Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28833688
TITLE
Effects of high Alcohol Intake, Alcohol-related Symptoms, and Smoking on Mortality.
ABSTRACT
BACKGROUND AND AIMS NlmCategory: OBJECTIVE
Both high alcohol intake and alcohol dependence increase mortality, and both are associated with smoking. We aimed to compare the associations of quantity of alcohol, number of alcohol-related symptoms, and smoking history with all-cause mortality, and to assess symptom count and smoking history as confounders or mediators of the effects of high alcohol intake.
DESIGN NlmCategory: METHODS
Survival was analysed by Cox regression with sex, body mass index, alcohol intake (overall and by beverage), maximum drinks on any day, alcohol symptom count and smoking status as potential predictors of age at death.
SETTING NlmCategory: METHODS
Australia.
PARTICIPANTS NlmCategory: METHODS
Participants were apparently healthy volunteers consisting of 33,593 Australian adult twins and their relatives who completed questionnaires or interviews between 1979 and 2005.
MEASUREMENTS NlmCategory: METHODS
Data on alcohol use, smoking, and occurrence of symptoms related to alcohol use disorders, and death records from the Australian National Death Index.
FINDINGS NlmCategory: RESULTS
3764 participants were matched with deaths occurring within Australia up to July 2014. Individually, alcohol intake (hazard ratio (HR) 1.0082, 95% CI 1.0063-1.0102, per drink per week), beer intake (HR 1.0159, 95% CI 1.0123-1.0195, per drink per week), lifetime maximum number of drinks in one day (HR 1.0176, 95% CI 1.0130-1.0221, per drink), symptom count (HR 1.0867, 95% CI 1.0633-1.1106, per symptom) and smoking status (HR 2.82, 95% CI 2.52-3.16, for smokers of 10+ cigarettes/day versus never-smokers) were each significant predictors of all-cause mortality. After adjustment for the independently significant predictors alcohol symptom count and smoking status, alcohol intake was no longer significant (adjusted HR 1.0012 per drink per week, 95% CI 0.9979-1.0145).
CONCLUSIONS NlmCategory: CONCLUSIONS
Number of symptoms related to high alcohol intake, and tobacco smoking, appear to account for the positive association between alcohol consumption and premature mortality.
This article is protected by copyright. All rights reserved.
DATE PUBLISHED
2017 Aug 22
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/03/22
revised 2017/08/01
accepted 2017/08/03
entrez 2017/08/24 06:00
pubmed 2017/08/24 06:00
medline 2017/08/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield John B JB QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, 4006, Queensland, Australia.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MsO, 63110, USA.
Madden PAF Madden Pamela A F PAF Department of Psychiatry, Washington University School of Medicine, St Louis, MsO, 63110, USA.
George Landers J George Landers J J Skinner 58, Nea Chora, Chania, 73131, Greece.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, 4006, Queensland, Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Addiction (Abingdon, England)
ISOABBREVIATION: Addiction
YEAR: 2017
MONTH: Aug
DAY: 22
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1360-0443
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addiction
COUNTRY: England
ISSNLINKING: 0965-2140
NLMUNIQUEID: 9304118
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Alcohol intake
alcohol symptoms
all-cause mortality
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's