Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29127340
TITLE
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes.
ABSTRACT
Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.
DATE PUBLISHED
2017 Nov 10
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/05/18
accepted 2017/08/30
entrez 2017/11/12 06:00
pubmed 2017/11/12 06:00
medline 2017/11/12 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Rietschel L Rietschel Liz L SRH University Heidelberg, Academy for Psychotherapy, Heidelberg, Germany. Liz.Rietschel@srh.de.
Streit F Streit Fabian F Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Zhu G Zhu Gu G Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia.
McAloney K McAloney Kerrie K Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia.
Frank J Frank Josef J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Couvy-Duchesne B Couvy-Duchesne Baptiste B Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Witt SH Witt Stephanie H SH Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Binz TM Binz Tina M TM Zurich Institute of Forensic Medicine, Centre for Forensic Hair Analysis, University of Zurich, Zurich, Switzerland.
CORtisolNETwork (CORNET) Consortium
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC)
McGrath J McGrath John J National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Hickie IB Hickie Ian B IB Brain and Mind Centre, University of Sydney, Sydney, Australia.
Hansell NK Hansell Narelle K NK Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
Gillespie NA Gillespie Nathan A NA Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Forstner AJ Forstner Andreas J AJ Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Schulze TG Schulze Thomas G TG Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Goettingen, DE, Germany.
Wüst S Wüst Stefan S Institute of Experimental Psychology, University of Regensburg, Regensburg, Germany.
Nöthen MM Nöthen Markus M MM Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.
Baumgartner MR Baumgartner Markus R MR Zurich Institute of Forensic Medicine, Centre for Forensic Hair Analysis, University of Zurich, Zurich, Switzerland.
Walker BR Walker Brian R BR British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Crawford AA Crawford Andrew A AA Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Colodro-Conde L Colodro-Conde Lucía L Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia.
Medland SE Medland Sarah E SE Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia.
Martin NG Martin Nicholas G NG Genetics & Computational Biology Department, QIMR Berghofer Medical Research, Brisbane, Australia.
Rietschel M Rietschel Marcella M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Bolton Jennifer L JL
Hayward Caroline C
Direk Nese N
Anderson Anna A
Huffman Jennifer J
Wilson James F JF
Campbell Harry H
Rudan Igor I
Wright Alan A
Hastie Nicholas N
Wild Sarah H SH
Velders Fleur P FP
Hofman Albert A
Uitterlinden Andre G AG
Lahti Jari J
Räikkönen Katri K
Kajantie Eero E
Widen Elisabeth E
Palotie Aarno A
Eriksson Johan G JG
Kaakinen Marika M
Järvelin Marjo-Riitta MR
Timpson Nicholas J NJ
Davey Smith George G
Ring Susan M SM
Evans David M DM
St Pourcain Beate B
Tanaka Toshiko T
Milaneschi Yuri Y
Bandinelli Stefania S
Ferrucci Luigi L
van der Harst Pim P
Rosmalen Judith Gm JG
Bakker Stephen Jl SJ
Verweij Niek N
Dullaart Robin Pf RP
Mahajan Anubha A
Lindgren Cecilia M CM
Morris Andrew A
Lind Lars L
Ingelsson Erik E
Anderson Laura N LN
Pennell Craig E CE
Lye Stephen J SJ
Matthews Stephen G SG
Eriksson Joel J
