Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28724480
TITLE
Neuroticism and the Overlap Between Autistic and ADHD Traits: Findings From a Population Sample of Young Adult Australian Twins.
ABSTRACT
Neuroticism, a 'Big Five' personality trait, has been associated with sub-clinical traits of both autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). The objective of the current study was to examine whether causal overlap between ASD and ADHD traits can be accounted for by genetic and environmental risk factors that are shared with neuroticism. We performed twin-based structural equation modeling using self-report data from 12 items of the Neo Five-Factor Inventory Neuroticism domain, 11 Social Responsiveness Scale items, and 12 Adult ADHD Self-Report Scale items obtained from 3,170 young adult Australian individual twins (1,081 complete pairs). Univariate analysis for neuroticism, ASD, and ADHD traits suggested that the most parsimonious models were those with additive genetic and unique environmental components, without sex limitation effects. Heritability of neuroticism, ASD, and ADHD traits, as measured by these methods, was moderate (between 40% and 45% for each respective trait). In a trivariate model, we observed moderate phenotypic (between 0.45 and 0.62), genetic (between 0.56 and 0.71), and unique environmental correlations (between 0.37and 0.55) among neuroticism, ASD, and ADHD traits, with the highest value for the shared genetic influence between neuroticism and self-reported ASD traits (r g = 0.71). Together, our results suggest that in young adults, genetic, and unique environmental risk factors indexed by neuroticism overlap with those that are shared by ASD and ADHD.
DATE PUBLISHED
2017 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2017/07/21 06:00
pubmed 2017/07/21 06:00
medline 2017/07/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Park SH Park Shin-Ho SH Autism Clinic for Translational Research,Brain and Mind Centre,Central Clinical School,Faculty of Medicine,University of Sydney,Sydney,NSW,Australia.
Guastella AJ Guastella Adam J AJ Autism Clinic for Translational Research,Brain and Mind Centre,Central Clinical School,Faculty of Medicine,University of Sydney,Sydney,NSW,Australia.
Lynskey M Lynskey Michael M Institute of Psychiatry,Psychology,and Neuroscience,King's College London,London,UK.
Agrawal A Agrawal Arpana A Department of Psychiatry,Washington University School of Medicine,St. Louis,MO,USA.
Constantino JN Constantino John N JN Department of Psychiatry,Washington University School of Medicine,St. Louis,MO,USA.
Medland SE Medland Sarah E SE Genetics & Computational Biology Department,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Song YJC Song Yun Ju C YJC Autism Clinic for Translational Research,Brain and Mind Centre,Central Clinical School,Faculty of Medicine,University of Sydney,Sydney,NSW,Australia.
Martin NG Martin Nicholas G NG Genetics & Computational Biology Department,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Colodro-Conde L Colodro-Conde Lucía L Genetics & Computational Biology Department,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
INVESTIGATORS
JOURNAL
VOLUME: 20
ISSUE: 4
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2017
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
ADHD
autism
neuroticism
twin study
MESH HEADINGS
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GENE SYMBOLS
CHEMICALS
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