Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29273807
TITLE
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
ABSTRACT
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are ~10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed ~7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
DATE PUBLISHED
2018 01
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/08/14
accepted 2017/11/15
entrez 2017/12/24 06:00
pubmed 2017/12/24 06:00
medline 2019/04/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Turcot V Turcot Valérie V Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Lu Y Lu Yingchang Y Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Highland HM Highland Heather M HM Human Genetics Center, University of Texas School of Public Health, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
Schurmann C Schurmann Claudia C Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Justice AE Justice Anne E AE Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Fine RS Fine Rebecca S RS Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.
Bradfield JP Bradfield Jonathan P JP Quantinuum Research, LLC, San Diego, CA, USA.
Esko T Esko Tõnu T Estonian Genome Center, University of Tartu, Tartu, Estonia.
Giri A Giri Ayush A Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
Graff M Graff Mariaelisa M Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Guo X Guo Xiuqing X Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Hendricks AE Hendricks Audrey E AE Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA.
Karaderi T Karaderi Tugce T Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus.
Lempradl A Lempradl Adelheid A Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Locke AE Locke Adam E AE McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Mahajan A Mahajan Anubha A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Marouli E Marouli Eirini E William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Sivapalaratnam S Sivapalaratnam Suthesh S Department of Haematology, University of Cambridge, Cambridge, UK.
Young KL Young Kristin L KL Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Alfred T Alfred Tamuno T Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Feitosa MF Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Masca NGD Masca Nicholas G D NGD NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Manning AK Manning Alisa K AK Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA.
Medina-Gomez C Medina-Gomez Carolina C Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Mudgal P Mudgal Poorva P Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Ng MCY Ng Maggie C Y MCY Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Reiner AP Reiner Alex P AP Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Vedantam S Vedantam Sailaja S Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.
Willems SM Willems Sara M SM MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
Winkler TW Winkler Thomas W TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Abecasis G Abecasis Gonçalo G Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Aben KK Aben Katja K KK Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Alam DS Alam Dewan S DS School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada.
Alharthi SE Alharthi Sameer E SE Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
Allison M Allison Matthew M Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
Amouyel P Amouyel Philippe P Université de Lille, U1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Asselbergs FW Asselbergs Folkert W FW Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
Auer PL Auer Paul L PL Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Balkau B Balkau Beverley B INSERM U1018, Centre de Recherche en Épidémiologie et Santé des Populations (CESP), Villejuif, France.
Bang LE Bang Lia E LE Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Barroso I Barroso Inês I NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Bastarache L Bastarache Lisa L Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
Benn M Benn Marianne M Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bergmann S Bergmann Sven S Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Bielak LF Bielak Lawrence F LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Blüher M Blüher Matthias M Department of Medicine, University of Leipzig, Leipzig, Germany.
Boehnke M Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Boeing H Boeing Heiner H Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.
Boerwinkle E Boerwinkle Eric E Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Böger CA Böger Carsten A CA Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Bork-Jensen J Bork-Jensen Jette J Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bots ML Bots Michiel L ML Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Bottinger EP Bottinger Erwin P EP Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bowden DW Bowden Donald W DW Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Brandslund I Brandslund Ivan I Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Breen G Breen Gerome G NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Hospital, London, UK.
Brilliant MH Brilliant Murray H MH Marshfield Clinic Research Institute, Marshfield, WI, USA.
Broer L Broer Linda L Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Brumat M Brumat Marco M Department of Medical Sciences, University of Trieste, Trieste, Italy.
Burt AA Burt Amber A AA Department of Medicine, University of Washington, Seattle, WA, USA.
Butterworth AS Butterworth Adam S AS NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Campbell PT Campbell Peter T PT Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Cappellani S Cappellani Stefania S Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Carey DJ Carey David J DJ Weis Center for Research, Geisinger Health System, Danville, PA, USA.
Catamo E Catamo Eulalia E Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Caulfield MJ Caulfield Mark J MJ NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Chambers JC Chambers John C JC Imperial College Healthcare NHS Trust, London, UK.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA, USA.
Chen YI Chen Yii-Der I YI Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Chowdhury R Chowdhury Rajiv R MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Christensen C Christensen Cramer C Medical Department, Lillebaelt Hospital, Vejle, Denmark.
Chu AY Chu Audrey Y AY Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA.
Cocca M Cocca Massimiliano M Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Collins FS Collins Francis S FS Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
Cook JP Cook James P JP Department of Biostatistics, University of Liverpool, Liverpool, UK.
