Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28764680
TITLE
Validation and psychometric properties of the Somatic and Psychological HEalth REport (SPHERE) in a young Australian-based population sample using non-parametric item response theory.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
The Somatic and Psychological HEalth REport (SPHERE) is a 34-item self-report questionnaire that assesses symptoms of mental distress and persistent fatigue. As it was developed as a screening instrument for use mainly in primary care-based clinical settings, its validity and psychometric properties have not been studied extensively in population-based samples.
METHODS NlmCategory: METHODS
We used non-parametric Item Response Theory to assess scale validity and item properties of the SPHERE-34 scales, collected through four waves of the Brisbane Longitudinal Twin Study (N = 1707, mean age = 12, 51% females; N = 1273, mean age = 14, 50% females; N = 1513, mean age = 16, 54% females, N = 1263, mean age = 18, 56% females). We estimated the heritability of the new scores, their genetic correlation, and their predictive ability in a sub-sample (N = 1993) who completed the Composite International Diagnostic Interview.
RESULTS NlmCategory: RESULTS
After excluding items most responsible for noise, sex or wave bias, the SPHERE-34 questionnaire was reduced to 21 items (SPHERE-21), comprising a 14-item scale for anxiety-depression and a 10-item scale for chronic fatigue (3 items overlapping). These new scores showed high internal consistency (alpha > 0.78), moderate three months reliability (ICC = 0.47-0.58) and item scalability (Hi > 0.23), and were positively correlated (phenotypic correlations r = 0.57-0.70; rG = 0.77-1.00). Heritability estimates ranged from 0.27 to 0.51. In addition, both scores were associated with later DSM-IV diagnoses of MDD, social anxiety and alcohol dependence (OR in 1.23-1.47). Finally, a post-hoc comparison showed that several psychometric properties of the SPHERE-21 were similar to those of the Beck Depression Inventory.
CONCLUSIONS NlmCategory: CONCLUSIONS
The scales of SPHERE-21 measure valid and comparable constructs across sex and age groups (from 9 to 28 years). SPHERE-21 scores are heritable, genetically correlated and show good predictive ability of mental health in an Australian-based population sample of young people.
DATE PUBLISHED
2017 Aug 01
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/07/01
accepted 2017/07/04
entrez 2017/08/03 06:00
pubmed 2017/08/03 06:00
medline 2017/08/03 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Couvy-Duchesne B Couvy-Duchesne Baptiste B Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. b.couvyduchesne@uq.edu.au.
Davenport TA Davenport Tracey A TA Brain and Mind Centre, The University of Sydney, Sydney, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, the University of Queensland, Brisbane, Australia.
Hickie IB Hickie Ian B IB Brain and Mind Centre, The University of Sydney, Sydney, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 17
ISSUE: 1
TITLE: BMC psychiatry
ISOABBREVIATION: BMC Psychiatry
YEAR: 2017
MONTH: Aug
DAY: 01
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1471-244X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: BMC Psychiatry
COUNTRY: England
ISSNLINKING: 1471-244X
NLMUNIQUEID: 100968559
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Anxiety
Chronic fatigue
DSM-IV
Depression
Heritability
Non-parametric item response theory
Psychometrics
Test-retest
Twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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