|
|
| PMID |
|
|
| TITLE |
|
| Nineteen and Up study (19Up): understanding pathways to mental health disorders in young Australian twins. |
|
| ABSTRACT |
|
| PURPOSE |
|
| The Nineteen and Up study (19Up) assessed a range of mental health and behavioural problems and associated risk factors in a genetically informative Australian cohort of young adult twins and their non-twin siblings. As such, 19Up enables detailed investigation of genetic and environmental pathways to mental illness and substance misuse within the Brisbane Longitudinal Twin Sample (BLTS). |
| PARTICIPANTS |
|
| The Nineteen and Up study (19Up) assessed a range of mental health and behavioural problems and associated risk factors in a genetically informative Australian cohort of young adult twins and their non-twin siblings. As such, 19Up enables detailed investigation of genetic and environmental pathways to mental illness and substance misuse within the Brisbane Longitudinal Twin Sample (BLTS). Twins and their non-twin siblings from Queensland, Australia; mostly from European ancestry. Data were collected between 2009 and 2016 on 2773 participants (age range 18-38, 57.8% female, 372 complete monozygotic pairs, 493 dizygotic pairs, 640 non-twin siblings, 403 singleton twins). |
| FINDINGS TO DATE |
|
| The Nineteen and Up study (19Up) assessed a range of mental health and behavioural problems and associated risk factors in a genetically informative Australian cohort of young adult twins and their non-twin siblings. As such, 19Up enables detailed investigation of genetic and environmental pathways to mental illness and substance misuse within the Brisbane Longitudinal Twin Sample (BLTS). Twins and their non-twin siblings from Queensland, Australia; mostly from European ancestry. Data were collected between 2009 and 2016 on 2773 participants (age range 18-38, 57.8% female, 372 complete monozygotic pairs, 493 dizygotic pairs, 640 non-twin siblings, 403 singleton twins). A structured clinical assessment (Composite International Diagnostic Interview) was used to collect lifetime prevalence of diagnostic statistical manual (4th edition) (DSM-IV) diagnoses of major depressive disorder, (hypo)mania, social anxiety, cannabis use disorder, alcohol use disorder, panic disorder and psychotic symptoms. Here, we further describe the comorbidities and ages of onset for these mental disorders. Notably, two-thirds of the sample reported one or more lifetime mental disorder.In addition, the 19Up study assessed general health, drug use, work activity, education level, personality, migraine/headaches, suicidal thoughts, attention deficit hyperactivity disorder (ADHD) symptomatology, sleep-wake patterns, romantic preferences, friendships, familial environment, stress, anorexia and bulimia as well as baldness, acne, asthma, endometriosis, joint flexibility and internet use.The overlap with previous waves of the BLTS means that 84% of the 19Up participants are genotyped, 36% imaged using multimodal MRI and most have been assessed for psychological symptoms at up to four time points. Furthermore, IQ is available for 57%, parental report of ADHD symptomatology for 100% and electroencephalography for 30%. |
| FUTURE PLANS |
|
| The Nineteen and Up study (19Up) assessed a range of mental health and behavioural problems and associated risk factors in a genetically informative Australian cohort of young adult twins and their non-twin siblings. As such, 19Up enables detailed investigation of genetic and environmental pathways to mental illness and substance misuse within the Brisbane Longitudinal Twin Sample (BLTS). Twins and their non-twin siblings from Queensland, Australia; mostly from European ancestry. Data were collected between 2009 and 2016 on 2773 participants (age range 18-38, 57.8% female, 372 complete monozygotic pairs, 493 dizygotic pairs, 640 non-twin siblings, 403 singleton twins). A structured clinical assessment (Composite International Diagnostic Interview) was used to collect lifetime prevalence of diagnostic statistical manual (4th edition) (DSM-IV) diagnoses of major depressive disorder, (hypo)mania, social anxiety, cannabis use disorder, alcohol use disorder, panic disorder and psychotic symptoms. Here, we