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PMID |
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TITLE |
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Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. |
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ABSTRACT |
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) but not between CCT and primary open-angle glaucoma (r = -0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2017/06/24 |
accepted |
2018/03/02 |
entrez |
2018/05/16 06:00 |
pubmed |
2018/05/16 06:00 |
medline |
2018/05/16 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Iglesias AI |
|
Iglesias |
Adriana I |
AI |
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Department of Clinical Genetics, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands. |
Mishra A |
|
Mishra |
Aniket |
A |
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University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000, Bordeaux, France. |
Vitart V |
|
Vitart |
Veronique |
V |
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Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, EH42XU, Edinburgh, UK. |
Bykhovskaya Y |
|
Bykhovskaya |
Yelena |
Y |
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Cornea Genetic Eye Institute, CA 90048, Los Angeles, CA, USA. |
Höhn R |
|
Höhn |
René |
R |
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Department of Ophthalmology, Inselspital, University Hospital Bern, University of Bern, Bern, CH-3010, Switzerland. |
Springelkamp H |
|
Springelkamp |
Henriët |
H |
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Department of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands. |
Cuellar-Partida G |
|
Cuellar-Partida |
Gabriel |
G |
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Statistical Genetics, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia. |
Gharahkhani P |
|
Gharahkhani |
Puya |
P |
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Statistical Genetics, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia. |
Bailey JNC |
|
Bailey |
Jessica N Cooke |
JNC |
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Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA. |
Willoughby CE |
|
Willoughby |
Colin E |
CE |
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Royal Victoria Hospital, Belfast Health and Social Care Trust, BT12 6BA, Belfast, Northern Ireland, UK. |
Li X |
|
Li |
Xiaohui |
X |
|
Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, CA, USA. |
Yazar S |
|
Yazar |
Seyhan |
S |
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Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, WA 6009, Perth, WA, Australia. |
Nag A |
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Nag |
Abhishek |
A |
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Department of Twin Research and Genetic Epidemiology, King's College London, WC2R 2LS, London, UK. |
Khawaja AP |
|
Khawaja |
Anthony P |
AP |
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NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, EC1V 9EL, London, UK. |
Polašek O |
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Polašek |
Ozren |
O |
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Faculty of Medicine, University of Split, HR-21000, Split, Croatia. |
Siscovick D |
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Siscovick |
David |
D |
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The New York Academy of Medicine, NY 10029, New York, NY, USA. |
Mitchell P |
|
Mitchell |
Paul |
P |
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Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, NSW 2145, Sydney, NSW, Australia. |
Tham YC |
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Tham |
Yih Chung |
YC |
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Singapore Eye Research Institute, Singapore National Eye Centre, 168751, Singapore, Singapore. |
Haines JL |
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Haines |
Jonathan L |
JL |
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Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA. |
Kearns LS |
|
Kearns |
Lisa S |
LS |
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Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, VIC 3002, East Melbourne, Australia. |
Hayward C |
|
Hayward |
Caroline |
C |
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Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, EH42XU, Edinburgh, UK. |
Shi Y |
|
Shi |
Yuan |
Y |
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Singapore Eye Research Institute, Singapore National Eye Centre, 168751, Singapore, Singapore. |
van Leeuwen EM |
|
van Leeuwen |
Elisabeth M |
EM |
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Department of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands. |
Taylor KD |
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Taylor |
Kent D |
KD |
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Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, CA, USA. |
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Blue Mountains Eye Study—GWAS group |
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|
|
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Bonnemaijer P |
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Bonnemaijer |
Pieter |
P |
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Department of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands. |
Rotter JI |
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Rotter |
Jerome I |
JI |
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Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, CA, USA. |
Martin NG |
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Martin |
Nicholas G |
NG |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia. |
Zeller T |
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Zeller |
Tanja |
T |
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German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246, Hamburg, Germany. |
Mills RA |
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Mills |
Richard A |
RA |
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Department of Ophthalmology, Flinders University, SA 5042, Adelaide, Australia. |
Staffieri SE |
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Staffieri |
Sandra E |
SE |
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Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, VIC 3002, East Melbourne, Australia. |
Jonas JB |
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Jonas |
Jost B |
JB |
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Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, 68167, Mannheim, Germany. |
Schmidtmann I |
