|
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| PMID |
|
|
| TITLE |
|
| Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. |
|
| ABSTRACT |
|
|
|
| Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables. |
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| DATE PUBLISHED |
|
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2017/05/18 |
| accepted |
2017/08/30 |
| entrez |
2017/11/12 06:00 |
| pubmed |
2017/11/12 06:00 |
| medline |
2019/07/03 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Rietschel L |
|
Rietschel |
Liz |
L |
|
SRH University Heidelberg, Academy for Psychotherapy, Heidelberg, Germany. Liz.Rietschel@srh.de. |
| Streit F |
|
Streit |
Fabian |
F |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. |
| Zhu G |
|
Zhu |
Gu |
G |
|
Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia. |
| McAloney K |
|
McAloney |
Kerrie |
K |
|
Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia. |
| Frank J |
|
Frank |
Josef |
J |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. |
| Couvy-Duchesne B |
|
Couvy-Duchesne |
Baptiste |
B |
|
Queensland Brain Institute, University of Queensland, Brisbane, Australia. |
| Witt SH |
|
Witt |
Stephanie H |
SH |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. |
| Binz TM |
|
Binz |
Tina M |
TM |
|
Zurich Institute of Forensic Medicine, Centre for Forensic Hair Analysis, University of Zurich, Zurich, Switzerland. |
|
CORtisolNETwork (CORNET) Consortium |
|
|
|
|
|
|
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) |
|
|
|
|
|
| McGrath J |
|
McGrath |
John |
J |
|
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre, University of Sydney, Sydney, Australia. |
| Hansell NK |
|
Hansell |
Narelle K |
NK |
|
Queensland Brain Institute, University of Queensland, Brisbane, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. |
| Forstner AJ |
|
Forstner |
Andreas J |
AJ |
|
Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland. |
| Schulze TG |
|
Schulze |
Thomas G |
TG |
|
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Goettingen, DE, Germany. |
| Wüst S |
|
Wüst |
Stefan |
S |
|
Institute of Experimental Psychology, University of Regensburg, Regensburg, Germany. |
| Nöthen MM |
|
Nöthen |
Markus M |
MM |
|
Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany. |
| Baumgartner MR |
|
Baumgartner |
Markus R |
MR |
|
Zurich Institute of Forensic Medicine, Centre for Forensic Hair Analysis, University of Zurich, Zurich, Switzerland. |
| Walker BR |
|
Walker |
Brian R |
BR |
|
British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. |
| Crawford AA |
|
Crawford |
Andrew A |
AA |
|
Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
|
Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia. |
| Rietschel M |
|
Rietschel |
Marcella |
M |
|
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Bolton |
Jennifer L |
JL |
|
| Hayward |
Caroline |
C |
|
| Direk |
Nese |
N |
|
| Anderson |
Anna |
A |
|
| Huffman |
Jennifer |
J |
|
| Wilson |
James F |
JF |
|
| Campbell |
Harry |
H |
|
| Rudan |
Igor |
I |
|
| Wright |
Alan |
A |
|
| Hastie |
Nicholas |
N |
|
| Wild |
Sarah H |
SH |
|
| Velders |
Fleur P |
FP |
|
| Hofman |
Albert |
A |
|
| Uitterlinden |
Andre G |
AG |
|
| Lahti |
Jari |
J |
|
| Räikkönen |
Katri |
K |
|
| Kajantie |
Eero |
E |
|
| Widen |
Elisabeth |
E |
|
| Palotie |
Aarno |
A |
|
| Eriksson |
Johan G |
JG |
