Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28824215
TITLE
Sensation seeking and impulsive traits as personality endophenotypes for antisocial behavior: Evidence from two independent samples.
ABSTRACT
Sensation seeking and impulsivity are personality traits that are correlated with risk for antisocial behavior (ASB). This paper uses two independent samples of twins to (a) test the extent to which sensation seeking and impulsivity statistically mediate genetic influence on ASB, and (b) compare this to genetic influences accounted for by other personality traits. In Sample 1, delinquent behavior, as well as impulsivity, sensation seeking and Big Five personality traits, were measured in adolescent twins from the Texas Twin Project. In Sample 2, adult twins from the Australian Twin Registry responded to questionnaires that assessed individual differences in Eysenck's and Cloninger's personality dimensions, and a structured telephone interview that asked participants to retrospectively report DSM-defined symptoms of conduct disorder. Bivariate quantitative genetic models were used to identify genetic overlap between personality traits and ASB. Across both samples, novelty/sensation seeking and impulsive traits accounted for larger portions of genetic variance in ASB than other personality traits. We discuss whether sensation seeking and impulsive personality are causal endophenotypes for ASB, or merely index genetic liability for ASB.
DATE PUBLISHED
2017 Jan 15
HISTORY
PUBSTATUS PUBSTATUSDATE
pmc-release 2018/01/15
entrez 2017/08/22 06:00
pubmed 2017/08/22 06:00
medline 2017/08/22 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Mann FD Mann Frank D FD Department of Psychology, University of Texas at Austin, Austin, TX, United States.
Engelhardt L Engelhardt Laura L Department of Psychology, University of Texas at Austin, Austin, TX, United States.
Briley DA Briley Daniel A DA Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Grotzinger AD Grotzinger Andrew D AD Department of Psychology, University of Texas at Austin, Austin, TX, United States.
Patterson MW Patterson Megan W MW Department of Psychology, University of Texas at Austin, Austin, TX, United States.
Tackett JL Tackett Jennifer L JL Department of Psychology, Northwestern University, Evanston, IL, United States.
Strathan DB Strathan Dixie B DB Faculty of Arts and Business, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.
Heath A Heath Andrew A Psychiatry, Washington University School of Medicine, St Louis, MI, United States.
Lynskey M Lynskey Michael M Institute of Psychiatry, King's College London, London, UK.
Slutske W Slutske Wendy W Department of Psychological Sciences, University of Missouri, Columbia, MO, United States.
Martin NG Martin Nicholas G NG Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, Queensland Institute of Medial Research, Brisbane, Queensland, Australia.
Tucker-Drob EM Tucker-Drob Elliot M EM Population Research Center, University of Texas at Austin, Austin, TX, United States.
Harden KP Harden K Paige KP Population Research Center, University of Texas at Austin, Austin, TX, United States.
INVESTIGATORS
JOURNAL
VOLUME: 105
ISSUE:
TITLE: Personality and individual differences
ISOABBREVIATION: Pers Individ Dif
YEAR: 2017
MONTH: Jan
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0191-8869
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Pers Individ Dif
COUNTRY: England
ISSNLINKING: 0191-8869
NLMUNIQUEID: 8006972
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R21 AA020588 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Antisocial behavior
Endophenotype
Impulsivity
Novelty seeking
Sensation seeking
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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