Corley J Corley Janie J Department of Psychology, University of Edinburgh, Edinburgh, UK.
Corominas Galbany J Corominas Galbany Jordi J Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Cox AJ Cox Amanda J AJ Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Crosslin DS Crosslin David S DS Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA.
Cuellar-Partida G Cuellar-Partida Gabriel G QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
D'Eustacchio A D'Eustacchio Angela A Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Danesh J Danesh John J British Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK.
Davies G Davies Gail G Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Bakker PIW Bakker Paul I W PIW Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Groot MCH Groot Mark C H MCH Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands.
Mutsert R Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Dedoussis G Dedoussis George G Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Demerath EW Demerath Ellen W EW Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Heijer M Heijer Martin M Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Hollander AI Hollander Anneke I AI Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Ruijter HM Ruijter Hester M HM Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Dennis JG Dennis Joe G JG Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Denny JC Denny Josh C JC Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
Di Angelantonio E Di Angelantonio Emanuele E NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Drenos F Drenos Fotios F MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Du M Du Mengmeng M Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Dubé MP Dubé Marie-Pierre MP Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Edwards TL Edwards Todd L TL Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
Ellinghaus D Ellinghaus David D Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Ellinor PT Ellinor Patrick T PT Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA.
Elliott P Elliott Paul P Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Evangelou E Evangelou Evangelos E Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Farmaki AE Farmaki Aliki-Eleni AE Department of Health Sciences, University of Leicester, Leicester, UK.
Farooqi IS Farooqi I Sadaf IS NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Fauser S Fauser Sascha S Department of Ophthalmology, University of Cologne, Cologne, Germany.
Feng S Feng Shuang S Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Ferrannini E Ferrannini Ele E Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Ferrieres J Ferrieres Jean J Toulouse University School of Medicine, Toulouse, France.
Florez JC Florez Jose C JC Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA.
Ford I Ford Ian I University of Glasgow, Glasgow, UK.
Fornage M Fornage Myriam M Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Franco OH Franco Oscar H OH Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Franke A Franke Andre A Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Franks PW Franks Paul W PW Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden.
Friedrich N Friedrich Nele N Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Frikke-Schmidt R Frikke-Schmidt Ruth R Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Galesloot TE Galesloot Tessel E TE Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Gan W Gan Wei W Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Gandin I Gandin Ilaria I Research Unit, AREA Science Park, Trieste, Italy.
Gasparini P Gasparini Paolo P Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Gibson J Gibson Jane J Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK.
Giedraitis V Giedraitis Vilmantas V Geriatrics, Department of Public Health, Uppsala University, Uppsala, Sweden.
Gjesing AP Gjesing Anette P AP Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gordon-Larsen P Gordon-Larsen Penny P Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Gorski M Gorski Mathias M Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Grabe HJ Grabe Hans-Jörgen HJ German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany.
Grant SFA Grant Struan F A SFA Division of Endocrinology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Grarup N Grarup Niels N Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Griffiths HL Griffiths Helen L HL Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK.
Grove ML Grove Megan L ML School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Gudnason V Gudnason Vilmundur V Icelandic Heart Association, Kopavogur, Iceland.
Gustafsson S Gustafsson Stefan S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Haessler J Haessler Jeff J Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hakonarson H Hakonarson Hakon H Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hammerschlag AR Hammerschlag Anke R AR Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands.
Hansen T Hansen Torben T Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Harris KM Harris Kathleen Mullan KM Department of Sociology, University of North Carolina, Chapel Hill, NC, USA.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA.
Hattersley AT Hattersley Andrew T AT University of Exeter Medical School, University of Exeter, Exeter, UK.
Have CT Have Christian T CT Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
He L He Liang L Department of Public Health, University of Helsinki, Helsinki, Finland.
Heard-Costa NL Heard-Costa Nancy L NL Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University, St. Louis, MO, USA.
Heid IM Heid Iris M IM Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Helgeland Ø Helgeland Øyvind Ø KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Hernesniemi J Hernesniemi Jussi J Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Hewitt AW Hewitt Alex W AW Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
Holmen OL Holmen Oddgeir L OL KG Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Hovingh GK Hovingh G Kees GK Department of Vascular Medicine, AMC, Amsterdam, The Netherlands.
Howson JMM Howson Joanna M M JMM MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Hu Y Hu Yao Y Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
Huang PL Huang Paul L PL Massachusetts General Hospital, Boston, MA, USA.
