Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
29729685
TITLE
Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Prior research has documented shared heritable contributions to non-suicidal self-injury (NSSI) and suicidal ideation (SI) as well as NSSI and suicide attempt (SA). In addition, trauma exposure has been implicated in risk for NSSI and suicide. Genetically informative studies are needed to determine common sources of liability to all three self-injurious thoughts and behaviors, and to clarify the nature of their associations with traumatic experiences.
METHODS NlmCategory: METHODS
Multivariate biometric modeling was conducted using data from 9526 twins [59% female, mean age = 31.7 years (range 24-42)] from two cohorts of the Australian Twin Registry, some of whom also participated in the Childhood Trauma Study and the Nicotine Addiction Genetics Project.
RESULTS NlmCategory: RESULTS
The prevalences of high-risk trauma exposure (HRT), NSSI, SI, and SA were 24.4, 5.6, 27.1, and 4.6%, respectively. All phenotypes were moderately to highly correlated. Genetic influences on self-injurious thoughts and behaviors and HRT were significant and highly correlated among men [rG = 0.59, 95% confidence interval (CI) (0.37-0.81)] and women [rG = 0.56 (0.49-0.63)]. Unique environmental influences were modestly correlated in women [rE = 0.23 (0.01-0.45)], suggesting that high-risk trauma may confer some direct risk for self-injurious thoughts and behaviors among females.
CONCLUSIONS NlmCategory: CONCLUSIONS
Individuals engaging in NSSI are at increased risk for suicide, and common heritable factors contribute to these associations. Preventing trauma exposure may help to mitigate risk for self-harm and suicide, either directly or indirectly via reductions in liability to psychopathology more broadly. In addition, targeting pre-existing vulnerability factors could significantly reduce risk for life-threatening behaviors among those who have experienced trauma.
DATE PUBLISHED
2018 May 06
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2018/05/07 06:00
pubmed 2018/05/08 06:00
medline 2018/05/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Richmond-Rakerd LS Richmond-Rakerd Leah S LS Department of Psychology & Neuroscience,Duke University,Durham, NC,USA.
Trull TJ Trull Timothy J TJ Department of Psychological Sciences,University of Missouri,Columbia, MO,USA.
Gizer IR Gizer Ian R IR Department of Psychological Sciences,University of Missouri,Columbia, MO,USA.
McLaughlin K McLaughlin Kristin K Department of Psychological Sciences,University of Missouri,Columbia, MO,USA.
Scheiderer EM Scheiderer Emily M EM Department of Psychological Sciences,University of Missouri,Columbia, MO,USA.
Nelson EC Nelson Elliot C EC Department of Psychiatry,Washington University School of Medicine,St. Louis, MO,USA.
Agrawal A Agrawal Arpana A Department of Psychiatry,Washington University School of Medicine,St. Louis, MO,USA.
Lynskey MT Lynskey Michael T MT National Addiction Centre,Institute of Psychiatry, Psychology & Neuroscience, King's College London,London,UK.
Madden PAF Madden Pamela A F PAF Department of Psychiatry,Washington University School of Medicine,St. Louis, MO,USA.
Heath AC Heath Andrew C AC Department of Psychiatry,Washington University School of Medicine,St. Louis, MO,USA.
Statham DJ Statham Dixie J DJ University of the Sunshine Coast,Queensland,Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute,Brisbane,Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2018
MONTH: May
DAY: 06
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1469-8978
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
High-risk trauma
non-suicidal self-injury
suicidal ideation
suicide attempt
twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's