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PMID |
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TITLE |
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Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts. |
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ABSTRACT |
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Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m )], but factors modifying these variance components are poorly understood. We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20-29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI. The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population. |
© 2017 American Society for Nutrition. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2017/01/26 |
accepted |
2017/06/08 |
pubmed |
2017/07/07 06:00 |
medline |
2017/08/17 06:00 |
entrez |
2017/07/07 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Silventoinen K |
|
Silventoinen |
Karri |
K |
|
Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
Jelenkovic A |
|
Jelenkovic |
Aline |
A |
|
Department of Genetics, Physical Anthropology, and Animal Physiology, University of the Basque Country, Leioa, Spain. |
Sund R |
|
Sund |
Reijo |
R |
|
Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. |
Yokoyama Y |
|
Yokoyama |
Yoshie |
Y |
|
Department of Public Health Nursing, Osaka City University, Osaka, Japan. |
Hur YM |
|
Hur |
Yoon-Mi |
YM |
|
Department of Education, Mokpo National University, Jeonnam, South Korea. |
Cozen W |
|
Cozen |
Wendy |
W |
|
Norris Comprehensive Cancer Center, and. |
Hwang AE |
|
Hwang |
Amie E |
AE |
|
Department of Preventive Medicine, Keck School of Medicine. |
Mack TM |
|
Mack |
Thomas M |
TM |
|
Norris Comprehensive Cancer Center, and. |
Honda C |
|
Honda |
Chika |
C |
|
Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
Inui F |
|
Inui |
Fujio |
F |
|
Faculty of Health Science, Kio University, Nara, Japan. |
Iwatani Y |
|
Iwatani |
Yoshinori |
Y |
|
Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
Watanabe M |
|
Watanabe |
Mikio |
M |
|
Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
Tomizawa R |
|
Tomizawa |
Rie |
R |
|
Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
Pietiläinen KH |
|
Pietiläinen |
Kirsi H |
KH |
|
Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. |
Rissanen A |
|
Rissanen |
Aila |
A |
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Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. |
Siribaddana SH |
|
Siribaddana |
Sisira H |
SH |
|
Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka. |
Hotopf M |
|
Hotopf |
Matthew |
M |
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National Institute for Health Research Mental Health Biomedical Research Centre, South London and Maudsley National Health Service Foundation Trust, Institute of Psychiatry Psychology and Neuroscience. |
Sumathipala A |
|
Sumathipala |
Athula |
A |
|
Research Institute for Primary Care and Health Sciences, School for Primary Care Research, Faculty of Health, Keele University, Staffordshire, United Kingdom. |
Rijsdijk F |
|
Rijsdijk |
Fruhling |
F |
|
Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, and. |
Tan Q |
|
Tan |
Qihua |
Q |
|
Unit of Epidemiology, Biostatistics, and Biodemography, Departments of Public Health and. |
Zhang D |
|
Zhang |
Dongfeng |
D |
|
Department of Public Health, Qingdao University Medical College, Qingdao, China. |
Pang Z |
|
Pang |
Zengchang |
Z |
|
Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China. |
Piirtola M |
|
Piirtola |
Maarit |
M |
|
Institute for Molecular Medicine, Helsinki, Finland. |
Aaltonen S |
|
Aaltonen |
Sari |
S |
|
Public Health, and. |
Öncel SY |
|
Öncel |
Sevgi Y |
SY |
|
Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey. |
Aliev F |
|
Aliev |
Fazil |
F |
|
African American Studies. |
Rebato E |
|
Rebato |
Esther |
E |
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Department of Genetics, Physical Anthropology, and Animal Physiology, University of the Basque Country, Leioa, Spain. |
Hjelmborg JB |
|
Hjelmborg |
Jacob B |
JB |
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The Danish Twin Registry. |
Christensen K |
|
Christensen |
Kaare |
K |
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Departments of Clinical Biochemistry and Pharmacology and Clinical Genetics, and. |
Skytthe A |
|
Skytthe |
Axel |
A |
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The Danish Twin Registry. |
Kyvik KO |
|
Kyvik |
Kirsten O |
KO |
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Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark. |
Silberg JL |
|
Silberg |
Judy L |
JL |
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Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, and. |
Eaves LJ |
|
Eaves |
Lindon J |
LJ |
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Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, and. |
Cutler TL |
|
Cutler |
Tessa L |
TL |
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The Australian Twin Registry, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia. |
Ordoñana JR |
|
Ordoñana |
Juan R |
JR |
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Biomedical Research Institute of Murcia (IMIB)-Arrixaca, Murcia, Spain. |
Sánchez-Romera JF |
|
Sánchez-Romera |
Juan F |
JF |
|
Biomedical Research Institute of Murcia (IMIB)-Arrixaca, Murcia, Spain. |
Colodro-Conde L |
|
Colodro-Conde |
Lucia |
L |
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Quantitative Genetics Laboratory and. |
Song YM |
|
Song |
Yun-Mi |
YM |
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Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. |
Yang S |
|
Yang |
Sarah |
S |
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Institute of Health and Environment, Seoul National University, Seoul, South Korea. |
Lee K |
|
Lee |
Kayoung |
K |
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Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. |
Franz CE |
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Franz |
Carol E |
CE |
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Department of Psychiatry, University of California, San Diego, CA. |
Kremen WS |
|
Kremen |