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Schmidtmann |
Irene |
I |
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Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, 55131, Mainz, Germany. |
Boutin T |
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Boutin |
Thibaud |
T |
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Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, EH42XU, Edinburgh, UK. |
Kang JH |
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Kang |
Jae H |
JH |
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Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, MA, USA. |
Lucas SEM |
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Lucas |
Sionne E M |
SEM |
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Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7005, TAS, Australia. |
Wong TY |
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Wong |
Tien Yin |
TY |
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Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117549, Singapore. |
Beutel ME |
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Beutel |
Manfred E |
ME |
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Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Mainz, 55131, Germany. |
Wilson JF |
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Wilson |
James F |
JF |
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Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, EH16 4UX, Edinburgh, UK. |
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NEIGHBORHOOD Consortium |
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Wellcome Trust Case Control Consortium 2 (WTCCC2) |
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Uitterlinden AG |
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Uitterlinden |
André G |
AG |
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Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, 2593 HW, The Hague, The Netherlands. |
Vithana EN |
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Vithana |
Eranga N |
EN |
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Singapore Eye Research Institute, Singapore National Eye Centre, 168751, Singapore, Singapore. |
Foster PJ |
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Foster |
Paul J |
PJ |
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NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, EC1V 9EL, London, UK. |
Hysi PG |
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Hysi |
Pirro G |
PG |
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Department of Twin Research and Genetic Epidemiology, King's College London, WC2R 2LS, London, UK. |
Hewitt AW |
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Hewitt |
Alex W |
AW |
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School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7005, TAS, Australia. |
Khor CC |
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Khor |
Chiea Chuen |
CC |
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Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Singapore. |
Pasquale LR |
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Pasquale |
Louis R |
LR |
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Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, MA, USA. |
Montgomery GW |
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Montgomery |
Grant W |
GW |
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Institute for Molecular Bioscience, University of Queensland, QLD 4067, Brisbane, Australia. |
Klaver CCW |
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Klaver |
Caroline C W |
CCW |
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Department of Ophthalmology, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands. |
Aung T |
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Aung |
Tin |
T |
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Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117549, Singapore. |
Pfeiffer N |
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Pfeiffer |
Norbert |
N |
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Department of Ophthalmology, University Medical Center Mainz, 55131, Mainz, Germany. |
Mackey DA |
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Mackey |
David A |
DA |
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Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, WA 6009, Perth, WA, Australia. |
Hammond CJ |
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Hammond |
Christopher J |
CJ |
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Department of Twin Research and Genetic Epidemiology, King's College London, WC2R 2LS, London, UK. |
Cheng CY |
|
Cheng |
Ching-Yu |
CY |
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Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117549, Singapore. |
Craig JE |
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Craig |
Jamie E |
JE |
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Department of Ophthalmology, Flinders University, SA 5042, Adelaide, Australia. |
Rabinowitz YS |
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Rabinowitz |
Yaron S |
YS |
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Cornea Genetic Eye Institute, CA 90048, Los Angeles, CA, USA. |
Wiggs JL |
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Wiggs |
Janey L |
JL |
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Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, MA, USA. |
Burdon KP |
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Burdon |
Kathryn P |
KP |
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Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7005, TAS, Australia. |
van Duijn CM |
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van Duijn |
Cornelia M |
CM |
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Department of Epidemiology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands. |
MacGregor S |
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MacGregor |
Stuart |
S |
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Statistical Genetics, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia. Stuart.MacGregor@qimrberghofer.edu.au. |
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INVESTIGATORS |
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LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
Wang |
Jie Jin |
JJ |
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Rochtchina |
Elena |
E |
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Attia |
John |
J |
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Scott |
Rodney |
R |
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Holliday |
Elizabeth G |
EG |
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Wong |
