |
Liisa |
L |
|
| Kiemeney |
Lambertus A L M |
LALM |
|
| Kolcic |
Ivana |
I |
|
| Koskinen |
Seppo |
S |
|
| Kraja |
Aldi T |
AT |
|
| Kroh |
Martin |
M |
|
| Kutalik |
Zoltan |
Z |
|
| Latvala |
Antti |
A |
|
| Launer |
Lenore J |
LJ |
|
| Lebreton |
Maël P |
MP |
|
| Levinson |
Douglas F |
DF |
|
| Lichtenstein |
Paul |
P |
|
| Lichtner |
Peter |
P |
|
| Liewald |
David C M |
DCM |
|
| Loukola |
LifeLines Cohort Study Anu |
LCSA |
|
| Madden |
Pamela A |
PA |
|
| Mägi |
Reedik |
R |
|
| Mäki-Opas |
Tomi |
T |
|
| Marioni |
Riccardo E |
RE |
|
| Marques-Vidal |
Pedro |
P |
|
| Meddens |
Gerardus A |
GA |
|
| McMahon |
George |
G |
|
| Meisinger |
Christa |
C |
|
| Meitinger |
Thomas |
T |
|
| Milaneschi |
Yusplitri |
Y |
|
| Milani |
Lili |
L |
|
| Montgomery |
Grant W |
GW |
|
| Myhre |
Ronny |
R |
|
| Nelson |
Christopher P |
CP |
|
| Nyholt |
Dale R |
DR |
|
| Ollier |
William E R |
WER |
|
| Palotie |
Aarno |
A |
|
| Paternoster |
Lavinia |
L |
|
| Pedersen |
Nancy L |
NL |
|
| Petrovic |
Katja E |
KE |
|
| Porteous |
David J |
DJ |
|
| Räikkönen |
Katri |
K |
|
| Ring |
Susan M |
SM |
|
| Robino |
Antonietta |
A |
|
| Rostapshova |
Olga |
O |
|
| Rudan |
Igor |
I |
|
| Rustichini |
Aldo |
A |
|
| Salomaa |
Veikko |
V |
|
| Sanders |
Alan R |
AR |
|
| Sarin |
Antti-Pekka |
AP |
|
| Schmidt |
Helena |
H |
|
| Scott |
Rodney J |
RJ |
|
| Smith |
Blair H |
BH |
|
| Smith |
Jennifer A |
JA |
|
| Staessen |
Jan A |
JA |
|
| Steinhagen-Thiessen |
Elisabeth |
E |
|
| Strauch |
Konstantin |
K |
|
| Terracciano |
Antonio |
A |
|
| Tobin |
Martin D |
MD |
|
| Ulivi |
Sheila |
S |
|
| Vaccargiu |
Simona |
S |
|
| Quaye |
Lydia |
L |
|
| van Rooij |
Frank J A |
FJA |
|
| Venturini |
Cristina |
C |
|
| Vinkhuyzen |
Anna A E |
AAE |
|
| Völker |
Uwe |
U |
|
| Völzke |
Henry |
H |
|
| Vonk |
Judith M |
JM |
|
| Vozzi |
Diego |
D |
|
| Waage |
Johannes |
J |
|
| Ware |
Erin B |
EB |
|
| Willemsen |
Gonneke |
G |
|
| Attia |
John R |
JR |
|
| Bennett |
David A |
DA |
|
| Berger |
Klaus |
K |
|
| Bertram |
Lars |
L |
|
| Bisgaard |
Hans |
H |
|
| Boomsma |
Dorret I |
DI |
|
| Borecki |
Ingrid B |
IB |
|
| Bültmann |
Ute |
U |
|
| Chabris |
Christopher F |
CF |
|
| Cucca |
Francesco |
F |
|
| Cusi |
Daniele |
D |
|
| Deary |
Ian J |
IJ |
|
| Dedoussis |
George V |
GV |
|
| van Duijn |
Cornelia M |
CM |
|
| Eriksson |
Johan G |
JG |
|
| Franke |
Barbara |
B |
|
| Franke |
Lude |
L |
|
| Gasparini |
Paolo |
P |
|
| Gejman |
Pablo V |
PV |
|
| Gieger |
Christian |
C |
|
| Grabe |
Hans-Jörgen |
HJ |
|
| Gratten |
Jacob |
J |
|
| Groenen |
Patrick J F |
PJF |
|
| Gudnason |
Vilmundur |
V |
|
| van der Harst |
Pim |
P |
|
| Hayward |
Caroline |
C |
|
| Hinds |
David A |
DA |
|
| Hoffmann |
Wolfgang |
W |
|
| Hyppönen |
Elina |
E |
|
| Iacono |
William G |
WG |
|
| Jacobsson |
Bo |
B |
|
| Järvelin |
Marjo-Riitta |
MR |
|
| Jöckel |
Karl-Heinz |
KH |
|
| Kaprio |
Jaakko |
J |
|
| Kardia |
Sharon L R |
SLR |
|
| Lehtimäki |
Terho |
T |
|
| Lehrer |
Steven F |
SF |
|
| Magnusson |
Patrik K E |
PKE |
|
| Martin |
Nicholas G |
NG |
|
| McGue |
Matt |
M |
|
| Metspalu |
Andres |
A |
|
| Pendleton |
Neil |
N |
|
| Penninx |
Brenda W J H |
BWJH |
|
| Perola |
Markus |
M |
|
| Pirastu |
Nicola |
