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PMID |
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TITLE |
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. |
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ABSTRACT |
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Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2017/07/28 |
accepted |
2018/02/14 |
pubmed |
2018/04/28 06:00 |
medline |
2019/04/25 06:00 |
entrez |
2018/04/28 06:00 |
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AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Wray NR |
|
Wray |
Naomi R |
NR |
|
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. naomi.wray@uq.edu.au. |
Ripke S |
|
Ripke |
Stephan |
S |
|
Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany. |
Mattheisen M |
|
Mattheisen |
Manuel |
M |
|
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. |
Trzaskowski M |
|
Trzaskowski |
Maciej |
M |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Byrne EM |
|
Byrne |
Enda M |
EM |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Abdellaoui A |
|
Abdellaoui |
Abdel |
A |
|
Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Adams MJ |
|
Adams |
Mark J |
MJ |
|
Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
Agerbo E |
|
Agerbo |
Esben |
E |
|
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark. |
Air TM |
|
Air |
Tracy M |
TM |
|
Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia. |
Andlauer TMF |
|
Andlauer |
Till M F |
TMF |
|
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. |
Bacanu SA |
|
Bacanu |
Silviu-Alin |
SA |
|
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. |
Bækvad-Hansen M |
|
Bækvad-Hansen |
Marie |
M |
|
Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. |
Beekman AFT |
|
Beekman |
Aartjan F T |
AFT |
|
Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands. |
Bigdeli TB |
|
Bigdeli |
Tim B |
TB |
|
Virginia Institute for Psychiatric and Behavior Genetics, Richmond, VA, USA. |
Binder EB |
|
Binder |
Elisabeth B |
EB |
|
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. |
Blackwood DRH |
|
Blackwood |
Douglas R H |
DRH |
|
Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
Bryois J |
|
Bryois |
Julien |
J |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Buttenschøn HN |
|
Buttenschøn |
Henriette N |
HN |
|
Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark. |
Bybjerg-Grauholm J |
|
Bybjerg-Grauholm |
Jonas |
J |
|
Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. |
Cai N |
|
Cai |
Na |
N |
|
Human Genetics, Wellcome Trust Sanger Institute, Cambridge, UK. |
Castelao E |
|
Castelao |
Enrique |
E |
|
Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland. |
Christensen JH |
|
Christensen |
Jane Hvarregaard |
JH |
|
iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark. |
Clarke TK |
|
Clarke |
Toni-Kim |
TK |
|
Division of Psychiatry, University of Edinburgh, Edinburgh, UK. |
Coleman JIR |
|
Coleman |
Jonathan I R |
JIR |
|
MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK. |
Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
|
Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
Couvy-Duchesne B |
|
Couvy-Duchesne |
Baptiste |
B |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia. |
Craddock N |
|
Craddock |
Nick |
N |
|
Psychological Medicine, Cardiff University, Cardiff, UK. |
Crawford GE |
|
Crawford |
Gregory E |
GE |
|
Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC, USA. |
Crowley CA |
|
Crowley |
Cheynna A |
CA |
|
Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
Dashti HS |
|
Dashti |
Hassan S |
HS |
|
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. |
Davies G |
|
Davies |
Gail |
G |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
Deary IJ |
|
Deary |
Ian J |
IJ |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
Degenhardt F |
|
Degenhardt |
Franziska |
F |
|
Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany. |
Derks EM |
|
Derks |
Eske M |
EM |
|
Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
Direk N |
|
Direk |
Nese |
N |
|
Epidemiology, Erasmus MC, Rotterdam, The Netherlands. |
Dolan CV |
|
Dolan |
Conor V |
CV |
|
Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Dunn EC |
|
Dunn |
Erin C |
EC |
|
Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA. |
Eley TC |
|
Eley |
Thalia C |
TC |
|
MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK. |
Eriksson N |
|
Eriksson |
Nicholas |
N |
|
Research, 23andMe, Inc., Mountain View, CA, USA. |
