Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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29700475
TITLE
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
ABSTRACT
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
DATE PUBLISHED
2018 05
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/07/28
accepted 2018/02/14
pubmed 2018/04/28 06:00
medline 2019/04/25 06:00
entrez 2018/04/28 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wray NR Wray Naomi R NR Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. naomi.wray@uq.edu.au.
Ripke S Ripke Stephan S Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany.
Mattheisen M Mattheisen Manuel M Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Trzaskowski M Trzaskowski Maciej M Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Byrne EM Byrne Enda M EM Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Abdellaoui A Abdellaoui Abdel A Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Adams MJ Adams Mark J MJ Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Agerbo E Agerbo Esben E National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Air TM Air Tracy M TM Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia.
Andlauer TMF Andlauer Till M F TMF Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Bacanu SA Bacanu Silviu-Alin SA Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Bækvad-Hansen M Bækvad-Hansen Marie M Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Beekman AFT Beekman Aartjan F T AFT Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Bigdeli TB Bigdeli Tim B TB Virginia Institute for Psychiatric and Behavior Genetics, Richmond, VA, USA.
Binder EB Binder Elisabeth B EB Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Blackwood DRH Blackwood Douglas R H DRH Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Bryois J Bryois Julien J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Buttenschøn HN Buttenschøn Henriette N HN Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark.
Bybjerg-Grauholm J Bybjerg-Grauholm Jonas J Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Cai N Cai Na N Human Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.
Castelao E Castelao Enrique E Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland.
Christensen JH Christensen Jane Hvarregaard JH iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Clarke TK Clarke Toni-Kim TK Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Coleman JIR Coleman Jonathan I R JIR MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Colodro-Conde L Colodro-Conde Lucía L Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Couvy-Duchesne B Couvy-Duchesne Baptiste B Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
Craddock N Craddock Nick N Psychological Medicine, Cardiff University, Cardiff, UK.
Crawford GE Crawford Gregory E GE Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC, USA.
Crowley CA Crowley Cheynna A CA Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Dashti HS Dashti Hassan S HS Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Davies G Davies Gail G Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Degenhardt F Degenhardt Franziska F Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.
Derks EM Derks Eske M EM Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Direk N Direk Nese N Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Dolan CV Dolan Conor V CV Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Dunn EC Dunn Erin C EC Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA.
Eley TC Eley Thalia C TC MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Eriksson N Eriksson Nicholas N Research, 23andMe, Inc., Mountain View, CA, USA.
Escott-Price V Escott-Price Valentina V Neuroscience and Mental Health, Cardiff University, Cardiff, UK.
Kiadeh FHF Kiadeh Farnush Hassan Farhadi FHF Bioinformatics, University of British Columbia, Vancouver, British Columbia, Canada.
Finucane HK Finucane Hilary K HK Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Forstner AJ Forstner Andreas J AJ Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Frank J Frank Josef J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gaspar HA Gaspar Héléna A HA MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Gill M Gill Michael M Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
Giusti-Rodríguez P Giusti-Rodríguez Paola P Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Goes FS Goes Fernando S FS Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Gordon SD Gordon Scott D SD Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Grove J Grove Jakob J Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Hall LS Hall Lynsey S LS Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
Hannon E Hannon Eilis E University of Exeter Medical School, Exeter, UK.
Hansen CS Hansen Christine Søholm CS Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Hansen TF Hansen Thomas F TF iPSYCH, Lundbeck Foundation Initiative for Psychiatric Research, Copenhagen, Denmark.
Herms S Herms Stefan S Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Hickie IB Hickie Ian B IB Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Hoffmann P Hoffmann Per P Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
Horn C Horn Carsten C Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd, Basel, Switzerland.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Hougaard DM Hougaard David M DM Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Hu M Hu Ming M Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Hyde CL Hyde Craig L CL Statistics, Pfizer Global Research and Development, Groton, CT, USA.
Ising M Ising Marcus M Max Planck Institute of Psychiatry, Munich, Germany.
Jansen R Jansen Rick R Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Jin F Jin Fulai F Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Jorgenson E Jorgenson Eric E Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Knowles JA Knowles James A JA Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Kohane IS Kohane Isaac S IS Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Kraft J Kraft Julia J Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany.
Kretzschmar WW Kretzschmar Warren W WW Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Krogh J Krogh Jesper J Department of Endocrinology at Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark.
Kutalik Z Kutalik Zoltán Z Institute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne, Lausanne, Switzerland.
Lane JM Lane Jacqueline M JM Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Li Y Li Yihan Y Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Li Y Li Yun Y Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lind PA Lind Penelope A PA Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Liu X Liu Xiaoxiao X Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Lu L Lu Leina L Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
MacIntyre DJ MacIntyre Donald J DJ Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
MacKinnon DF MacKinnon Dean F DF Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Maier RM Maier Robert M RM Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Maier W Maier Wolfgang W Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Marchini J Marchini Jonathan J Statistics, University of Oxford, Oxford, UK.
