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PMID |
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TITLE |
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Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and 'Omics' Studies. |
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ABSTRACT |
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Twin registers are wonderful research resources for research applications in medical and behavioral genetics, epidemiology, psychology, molecular genetics, and other areas of research. New registers continue to be launched all over the world as researchers from different disciplines recognize the potential to boost and widen their research agenda. In this article, we discuss multiple aspects that need to be taken into account when initiating a register, from its preliminary sketch to its actual development. This encompasses aspects related to the strategic planning and key elements of research designs, promotion and management of a twin register, including recruitment and retaining of twins and family members of twins, phenotyping, database organization, and collaborations between registers. We also present information on questions unique to twin registers and twin-biobanks, such as the assessment of zygosity by SNP arrays, the design of (biomarker) studies involving related participants, and the analyses of clustered data. Altogether, we provide a number of basic guidelines and recommendations for reflection when planning a twin register. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
entrez |
2018/05/11 06:00 |
pubmed |
2018/05/11 06:00 |
medline |
2018/05/11 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Odintsova VV |
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Odintsova |
Veronika V |
VV |
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Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands. |
Willemsen G |
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Willemsen |
Gonneke |
G |
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Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands. |
Dolan CV |
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Dolan |
Conor V |
CV |
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Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands. |
Hottenga JJ |
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Hottenga |
Jouke-Jan |
JJ |
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Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands. |
Martin NG |
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Martin |
Nicholas G |
NG |
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Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Australia. |
Slagboom PE |
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Slagboom |
P Eline |
PE |
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Department of Molecular Epidemiology,Leiden University Medical Centre,Leiden,the Netherlands. |
Ordoñana JR |
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Ordoñana |
Juan R |
JR |
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Department of Human Anatomy and Psychobiology,University of Murcia, andMurcia Institute for BioHealth Research (IMIB-Arrixaca-UMU),Murcia,Spain. |
Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: |
ISSUE: |
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
ISOABBREVIATION: Twin Res Hum Genet |
YEAR: 2018 |
MONTH: May |
DAY: 10 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1832-4274 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Twin Res Hum Genet |
COUNTRY: England |
ISSNLINKING: 1832-4274 |
NLMUNIQUEID: 101244624 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
recruitment |
twin register |
twin research |
zygosity determination |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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