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| PMID |
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| TITLE |
|
| Individual differences in plasma ALT, AST and GGT: contributions of genetic and environmental factors, including alcohol consumption. |
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| ABSTRACT |
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|
| The causes of individuality of the plasma enzymes alanine aminotransferase (ALT; EC 2.6.1.2), aspartate aminotransferase (AST; EC 2.6.1.1) and gamma-glutamyl transferase (GGT; EC 2.3.2.2) were investigated in a study of 206 pairs of twins. Between-person variance was greater in men than women, while within-person variation was similar in both sexes. Plasma ALT and AST levels were affected by genetic factors, while GGT was affected by some environmental factor shared by co-twins. In the men, alcohol intake had a significant but small effect on all three enzyme levels, and since alcohol consumption was highly heritable, this appeared as a genetic influence on enzyme activities. The major factors involved in the observed correlations between these enzymes were a non-shared environmental factor other than alcohol affecting ALT, AST and GGT, and a genetic factor affecting only ALT and AST. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1985/01/01 |
| medline |
1985/01/01 00:01 |
| entrez |
1985/01/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Whitfield JB |
|
Whitfield |
J B |
JB |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 33 |
| ISSUE: 2 |
| TITLE: Enzyme |
| ISOABBREVIATION: Enzyme |
| YEAR: 1985 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0013-9432 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Enzyme |
| COUNTRY: SWITZERLAND |
| ISSNLINKING: 0013-9432 |
| NLMUNIQUEID: 1262265 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
|
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Alanine Transaminase |
genetics |
| Alcohol Drinking |
genetics |
| Aspartate Aminotransferases |
genetics |
| Environment |
genetics |
| Female |
genetics |
| Genetic Variation |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Pregnancy |
genetics |
| Sex Factors |
genetics |
| Twins |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
| gamma-Glutamyltransferase |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| EC 2.3.2.2 |
gamma-Glutamyltransferase |
| EC 2.6.1.1 |
Aspartate Aminotransferases |
| EC 2.6.1.2 |
Alanine Transaminase |
|
| OTHER ID's |
|
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|
