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| PMID |
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| TITLE |
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| No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease. |
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| ABSTRACT |
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| Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2017/06/07 06:00 |
| medline |
2018/04/07 06:00 |
| entrez |
2017/06/07 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Lupton MK |
|
Lupton |
Michelle K |
MK |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Benyamin B |
|
Benyamin |
Beben |
B |
|
Queensland Brain Institute, University of Queensland, Brisbane, Australia. |
| Proitsi P |
|
Proitsi |
Petroula |
P |
|
Institute of Psychiatry Psychology and Neuroscience, Kings College London, UK. |
| Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. |
| Ferreira MA |
|
Ferreira |
Manuel A |
MA |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Washington University School of Medicine, StLouis, MO, USA. |
| Madden PA |
|
Madden |
Pamela A |
PA |
|
Washington University School of Medicine, StLouis, MO, USA. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Gordon SD |
|
Gordon |
Scott D |
SD |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
|
GERAD1 Consortium |
|
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|
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Alzheimer’s Disease Neuroimaging Initiative |
|
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|
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| Lovestone S |
|
Lovestone |
Simon |
S |
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Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK. |
| Tsolaki M |
|
Tsolaki |
Magda |
M |
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Memory and Dementia Centre, 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece. |
| Kloszewska I |
|
Kloszewska |
Iwona |
I |
|
Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland. |
| Soininen H |
|
Soininen |
Hilkka |
H |
|
Department of Neurology, University of EasternFinland and Kuopio University Hospital, Kuopio, Finland. |
| Mecocci P |
|
Mecocci |
Patrizia |
P |
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Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. |
| Vellas B |
|
Vellas |
Bruno |
B |
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Gerontopole, CHU, UMR INSERM 1027, University ofToulouse, France. |
| Powell JF |
|
Powell |
John F |
JF |
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Institute of Psychiatry Psychology and Neuroscience, Kings College London, UK. |
| Bush AI |
|
Bush |
Ashley I |
AI |
|
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
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Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Whitfield JB |
|
Whitfield |
John B |
JB |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 59 |
| ISSUE: 1 |
| TITLE: Journal of Alzheimer's disease : JAD |
| ISOABBREVIATION: J Alzheimers Dis |
| YEAR: 2017 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1875-8908 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: J Alzheimers Dis |
| COUNTRY: Netherlands |
| ISSNLINKING: 1387-2877 |
| NLMUNIQUEID: 9814863 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| G1001799 |
Medical Research Council |
United Kingdom |
| MR/N01104X/1 |
Medical Research Council |
United Kingdom |
| MR/N01104X/2 |
Medical Research Council |
United Kingdom |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Alzheimer’s disease |
| apolipoproteins E |
| dementia |
| ferritin |
| genetic profile scores |
| genome-wide association study |
| iron |
| population genetics |
| transferrin |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Aged |
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| Aged, 80 and over |
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| Alzheimer Disease |
genetics |
| Apolipoproteins E |
genetics |
| Cohort Studies |
genetics |
| Community Health Planning |
genetics |
| Female |
genetics |
| Ferritins |
blood |
| Genetic Association Studies |
statistics & numerical data |
| Humans |
statistics & numerical data |
| Iron |
blood |
| Male |
blood |
| Meta-Analysis as Topic |
blood |
| Middle Aged |
blood |
| Polymorphism, Single Nucleotide |
genetics |
| Transferrin |
metabolism |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
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| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Apolipoproteins E |
| 0 |
Transferrin |
| 9007-73-2 |
Ferritins |
| E1UOL152H7 |
Iron |
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| OTHER ID's |
|
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