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| PMID |
|
|
| TITLE |
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| Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Prior research has documented shared heritable contributions to non-suicidal self-injury (NSSI) and suicidal ideation (SI) as well as NSSI and suicide attempt (SA). In addition, trauma exposure has been implicated in risk for NSSI and suicide. Genetically informative studies are needed to determine common sources of liability to all three self-injurious thoughts and behaviors, and to clarify the nature of their associations with traumatic experiences. |
| METHODS |
NlmCategory: METHODS |
| Multivariate biometric modeling was conducted using data from 9526 twins [59% female, mean age = 31.7 years (range 24-42)] from two cohorts of the Australian Twin Registry, some of whom also participated in the Childhood Trauma Study and the Nicotine Addiction Genetics Project. |
| RESULTS |
NlmCategory: RESULTS |
| The prevalences of high-risk trauma exposure (HRT), NSSI, SI, and SA were 24.4, 5.6, 27.1, and 4.6%, respectively. All phenotypes were moderately to highly correlated. Genetic influences on self-injurious thoughts and behaviors and HRT were significant and highly correlated among men [rG = 0.59, 95% confidence interval (CI) (0.37-0.81)] and women [rG = 0.56 (0.49-0.63)]. Unique environmental influences were modestly correlated in women [rE = 0.23 (0.01-0.45)], suggesting that high-risk trauma may confer some direct risk for self-injurious thoughts and behaviors among females. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Individuals engaging in NSSI are at increased risk for suicide, and common heritable factors contribute to these associations. Preventing trauma exposure may help to mitigate risk for self-harm and suicide, either directly or indirectly via reductions in liability to psychopathology more broadly. In addition, targeting pre-existing vulnerability factors could significantly reduce risk for life-threatening behaviors among those who have experienced trauma. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2018/05/07 06:00 |
| pubmed |
2018/05/08 06:00 |
| medline |
2018/05/08 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Richmond-Rakerd LS |
|
Richmond-Rakerd |
Leah S |
LS |
|
Department of Psychology & Neuroscience,Duke University,Durham, NC,USA. |
| Trull TJ |
|
Trull |
Timothy J |
TJ |
|
Department of Psychological Sciences,University of Missouri,Columbia, MO,USA. |
| Gizer IR |
|
Gizer |
Ian R |
IR |
|
Department of Psychological Sciences,University of Missouri,Columbia, MO,USA. |
| McLaughlin K |
|
McLaughlin |
Kristin |
K |
|
Department of Psychological Sciences,University of Missouri,Columbia, MO,USA. |
| Scheiderer EM |
|
Scheiderer |
Emily M |
EM |
|
Department of Psychological Sciences,University of Missouri,Columbia, MO,USA. |
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
Department of Psychiatry,Washington University School of Medicine,St. Louis, MO,USA. |
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
Department of Psychiatry,Washington University School of Medicine,St. Louis, MO,USA. |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
National Addiction Centre,Institute of Psychiatry, Psychology & Neuroscience, King's College London,London,UK. |
| Madden PAF |
|
Madden |
Pamela A F |
PAF |
|
Department of Psychiatry,Washington University School of Medicine,St. Louis, MO,USA. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Department of Psychiatry,Washington University School of Medicine,St. Louis, MO,USA. |
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
University of the Sunshine Coast,Queensland,Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute,Brisbane,Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Psychological medicine |
| ISOABBREVIATION: Psychol Med |
| YEAR: 2018 |
| MONTH: May |
| DAY: 06 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1469-8978 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Psychol Med |
| COUNTRY: England |
| ISSNLINKING: 0033-2917 |
| NLMUNIQUEID: 1254142 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| High-risk trauma |
| non-suicidal self-injury |
| suicidal ideation |
| suicide attempt |
| twins |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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