Escott-Price V |
|
Escott-Price |
Valentina |
V |
|
Neuroscience and Mental Health, Cardiff University, Cardiff, UK. |
Kiadeh FHF |
|
Kiadeh |
Farnush Hassan Farhadi |
FHF |
|
Bioinformatics, University of British Columbia, Vancouver, British Columbia, Canada. |
Finucane HK |
|
Finucane |
Hilary K |
HK |
|
Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA. |
Forstner AJ |
|
Forstner |
Andreas J |
AJ |
|
Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland. |
Frank J |
|
Frank |
Josef |
J |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Gaspar HA |
|
Gaspar |
Héléna A |
HA |
|
MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK. |
Gill M |
|
Gill |
Michael |
M |
|
Department of Psychiatry, Trinity College Dublin, Dublin, Ireland. |
Giusti-Rodríguez P |
|
Giusti-Rodríguez |
Paola |
P |
|
Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
Goes FS |
|
Goes |
Fernando S |
FS |
|
Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA. |
Gordon SD |
|
Gordon |
Scott D |
SD |
|
Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Grove J |
|
Grove |
Jakob |
J |
|
Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. |
Hall LS |
|
Hall |
Lynsey S |
LS |
|
Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK. |
Hannon E |
|
Hannon |
Eilis |
E |
|
University of Exeter Medical School, Exeter, UK. |
Hansen CS |
|
Hansen |
Christine Søholm |
CS |
|
Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. |
Hansen TF |
|
Hansen |
Thomas F |
TF |
|
iPSYCH, Lundbeck Foundation Initiative for Psychiatric Research, Copenhagen, Denmark. |
Herms S |
|
Herms |
Stefan |
S |
|
Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland. |
Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. |
Hoffmann P |
|
Hoffmann |
Per |
P |
|
Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland. |
Homuth G |
|
Homuth |
Georg |
G |
|
Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Germany. |
Horn C |
|
Horn |
Carsten |
C |
|
Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd, Basel, Switzerland. |
Hottenga JJ |
|
Hottenga |
Jouke-Jan |
JJ |
|
Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Hougaard DM |
|
Hougaard |
David M |
DM |
|
Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. |
Hu M |
|
Hu |
Ming |
M |
|
Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. |
Hyde CL |
|
Hyde |
Craig L |
CL |
|
Statistics, Pfizer Global Research and Development, Groton, CT, USA. |
Ising M |
|
Ising |
Marcus |
M |
|
Max Planck Institute of Psychiatry, Munich, Germany. |
Jansen R |
|
Jansen |
Rick |
R |
|
Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands. |
Jin F |
|
Jin |
Fulai |
F |
|
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA. |
Jorgenson E |
|
Jorgenson |
Eric |
E |
|
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. |
Knowles JA |
|
Knowles |
James A |
JA |
|
Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA. |
Kohane IS |
|
Kohane |
Isaac S |
IS |
|
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. |
Kraft J |
|
Kraft |
Julia |
J |
|
Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany. |
Kretzschmar WW |
|
Kretzschmar |
Warren W |
WW |
|
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. |
Krogh J |
|
Krogh |
Jesper |
J |
|
Department of Endocrinology at Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark. |
Kutalik Z |
|
Kutalik |
Zoltán |
Z |
|
Institute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne, Lausanne, Switzerland. |
Lane JM |
|
Lane |
Jacqueline M |
JM |
|
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA. |
Li Y |
|
Li |
Yihan |
Y |
|
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. |
Li Y |
|
Li |
Yun |
Y |
|
Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
Lind PA |
|
Lind |
Penelope A |
PA |
|
Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
Liu X |
|
Liu |
Xiaoxiao |
X |
|
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA. |
Lu L |
|
Lu |
Leina |
L |
|
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA. |
MacIntyre DJ |
|
MacIntyre |
Donald J |
DJ |
|
Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. |
MacKinnon DF |
|
MacKinnon |
Dean F |
DF |
|
Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA. |
Maier RM |
|
Maier |
Robert M |
RM |
|
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Maier W |
|
Maier |
Wolfgang |
W |
|
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. |
Marchini J |
|
Marchini |
Jonathan |
J |
|
Statistics, University of Oxford, Oxford, UK. |
Mbarek H |
|
Mbarek |
Hamdi |
H |
|
Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
McGrath P |
|
McGrath |
Patrick |
P |
|
Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA. |
McGuffin P |
|
McGuffin |
Peter |
P |
|
MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK. |
Medland SE |
|
Medland |
Sarah E |
SE |
|
Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
Mehta D |
|
Mehta |
Divya |
D |
|
School of Psychology and Counseling, Queensland University of Technology, Brisbane, Queensland, Australia. |
Middeldorp CM |
|
Middeldorp |
Christel M |
CM |
|
Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia. |
Mihailov E |
|
Mihailov |
Evelin |
E |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Milaneschi Y |
|
Milaneschi |
Yuri |
Y |
|
Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands. |
Milani L |
|
Milani |
Lili |
L |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Mill J |
|
Mill |
Jonathan |
J |
|
University of Exeter Medical School, Exeter, UK. |
Mondimore FM |
|
Mondimore |
Francis M |
FM |
|
Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Mostafavi S |
|
Mostafavi |
Sara |
S |
|
Statistics, University of British Columbia, Vancouver, British Columbia, Canada. |
Mullins N |
|
Mullins |
Niamh |
N |
|
MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK. |
Nauck M |
|
Nauck |
Matthias |
M |
|
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. |
Ng B |
|
Ng |
Bernard |
B |
|
Statistics, University of British Columbia, Vancouver, British Columbia, Canada. |
Nivard MG |
|
Nivard |
Michel G |
MG |
|
Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. |
O'Reilly PF |
|
O'Reilly |
Paul F |
PF |
|
MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK. |
Oskarsson H |
|
Oskarsson |
Hogni |
H |
|
Humus, Reykjavik, Iceland. |
Owen MJ |
|
Owen |
Michael J |
MJ |
|
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. |
Painter JN |
|
Painter |
Jodie N |
JN |
|
Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. |
Pedersen CB |
|
Pedersen |
Carsten Bøcker |
CB |
|
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark. |
Pedersen MG |
|
Pedersen |
Marianne Giørtz |
MG |
|
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark. |
Peterson RE |
|
Peterson |
Roseann E |
RE |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. |
Pettersson E |
|
Pettersson |
Erik |
E |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Peyrot WJ |
|
Peyrot |
Wouter J |
WJ |
|
Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands. |
Pistis G |
|
Pistis |
Giorgio |
G |
|
Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland. |
Posthuma D |
|
Posthuma |
Danielle |
D |
|
Clinical Genetics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. |
Purcell SM |
|
Purcell |
Shaun M |
SM |
|
Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA. |
Quiroz JA |
|
Quiroz |
Jorge A |
JA |
|
Solid Biosciences, Boston, MA, USA. |
Qvist P |
|
Qvist |
Per |
P |
|
iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark. |
Rice JP |
|
Rice |
John P |
JP |
|
Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. |
Riley BP |
|
Riley |
Brien P |
BP |
|
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. |
Rivera M |
|
Rivera |
Margarita |
M |
|
Department of Biochemistry and Molecular Biology II, Institute of Neurosciences, Center for Biomedical Research, University of Granada, Granada, Spain. |
Saeed Mirza S |
|
Saeed Mirza |
Saira |
S |
|
Epidemiology, Erasmus MC, Rotterdam, The Netherlands. |
Saxena R |
|
Saxena |
Richa |
R |
|
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA. |
Schoevers R |
|
Schoevers |
Robert |
R |
|
Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. |
Schulte EC |
|
Schulte |
Eva C |
EC |
|
Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany. |
Shen L |
|
Shen |
Ling |
L |
|
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. |
Shi J |
|
Shi |
Jianxin |
J |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. |
Shyn SI |
|
Shyn |
Stanley I |
SI |
|
Behavioral Health Services, Kaiser Permanente Washington, Seattle, WA, USA. |
Sigurdsson E |
|
Sigurdsson |
Engilbert |
E |
|
Faculty of Medicine, Department of Psychiatry, University of Iceland, Reykjavik, Iceland. |
Sinnamon GBC |
|
Sinnamon |
Grant B C |
GBC |
|
School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia. |
Smit JH |
|
Smit |
Johannes H |
JH |
|
Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands. |
Smith DJ |
|
Smith |
Daniel J |
DJ |
|
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK. |
Stefansson H |
|
Stefansson |