Huffman JE Huffman Jennifer E JE MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Ikram MA Ikram M Arfan MA Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Ingelsson E Ingelsson Erik E Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jackson AU Jackson Anne U AU Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Jansson JH Jansson Jan-Håkan JH Research Unit Skellefteå, Skellefteå, Sweden.
Jarvik GP Jarvik Gail P GP Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Jensen GB Jensen Gorm B GB Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, Denmark.
Jia Y Jia Yucheng Y Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Johansson S Johansson Stefan S Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Jørgensen ME Jørgensen Marit E ME Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Jørgensen T Jørgensen Torben T Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.
Jukema JW Jukema J Wouter JW Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands.
Kahali B Kahali Bratati B Centre for Brain Research, Indian Institute of Science, Bangalore, India.
Kahn RS Kahn René S RS Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Kamstrup PR Kamstrup Pia R PR Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Kanoni S Kanoni Stavroula S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Kaprio J Kaprio Jaakko J National Institute for Health and Welfare, Helsinki, Finland.
Karaleftheri M Karaleftheri Maria M Echinos Medical Centre, Echinos, Greece.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Karpe F Karpe Fredrik F Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Kathiresan S Kathiresan Sekar S Harvard Medical School, Boston, MA, USA.
Kee F Kee Frank F UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast, UK.
Kiemeney LA Kiemeney Lambertus A LA Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Kim E Kim Eric E Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kitajima H Kitajima Hidetoshi H Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Komulainen P Komulainen Pirjo P Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Kooner JS Kooner Jaspal S JS MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Kooperberg C Kooperberg Charles C Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Korhonen T Korhonen Tellervo T Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Kovacs P Kovacs Peter P IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Kuivaniemi H Kuivaniemi Helena H Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Kutalik Z Kutalik Zoltán Z Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Kuulasmaa K Kuulasmaa Kari K National Institute for Health and Welfare, Helsinki, Finland.
Kuusisto J Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Laakso M Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Lakka TA Lakka Timo A TA Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Lamparter D Lamparter David D Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Lange EM Lange Ethan M EM Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Lange LA Lange Leslie A LA Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Langenberg C Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
Larson EB Larson Eric B EB Department of Health Services, University of Washington, Seattle, WA, USA.
Lee NR Lee Nanette R NR USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Lewis CE Lewis Cora E CE Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Li H Li Huaixing H Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
Li J Li Jin J Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Li-Gao R Li-Gao Ruifang R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Lin H Lin Honghuang H Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Lin KH Lin Keng-Hung KH Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan.
Lin LA Lin Li-An LA Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Lin X Lin Xu X Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
Lind L Lind Lars L Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Lindström J Lindström Jaana J National Institute for Health and Welfare, Helsinki, Finland.
Linneberg A Linneberg Allan A Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Liu CT Liu Ching-Ti CT Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Liu DJ Liu Dajiang J DJ Department of Public Health Sciences, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Liu Y Liu Yongmei Y Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lo KS Lo Ken S KS Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Lophatananon A Lophatananon Artitaya A Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.
Lotery AJ Lotery Andrew J AJ Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK.
Loukola A Loukola Anu A Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
Lubitz SA Lubitz Steven A SA Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Männistö S Männistö Satu S National Institute for Health and Welfare, Helsinki, Finland.
Marenne G Marenne Gaëlle G Wellcome Trust Sanger Institute, Hinxton, UK.
Mazul AL Mazul Angela L AL Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
McCarthy MI McCarthy Mark I MI Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
McKean-Cowdin R McKean-Cowdin Roberta R Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Meidtner K Meidtner Karina K German Center for Diabetes Research, Neuherberg, Germany.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, Estonia.
Mistry V Mistry Vanisha V NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Mitchell P Mitchell Paul P Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Moilanen L Moilanen Leena L Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
Moitry M Moitry Marie M Department of Public Health, University Hospital of Strasbourg, Strasbourg, France.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Mook-Kanamori DO Mook-Kanamori Dennis O DO Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Moore C Moore Carmel C INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mori TA Mori Trevor A TA School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
Morris AD Morris Andrew D AD Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Morris AP Morris Andrew P AP Department of Biostatistics, University of Liverpool, Liverpool, UK.
Müller-Nurasyid M Müller-Nurasyid Martina M German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
Munroe PB Munroe Patricia B PB NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Nalls MA Nalls Mike A MA Data Tecnica International, Glen Echo, MD, USA.
