Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30001359
TITLE
Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts.
ABSTRACT
BACKGROUND
Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we analysed data from twin pairs in which the co-twins differed by their smoking behaviour to evaluate if the association between smoking and body mass index (BMI) remains after controlling for family background.
METHODS AND FINDINGS
Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we analysed data from twin pairs in which the co-twins differed by their smoking behaviour to evaluate if the association between smoking and body mass index (BMI) remains after controlling for family background. The international CODATwins database includes information on smoking and BMI measured between 1960 and 2012 from 156,593 twin individuals 18-69 years of age. Individual-based data (230,378 measurements) and data of smoking discordant twin pairs (altogether 30,014 pairwise measurements, 36% from monozygotic [MZ] pairs) were analysed with linear fixed-effects regression models by 10-year periods. In MZ pairs, the smoking co-twin had, on average, 0.57 kg/m2 lower BMI in men (95% confidence interval (CI): 0.49, 0.70) and 0.65 kg/m2 lower BMI in women (95% CI: 0.52, 0.79) than the never smoking co-twin. Former smokers had 0.70 kg/m2 higher BMI among men (95% CI: 0.63, 0.78) and 0.62 kg/m2 higher BMI among women (95% CI: 0.51, 0.73) than their currently smoking MZ co-twins. Little difference in BMI was observed when comparing former smoking co-twins with their never smoking MZ co-twins (0.13 kg/m2, 95% CI 0.04, 0.23 among men; -0.04 kg/m2, 95% CI -0.16, 0.09 among women). The associations were similar within dizygotic pairs and when analysing twins as individuals. The observed series of cross-sectional associations were independent of sex, age, and measurement decade.
CONCLUSIONS
Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we analysed data from twin pairs in which the co-twins differed by their smoking behaviour to evaluate if the association between smoking and body mass index (BMI) remains after controlling for family background. The international CODATwins database includes information on smoking and BMI measured between 1960 and 2012 from 156,593 twin individuals 18-69 years of age. Individual-based data (230,378 measurements) and data of smoking discordant twin pairs (altogether 30,014 pairwise measurements, 36% from monozygotic [MZ] pairs) were analysed with linear fixed-effects regression models by 10-year periods. In MZ pairs, the smoking co-twin had, on average, 0.57 kg/m2 lower BMI in men (95% confidence interval (CI): 0.49, 0.70) and 0.65 kg/m2 lower BMI in women (95% CI: 0.52, 0.79) than the never smoking co-twin. Former smokers had 0.70 kg/m2 higher BMI among men (95% CI: 0.63, 0.78) and 0.62 kg/m2 higher BMI among women (95% CI: 0.51, 0.73) than their currently smoking MZ co-twins. Little difference in BMI was observed when comparing former smoking co-twins with their never smoking MZ co-twins (0.13 kg/m2, 95% CI 0.04, 0.23 among men; -0.04 kg/m2, 95% CI -0.16, 0.09 among women). The associations were similar within dizygotic pairs and when analysing twins as individuals. The observed series of cross-sectional associations were independent of sex, age, and measurement decade. Smoking is associated with lower BMI and smoking cessation with higher BMI. However, the net effect of smoking and subsequent cessation on weight development appears to be minimal, i.e. never more than an average of 0.7 kg/m2.
DATE PUBLISHED
2018
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/01/30
accepted 2018/06/20
entrez 2018/07/13 06:00
pubmed 2018/07/13 06:00
medline 2019/01/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Piirtola M Piirtola Maarit M Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Jelenkovic A Jelenkovic Aline A Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Latvala A Latvala Antti A Department of Public Health, University of Helsinki, Helsinki, Finland.
Sund R Sund Reijo R Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Honda C Honda Chika C Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Inui F Inui Fujio F Faculty of Health Science, Kio University, Nara, Japan.
Watanabe M Watanabe Mikio M Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Tomizawa R Tomizawa Rie R Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Iwatani Y Iwatani Yoshinori Y Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Ordoñana JR Ordoñana Juan R JR IMIB-Arrixaca, Murcia, Spain.