Hreinn |
H |
|
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. |
Steinberg S |
|
Steinberg |
Stacy |
S |
|
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. |
Stockmeier CA |
|
Stockmeier |
Craig A |
CA |
|
Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA. |
Streit F |
|
Streit |
Fabian |
F |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Strohmaier J |
|
Strohmaier |
Jana |
J |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Tansey KE |
|
Tansey |
Katherine E |
KE |
|
College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK. |
Teismann H |
|
Teismann |
Henning |
H |
|
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. |
Teumer A |
|
Teumer |
Alexander |
A |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
Thompson W |
|
Thompson |
Wesley |
W |
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Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. |
Thomson PA |
|
Thomson |
Pippa A |
PA |
|
Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK. |
Thorgeirsson TE |
|
Thorgeirsson |
Thorgeir E |
TE |
|
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. |
Tian C |
|
Tian |
Chao |
C |
|
Research, 23andMe, Inc., Mountain View, CA, USA. |
Traylor M |
|
Traylor |
Matthew |
M |
|
Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
Treutlein J |
|
Treutlein |
Jens |
J |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Trubetskoy V |
|
Trubetskoy |
Vassily |
V |
|
Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany. |
Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. |
Umbricht D |
|
Umbricht |
Daniel |
D |
|
Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery and Translational Medicine Area, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd, Basel, Switzerland. |
Van der Auwera S |
|
Van der Auwera |
Sandra |
S |
|
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. |
van Hemert AM |
|
van Hemert |
Albert M |
AM |
|
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. |
Viktorin A |
|
Viktorin |
Alexander |
A |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Visscher PM |
|
Visscher |
Peter M |
PM |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Wang Y |
|
Wang |
Yunpeng |
Y |
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KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. |
Webb BT |
|
Webb |
Bradley T |
BT |
|
Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. |
Weinsheimer SM |
|
Weinsheimer |
Shantel Marie |
SM |
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Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark. |
Wellmann J |
|
Wellmann |
Jürgen |
J |
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Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. |
Willemsen G |
|
Willemsen |
Gonneke |
G |
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Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Witt SH |
|
Witt |
Stephanie H |
SH |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Wu Y |
|
Wu |
Yang |
Y |
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Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Xi HS |
|
Xi |
Hualin S |
HS |
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Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA. |
Yang J |
|
Yang |
Jian |
J |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Zhang F |
|
Zhang |
Futao |
F |
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Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
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eQTLGen |
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23andMe |
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Arolt V |
|
Arolt |
Volker |
V |
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Department of Psychiatry, University of Münster, Munster, Germany. |
Baune BT |
|
Baune |
Bernhard T |
BT |
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Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia. |
Berger K |
|
Berger |
Klaus |
K |
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Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. |
Boomsma DI |
|
Boomsma |
Dorret I |
DI |
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Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Cichon S |
|
Cichon |
Sven |
S |
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Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland. |
Dannlowski U |
|
Dannlowski |
Udo |
U |
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Department of Psychiatry, University of Münster, Munster, Germany. |
