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| PMID |
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| TITLE |
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| Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design. |
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| ABSTRACT |
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| BACKGROUND |
NlmCategory: BACKGROUND |
| The genetic component of Cannabis Use Disorder may overlap with influences acting more generally on early stages of cannabis use. This paper aims to determine the extent to which genetic influences on the development of cannabis abuse/dependence are correlated with those acting on the opportunity to use cannabis and frequency of use. |
| METHODS |
NlmCategory: METHODS |
| A cross-sectional study of 3303 Australian twins, measuring age of onset of cannabis use opportunity, lifetime frequency of cannabis use, and lifetime DSM-IV cannabis abuse/dependence. A trivariate Cholesky decomposition estimated additive genetic (A), shared environment (C) and unique environment (E) contributions to the opportunity to use cannabis, the frequency of cannabis use, cannabis abuse/dependence, and the extent of overlap between genetic and environmental factors associated with each phenotype. |
| RESULTS |
NlmCategory: RESULTS |
| Variance components estimates were A = 0.64 [95% confidence interval (CI) 0.58-0.70] and E = 0.36 (95% CI 0.29-0.42) for age of opportunity to use cannabis, A = 0.74 (95% CI 0.66-0.80) and E = 0.26 (95% CI 0.20-0.34) for cannabis use frequency, and A = 0.78 (95% CI 0.65-0.88) and E = 0.22 (95% CI 0.12-0.35) for cannabis abuse/dependence. Opportunity shares 45% of genetic influences with the frequency of use, and only 17% of additive genetic influences are unique to abuse/dependence from those acting on opportunity and frequency. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| There are significant genetic contributions to lifetime cannabis abuse/dependence, but a large proportion of this overlaps with influences acting on opportunity and frequency of use. Individuals without drug use opportunity are uninformative, and studies of drug use disorders must incorporate individual exposure to accurately identify aetiology. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2018/03/14 06:00 |
| pubmed |
2018/03/14 06:00 |
| medline |
2018/03/14 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hines LA |
|
Hines |
Lindsey A |
LA |
|
Addictions Department,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England. |
| Morley KI |
|
Morley |
Katherine I |
KI |
|
Addictions Department,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England. |
| Rijsdijk F |
|
Rijsdijk |
Fruhling |
F |
|
Social Genetic and Developmental Psychiatry Centre,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England. |
| Strang J |
|
Strang |
John |
J |
|
Addictions Department,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England. |
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA. |
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA. |
| Statham D |
|
Statham |
Dixie |
D |
|
School of Social Sciences,University of the Sunshine Coast,Queensland,Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Addictions Department,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Psychological medicine |
| ISOABBREVIATION: Psychol Med |
| YEAR: 2018 |
| MONTH: Mar |
| DAY: 13 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1469-8978 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Psychol Med |
| COUNTRY: England |
| ISSNLINKING: 0033-2917 |
| NLMUNIQUEID: 1254142 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Abuse |
| addiction |
| behavioural genetics |
| cannabis |
| dependence |
| frequency |
| opportunity |
| twins |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| CHEMICALS |
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