Narisu N Narisu Narisu N Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
Nelson CP Nelson Christopher P CP NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Neville M Neville Matt M Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Nielsen SF Nielsen Sune F SF Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nikus K Nikus Kjell K Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Njølstad PR Njølstad Pål R PR KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Nordestgaard BG Nordestgaard Børge G BG Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nyholt DR Nyholt Dale R DR Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
O'Connel JR O'Connel Jeffrey R JR Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
O'Donoghue ML O'Donoghue Michelle L ML Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Olde Loohuis LM Olde Loohuis Loes M LM Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Ophoff RA Ophoff Roel A RA Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Owen KR Owen Katharine R KR Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Packard CJ Packard Chris J CJ University of Glasgow, Glasgow, UK.
Padmanabhan S Padmanabhan Sandosh S University of Glasgow, Glasgow, UK.
Palmer CNA Palmer Colin N A CNA Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK.
Palmer ND Palmer Nicholette D ND Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Pasterkamp G Pasterkamp Gerard G Laboratory of Clinical Chemistry and Hematology, Division of Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands.
Patel AP Patel Aniruddh P AP Harvard Medical School, Boston, MA, USA.
Pattie A Pattie Alison A Department of Psychology, University of Edinburgh, Edinburgh, UK.
Pedersen O Pedersen Oluf O Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Peissig PL Peissig Peggy L PL Marshfield Clinic Research Institute, Marshfield, WI, USA.
Peloso GM Peloso Gina M GM Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Pennell CE Pennell Craig E CE School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
Perola M Perola Markus M Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland.
Perry JA Perry James A JA Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Perry JRB Perry John R B JRB MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
Pers TH Pers Tune H TH Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Person TN Person Thomas N TN Marshfield Clinic Research Institute, Marshfield, WI, USA.
Peters A Peters Annette A Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Petersen ERB Petersen Eva R B ERB Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Peyser PA Peyser Patricia A PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Pirie A Pirie Ailith A Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Polasek O Polasek Ozren O School of Medicine, University of Split, Split, Croatia.
Polderman TJ Polderman Tinca J TJ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands.
Puolijoki H Puolijoki Hannu H Central Hospital of Southern Ostrobothnia, Seinäjoki, Finland.
Raitakari OT Raitakari Olli T OT Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Rasheed A Rasheed Asif A Centre for Non-Communicable Diseases, Karachi, Pakistan.
Rauramaa R Rauramaa Rainer R Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Reilly DF Reilly Dermot F DF Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA.
Renström F Renström Frida F Department of Biobank Research, Umeå University, Umeå, Sweden.
Rheinberger M Rheinberger Myriam M Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Ridker PM Ridker Paul M PM Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Rioux JD Rioux John D JD Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Rivas MA Rivas Manuel A MA Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Roberts DJ Roberts David J DJ BRC Haematology Theme and Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Robertson NR Robertson Neil R NR Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Robino A Robino Antonietta A Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Rolandsson O Rolandsson Olov O Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, Sweden.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Ruth KS Ruth Katherine S KS Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Saleheen D Saleheen Danish D Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Salomaa V Salomaa Veikko V National Institute for Health and Welfare, Helsinki, Finland.
Samani NJ Samani Nilesh J NJ NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Sapkota Y Sapkota Yadav Y QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Sattar N Sattar Naveed N University of Glasgow, Glasgow, UK.
Schoen RE Schoen Robert E RE Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Schreiner PJ Schreiner Pamela J PJ Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Schulze MB Schulze Matthias B MB German Center for Diabetes Research, Neuherberg, Germany.
Scott RA Scott Robert A RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
Segura-Lepe MP Segura-Lepe Marcelo P MP Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Shah SH Shah Svati H SH Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Sheu WH Sheu Wayne H-H WH School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Sim X Sim Xueling X Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.
Slater AJ Slater Andrew J AJ OmicSoft at Qiagen Company, Cary, NC, USA.
Small KS Small Kerrin S KS Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Smith AV Smith Albert V AV Icelandic Heart Association, Kopavogur, Iceland.
Southam L Southam Lorraine L Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Spector TD Spector Timothy D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Speliotes EK Speliotes Elizabeth K EK Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Starr JM Starr John M JM Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Stefansson K Stefansson Kari K deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Steinthorsdottir V Steinthorsdottir Valgerdur V deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Stirrups KE Stirrups Kathleen E KE Department of Haematology, University of Cambridge, Cambridge, UK.
Strauch K Strauch Konstantin K Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
Stringham HM Stringham Heather M HM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Stumvoll M Stumvoll Michael M Department of Medicine, University of Leipzig, Leipzig, Germany.