de Geus ECJ |
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de Geus |
E C J |
ECJ |
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Amsterdam Public Health Institute, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. |
DePaulo JR |
|
DePaulo |
J Raymond |
JR |
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Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA. |
Domenici E |
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Domenici |
Enrico |
E |
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Centre for Integrative Biology, Università degli Studi di Trento, Trento, Italy. |
Domschke K |
|
Domschke |
Katharina |
K |
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Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. |
Esko T |
|
Esko |
Tõnu |
T |
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Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Grabe HJ |
|
Grabe |
Hans J |
HJ |
|
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. |
Hamilton SP |
|
Hamilton |
Steven P |
SP |
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Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, USA. |
Hayward C |
|
Hayward |
Caroline |
C |
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MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Heath AC |
|
Heath |
Andrew C |
AC |
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Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. |
Hinds DA |
|
Hinds |
David A |
DA |
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Research, 23andMe, Inc., Mountain View, CA, USA. |
Kendler KS |
|
Kendler |
Kenneth S |
KS |
|
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. |
Kloiber S |
|
Kloiber |
Stefan |
S |
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Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. |
Lewis G |
|
Lewis |
Glyn |
G |
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Division of Psychiatry, University College London, London, UK. |
Li QS |
|
Li |
Qingqin S |
QS |
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Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA. |
Lucae S |
|
Lucae |
Susanne |
S |
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Max Planck Institute of Psychiatry, Munich, Germany. |
Madden PFA |
|
Madden |
Pamela F A |
PFA |
|
Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. |
Magnusson PK |
|
Magnusson |
Patrik K |
PK |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
McIntosh AM |
|
McIntosh |
Andrew M |
AM |
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Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
Metspalu A |
|
Metspalu |
Andres |
A |
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Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. |
Mors O |
|
Mors |
Ole |
O |
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Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, Denmark. |
Mortensen PB |
|
Mortensen |
Preben Bo |
PB |
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National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark. |
Müller-Myhsok B |
|
Müller-Myhsok |
Bertram |
B |
|
Institute of Translational Medicine, University of Liverpool, Liverpool, UK. |
Nordentoft M |
|
Nordentoft |
Merete |
M |
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Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. |
Nöthen MM |
|
Nöthen |
Markus M |
MM |
|
Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany. |
O'Donovan MC |
|
O'Donovan |
Michael C |
MC |
|
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. |
Paciga SA |
|
Paciga |
Sara A |
SA |
|
Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA. |
Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Penninx BWJH |
|
Penninx |
Brenda W J H |
BWJH |
|
Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands. |
Perlis RH |
|
Perlis |
Roy H |
RH |
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Psychiatry, Harvard Medical School, Boston, MA, USA. |
Porteous DJ |
|
Porteous |
David J |
DJ |
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Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK. |
Potash JB |
|
Potash |
James B |
JB |
|
Psychiatry, University of Iowa, Iowa City, IA, USA. |
Preisig M |
|
Preisig |
Martin |
M |
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Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland. |
Rietschel M |
|
Rietschel |
Marcella |
M |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. |
Schaefer C |
|
