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PMID |
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TITLE |
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MAPPING AGE EFFECTS ALONG FIBER TRACTS IN YOUNG ADULTS. |
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ABSTRACT |
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Brain development is a protracted and dynamic process. Many studies have charted the trajectory of white matter development, but here we sought to map these effects in greater detail, based on a large set of fiber tracts automatically extracted from HARDI (high angular resolution diffusion imaging) at 4 tesla. We used autoMATE (automated multi-atlas tract extraction) to extract diffusivity measures along 18 of the brain's major fiber bundles in 667 young adults, aged 18-30. We examined linear and non-linear age effects on diffusivity measures, pointwise along tracts. All diffusivity measures showed both linear and non-linear age effects. Tracts with the most pronounced age effects were those that connected the temporal lobe to the rest of the brain. Nonlinear age effects were picked up strongly in the anterior corpus callosum and right temporo-parietal tracts. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pmc-release |
2018/06/19 |
entrez |
2017/12/05 06:00 |
pubmed |
2017/12/05 06:00 |
medline |
2017/12/05 06:01 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Dennis EL |
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Dennis |
Emily L |
EL |
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Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA. |
Rashid F |
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Rashid |
Faisal |
F |
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Imaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA. |
Faskowitz J |
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Faskowitz |
Josh |
J |
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Imaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA. |
Jin Y |
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Jin |
Yan |
Y |
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Imaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA. |
McMahon KL |
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McMahon |
Katie L |
KL |
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Center for Advanced Imaging, Univ. of Queensland, Brisbane, Australia. |
de Zubicaray GI |
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de Zubicaray |
Greig I |
GI |
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School of Psychology, University of Queensland, Brisbane, Australia. |
Martin NG |
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Martin |
Nicholas G |
NG |
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Queensland Institute of Medical Research, Brisbane, Australia. |
Hickie IB |
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Hickie |
Ian B |
IB |
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Brain and Mind Centre, University of Sydney, Australia. |
Wright MJ |
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Wright |
Margaret J |
MJ |
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Queensland Brain Institute, University of Queensland, Brisbane, Australia. |
Jahanshad N |
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Jahanshad |
Neda |
N |
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Imaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA. |
Thompson PM |
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Thompson |
Paul M |
PM |
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Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 2017 |
ISSUE: |
TITLE: Proceedings. IEEE International Symposium on Biomedical Imaging |
ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging |
YEAR: 2017 |
MONTH: |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 1945-7928 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Proc IEEE Int Symp Biomed Imaging |
COUNTRY: United States |
ISSNLINKING: 1945-7928 |
NLMUNIQUEID: 101492570 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
R01 EB007813 |
NIBIB NIH HHS |
United States |
R01 AG040060 |
NIA NIH HHS |
United States |
K99 NS096116 |
NINDS NIH HHS |
United States |
U54 EB020403 |
NIBIB NIH HHS |
United States |
R01 HD050735 |
NICHD NIH HHS |
United States |
R01 EB008432 |
NIBIB NIH HHS |
United States |
P41 RR013642 |
NCRR NIH HHS |
United States |
R01 NS080655 |
NINDS NIH HHS |
United States |
R01 EB008281 |
NIBIB NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
development |
diffusion weighted imaging |
structural connectivity |
tractography |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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