Mbarek H Mbarek Hamdi H Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
McGrath P McGrath Patrick P Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA.
McGuffin P McGuffin Peter P MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Medland SE Medland Sarah E SE Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Mehta D Mehta Divya D School of Psychology and Counseling, Queensland University of Technology, Brisbane, Queensland, Australia.
Middeldorp CM Middeldorp Christel M CM Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia.
Mihailov E Mihailov Evelin E Estonian Genome Center, University of Tartu, Tartu, Estonia.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, Estonia.
Mill J Mill Jonathan J University of Exeter Medical School, Exeter, UK.
Mondimore FM Mondimore Francis M FM Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Mostafavi S Mostafavi Sara S Statistics, University of British Columbia, Vancouver, British Columbia, Canada.
Mullins N Mullins Niamh N MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Nauck M Nauck Matthias M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Ng B Ng Bernard B Statistics, University of British Columbia, Vancouver, British Columbia, Canada.
Nivard MG Nivard Michel G MG Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Nyholt DR Nyholt Dale R DR Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
O'Reilly PF O'Reilly Paul F PF MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Oskarsson H Oskarsson Hogni H Humus, Reykjavik, Iceland.
Owen MJ Owen Michael J MJ MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Painter JN Painter Jodie N JN Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Pedersen CB Pedersen Carsten Bøcker CB National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Pedersen MG Pedersen Marianne Giørtz MG National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Peterson RE Peterson Roseann E RE Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Pettersson E Pettersson Erik E Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Peyrot WJ Peyrot Wouter J WJ Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Pistis G Pistis Giorgio G Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland.
Posthuma D Posthuma Danielle D Clinical Genetics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
Purcell SM Purcell Shaun M SM Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Quiroz JA Quiroz Jorge A JA Solid Biosciences, Boston, MA, USA.
Qvist P Qvist Per P iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Rice JP Rice John P JP Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Riley BP Riley Brien P BP Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Rivera M Rivera Margarita M Department of Biochemistry and Molecular Biology II, Institute of Neurosciences, Center for Biomedical Research, University of Granada, Granada, Spain.
Saeed Mirza S Saeed Mirza Saira S Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Saxena R Saxena Richa R Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Schoevers R Schoevers Robert R Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Schulte EC Schulte Eva C EC Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany.
Shen L Shen Ling L Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Shi J Shi Jianxin J Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Shyn SI Shyn Stanley I SI Behavioral Health Services, Kaiser Permanente Washington, Seattle, WA, USA.
Sigurdsson E Sigurdsson Engilbert E Faculty of Medicine, Department of Psychiatry, University of Iceland, Reykjavik, Iceland.
Sinnamon GBC Sinnamon Grant B C GBC School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.
Smit JH Smit Johannes H JH Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Smith DJ Smith Daniel J DJ Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Stefansson H Stefansson Hreinn H deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Steinberg S Steinberg Stacy S deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Stockmeier CA Stockmeier Craig A CA Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Streit F Streit Fabian F Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Strohmaier J Strohmaier Jana J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Tansey KE Tansey Katherine E KE College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Teismann H Teismann Henning H Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Thompson W Thompson Wesley W Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Thomson PA Thomson Pippa A PA Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK.
Thorgeirsson TE Thorgeirsson Thorgeir E TE deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Tian C Tian Chao C Research, 23andMe, Inc., Mountain View, CA, USA.
Traylor M Traylor Matthew M Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Treutlein J Treutlein Jens J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Trubetskoy V Trubetskoy Vassily V Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany.
Uitterlinden AG Uitterlinden André G AG Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Umbricht D Umbricht Daniel D Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery and Translational Medicine Area, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd, Basel, Switzerland.
Van der Auwera S Van der Auwera Sandra S Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
van Hemert AM van Hemert Albert M AM Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Viktorin A Viktorin Alexander A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Visscher PM Visscher Peter M PM Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Wang Y Wang Yunpeng Y KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Webb BT Webb Bradley T BT Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Weinsheimer SM Weinsheimer Shantel Marie SM Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.
Wellmann J Wellmann Jürgen J Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Willemsen G Willemsen Gonneke G Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Witt SH Witt Stephanie H SH Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Wu Y Wu Yang Y Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Xi HS Xi Hualin S HS Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA.
Yang J Yang Jian J Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Zhang F Zhang Futao F Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
eQTLGen
23andMe
Arolt V Arolt Volker V Department of Psychiatry, University of Münster, Munster, Germany.
Baune BT Baune Bernhard T BT Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia.
Berger K Berger Klaus K Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Cichon S Cichon Sven S Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Dannlowski U Dannlowski Udo U Department of Psychiatry, University of Münster, Munster, Germany.
de Geus ECJ de Geus E C J ECJ Amsterdam Public Health Institute, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
DePaulo JR DePaulo J Raymond JR Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Domenici E Domenici Enrico E Centre for Integrative Biology, Università degli Studi di Trento, Trento, Italy.