|
| Kaakinen |
Marika |
M |
|
| Järvelin |
Marjo-Riitta |
MR |
|
| Timpson |
Nicholas J |
NJ |
|
| Davey Smith |
George |
G |
|
| Ring |
Susan M |
SM |
|
| Evans |
David M |
DM |
|
| St Pourcain |
Beate |
B |
|
| Tanaka |
Toshiko |
T |
|
| Milaneschi |
Yuri |
Y |
|
| Bandinelli |
Stefania |
S |
|
| Ferrucci |
Luigi |
L |
|
| van der Harst |
Pim |
P |
|
| Rosmalen |
Judith Gm |
JG |
|
| Bakker |
Stephen Jl |
SJ |
|
| Verweij |
Niek |
N |
|
| Dullaart |
Robin Pf |
RP |
|
| Mahajan |
Anubha |
A |
|
| Lindgren |
Cecilia M |
CM |
|
| Morris |
Andrew |
A |
|
| Lind |
Lars |
L |
|
| Ingelsson |
Erik |
E |
|
| Anderson |
Laura N |
LN |
|
| Pennell |
Craig E |
CE |
|
| Lye |
Stephen J |
SJ |
|
| Matthews |
Stephen G |
SG |
|
| Eriksson |
Joel |
J |
|
| Mellstrom |
Dan |
D |
|
| Ohlsson |
Claes |
C |
|
| Price |
Jackie F |
JF |
|
| Strachan |
Mark Wj |
MW |
|
| Reynolds |
Rebecca M |
RM |
|
| Tiemeier |
Henning |
H |
|
| Ripke |
Stephan |
S |
|
| Mattheisen |
Manuel |
M |
|
| Abdellaoui |
Abdel |
A |
|
| Adams |
Mark J |
MJ |
|
| Agerbo |
Esben |
E |
|
| Air |
Tracy M |
TM |
|
| Andlauer |
Till Fm |
TF |
|
| Bacanu |
Silviu-Alin |
SA |
|
| Bækvad-Hansen |
Marie |
M |
|
| Beekman |
Aartjan Tf |
AT |
|
| Bennett |
David A |
DA |
|
| Berger |
Klaus |
K |
|
| Bigdeli |
Tim B |
TB |
|
| Bybjerg-Grauholm |
Jonas |
J |
|
| Byrne |
Enda M |
EM |
|
| Cai |
Na |
N |
|
| Castelao |
Enrique |
E |
|
| Clarke |
Toni-Kim |
TK |
|
| Coleman |
Jonathan Ri |
JR |
|
| Consortium |
Converge |
C |
|
| Craddock |
Nick |
N |
|
| Dannlowski |
Udo |
U |
|
| Davies |
Gareth |
G |
|
| Davies |
Gail |
G |
|
| de Geus |
Eco J C |
EJC |
|
| De Jager |
Philip |
P |
|
| Deary |
Ian J |
IJ |
|
| Degenhardt |
Franziska |
F |
|
| Dunn |
Erin C |
EC |
|
| Ehli |
Erik A |
EA |
|
| Eley |
Thalia C |
TC |
|
| Escott-Price |
Valentina |
V |
|
| Esko |
Tõnu |
T |
|
| Finucane |
Hilary K |
HK |
|
| Gill |
Michael |
M |
|
| Gordon |
Scott D |
SD |
|
| Grove |
Jakob |
J |
|
| Hall |
Lynsey S |
LS |
|
| Hansen |
Thomas F |
TF |
|
| Søholm Hansen |
Christine |
C |
|
| Hansen |
Thomas F |
TF |
|
| Heath |
Andrew C |
AC |
|
| Henders |
Anjali K |
AK |
|
| Herms |
Stefan |
S |
|
| Hoffmann |
Per |
P |
|
| Homuth |
Georg |
G |
|
| Horn |
Carsten |
C |
|
| Hottenga |
Jouke- Jan |
JJ |
|
| Hougaard |
David |
D |
|
| Huang |
Hailiang |
H |
|
| Ising |
Marcus |
M |
|
| Jansen |
Rick |
R |
|
| Jorgenson |
Eric |
E |
|
| Kloiber |
Stefan |
S |
|
| Knowles |
James A |
JA |
|
| Kretzschmar |
Warren W |
WW |
|
| Krogh |
Jesper |
J |
|
| Kutalik |
Zoltán |
Z |
|
| Lang |
Maren |
M |
|
| Lewis |
Glyn |
G |
|
| Li |
Yihan |
Y |
|
| MacIntyre |
Donald J |
DJ |
|
| Madden |
Pamela Af |
PA |
|
| Marchine |
Jonathan |
J |
|
| Mbarek |
Hamdi |
H |
|
| McGuffin |
Peter |
P |
|
| Mehta |
Divya |
D |
|
| Metspalu |
Andres |
A |
|
| Middeldorp |
Christel M |
CM |
|
| Mihailov |
Evelin |
E |
|
| Milani |
Lili |
L |
|
| Montgomery |
Grant W |
GW |
|
| Mostafavi |
Sara |
S |
|
| Mullins |
Niamh |
N |
|
| Nauck |
Matthias |
M |
|
| Ng |
Bernard |
B |
|
| Nordentoft |
Merete |
M |
|
| Nyholt |
Dale R |
DR |
|
| O'Donovan |
Michael C |
MC |
|
| O'Reilly |
Paul F |
PF |
|
| Oskarsson |
Hogni |
H |
|
| Owen |
Michael J |
MJ |
|
| Paciga |
Sara A |
SA |
|
| Pedersen |
Carsten Bøcker |
CB |
|
| Pedersen |
Marianne Giørtz |
MG |
|
| Pedersen |
Nancy L |
NL |
|
| Pergadia |
Michele L |
ML |
|
| Peterson |
Roseann E |