Mellstrom Dan D
Ohlsson Claes C
Price Jackie F JF
Strachan Mark Wj MW
Reynolds Rebecca M RM
Tiemeier Henning H
Ripke Stephan S
Mattheisen Manuel M
Abdellaoui Abdel A
Adams Mark J MJ
Agerbo Esben E
Air Tracy M TM
Andlauer Till Fm TF
Bacanu Silviu-Alin SA
Bækvad-Hansen Marie M
Beekman Aartjan Tf AT
Bennett David A DA
Berger Klaus K
Bigdeli Tim B TB
Bybjerg-Grauholm Jonas J
Byrne Enda M EM
Cai Na N
Castelao Enrique E
Clarke Toni-Kim TK
Coleman Jonathan Ri JR
Consortium Converge C
Craddock Nick N
Dannlowski Udo U
Davies Gareth G
Davies Gail G
de Geus Eco J C EJC
De Jager Philip P
Deary Ian J IJ
Degenhardt Franziska F
Dunn Erin C EC
Ehli Erik A EA
Eley Thalia C TC
Escott-Price Valentina V
Esko Tõnu T
Finucane Hilary K HK
Gill Michael M
Gordon Scott D SD
Grove Jakob J
Hall Lynsey S LS
Hansen Thomas F TF
Søholm Hansen Christine C
Hansen Thomas F TF
Heath Andrew C AC
Henders Anjali K AK
Herms Stefan S
Hoffmann Per P
Homuth Georg G
Horn Carsten C
Hottenga Jouke- Jan JJ
Hougaard David D
Huang Hailiang H
Ising Marcus M
Jansen Rick R
Jorgenson Eric E
Kloiber Stefan S
Knowles James A JA
Kretzschmar Warren W WW
Krogh Jesper J
Kutalik Zoltán Z
Lang Maren M
Lewis Glyn G
Li Yihan Y
MacIntyre Donald J DJ
Madden Pamela Af PA
Marchine Jonathan J
Mbarek Hamdi H
McGuffin Peter P
Mehta Divya D
Metspalu Andres A
Middeldorp Christel M CM
Mihailov Evelin E
Milani Lili L
Montgomery Grant W GW
Mostafavi Sara S
Mullins Niamh N
Nauck Matthias M
Ng Bernard B
Nordentoft Merete M
Nyholt Dale R DR
O'Donovan Michael C MC
O'Reilly Paul F PF
Oskarsson Hogni H
Owen Michael J MJ
Paciga Sara A SA
Pedersen Carsten Bøcker CB
Pedersen Marianne Giørtz MG
Pedersen Nancy L NL
Pergadia Michele L ML
Peterson Roseann E RE
Pettersson Erik E
Peyrot Wouter J WJ
Porteous David J DJ
Posthuma Danielle D
Potash James B JB
Quiroz Jorge A JA
Rice John P JP
Riley Brien P BP
Rivera Margarita M
Ruderfer Douglas M DM
Saeed Mirza Saira S
Schoevers Robert R
Shen Ling L
Shi Jianxin J
Sigurdsson Engilbert E
Sinnamon Grant Cb GC
Smit Johannes H JH
Smith Daniel J DJ
Smoller Jordan W JW
Stephansson Hreinn H
Steinberg Stacy S
Strohmaier Jana J
Tansey Katherine E KE
Teumer Alexander A
Thompson Wesley W
Thomson Pippa A PA
Thorgeirsson Thorgeir E TE
Treutlein Jens J
Trzaskowski Maciej M
Umbricht Daniel D
van der Auwera Sandra S
van Grootheest Gerard G
van Hemert Albert M AM
Viktorin Alexander A
Völzke Henry H
Wang Yunpeng Y
Webb Bradley T BT
Weissman Myrna M MM
Wellmann Jürgen J
Willemsen Gonneke G
Xi Hualin S HS
Baune Bernhard T BT
Blackwood Douglas H R DHR
Boomsma Dorret I DI
Børglum Anders D AD
Buttenschøn Henriette N HN
Cichon Sven S
Domenici Enrico E
Flint Jonathan J
Grabe Hans J HJ
Hamilton Steven P SP
Kendler Kenneth S KS
Li Qingqin S QS
Lucae Susanne S
Magnusson Patrik K PK
McIntosh Andrew M AM
Mors Ole O
Bo Mortensen Preben P
Müller-Myhsok Bertram B
Penninx Brenda Wjh BW
Perlis Roy H RH
Preisig Martin M
Schaefer Catherine C
Smoller Jordan W JW
Stephansson Kari K
Tiemeier Henning H
Uher Rudolf R
Werge Thomas T
Winslow Ashley R AR
Breen Gerome G
Levinson Douglas F DF
Lewis Cathryn M CM
Wray Naomi R NR
Sullivan Patrick F PF
JOURNAL
VOLUME: 7
ISSUE: 1
TITLE: Scientific reports
ISOABBREVIATION: Sci Rep
YEAR: 2017
MONTH: Nov
DAY: 10
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2045-2322
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sci Rep
COUNTRY: England
ISSNLINKING: 2045-2322
NLMUNIQUEID: 101563288
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Journal Article
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