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PMID |
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TITLE |
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Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure. |
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ABSTRACT |
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The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2016/12/14 |
accepted |
2018/04/03 |
entrez |
2018/05/10 06:00 |
pubmed |
2018/05/10 06:00 |
medline |
2018/05/10 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Visconti A |
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Visconti |
Alessia |
A |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK. |
Duffy DL |
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Duffy |
David L |
DL |
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QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia. |
Liu F |
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Liu |
Fan |
F |
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Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands. |
Zhu G |
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Zhu |
Gu |
G |
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QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia. |
Wu W |
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Wu |
Wenting |
W |
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Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, Indianapolis, 46202, IN, USA. |
Chen Y |
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Chen |
Yan |
Y |
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University of Chinese Academy of Sciences, Beijing, 100049, China. |
Hysi PG |
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Hysi |
Pirro G |
PG |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK. |
Zeng C |
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Zeng |
Changqing |
C |
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CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. |
Sanna M |
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Sanna |
Marianna |
M |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK. |
Iles MM |
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Iles |
Mark M |
MM |
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Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, LS9 7TF, UK. |
Kanetsky PA |
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Kanetsky |
Peter A |
PA |
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Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, 33612, FL, USA. |
Demenais F |
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Demenais |
Florence |
F |
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Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, 75010, France. |
Hamer MA |
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Hamer |
Merel A |
MA |
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Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands. |
Uitterlinden AG |
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Uitterlinden |
Andre G |
AG |
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Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands. |
Ikram MA |
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Ikram |
M Arfan |
MA |
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Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands. |
Nijsten T |
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Nijsten |
Tamar |
T |
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Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands. |
Martin NG |
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Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia. |
Kayser M |
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Kayser |
Manfred |
M |
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Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3000 CA, The Netherlands. |
Spector TD |
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Spector |
Tim D |
TD |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK. |
Han J |
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Han |
Jiali |
J |
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Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, 02115, MA, USA. |
Bataille V |
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Bataille |
Veronique |
V |
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Department of Dermatology, West Herts NHS Trust, Herts, HP2 4AD, UK. |
Falchi M |
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Falchi |
Mario |
M |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK. mario.falchi@kcl.ac.uk. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 9 |
ISSUE: 1 |
TITLE: Nature communications |
ISOABBREVIATION: Nat Commun |
YEAR: 2018 |
MONTH: May |
DAY: 08 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2041-1723 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Commun |
COUNTRY: England |
ISSNLINKING: 2041-1723 |
NLMUNIQUEID: 101528555 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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