Domschke K Domschke Katharina K Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Esko T Esko Tõnu T Estonian Genome Center, University of Tartu, Tartu, Estonia.
Grabe HJ Grabe Hans J HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Hamilton SP Hamilton Steven P SP Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, USA.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Hinds DA Hinds David A DA Research, 23andMe, Inc., Mountain View, CA, USA.
Kendler KS Kendler Kenneth S KS Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Kloiber S Kloiber Stefan S Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Lewis G Lewis Glyn G Division of Psychiatry, University College London, London, UK.
Li QS Li Qingqin S QS Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.
Lucae S Lucae Susanne S Max Planck Institute of Psychiatry, Munich, Germany.
Madden PFA Madden Pamela F A PFA Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Magnusson PK Magnusson Patrik K PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Martin NG Martin Nicholas G NG Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
McIntosh AM McIntosh Andrew M AM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Metspalu A Metspalu Andres A Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Mors O Mors Ole O Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, Denmark.
Mortensen PB Mortensen Preben Bo PB National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Müller-Myhsok B Müller-Myhsok Bertram B Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Nordentoft M Nordentoft Merete M Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
Nöthen MM Nöthen Markus M MM Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.
O'Donovan MC O'Donovan Michael C MC MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Paciga SA Paciga Sara A SA Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Perlis RH Perlis Roy H RH Psychiatry, Harvard Medical School, Boston, MA, USA.
Porteous DJ Porteous David J DJ Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK.
Potash JB Potash James B JB Psychiatry, University of Iowa, Iowa City, IA, USA.
Preisig M Preisig Martin M Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland.
Rietschel M Rietschel Marcella M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Schaefer C Schaefer Catherine C Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Schulze TG Schulze Thomas G TG Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Smoller JW Smoller Jordan W JW Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Tiemeier H Tiemeier Henning H Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
Uher R Uher Rudolf R Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Weissman MM Weissman Myrna M MM Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.
Werge T Werge Thomas T Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Winslow AR Winslow Ashley R AR Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lewis CM Lewis Cathryn M CM Department of Medical and Molecular Genetics, King's College London, London, UK.
Levinson DF Levinson Douglas F DF Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Breen G Breen Gerome G NIHR BRC for Mental Health, King's College London, London, UK.
Børglum AD Børglum Anders D AD iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Sullivan PF Sullivan Patrick F PF Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu.
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
INVESTIGATORS
JOURNAL
VOLUME: 50
ISSUE: 5
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2018
MONTH: 05
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
U01 MH085520 NIMH NIH HHS United States
P50 CA097007 NCI NIH HHS United States
U01 MH046276 NIMH NIH HHS United States
MC_QA137853 Medical Research Council United Kingdom
MR/K026992/1 Medical Research Council United Kingdom
R01 MH067257 NIMH NIH HHS United States
R01 MH059587 NIMH NIH HHS United States
MC_PC_U127561128 Medical Research Council United Kingdom
R01 MH059586 NIMH NIH HHS United States
P50 CA093459 NCI NIH HHS United States
U01 MH109528 NIMH NIH HHS United States
R01 MH060879 NIMH NIH HHS United States
R01 MH061675 NIMH NIH HHS United States
MC_UU_00007/10 Medical Research Council United Kingdom
MR/N015746/1 Medical Research Council United Kingdom
R01 CA133996 NCI NIH HHS United States
T32 HL007901 NHLBI NIH HHS United States
R01 ES011740 NIEHS NIH HHS United States
U01 MH079469 NIMH NIH HHS United States
R01 MH060870 NIMH NIH HHS United States
R01 MH081800 NIMH NIH HHS United States
R01 DA034076 NIDA NIH HHS United States
R01 MH059571 NIMH NIH HHS United States
G0200243 Medical Research Council United Kingdom
R01 MH059565 NIMH NIH HHS United States
U01 MH109536 NIMH NIH HHS United States
U01 MH079470 NIMH NIH HHS United States
R01 HG009658 NHGRI NIH HHS United States
U01 MH109532 NIMH NIH HHS United States
R01 MH059566 NIMH NIH HHS United States
K01 MH109772 NIMH NIH HHS United States
U01 MH094421 NIMH NIH HHS United States
P30 GM103328 NIGMS NIH HHS United States
MC_PC_17228 Medical Research Council United Kingdom
S10 OD018164 NIH HHS United States
R01 MH059588 NIMH NIH HHS United States
U01 MH046318 NIMH NIH HHS United States
MR/L023784/2 Medical Research Council United Kingdom
MR/L010305/1 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Case-Control Studies
Depressive Disorder, Major genetics
Female genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study methods
Humans methods
Male methods
Multifactorial Inheritance methods
Phenotype methods
Polymorphism, Single Nucleotide methods
Risk Factors methods
Schizophrenia genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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Last Modified: Oct 15 2007