Tien Yin |
TY |
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Baird |
Paul N |
PN |
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Xie |
Jing |
J |
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Inouye |
Michael |
M |
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Viswanathan |
Ananth |
A |
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Sim |
Xueling |
X |
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Allingham |
R Rand |
RR |
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Brilliant |
Murray H |
MH |
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Budenz |
Donald L |
DL |
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Christen |
William G |
WG |
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Fingert |
John |
J |
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Friedman |
David S |
DS |
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Gaasterland |
Douglas |
D |
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Gaasterland |
Terry |
T |
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Hauser |
Michael A |
MA |
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Kraft |
Peter |
P |
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Lee |
Richard K |
RK |
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Lichter |
Paul R |
PR |
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Liu |
Yutao |
Y |
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Loomis |
Stephanie J |
SJ |
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Moroi |
Sayoko E |
SE |
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Pericak-Vance |
Margaret A |
MA |
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Realini |
Anthony |
A |
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Richards |
Julia E |
JE |
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Schuman |
Joel S |
JS |
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Scott |
William K |
WK |
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Singh |
Kuldev |
K |
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Sit |
Arthur J |
AJ |
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Vollrath |
Douglas |
D |
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Weinreb |
Robert N |
RN |
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Wollstein |
Gadi |
G |
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Zack |
Donald J |
DJ |
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Zhang |
Kang |
K |
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Donnelly |
Peter |
P |
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Barroso |
Ines |
I |
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Blackwell |
Jenefer M |
JM |
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Bramon |
Elvira |
E |
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Brown |
Matthew A |
MA |
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Casas |
Juan P |
JP |
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Corvin |
Aiden |
A |
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Deloukas |
Panos |
P |
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Duncanson |
Audrey |
A |
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Jankowski |
Janusz |
J |
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Markus |
Hugh S |
HS |
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Mathew |
Christopher G |
CG |
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Palmer |
Colin N A |
CNA |
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Plomin |
Robert |
R |
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Rautanen |
Anna |
A |
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Sawcer |
Stephen J |
SJ |
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Trembath |
Richard C |
RC |
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Wood |
Nicholas W |
NW |
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Spencer |
Chris C A |
CCA |
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Band |
Gavin |
G |
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Bellenguez |
Céline |
C |
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Freeman |
Colin |
C |
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Hellenthal |
Garrett |
G |
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Giannoulatou |
Eleni |
E |
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Pirinen |
Matti |
M |
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Pearson |
Richard |
R |
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Strange |
Amy |
A |
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Su |
Zhan |
Z |
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Vukcevic |
Damjan |
D |
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Langford |
Cordelia |
C |
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Hunt |
Sarah E |
SE |
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Edkins |
Sarah |
S |
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Gwilliam |
Rhian |
R |
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Blackburn |
Hannah |
H |
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Bumpstead |
Suzannah J |
SJ |
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Dronov |
Serge |
S |
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Gillman |
Matthew |
M |
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Gray |
Emma |
E |
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Hammond |
Naomi |
N |
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Jayakumar |
Alagurevathi |
A |
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McCann |
Owen T |
OT |
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Liddle |
Jennifer |
J |
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Potter |
Simon C |
SC |
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Ravindrarajah |
Radhi |
R |
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Ricketts |
Michelle |
M |
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Waller |
Matthew |
M |
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Weston |
Paul |
P |
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Widaa |
Sara |
S |
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Whittaker |
Pamela |
P |
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JOURNAL |
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VOLUME: 9 |
ISSUE: 1 |
TITLE: Nature communications |
ISOABBREVIATION: Nat Commun |
YEAR: 2018 |
MONTH: May |
DAY: 14 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2041-1723 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Commun |
COUNTRY: England |
ISSNLINKING: 2041-1723 |
NLMUNIQUEID: 101528555 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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