Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29739929
TITLE
Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.
ABSTRACT
The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.
DATE PUBLISHED
2018 May 08
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/12/14
accepted 2018/04/03
entrez 2018/05/10 06:00
pubmed 2018/05/10 06:00
medline 2018/05/10 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Visconti A Visconti Alessia A Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Duffy DL Duffy David L DL QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Liu F Liu Fan F Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands.
Zhu G Zhu Gu G QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Wu W Wu Wenting W Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, Indianapolis, 46202, IN, USA.
Chen Y Chen Yan Y University of Chinese Academy of Sciences, Beijing, 100049, China.
Hysi PG Hysi Pirro G PG Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Zeng C Zeng Changqing C CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
Sanna M Sanna Marianna M Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Iles MM Iles Mark M MM Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, LS9 7TF, UK.
Kanetsky PA Kanetsky Peter A PA Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, 33612, FL, USA.
Demenais F Demenais Florence F Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, 75010, France.
Hamer MA Hamer Merel A MA Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands.
Uitterlinden AG Uitterlinden Andre G AG Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands.
Nijsten T Nijsten Tamar T Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Kayser M Kayser Manfred M Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Han J Han Jiali J Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, 02115, MA, USA.
Bataille V Bataille Veronique V Department of Dermatology, West Herts NHS Trust, Herts, HP2 4AD, UK.
Falchi M Falchi Mario M Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK. mario.falchi@kcl.ac.uk.
INVESTIGATORS
JOURNAL
VOLUME: 9
ISSUE: 1
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2018
MONTH: May
DAY: 08
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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