Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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29331681
TITLE
Endogenous cortisol in keratinized matrices: Systematic determination of baseline cortisol levels in hair and the influence of sex, age and hair color.
ABSTRACT
The measurement of hair cortisol is increasingly used to measure long-term cumulative cortisol levels and investigate its role as an important stress mediator. In this study a comparative statistical analysis of five independent studies (all analyzed in our laboratory) was performed to investigate baseline ranges of cortisol values in hair and evaluate potential influences of sex, age and hair color. Cortisol concentrations in hair of 554 subjects were measured and a comparative statistical analysis was performed. The analysis showed that cortisol levels significantly differ depending on age. The toddler group (7 months (0.6 years) to 3 years) showed significantly higher values (median 10pg/mg, p-value<0.0001, d=0.78) than the adolescent group. The adolescent groups showed significantly lower (p-value<0.0001, d=0.58 and p<0.0001, d=0.13) values (median 2.4pg/mg and 2.8pg/mg) than the adult group (median 5.8pg/mg). Furthermore, in the adult group men showed significantly higher cortisol values than women (p-value<0.05, d=0.17). This effect could not be seen in the adolescent group. Black hair showed higher cortisol concentrations than blond hair (p-value<0.0001, d=1.3). In addition, two rounds of interlaboratory comparisons for hair cortisol samples between four laboratories revealed very consistent results. Our results demonstrate that baseline cortisol levels are generally low in hair thus making a standardized and well-elaborated analytical method indispensable for accurate determination. Age-dependent normative baseline cortisol levels (toddlers, adolescents and adults) are highly recommended based on the comparative analysis comprising five independent studies.
Copyright © 2018 Elsevier B.V. All rights reserved.
DATE PUBLISHED
2017 Dec 24
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/09/25
revised 2017/12/15
accepted 2017/12/16
entrez 2018/01/15 06:00
pubmed 2018/01/15 06:00
medline 2018/01/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Binz TM Binz T M TM Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. Electronic address: TinaMaria.Binz@irm.uzh.ch.
Rietschel L Rietschel L L SRH University Heidelberg, Academy for Psychotherapy, Heidelberg, Germany.
Streit F Streit F F Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Hofmann M Hofmann M M Swiss Federal Institute for Forest, Snow and Landscape Research, Birmensdorf, Switzerland.
Gehrke J Gehrke J J Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.
Herdener M Herdener M M Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Quednow BB Quednow B B BB Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Martin NG Martin N G NG Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia.
Rietschel M Rietschel M M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Kraemer T Kraemer T T Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.
Baumgartner MR Baumgartner M R MR Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.
INVESTIGATORS
JOURNAL
VOLUME: 284
ISSUE:
TITLE: Forensic science international
ISOABBREVIATION: Forensic Sci. Int.
YEAR: 2017
MONTH: Dec
DAY: 24
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1872-6283
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Forensic Sci Int
COUNTRY: Ireland
ISSNLINKING: 0379-0738
NLMUNIQUEID: 7902034
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Age
Endogenous hair cortisol
Hair color
LC–MS/MS
Sex
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's