|
|
| PMID |
|
|
| TITLE |
|
| Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. |
|
| ABSTRACT |
|
| Background |
|
| Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. |
| Methods |
|
| Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator. |
| Results |
|
| Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator. For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases. |
| Conclusions |
|
| Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator. For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases. We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| accepted |
2017/10/21 |
| pubmed |
2017/12/01 06:00 |
| medline |
2019/03/05 06:00 |
| entrez |
2017/11/30 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ong JS |
|
Ong |
Jue-Sheng |
JS |
|
School of Medicine, University of Queensland, St Lucia, QLD, Australia. |
| Hwang LD |
|
Hwang |
Liang-Dar |
LD |
|
School of Medicine, University of Queensland, St Lucia, QLD, Australia. |
| Cuellar-Partida G |
|
Cuellar-Partida |
Gabriel |
G |
|
Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Chenevix-Trench G |
|
Chenevix-Trench |
Georgia |
G |
|
Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Quinn MCJ |
|
Quinn |
Michael C J |
MCJ |
|
Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Cornelis MC |
|
Cornelis |
Marilyn C |
MC |
|
Northwestern University Feinberg School of Medicine, Preventive Medicine, Chicago, IL, USA. |
| Gharahkhani P |
|
Gharahkhani |
Puya |
P |
|
Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Webb PM |
|
Webb |
Penelope M |
PM |
|
Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| MacGregor S |
|
MacGregor |
Stuart |
S |
|
Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
|
Ovarian Cancer Association Consortium |
|
|
|
|
|
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Ong |
Jue-Sheng |
JS |
|
| Hwang |
Liang-Dar |
LD |
|
| Cuellar-Partida |
Gabriel |
G |
|
| Bryne |
Enda |
E |
|
| Fasching |
Peter A |
PA |
|
| Hein |
Alexander |
A |
|
| Burghaus |
Stefanie |
S |
|
| Beckmann |
Matthias W |
MW |
|
| Lambrechts |
Diether |
D |
|
| Van Nieuwenhuysen |
Els |
E |
|
| Vergote |
Ignace |
I |
|
| Vanderstichele |
Adriaan |
A |
|
| Swerdlow |
Anthony J |
AJ |
|
| Jones |
Michael |
M |
|
| Orr |
Nicholas |
N |
|
| Schoemaker |
Minouk |
M |
|
| Edwards |
Digna Velez |
DV |
|
| Brenton |
James |
J |
|
| Benítez |
Javier |
J |
|
| García |
María J |
MJ |
|
| Rodriguez-Antona |
Cristina |
C |
|
| Rossing |
Mary Anne |
MA |
|
| Fortner |
Renée T |
RT |
|
| Riboli |
Elio |
E |
|
| Chang-Claude |
Jenny |
J |
|
| Eilber |
Ursula |
U |
|
| Wang-Gohrke |
Shan |
S |
|
| Yannoukakos |
Drakoulis |
D |
|
| Goodman |
Marc T |
MT |
|
| Bogdanova |
Natalia |
N |
|
| Dörk |
Thilo |
T |
|
| Duerst |
Matthias |
M |
|
| Hillemanns |
Peter |
P |
|
| Runnebaum |
Ingo B |
IB |
|
| Antonenkova |
Natalia |
N |
|
| Butzow |
Ralf |
R |
|
| Nevanlinna |
Heli |