N |
|
| Pirastu |
Mario |
M |
|
| Polasek |
Ozren |
O |
|
| Posthuma |
Danielle |
D |
|
| Power |
Christine |
C |
|
| Province |
Michael A |
MA |
|
| Samani |
Nilesh J |
NJ |
|
| Schlessinger |
David |
D |
|
| Schmidt |
Reinhold |
R |
|
| Sørensen |
Thorkild I A |
TIA |
|
| Spector |
Tim D |
TD |
|
| Stefansson |
Kari |
K |
|
| Thorsteinsdottir |
Unnur |
U |
|
| Thurik |
A Roy |
AR |
|
| Timpson |
Nicholas J |
NJ |
|
| Tiemeier |
Henning |
H |
|
| Tung |
Joyce Y |
JY |
|
| Uitterlinden |
André G |
AG |
|
| Vitart |
Veronique |
V |
|
| Vollenweider |
Peter |
P |
|
| Weir |
David R |
DR |
|
| Wilson |
James F |
JF |
|
| Wright |
Alan F |
AF |
|
| Conley |
Dalton C |
DC |
|
| Krueger |
Robert F |
RF |
|
| Smith |
George Davey |
GD |
|
| Hofman |
Albert |
A |
|
| Laibson |
David I |
DI |
|
| Medland |
Sarah E |
SE |
|
| Meyer |
Michelle N |
MN |
|
| Yang |
Jian |
J |
|
| Johannesson |
Magnus |
M |
|
| Visscher |
Peter M |
PM |
|
| Esko |
Tõnu |
T |
|
| Koellinger |
Philipp D |
PD |
|
| Cesarini |
David |
D |
|
| Benjamin |
Daniel J |
DJ |
|
|
| JOURNAL |
|
| VOLUME: 50 |
| ISSUE: 8 |
| TITLE: Nature genetics |
| ISOABBREVIATION: Nat Genet |
| YEAR: 2018 |
| MONTH: 07 |
| DAY: 23 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1546-1718 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Nat Genet |
| COUNTRY: United States |
| ISSNLINKING: 1061-4036 |
| NLMUNIQUEID: 9216904 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Meta-Analysis |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
Nat Rev Genet. 2018 Oct;19(10):592-593 |
30093724 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| G1001799 |
Medical Research Council |
United Kingdom |
| MR/N01104X/2 |
Medical Research Council |
United Kingdom |
| R01 HD073342 |
NICHD NIH HHS |
United States |
| L30 MH104879 |
NIMH NIH HHS |
United States |
| MR/K026992/1 |
Medical Research Council |
United Kingdom |
| MC_UU_12015/1 |
Medical Research Council |
United Kingdom |
| P30 AG010161 |
NIA NIH HHS |
United States |
| R01 AG055406 |
NIA NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
| R01 AG015819 |
NIA NIH HHS |
United States |
| 647648 |
European Research Council |
International |
| MC_UU_12015/2 |
Medical Research Council |
United Kingdom |
| P2C HD047879 |
NICHD NIH HHS |
United States |
| P2C HD066613 |
NICHD NIH HHS |
United States |
| BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| P01 AG005842 |
NIA NIH HHS |
United States |
| P2C HD050924 |
NICHD NIH HHS |
United States |
| G0600237 |
Medical Research Council |
United Kingdom |
| G0100594 |
Medical Research Council |
United Kingdom |
| P30 AG012810 |
NIA NIH HHS |
United States |
| R01 AG042568 |
NIA NIH HHS |
United States |
| T32 AG000186 |
NIA NIH HHS |
United States |
| BB/F022441/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| G0901461 |
Medical Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Cohort Studies |
|
| Educational Status |
|
| Female |
|
| Genome-Wide Association Study |
methods |
| Humans |
methods |
| Male |
methods |
| Middle Aged |
methods |
| Multifactorial Inheritance |
methods |
| Phenotype |
methods |
| Polymorphism, Single Nucleotide |
methods |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