Sánchez-Romera JF Sánchez-Romera Juan F JF Department of Developmental and Educational Psychology, University of Murcia, Murcia, Spain.
Colodro-Conde L Colodro-Conde Lucia L QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Tarnoki AD Tarnoki Adam D AD Hungarian Twin Registry, Budapest, Hungary.
Tarnoki DL Tarnoki David L DL Hungarian Twin Registry, Budapest, Hungary.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Rasmussen F Rasmussen Finn F Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Tynelius P Tynelius Per P Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Tan Q Tan Qihua Q Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Zhang D Zhang Dongfeng D Department of Public Health, Qingdao University Medical College, Qingdao, China.
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Rebato E Rebato Esther E Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Stazi MA Stazi Maria A MA Istituto Superiore di Sanità-Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Fagnani C Fagnani Corrado C Istituto Superiore di Sanità-Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Brescianini S Brescianini Sonia S Istituto Superiore di Sanità-Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Busjahn A Busjahn Andreas A HealthTwiSt GmbH, Berlin, Germany.
Harris JR Harris Jennifer R JR Norwegian Institute of Public Health, Oslo, Norway.
Brandt I Brandt Ingunn I Norwegian Institute of Public Health, Oslo, Norway.
Nilsen TS Nilsen Thomas Sevenius TS Norwegian Institute of Public Health, Oslo, Norway.
Cutler TL Cutler Tessa L TL Twins Research Australia, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia.
Hopper JL Hopper John L JL Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Corley RP Corley Robin P RP Institute for Behavioral Genetics, University of Colorado, Boulder, CO, United States of America.
Huibregtse BM Huibregtse Brooke M BM Institute for Behavioral Genetics, University of Colorado, Boulder, CO, United States of America.
Sung J Sung Joohon J Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Kim J Kim Jina J Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Lee J Lee Jooyeon J Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Lee S Lee Sooji S Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Gatz M Gatz Margaret M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Butler DA Butler David A DA Health and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, DC, United States of America.
Franz CE Franz Carol E CE Department of Psychiatry, University of California, San Diego, CA, United States of America.
Kremen WS Kremen William S WS VA San Diego Center of Excellence for Stress and Mental Health, La Jolla, CA, United States of America.
Lyons MJ Lyons Michael J MJ Department of Psychology, Boston University, Boston, MA, United States of America.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dahl Aslan AK Dahl Aslan Anna K AK Institute of Gerontology and Aging Research Network-Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.
Öncel SY Öncel Sevgi Y SY Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey.
Aliev F Aliev Fazil F Faculty of Business, Karabuk University, Karabuk, Turkey.
Derom CA Derom Catherine A CA Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Loos RJF Loos Ruth J F RJF The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States of America.
Maes HH Maes Hermine H HH Department of Human and Molecular Genetics, Psychiatry & Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, United States of America.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Sørensen TIA Sørensen Thorkild I A TIA Department of Public Health (Section of Epidemiology), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Korhonen T Korhonen Tellervo T Department of Public Health, University of Helsinki, Helsinki, Finland.
Kaprio J Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, Finland.
Silventoinen K Silventoinen Karri K Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
INVESTIGATORS
JOURNAL
VOLUME: 13
ISSUE: 7
TITLE: PloS one
ISOABBREVIATION: PLoS One
YEAR: 2018
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1932-6203
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS One
COUNTRY: United States
ISSNLINKING: 1932-6203
NLMUNIQUEID: 101285081
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
P60 DA011015 NIDA NIH HHS United States
R01 HD010333 NICHD NIH HHS United States
T32 AG052371 NIA NIH HHS United States
T32 DA017637 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Body Mass Index
Cohort Studies
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Smoking pathology
Smoking Cessation pathology
Twins, Dizygotic pathology
Twins, Monozygotic pathology
Young Adult pathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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Last Modified: Oct 15 2007