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| PMID |
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| TITLE |
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| Lingual Gyrus Surface Area Is Associated with Anxiety-Depression Severity in Young Adults: A Genetic Clustering Approach. |
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| ABSTRACT |
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| Here we aimed to identify cortical endophenotypes for anxiety-depression. Our data-driven approach used vertex-wise genetic correlations (estimated from a twin sample: 157 monozygotic and 194 dizygotic twin pairs) to parcellate cortical thickness (CT) and surface area (SA) into genetically homogeneous regions (Chen et al., 2013). In an overlapping twin and sibling sample (n = 834; aged 15-29, 66% female), in those with anxiety-depression Somatic and Psychological Health Report (SPHERE) scores (Hickie et al., 2001) above median, we found a reduction of SA in an occipito-temporal cluster, which comprised part of the right lingual, fusiform and parahippocampal gyrii. A similar reduction was observed in the Human Connectome Project (HCP) sample (n = 890, age 22-37, 56.5% female) in those with Adult Self Report (ASR) DSM-oriented scores (Achenbach et al., 2005) in the 25-95% quantiles. A post hoc vertex-wise analysis identified the right lingual and, to a lesser extent the fusiform gyrus. Overall, the surface reduction explained by the anxiety-depression scores was modest (r = -0.10, 3rd order spline, and r = -0.040, 1st order spline in the HCP). The discordant results in the top 5% of the anxiety-depression scores may be explained by differences in recruitment between the studies. However, we could not conclude whether this cortical region was an endophenotype for anxiety-depression as the genetic correlations did not reach significance, which we attribute to the modest effect size (post hoc statistical power <10%). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2017/05/08 |
| revised |
2017/12/21 |
| accepted |
2017/12/25 |
| entrez |
2018/01/23 06:00 |
| pubmed |
2018/01/23 06:00 |
| medline |
2018/01/23 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Couvy-Duchesne B |
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Couvy-Duchesne |
Baptiste |
B |
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Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia. |
| Strike LT |
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Strike |
Lachlan T |
LT |
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Queensland Brain Institute, University of Queensland, Brisbane 4072, Australia. |
| de Zubicaray GI |
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de Zubicaray |
Greig I |
GI |
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Institute of Health Biomedical Innovations, Queensland Institute of Technology, Brisbane 4006, Australia. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
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Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
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Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA 90292. |
| Hickie IB |
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Hickie |
Ian B |
IB |
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Brain and Mind Research Institute, University of Sydney, Sydney 2050, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia. |
| Wright MJ |
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Wright |
Margaret J |
MJ |
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Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 5 |
| ISSUE: 1 |
| TITLE: eNeuro |
| ISOABBREVIATION: eNeuro |
| YEAR: |
| MONTH: |
| DAY: |
| MEDLINEDATE: 2018 Jan-Feb |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2373-2822 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: eNeuro |
| COUNTRY: United States |
| ISSNLINKING: 2373-2822 |
| NLMUNIQUEID: 101647362 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| cortical surface area |
| depression anxiety |
| endophenotype |
| genetic clustering |
| lingual gyrus |
| nonlinear effect |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| CHEMICALS |
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