|
|
| PMID |
|
|
| TITLE |
|
| Extended Twin Study of Alcohol Use in Virginia and Australia. |
|
| ABSTRACT |
|
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|
| Drinking alcohol is a normal behavior in many societies, and prior studies have demonstrated it has both genetic and environmental sources of variation. Using two very large samples of twins and their first-degree relatives (Australia ≈ 20,000 individuals from 8,019 families; Virginia ≈ 23,000 from 6,042 families), we examine whether there are differences: (1) in the genetic and environmental factors that influence four interrelated drinking behaviors (quantity, frequency, age of initiation, and number of drinks in the last week), (2) between the twin-only design and the extended twin design, and (3) the Australian and Virginia samples. We find that while drinking behaviors are interrelated, there are substantial differences in the genetic and environmental architectures across phenotypes. Specifically, drinking quantity, frequency, and number of drinks in the past week have large broad genetic variance components, and smaller but significant environmental variance components, while age of onset is driven exclusively by environmental factors. Further, the twin-only design and the extended twin design come to similar conclusions regarding broad-sense heritability and environmental transmission, but the extended twin models provide a more nuanced perspective. Finally, we find a high level of similarity between the Australian and Virginian samples, especially for the genetic factors. The observed differences, when present, tend to be at the environmental level. Implications for the extended twin model and future directions are discussed. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2018/04/26 06:00 |
| medline |
2018/12/12 06:00 |
| entrez |
2018/04/26 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Verhulst B |
|
Verhulst |
Brad |
B |
|
Department of Psychology,Michigan State University,East Lansing,MI,USA. |
| Neale MC |
|
Neale |
Michael C |
MC |
|
Department of Psychiatry and Department of Human Genetics,Virginia Commonwealth University,Richmond,VA,USA. |
| Eaves LJ |
|
Eaves |
Lindon J |
LJ |
|
Department of Psychiatry and Department of Human Genetics,Virginia Commonwealth University,Richmond,VA,USA. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Department of Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Royal Brisbane Hospital,Brisbane,Australia. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Department of Psychiatry Washington University,St. Louis,MO,USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Department of Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Royal Brisbane Hospital,Brisbane,Australia. |
| Maes HH |
|
Maes |
Hermine H |
HH |
|
Department of Psychiatry and Department of Human Genetics,Virginia Commonwealth University,Richmond,VA,USA. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 21 |
| ISSUE: 3 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2018 |
| MONTH: 06 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 DA018673 |
NIDA NIH HHS |
United States |
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| GENERAL NOTE |
|
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| KEYWORDS |
|
| KEYWORD |
| age of drinking onset |
| broad-sense heritability |
| drinking frequency |
| drinking quantity |
| extended twin model |
| number of drinks in the last week |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Age of Onset |
|
| Alcohol Drinking |
genetics |
| Australia |
epidemiology |
| Female |
epidemiology |
| Humans |
epidemiology |
| Male |
epidemiology |
| Middle Aged |
epidemiology |
| Models, Biological |
epidemiology |
| Twins |
genetics |
| Virginia |
epidemiology |
|
| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
|
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| CHEMICALS |
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| OTHER ID's |
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|