Sun L Sun Liang L Department of Public Health, University of Helsinki, Helsinki, Finland.
Surendran P Surendran Praveen P MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Swift AJ Swift Amy J AJ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.
Tada H Tada Hayato H Kanazawa University, Kanazawa, Japan.
Tansey KE Tansey Katherine E KE College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Tardif JC Tardif Jean-Claude JC Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Taylor KD Taylor Kent D KD Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Thorleifsson G Thorleifsson Gudmar G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Thorsteinsdottir U Thorsteinsdottir Unnur U deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Thuesen BH Thuesen Betina H BH Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.
Tönjes A Tönjes Anke A Center for Pediatric Research, Department for Women's and Child Health, University of Leipzig, Leipzig, Germany.
Tromp G Tromp Gerard G Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Trompet S Trompet Stella S Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Tsafantakis E Tsafantakis Emmanouil E Anogia Medical Centre, Anogia, Greece.
Tuomilehto J Tuomilehto Jaakko J Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
Tybjaerg-Hansen A Tybjaerg-Hansen Anne A Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Tyrer JP Tyrer Jonathan P JP Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Uher R Uher Rudolf R Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Uitterlinden AG Uitterlinden André G AG Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Uusitupa M Uusitupa Matti M Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Laan SW Laan Sander W SW Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Duijn CM Duijn Cornelia M CM Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Leeuwen N Leeuwen Nienke N Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.
van Setten J van Setten Jessica J Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Vanhala M Vanhala Mauno M Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland.
Varbo A Varbo Anette A Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Varga TV Varga Tibor V TV Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden.
Varma R Varma Rohit R USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Velez Edwards DR Velez Edwards Digna R DR Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
Vermeulen SH Vermeulen Sita H SH Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Veronesi G Veronesi Giovanni G Research Center on Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Vestergaard H Vestergaard Henrik H Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Vitart V Vitart Veronique V MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Vogt TF Vogt Thomas F TF Cardiometabolic Disease, Merck, Sharp & Dohme, Kenilworth, NJ, USA.
Völker U Völker Uwe U Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Vuckovic D Vuckovic Dragana D Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Wagenknecht LE Wagenknecht Lynne E LE Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Walker M Walker Mark M Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle, UK.
Wallentin L Wallentin Lars L Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Wang F Wang Feijie F Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
Wang CA Wang Carol A CA School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
Wang S Wang Shuai S Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Wang Y Wang Yiqin Y Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
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Warren HR Warren Helen R HR NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
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Wilson JG Wilson James G JG Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
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Young R Young Robin R University of Glasgow, Glasgow, UK.
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Zhang W Zhang Weihua W Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Zhao JH Zhao Jing Hua JH MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
Zhao W Zhao Wei W Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Zhou W Zhou Wei W Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Zondervan KT Zondervan Krina T KT Endometriosis CaRe Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.
CHD Exome+ Consortium
EPIC-CVD Consortium
ExomeBP Consortium
Global Lipids Genetic Consortium
GoT2D Genes Consortium
EPIC InterAct Consortium
INTERVAL Study
ReproGen Consortium
T2D-Genes Consortium
MAGIC Investigators
Understanding Society Scientific Group
Rotter JI Rotter Jerome I JI Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Pospisilik JA Pospisilik John A JA Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Rivadeneira F Rivadeneira Fernando F Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Borecki IB Borecki Ingrid B IB Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Deloukas P Deloukas Panos P Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
Frayling TM Frayling Timothy M TM Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Lettre G Lettre Guillaume G Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
North KE North Kari E KE Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, NC, USA.
Lindgren CM Lindgren Cecilia M CM Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK.
Hirschhorn JN Hirschhorn Joel N JN Department of Pediatrics, Harvard Medical School, Boston, MA, USA. joelh@broadinstitute.org.
Loos RJF Loos Ruth J F RJF Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@mssm.edu.
INVESTIGATORS
JOURNAL
VOLUME: 50
ISSUE: 1
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2018
MONTH: 01
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
ErratumIn Nat Genet. 2018 Mar 16;: 29549329
ErratumIn Nat Genet. 2018 Mar 16;: 29549330
ErratumIn Nat Genet. 2019 Jul;51(7):1191-1192 31160809
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GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Animals
Body Mass Index
Drosophila genetics
Energy Intake genetics
Energy Metabolism genetics
Female genetics
Gene Frequency genetics
Genetic Variation genetics
Humans genetics
Male genetics
Obesity genetics
Proteins genetics
Syndrome genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Proteins
OTHER ID's
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