Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29608257
TITLE
Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.
ABSTRACT
, OR = 1.11, 95% CI = 1.07-1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross-disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases.
2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
DATE PUBLISHED
2018 Apr 02
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/10/09
revised 2018/01/17
accepted 2018/01/21
entrez 2018/04/03 06:00
pubmed 2018/04/03 06:00
medline 2018/04/03 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Painter JN Painter Jodie N JN Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
O'Mara TA O'Mara Tracy A TA Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Morris AP Morris Andrew P AP Department of Biostatistics, University of Liverpool, Liverpool, UK.
Cheng THT Cheng Timothy H T THT Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Gorman M Gorman Maggie M Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Martin L Martin Lynn L Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Hodson S Hodson Shirley S Department of Clinical Genetics, St George's, University of London, London, UK.
Jones A Jones Angela A Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Martin NG Martin Nicholas G NG Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gordon S Gordon Scott S Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Henders AK Henders Anjali K AK Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Attia J Attia John J Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
McEvoy M McEvoy Mark M Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Holliday EG Holliday Elizabeth G EG Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Scott RJ Scott Rodney J RJ Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia.
Webb PM Webb Penelope M PM QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Fasching PA Fasching Peter A PA David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California.
Beckmann MW Beckmann Matthias W MW Department of Gynaecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Ekici AB Ekici Arif B AB Institute of Human Genetics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Hein A Hein Alexander A Department of Gynaecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Rübner M Rübner Matthias M Department of Gynaecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Hall P Hall Per P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Czene K Czene Kamila K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dörk T Dörk Thilo T Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Dürst M Dürst Matthias M Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Hillemanns P Hillemanns Peter P Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Runnebaum I Runnebaum Ingo I Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Lambrechts D Lambrechts Diether D Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.
Amant F Amant Frederic F Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
Annibali D Annibali Daniela D Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
Depreeuw J Depreeuw Jeroen J Vesalius Research Center, VIB, Leuven, Belgium.
Vanderstichele A Vanderstichele Adriaan A Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
Goode EL Goode Ellen L EL Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Cunningham JM Cunningham Julie M JM Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Dowdy SC Dowdy Sean C SC Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, Minnesota.
Winham SJ Winham Stacey J SJ Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Trovik J Trovik Jone J Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Hoivik E Hoivik Erling E Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Werner HMJ Werner Henrica M J HMJ Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Krakstad C Krakstad Camilla C Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Ashton K Ashton Katie K Centre for Information Based Medicine, University of Newcastle, Callaghan, New South Wales, Australia.
Otton G Otton Geoffrey G School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Proietto T Proietto Tony T School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Tham E Tham Emma E Clinical Genetics, Karolinska Institutet, Stockholm, Sweden.
Mints M Mints Miriam M Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Ahmed S Ahmed Shahana S Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Healey CS Healey Catherine S CS Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Shah M Shah Mitul M Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Pharoah PDP Pharoah Paul D P PDP Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Dunning AM Dunning Alison M AM Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Dennis J Dennis Joe J Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Bolla MK Bolla Manjeet K MK Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Michailidou K Michailidou Kyriaki K Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Wang Q Wang Qin Q Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Tyrer JP Tyrer Jonathan P JP Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Peto J Peto Julian J Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Swerdlow AJ Swerdlow Anthony J AJ Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Burwinkel B Burwinkel Barbara B Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brenner H Brenner Hermann H German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Meindl A Meindl Alfons A Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Brauch H Brauch Hiltrud H University of Tübingen, Tübingen, Germany.
Lindblom A Lindblom Annika A Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Chang-Claude J Chang-Claude Jenny J Research Group Genetic Cancer Epidemiology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Couch FJ Couch Fergus J FJ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Giles GG Giles Graham G GG Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Kristensen VN Kristensen Vessela N VN Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway.
Cox A Cox Angela A Department of Oncology and Metabolism, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, UK.
Zondervan KT Zondervan Krina T KT Department of Obstetrics & Gynaecology, Endometriosis CaRe Centre, Nuffield, University of Oxford, Oxford, UK.
Nyholt DR Nyholt Dale R DR Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, Queensland, Australia.
MacGregor S MacGregor Stuart S Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Tomlinson I Tomlinson Ian I Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Easton DF Easton Douglas F DF Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Thompson DJ Thompson Deborah J DJ Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Spurdle AB Spurdle Amanda B AB Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Cancer medicine
ISOABBREVIATION: Cancer Med
YEAR: 2018
MONTH: Apr
DAY: 02
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2045-7634
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Cancer Med
COUNTRY: United States
ISSNLINKING: 2045-7634
NLMUNIQUEID: 101595310
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Cross-disease analysis
endometrial cancer
endometriosis
genetic correlation
genome-wide association study
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's