H |
|
| Pelttari |
Liisa M |
LM |
|
| Edwards |
Robert P |
RP |
|
| Kelley |
Joseph L |
JL |
|
| Modugno |
Francesmary |
F |
|
| Moysich |
Kirsten B |
KB |
|
| Ness |
Roberta B |
RB |
|
| Cannioto |
Rikki |
R |
|
| Heitz |
Florian |
F |
|
| Karlan |
Beth |
B |
|
| Olsson |
Håkan |
H |
|
| Kjaer |
Susanne K |
SK |
|
| Jensen |
Allan |
A |
|
| Giles |
Graham G |
GG |
|
| Bruinsma |
Fiona |
F |
|
| Hildebrandt |
Michelle A T |
MAT |
|
| Liang |
Dong |
D |
|
| Wu |
Xifeng |
X |
|
| Le Marchand |
Loic |
L |
|
| Setiawan |
V Wendy |
VW |
|
| Permuth |
Jennifer B |
JB |
|
| Bisogna |
Maria |
M |
|
| Dao |
Fanny |
F |
|
| Levine |
Douglas A |
DA |
|
| Cramer |
Daniel W |
DW |
|
| Terry |
Kathryn L |
KL |
|
| Tworoger |
Shelley S |
SS |
|
| Stampfer |
Meir |
M |
|
| Willet |
Walter |
W |
|
| Missmer |
Stacey |
S |
|
| Bjorge |
Line |
L |
|
| Kopperud |
Reidun K |
RK |
|
| Bischof |
Katharina |
K |
|
| Thomsen |
Liv Cecilie Vestrheim |
LCV |
|
| Kiemeney |
Lambertus A |
LA |
|
| Massuger |
Leon Fag |
LF |
|
| Pejovic |
Tanja |
T |
|
| Brooks-Wilson |
Angela |
A |
|
| Olson |
Sara H |
SH |
|
| McGuire |
Valerie |
V |
|
| Rothstein |
Joseph H |
JH |
|
| Sieh |
Weiva |
W |
|
| Whittemore |
Alice S |
AS |
|
| Cook |
Linda S |
LS |
|
| Le |
Nhu D |
ND |
|
| Gilks |
C Blake |
CB |
|
| Gronwald |
Jacek |
J |
|
| Jakubowska |
Anna |
A |
|
| Lubiński |
Jan |
J |
|
| Kluz |
Tomasz |
T |
|
| Wentzensen |
Nicolas |
N |
|
| Brinton |
Louise |
L |
|
| Trabert |
Britton |
B |
|
| Lissowska |
Jolanta |
J |
|
| Høgdall |
Estrid |
E |
|
| Høgdall |
Claus K |
CK |
|
| Sandler |
Dale P |
DP |
|
| Wolk |
Alicja |
A |
|
| Tyrer |
Jonathan P |
JP |
|
| Song |
Honglin |
H |
|
| Eccles |
Diana |
D |
|
| Campbell |
Ian |
I |
|
| Glasspool |
Ros |
R |
|
| McNeish |
Iain |
I |
|
| Paul |
James |
J |
|
| Siddiqui |
Nadeem |
N |
|
| Sutphen |
Rebecca |
R |
|
| McLaughlin |
John R |
JR |
|
| Phelan |
Catherine |
C |
|
| Anton-Culver |
Hoda |
H |
|
| Ziogas |
Argyrios |
A |
|
| May |
Taymaa |
T |
|
| Gayther |
Simon A |
SA |
|
| Gentry-Maharaj |
Aleksandra |
A |
|
| Menon |
Usha |
U |
|
| Ramus |
Susan J |
SJ |
|
| Wu |
Anna H |
AH |
|
| Huntsman |
David |
D |
|
| deFazio |
Anna |
A |
|
| Dansonka-Mieszkowska |
Agnieszka |
A |
|
| Kupryjanczyk |
Jolanta |
J |
|
| Moes-Sosnowska |
Joanna |
J |
|
| Szafron |
Lukasz Michal |
LM |
|
| Cunningham |
Julie M |
JM |
|
| Winham |
Stacey J |
SJ |
|
| Risch |
Harvey A |
HA |
|
| Goode |
Ellen L |
EL |
|
| Schildkraut |
Joellen M |
JM |
|
| Pearce |
Celeste L |
CL |
|
| Berchuck |
Andrew |
A |
|
| Pharoah |
Paul D P |
PDP |
|
| Martin |
Nicholas G |
NG |
|
| Chenevix-Trench |
Georgia |
G |
|
| Quinn |
Michael C J |
MCJ |
|
| Cornelis |
Marilyn C |
MC |
|
| Gharahkhani |
Puya |
P |
|
| Webb |
Penelope M |
PM |
|
| MacGregor |
Stuart |
S |
|
|
| JOURNAL |
|
| VOLUME: 47 |
| ISSUE: 2 |
| TITLE: International journal of epidemiology |
| ISOABBREVIATION: Int J Epidemiol |
