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| PMID |
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| TITLE |
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| Investigating the relationship between iron and depression. |
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| ABSTRACT |
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| Lower levels of circulating iron have been associated with depression. Our objective was to investigate the phenotypic and genetic relationship between measures of circulating levels of iron (serum iron, transferrin, transferrin saturation, and ferritin) and depressive symptoms. Data were available from ongoing studies at QIMR Berghofer Medical Research Institute (QIMRB), including twin adolescents (mean age 15.1 years, standard deviation (SD) 3.2 years), and twin adults (mean age 23.2 years, SD 2.2 years). In the adolescent cohort, there were 3416 participants from 1688 families. In the adult cohort there were 9035 participants from 4533 families. We estimated heritabilities of, and phenotypic and genetic correlations between, traits. We conducted analyses that linked results from published large-scale genome-wide association studies (including iron and Major Depressive Disorder) with our study samples using single SNP and multi-SNP genetic risk score analyses, and LD score regression analyses. In both cohorts, measures of iron, transferrin, transferrin saturation, and log 10 of ferritin (L10Fer) were all highly heritable, while depressive measures were moderately heritable. In adolescents, depression measures were higher in those in the middle 10th versus top 10th percentile of transferrin saturation measures (p = 0.002). Genetic profile risk scores of the iron measures were not significantly associated with depression in study participants. LD score analyses showed no significant genetic relationship between iron and depression. Genetic factors strongly influence iron measures in adolescents and adults. Using several different strategies we find no evidence for a genetic contribution to the relationship between blood measures of iron and measures of depression. |
| Copyright © 2017 Elsevier Ltd. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2017/02/25 |
| revised |
2017/06/03 |
| accepted |
2017/07/07 |
| entrez |
2017/07/18 06:00 |
| pubmed |
2017/07/18 06:00 |
| medline |
2017/07/18 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Mills NT |
|
Mills |
Natalie T |
NT |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, 5000, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia. Electronic address: natalie.mills@adelaide.edu.au. |
| Maier R |
|
Maier |
Robert |
R |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. |
| Whitfield JB |
|
Whitfield |
John B |
JB |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucia |
L |
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Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. |
| Scott JG |
|
Scott |
James G |
JG |
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The University of Queensland, UQ Centre for Clinical Research, Herston, 4029, Australia; Metro North Mental Health, Royal Brisbane and Women's Hospital, Brisbane, 4006, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Brisbane, 4076, Australia. |
| Byrne GJ |
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Byrne |
Gerard J |
GJ |
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Academic Discipline of Psychiatry, School of Medicine, The University of Queensland, Brisbane, Australia. |
| Hansell NK |
|
Hansell |
Narelle K |
NK |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia. |
| Vinkhuyzen AAE |
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Vinkhuyzen |
Anna A E |
AAE |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. |
| CouvyDuchesne B |
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CouvyDuchesne |
Baptiste |
B |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. |
| Montgomery GW |
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Montgomery |
Grant W |
GW |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. |
| Henders AK |
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Henders |
Anjali K |
AK |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia. |
| Wray NR |
|
Wray |
Naomi R |
NR |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. |
| Benyamin B |
|
Benyamin |
Beben |
B |
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Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 94 |
| ISSUE: |
| TITLE: Journal of psychiatric research |
| ISOABBREVIATION: J Psychiatr Res |
| YEAR: 2017 |
| MONTH: Jul |
| DAY: 08 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1879-1379 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: J Psychiatr Res |
| COUNTRY: England |
| ISSNLINKING: 0022-3956 |
| NLMUNIQUEID: 0376331 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Depression |
| Ferritin |
| Iron |
| Transferrin |
| Transferrin saturation |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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