Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29845340
TITLE
Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project.
ABSTRACT
Childhood aggression and its resulting consequences inflict a huge burden on affected children, their relatives, teachers, peers and society as a whole. Aggression during childhood rarely occurs in isolation and is correlated with other symptoms of childhood psychopathology. In this paper, we aim to describe and improve the understanding of the co-occurrence of aggression with other forms of childhood psychopathology. We focus on the co-occurrence of aggression and other childhood behavioural and emotional problems, including other externalising problems, attention problems and anxiety-depression. The data were brought together within the EU-ACTION (Aggression in Children: unravelling gene-environment interplay to inform Treatment and InterventiON strategies) project. We analysed the co-occurrence of aggression and other childhood behavioural and emotional problems as a function of the child's age (ages 3 through 16 years), gender, the person rating the behaviour (father, mother or self) and assessment instrument. The data came from six large population-based European cohort studies from the Netherlands (2x), the UK, Finland and Sweden (2x). Multiple assessment instruments, including the Child Behaviour Checklist (CBCL), the Strengths and Difficulties Questionnaire (SDQ) and Multidimensional Peer Nomination Inventory (MPNI), were used. There was a good representation of boys and girls in each age category, with data for 30,523 3- to 4-year-olds (49.5% boys), 20,958 5- to 6-year-olds (49.6% boys), 18,291 7- to 8-year-olds (49.0% boys), 27,218 9- to 10-year-olds (49.4% boys), 18,543 12- to 13-year-olds (48.9% boys) and 10,088 15- to 16-year-olds (46.6% boys). We replicated the well-established gender differences in average aggression scores at most ages for parental ratings. The gender differences decreased with age and were not present for self-reports. Aggression co-occurred with the majority of other behavioural and social problems, from both externalising and internalising domains. At each age, the co-occurrence was particularly prevalent for aggression and oppositional and ADHD-related problems, with correlations of around 0.5 in general. Aggression also showed substantial associations with anxiety-depression and other internalizing symptoms (correlations around 0.4). Co-occurrence for self-reported problems was somewhat higher than for parental reports, but we found neither rater differences, nor differences across assessment instruments in co-occurrence patterns. There were large similarities in co-occurrence patterns across the different European countries. Finally, co-occurrence was generally stable across age and sex, and if any change was observed, it indicated stronger correlations when children grew older. We present an online tool to visualise these associations as a function of rater, gender, instrument and cohort. In addition, we present a description of the full EU-ACTION projects, its first results and the future perspectives.
DATE PUBLISHED
2018 May 29
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/01/27
accepted 2018/05/16
entrez 2018/05/31 06:00
pubmed 2018/05/31 06:00
medline 2018/05/31 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Bartels M Bartels Meike M Amsterdam Neuroscience, Amsterdam, The Netherlands. m.bartels@vu.nl.
Hendriks A Hendriks Anne A Amsterdam Public Health Research Institute, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Mauri M Mauri Matteo M University of Cagliari, Cagliari, Italy.
Krapohl E Krapohl Eva E Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Whipp A Whipp Alyce A Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Bolhuis K Bolhuis Koen K Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Conde LC Conde Lucia Colodro LC Psychiatric Genetics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Luningham J Luningham Justin J Department of Psychology, University of Notre Dame, Notre Dame, USA.
Fung Ip H Fung Ip Hill H Amsterdam Public Health Research Institute, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Hagenbeek F Hagenbeek Fiona F Amsterdam Public Health Research Institute, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Roetman P Roetman Peter P Curium-LUMC, Academic Centre of Child and Youth Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Gatej R Gatej Raluca R Curium-LUMC, Academic Centre of Child and Youth Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Lamers A Lamers Audri A Curium-LUMC, Academic Centre of Child and Youth Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Nivard M Nivard Michel M Amsterdam Public Health Research Institute, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
van Dongen J van Dongen Jenny J Amsterdam Public Health Research Institute, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Lu Y Lu Yi Y Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Middeldorp C Middeldorp Christel C University of Queensland, Brisbane, Australia.
van Beijsterveldt T van Beijsterveldt Toos T Amsterdam Public Health Research Institute, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Vermeiren R Vermeiren Robert R VU Medical Centre, Amsterdam, The Netherlands.
Hankemeijer T Hankemeijer Thomas T Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Kluft C Kluft Cees C Good Biomarker Sciences, Leiden, The Netherlands.
Medland S Medland Sarah S Psychiatric Genetics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Lundström S Lundström Sebastian S Centre for Ethics, Law and Mental Health (CELAM), University of Gothenburg, Gothenburg, Sweden.
Rose R Rose Richard R Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN, USA.
Pulkkinen L Pulkkinen Lea L Department of Psychology, University of Jyvaskyla, Jyvaskyla, Finland.
Vuoksimaa E Vuoksimaa Eero E Department of Public Health, University of Helsinki, Helsinki, Finland.
Korhonen T Korhonen Tellervo T Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Lubke G Lubke Gitta G Department of Psychology, University of Notre Dame, Notre Dame, USA.
Finkenauer C Finkenauer Catrin C Youth Studies, Interdisciplinary Center, Utrecht University, Utrecht, The Netherlands.
Fanos V Fanos Vassilios V University of Cagliari, Cagliari, Italy.
Tiemeier H Tiemeier Henning H Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.
Lichtenstein P Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Plomin R Plomin Robert R Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Kaprio J Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, Finland.
Boomsma DI Boomsma Dorret I DI Amsterdam Neuroscience, Amsterdam, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: European child & adolescent psychiatry
ISOABBREVIATION: Eur Child Adolesc Psychiatry
YEAR: 2018
MONTH: May
DAY: 29
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1435-165X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Eur Child Adolesc Psychiatry
COUNTRY: Germany
ISSNLINKING: 1018-8827
NLMUNIQUEID: 9212296
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
602768 FP7/2007-2013
480-04-004 Nederlandse Organisatie voor Wetenschappelijk Onderzoek
56-464-14192 Nederlandse Organisatie voor Wetenschappelijk Onderzoek
463-06-001 Nederlandse Organisatie voor Wetenschappelijk Onderzoek
451-04-034 Nederlandse Organisatie voor Wetenschappelijk Onderzoek
480-15-001/674 Nederlandse Organisatie voor Wetenschappelijk Onderzoek
912-10-020 ZonMw
PAH/6635 Koninklijke Nederlandse Akademie van Wetenschappen
201413 FP7-Heallth-F4-2007
AA-12502 National Institute on Drug Abuse
AA-00145 National Institute on Drug Abuse
AA-09203 National Institute on Drug Abuse
213506 Academy of Finland Center of Excellence Program
129680 Academy of Finland Center of Excellence Program
100499 Academy of Finland
205585 Academy of Finland
118555 Academy of Finland
141054 Academy of Finland
265240 Academy of Finland
263278 Academy of Finland
264146 Academy of Finland
CATSS Forskningsrådet för Arbetsliv och Socialvetenskap (SE)
TCHAD Forskningsrådet för Arbetsliv och Socialvetenskap (SE)
CATSS the Söderström-Königska Foundation
CATSS the Swedish Research Council
TCHAD the Swedish Research Council
MR/M021475/1 UK Medical Research Council
GenR Erasmus Medical Center, Rotterdam
GenR Netherlands Organization for Health Research and Development (ZonMw)
024.001.003 The Netherlands Organization for Scientific Research (NWO)
016.VICI.170.200 The Netherlands Organization for Scientific Research (NWO-ZonMw)
GENERAL NOTE
KEYWORDS
KEYWORD
Aggression
Behavioural and emotional problems
Childhood
Co-occurence
Comorbidity
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's