| YEAR: 2018 |
| MONTH: 04 |
| DAY: 01 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1464-3685 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Int J Epidemiol |
| COUNTRY: England |
| ISSNLINKING: 0300-5771 |
| NLMUNIQUEID: 7802871 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, Non-P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| U19 CA148112 |
NCI NIH HHS |
United States |
| MOP-86727 |
CIHR |
Canada |
| C490/A6187 |
Cancer Research UK |
United Kingdom |
| C490/A10119 |
Cancer Research UK |
United Kingdom |
| C490/A10124 |
Cancer Research UK |
United Kingdom |
| K07 CA095666 |
NCI NIH HHS |
United States |
| K07 CA080668 |
NCI NIH HHS |
United States |
| K07 CA143047 |
NCI NIH HHS |
United States |
| K22 CA138563 |
NCI NIH HHS |
United States |
| N01 PC067010 |
NCI NIH HHS |
United States |
| N01 PC035137 |
NCI NIH HHS |
United States |
| P01 CA017054 |
NCI NIH HHS |
United States |
| P30 CA072720 |
NCI NIH HHS |
United States |
| P30 CA015083 |
NCI NIH HHS |
United States |
| P30 CA008748 |
NCI NIH HHS |
United States |
| P50 CA159981 |
NCI NIH HHS |
United States |
| P50 CA105009 |
NCI NIH HHS |
United States |
| P50 CA136393 |
NCI NIH HHS |
United States |
| R01 CA149429 |
NCI NIH HHS |
United States |
| R01 CA049449 |
NCI NIH HHS |
United States |
| R01 CA050385 |
NCI NIH HHS |
United States |
| R01 CA054419 |
NCI NIH HHS |
United States |
| R01 CA058598 |
NCI NIH HHS |
United States |
| R01 CA058860 |
NCI NIH HHS |
United States |
| R01 CA063678 |
NCI NIH HHS |
United States |
| R01 CA063682 |
NCI NIH HHS |
United States |
| R01 CA067262 |
NCI NIH HHS |
United States |
| R01 CA074850 |
NCI NIH HHS |
United States |
| R01 CA083918 |
NCI NIH HHS |
United States |
| R01 CA087538 |
NCI NIH HHS |
United States |
| R01 CA095023 |
NCI NIH HHS |
United States |
| R01 CA122443 |
NCI NIH HHS |
United States |
| R01 CA112523 |
NCI NIH HHS |
United States |
| R01 CA114343 |
NCI NIH HHS |
United States |
| R01 CA126841 |
NCI NIH HHS |
United States |
| R01 CA136924 |
NCI NIH HHS |
United States |
| R03 CA113148 |
NCI NIH HHS |
United States |
| R03 CA115195 |
NCI NIH HHS |
United States |
| U01 CA069417 |
NCI NIH HHS |
United States |
| UM1 CA186107 |
NCI NIH HHS |
United States |
| UM1 CA176726 |
NCI NIH HHS |
United States |
| M01 RR000056 |
NCRR NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Mendelian randomization |
| caffeine |
| causality |
| coffee |
| ovarian cancer |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Carcinoma, Ovarian Epithelial |
genetics |
| Coffee |
adverse effects |
| Female |
adverse effects |
| Humans |
adverse effects |
| Mendelian Randomization Analysis |
adverse effects |
| Odds Ratio |
adverse effects |
| Ovarian Neoplasms |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
| Risk Factors |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Coffee |
|
| OTHER ID's |
|
|
|