Schaefer |
Catherine |
C |
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Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. |
Schulze TG |
|
Schulze |
Thomas G |
TG |
|
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany. |
Smoller JW |
|
Smoller |
Jordan W |
JW |
|
Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA. |
Stefansson K |
|
Stefansson |
Kari |
K |
|
Faculty of Medicine, University of Iceland, Reykjavik, Iceland. |
Tiemeier H |
|
Tiemeier |
Henning |
H |
|
Psychiatry, Erasmus MC, Rotterdam, The Netherlands. |
Uher R |
|
Uher |
Rudolf |
R |
|
Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. |
Völzke H |
|
Völzke |
Henry |
H |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
Weissman MM |
|
Weissman |
Myrna M |
MM |
|
Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. |
Werge T |
|
Werge |
Thomas |
T |
|
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. |
Winslow AR |
|
Winslow |
Ashley R |
AR |
|
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
Lewis CM |
|
Lewis |
Cathryn M |
CM |
|
Department of Medical and Molecular Genetics, King's College London, London, UK. |
Levinson DF |
|
Levinson |
Douglas F |
DF |
|
Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. |
Breen G |
|
Breen |
Gerome |
G |
|
NIHR BRC for Mental Health, King's College London, London, UK. |
Børglum AD |
|
Børglum |
Anders D |
AD |
|
iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark. |
Sullivan PF |
|
Sullivan |
Patrick F |
PF |
|
Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu. |
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Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium |
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INVESTIGATORS |
|
|
JOURNAL |
|
VOLUME: 50 |
ISSUE: 5 |
TITLE: Nature genetics |
ISOABBREVIATION: Nat Genet |
YEAR: 2018 |
MONTH: 05 |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1718 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Meta-Analysis |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
|
COMMENTS AND CORRECTIONS |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
U01 MH085520 |
NIMH NIH HHS |
United States |
P50 CA097007 |
NCI NIH HHS |
United States |
U01 MH046276 |
NIMH NIH HHS |
United States |
MC_QA137853 |
Medical Research Council |
United Kingdom |
MR/K026992/1 |
Medical Research Council |
United Kingdom |
R01 MH067257 |
NIMH NIH HHS |
United States |
R01 MH059587 |
NIMH NIH HHS |
United States |
MC_PC_U127561128 |
Medical Research Council |
United Kingdom |
R01 MH059586 |
NIMH NIH HHS |
United States |
P50 CA093459 |
NCI NIH HHS |
United States |
U01 MH109528 |
NIMH NIH HHS |
United States |
R01 MH060879 |
NIMH NIH HHS |
United States |
R01 MH061675 |
NIMH NIH HHS |
United States |
MC_UU_00007/10 |
Medical Research Council |
United Kingdom |
MR/N015746/1 |
Medical Research Council |
United Kingdom |
R01 CA133996 |
NCI NIH HHS |
United States |
T32 HL007901 |
NHLBI NIH HHS |
United States |
R01 ES011740 |
NIEHS NIH HHS |
United States |
U01 MH079469 |
NIMH NIH HHS |
United States |
R01 MH060870 |
NIMH NIH HHS |
United States |
R01 MH081800 |
NIMH NIH HHS |
United States |
R01 DA034076 |
NIDA NIH HHS |
United States |
R01 MH059571 |
NIMH NIH HHS |
United States |
G0200243 |
Medical Research Council |
United Kingdom |
R01 MH059565 |
NIMH NIH HHS |
United States |
U01 MH109536 |
NIMH NIH HHS |
United States |
U01 MH079470 |
NIMH NIH HHS |
United States |
R01 HG009658 |
NHGRI NIH HHS |
United States |
U01 MH109532 |
NIMH NIH HHS |
United States |
R01 MH059566 |
NIMH NIH HHS |
United States |
K01 MH109772 |
NIMH NIH HHS |
United States |
U01 MH094421 |
NIMH NIH HHS |
United States |
P30 GM103328 |
NIGMS NIH HHS |
United States |
MC_PC_17228 |
Medical Research Council |
United Kingdom |
S10 OD018164 |
NIH HHS |
United States |
R01 MH059588 |
NIMH NIH HHS |
United States |
U01 MH046318 |
NIMH NIH HHS |
United States |
MR/L023784/2 |
Medical Research Council |
United Kingdom |
MR/L010305/1 |
Medical Research Council |
United Kingdom |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Case-Control Studies |
|
Depressive Disorder, Major |
genetics |
Female |
genetics |
Genetic Predisposition to Disease |
genetics |
Genome-Wide Association Study |
methods |
Humans |
methods |
Male |
methods |
Multifactorial Inheritance |
methods |
Phenotype |
methods |
Polymorphism, Single Nucleotide |
methods |
Risk Factors |
methods |
Schizophrenia |
genetics |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
|
OTHER ID's |
|
|
|