William S |
WS |
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US Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health, La Jolla, CA. |
Lyons MJ |
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Lyons |
Michael J |
MJ |
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Department of Psychology, Boston University, Boston, MA. |
Busjahn A |
|
Busjahn |
Andreas |
A |
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HealthTwiSt GmbH, Berlin, Germany. |
Nelson TL |
|
Nelson |
Tracy L |
TL |
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Department of Health and Exercise Sciences, Colorado School of Public Health, Colorado State University, Aurora, CO. |
Whitfield KE |
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Whitfield |
Keith E |
KE |
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Psychology Department, Wayne State University, Detroit, MI. |
Kandler C |
|
Kandler |
Christian |
C |
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Department of Psychology, Bielefeld University, Bielefeld, Germany. |
Jang KL |
|
Jang |
Kerry L |
KL |
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Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada; Departments of. |
Gatz M |
|
Gatz |
Margaret |
M |
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Medical Epidemiology and Biostatistics and. |
Butler DA |
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Butler |
David A |
DA |
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Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine, Washington, DC. |
Stazi MA |
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Stazi |
Maria A |
MA |
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Italian National Institute of Health National Center for Epidemiology, Surveillance, and Health Promotion, Rome, Italy. |
Fagnani C |
|
Fagnani |
Corrado |
C |
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Italian National Institute of Health National Center for Epidemiology, Surveillance, and Health Promotion, Rome, Italy. |
D'Ippolito C |
|
D'Ippolito |
Cristina |
C |
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Italian National Institute of Health National Center for Epidemiology, Surveillance, and Health Promotion, Rome, Italy. |
Duncan GE |
|
Duncan |
Glen E |
GE |
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Washington State Twin Registry, Health Sciences, Washington State University, Spokane, WA. |
Buchwald D |
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Buchwald |
Dedra |
D |
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Washington State Twin Registry, Health Sciences, Washington State University, Spokane, WA. |
Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetic Epidemiology Department, Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Australia. |
Medland SE |
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Medland |
Sarah E |
SE |
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Genetic Epidemiology Department, Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Australia. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
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Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Jeong HU |
|
Jeong |
Hoe-Uk |
HU |
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Department of Education, Mokpo National University, Jeonnam, South Korea. |
Swan GE |
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Swan |
Gary E |
GE |
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Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA. |
Krasnow R |
|
Krasnow |
Ruth |
R |
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Center for Health Sciences, SRI International, Menlo Park, CA. |
Magnusson PK |
|
Magnusson |
Patrik Ke |
PK |
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Medical Epidemiology and Biostatistics and. |
Pedersen NL |
|
Pedersen |
Nancy L |
NL |
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Medical Epidemiology and Biostatistics and. |
Dahl Aslan AK |
|
Dahl Aslan |
Anna K |
AK |
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Institute of Gerontology and Aging Research Network, School of Health and Welfare, Jönköping University, Jönköping, Sweden. |
McAdams TA |
|
McAdams |
Tom A |
TA |
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Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, and. |
Eley TC |
|
Eley |
Thalia C |
TC |
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Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, and. |
Gregory AM |
|
Gregory |
Alice M |
AM |
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Department of Psychology, Goldsmiths, University of London, London, United Kingdom. |
Tynelius P |
|
Tynelius |
Per |
P |
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Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. |
Baker LA |
|
Baker |
Laura A |
LA |
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Department of Psychology, University of Southern California, Los Angeles, CA. |
Tuvblad C |
|
Tuvblad |
Catherine |
C |
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School of Law, Psychology, and Social Work, Örebro University, Örebro, Sweden. |
Bayasgalan G |
|
Bayasgalan |
Gombojav |
G |
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Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia. |
Narandalai D |
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Narandalai |
Danshiitsoodol |
D |
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Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. |
Spector TD |
|
Spector |
Timothy D |
TD |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom. |
Mangino M |
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Mangino |
Massimo |
M |
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National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, United Kingdom. |
Lachance G |
|
Lachance |
Genevieve |
G |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom. |
Burt SA |
|
Burt |
S Alexandra |
SA |
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Michigan State University, East Lansing, Michigan. |
Klump KL |
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Klump |