RE |
|
| Pettersson |
Erik |
E |
|
| Peyrot |
Wouter J |
WJ |
|
| Porteous |
David J |
DJ |
|
| Posthuma |
Danielle |
D |
|
| Potash |
James B |
JB |
|
| Quiroz |
Jorge A |
JA |
|
| Rice |
John P |
JP |
|
| Riley |
Brien P |
BP |
|
| Rivera |
Margarita |
M |
|
| Ruderfer |
Douglas M |
DM |
|
| Saeed Mirza |
Saira |
S |
|
| Schoevers |
Robert |
R |
|
| Shen |
Ling |
L |
|
| Shi |
Jianxin |
J |
|
| Sigurdsson |
Engilbert |
E |
|
| Sinnamon |
Grant Cb |
GC |
|
| Smit |
Johannes H |
JH |
|
| Smith |
Daniel J |
DJ |
|
| Smoller |
Jordan W |
JW |
|
| Stephansson |
Hreinn |
H |
|
| Steinberg |
Stacy |
S |
|
| Strohmaier |
Jana |
J |
|
| Tansey |
Katherine E |
KE |
|
| Teumer |
Alexander |
A |
|
| Thompson |
Wesley |
W |
|
| Thomson |
Pippa A |
PA |
|
| Thorgeirsson |
Thorgeir E |
TE |
|
| Treutlein |
Jens |
J |
|
| Trzaskowski |
Maciej |
M |
|
| Umbricht |
Daniel |
D |
|
| van der Auwera |
Sandra |
S |
|
| van Grootheest |
Gerard |
G |
|
| van Hemert |
Albert M |
AM |
|
| Viktorin |
Alexander |
A |
|
| Völzke |
Henry |
H |
|
| Wang |
Yunpeng |
Y |
|
| Webb |
Bradley T |
BT |
|
| Weissman |
Myrna M |
MM |
|
| Wellmann |
Jürgen |
J |
|
| Willemsen |
Gonneke |
G |
|
| Xi |
Hualin S |
HS |
|
| Baune |
Bernhard T |
BT |
|
| Blackwood |
Douglas H R |
DHR |
|
| Boomsma |
Dorret I |
DI |
|
| Børglum |
Anders D |
AD |
|
| Buttenschøn |
Henriette N |
HN |
|
| Cichon |
Sven |
S |
|
| Domenici |
Enrico |
E |
|
| Flint |
Jonathan |
J |
|
| Grabe |
Hans J |
HJ |
|
| Hamilton |
Steven P |
SP |
|
| Kendler |
Kenneth S |
KS |
|
| Li |
Qingqin S |
QS |
|
| Lucae |
Susanne |
S |
|
| Magnusson |
Patrik K |
PK |
|
| McIntosh |
Andrew M |
AM |
|
| Mors |
Ole |
O |
|
| Bo Mortensen |
Preben |
P |
|
| Müller-Myhsok |
Bertram |
B |
|
| Penninx |
Brenda Wjh |
BW |
|
| Perlis |
Roy H |
RH |
|
| Preisig |
Martin |
M |
|
| Schaefer |
Catherine |
C |
|
| Smoller |
Jordan W |
JW |
|
| Stephansson |
Kari |
K |
|
| Tiemeier |
Henning |
H |
|
| Uher |
Rudolf |
R |
|
| Werge |
Thomas |
T |
|
| Winslow |
Ashley R |
AR |
|
| Breen |
Gerome |
G |
|
| Levinson |
Douglas F |
DF |
|
| Lewis |
Cathryn M |
CM |
|
| Wray |
Naomi R |
NR |
|
| Sullivan |
Patrick F |
PF |
|
|
| JOURNAL |
|
| VOLUME: 7 |
| ISSUE: 1 |
| TITLE: Scientific reports |
| ISOABBREVIATION: Sci Rep |
| YEAR: 2017 |
| MONTH: 11 |
| DAY: 10 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2045-2322 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Sci Rep |
| COUNTRY: England |
| ISSNLINKING: 2045-2322 |
| NLMUNIQUEID: 101563288 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Clinical Trial |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| RG/11/4/28734 |
British Heart Foundation |
United Kingdom |
| CZB/4/733 |
Chief Scientist Office |
United Kingdom |
| MR/P005748/1 |
Medical Research Council |
United Kingdom |
| 107049/Z/15/Z |
Wellcome Trust |
United Kingdom |
| MR/L010305/1 |
Medical Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Child |
|
| Depression |
metabolism |
| Female |
metabolism |
| Hair |
metabolism |
| Humans |
metabolism |
| Hydrocortisone |
metabolism |
| Male |
metabolism |
| Models, Genetic |
metabolism |
| Multifactorial Inheritance |
metabolism |
| Stress, Psychological |
metabolism |
| Twins, Dizygotic |
metabolism |
| Twins, Monozygotic |
metabolism |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| WI4X0X7BPJ |
Hydrocortisone |
|
| OTHER ID's |
|
|
|