further describe the comorbidities and ages of onset for these mental disorders. Notably, two-thirds of the sample reported one or more lifetime mental disorder.In addition, the 19Up study assessed general health, drug use, work activity, education level, personality, migraine/headaches, suicidal thoughts, attention deficit hyperactivity disorder (ADHD) symptomatology, sleep-wake patterns, romantic preferences, friendships, familial environment, stress, anorexia and bulimia as well as baldness, acne, asthma, endometriosis, joint flexibility and internet use.The overlap with previous waves of the BLTS means that 84% of the 19Up participants are genotyped, 36% imaged using multimodal MRI and most have been assessed for psychological symptoms at up to four time points. Furthermore, IQ is available for 57%, parental report of ADHD symptomatology for 100% and electroencephalography for 30%. The 19Up study complements a phenotypically rich, longitudinal collection of environmental and psychological risk factors. Future publications will explore hypotheses related to disease onset and development across the waves of the cohort. A follow-up study at 25+years is ongoing. |
| © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2018/03/19 06:00 |
| pubmed |
2018/03/20 06:00 |
| medline |
2018/09/12 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Couvy-Duchesne B |
|
Couvy-Duchesne |
Baptiste |
B |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| O'Callaghan V |
|
O'Callaghan |
Victoria |
V |
|
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. |
| Parker R |
|
Parker |
Richard |
R |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Mills N |
|
Mills |
Natalie |
N |
|
School of Medicine, University of Adelaide, Adelaide, South Australia, Australia. |
| Kirk KM |
|
Kirk |
Katherine M |
KM |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Scott J |
|
Scott |
Jan |
J |
|
Institute of Neuroscience, Newcastle University, Newcastle, UK. |
| Vinkhuyzen A |
|
Vinkhuyzen |
Anna |
A |
|
Institute of Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. |
| Hermens DF |
|
Hermens |
Daniel F |
DF |
|
Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. |
| Lind PA |
|
Lind |
Penelope A |
PA |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Davenport TA |
|
Davenport |
Tracey A |
TA |
|
Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. |
| Burns JM |
|
Burns |
Jane M |
JM |
|
Young and Well CRC, University of Melbourne, Melbourne, Victoria, Australia. |
| Connell M |
|
Connell |
Melissa |
M |
|
UQCCR, The University of Queensland, Brisbane, Queensland, Australia. |
| Zietsch BP |
|
Zietsch |
Brendan P |
BP |
|
School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. |
| Scott J |
|
Scott |
James |
J |
|
UQCCR, The University of Queensland, Brisbane, Queensland, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| McGrath J |
|
McGrath |
John |
J |
|
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 8 |
| ISSUE: 3 |
| TITLE: BMJ open |
| ISOABBREVIATION: BMJ Open |
| YEAR: 2018 |
| MONTH: 03 |
| DAY: 17 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2044-6055 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: BMJ Open |
| COUNTRY: England |
| ISSNLINKING: 2044-6055 |
| NLMUNIQUEID: 101552874 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| K99 DA023549 |
NIDA NIH HHS |
United States |
| R00 DA023549 |
NIDA NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| R21 DA038852 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| comorbidity |
| prevalence |
| substance misuse |
| twins |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Comorbidity |
|
| Diseases in Twins |
metabolism |
| Female |
metabolism |
| Genome-Wide Association Study |
metabolism |
| Humans |
metabolism |
| Hydrocortisone |
analysis |
| Longitudinal Studies |
analysis |
| Male |
analysis |
| Mental Disorders |
metabolism |
| Prevalence |
metabolism |
| Queensland |
epidemiology |
| Risk Factors |
epidemiology |
| Sex Factors |
epidemiology |
| Vitamin D |
blood |
| Young Adult |
blood |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 1406-16-2 |
Vitamin D |
| WI4X0X7BPJ |
Hydrocortisone |
|
| OTHER ID's |
|
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|