Kelly L |
KL |
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Michigan State University, East Lansing, Michigan. |
Harris JR |
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Harris |
Jennifer R |
JR |
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Norwegian Institute of Public Health, Oslo, Norway. |
Brandt I |
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Brandt |
Ingunn |
I |
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Norwegian Institute of Public Health, Oslo, Norway. |
Nilsen TS |
|
Nilsen |
Thomas S |
TS |
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Norwegian Institute of Public Health, Oslo, Norway. |
Krueger RF |
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Krueger |
Robert F |
RF |
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Department of Psychology, University of Minnesota, Minneapolis, MN. |
McGue M |
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McGue |
Matt |
M |
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Department of Psychology, University of Minnesota, Minneapolis, MN. |
Pahlen S |
|
Pahlen |
Shandell |
S |
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Department of Psychology, University of Minnesota, Minneapolis, MN. |
Corley RP |
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Corley |
Robin P |
RP |
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Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado. |
Huibregtse BM |
|
Huibregtse |
Brooke M |
BM |
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Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado. |
Bartels M |
|
Bartels |
Meike |
M |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. |
van Beijsterveldt CE |
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van Beijsterveldt |
Catharina Em |
CE |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. |
Willemsen G |
|
Willemsen |
Gonneke |
G |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. |
Goldberg JH |
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Goldberg |
Jack H |
JH |
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Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA. |
Rasmussen F |
|
Rasmussen |
Finn |
F |
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Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. |
Tarnoki AD |
|
Tarnoki |
Adam D |
AD |
|
Hungarian Twin Registry, Budapest, Hungary. |
Tarnoki DL |
|
Tarnoki |
David L |
DL |
|
Hungarian Twin Registry, Budapest, Hungary. |
Derom CA |
|
Derom |
Catherine A |
CA |
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Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium. |
Vlietinck RF |
|
Vlietinck |
Robert F |
RF |
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Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium. |
Loos RJ |
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Loos |
Ruth Jf |
RJ |
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Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY. |
Hopper JL |
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Hopper |
John L |
JL |
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The Australian Twin Registry, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia. |
Sung J |
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Sung |
Joohon |
J |
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Institute of Health and Environment, Seoul National University, Seoul, South Korea. |
Maes HH |
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Maes |
Hermine H |
HH |
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Departments of Human and Molecular Genetics and Psychiatry, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA. |
Turkheimer E |
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Turkheimer |
Eric |
E |
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Department of Psychology, University of Virginia, Charlottesville, VA. |
Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. |
Sørensen TI |
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Sørensen |
Thorkild Ia |
TI |
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Department of Clinical Epidemiology, Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark. |
Kaprio J |
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Kaprio |
Jaakko |
J |
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Institute for Molecular Medicine, Helsinki, Finland. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 106 |
ISSUE: 2 |
TITLE: The American journal of clinical nutrition |
ISOABBREVIATION: Am J Clin Nutr |
YEAR: 2017 |
MONTH: Aug |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1938-3207 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Am J Clin Nutr |
COUNTRY: United States |
ISSNLINKING: 0002-9165 |
NLMUNIQUEID: 0376027 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Twin Study |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
T32 DA017637 |
NIDA NIH HHS |
United States |
G120/635 |
Medical Research Council |
United Kingdom |
R01 AG018384 |
NIA NIH HHS |
United States |
P30 DK020541 |
NIDDK NIH HHS |
United States |
P30 AG017265 |
NIA NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
BMI |
adults |
genetics |
international comparisons |
twins |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
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Age Factors |
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Aged |
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Aged, 80 and over |
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Australia |
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Body Mass Index |
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Body Weight |
genetics |
Culture |
genetics |
Environment |
genetics |
Europe |
genetics |
Female |
genetics |
Gene-Environment Interaction |
genetics |
Humans |
genetics |
Male |
genetics |
Middle Aged |
genetics |
North America |
genetics |
Obesity |
genetics |
Prevalence |
genetics |
Quantitative Trait, Heritable |
genetics |
Sex Factors |
genetics |
Twins, Dizygotic |
genetics |
Twins, Monozygotic |
genetics |
Young Adult |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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