Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28580697
TITLE
Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group.
ABSTRACT
Structural brain changes that occur during development and ageing are related to mental health and general cognitive functioning. Individuals differ in the extent to which their brain volumes change over time, but whether these differences can be attributed to differences in their genotypes has not been widely studied. Here we estimate heritability (h(2) ) of changes in global and subcortical brain volumes in five longitudinal twin cohorts from across the world and in different stages of the lifespan (N = 861). Heritability estimates of brain changes were significant and ranged from 16% (caudate) to 42% (cerebellar gray matter) for all global and most subcortical volumes (with the exception of thalamus and pallidum). Heritability estimates of change rates were generally higher in adults than in children suggesting an increasing influence of genetic factors explaining individual differences in brain structural changes with age. In children, environmental influences in part explained individual differences in developmental changes in brain structure. Multivariate genetic modeling showed that genetic influences of change rates and baseline volume significantly overlapped for many structures. The genetic influences explaining individual differences in the change rate for cerebellum, cerebellar gray matter and lateral ventricles were independent of the genetic influences explaining differences in their baseline volumes. These results imply the existence of genetic variants that are specific for brain plasticity, rather than brain volume itself. Identifying these genes may increase our understanding of brain development and ageing and possibly have implications for diseases that are characterized by deviant developmental trajectories of brain structure. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc.
2017 Wiley Periodicals, Inc.
DATE PUBLISHED
2017 Jun 05
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/09/27
revised 2017/05/16
accepted 2017/05/17
entrez 2017/06/06 06:00
pubmed 2017/06/06 06:00
medline 2017/06/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Brouwer RM Brouwer Rachel M RM Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Panizzon MS Panizzon Matthew S MS Department of Psychiatry, University of California, San Diego, California.
Glahn DC Glahn David C DC Department of Psychiatry, Yale University of Medicine, New Haven, Connecticut.
Hibar DP Hibar Derrek P DP Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, California.
Hua X Hua Xue X Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, California.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, California.
Abramovic L Abramovic Lucija L Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
de Zubicaray GI de Zubicaray Greig I GI Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia.
Franz CE Franz Carol E CE Department of Psychiatry, University of California, San Diego, California.
Hansell NK Hansell Narelle K NK Queensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia.
Hickie IB Hickie Ian B IB Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
Koenis MMG Koenis Marinka M G MMG Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Mather KA Mather Karen A KA Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, Australia.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, St. Lucia, QLD, Australia.
Schnack HG Schnack Hugo G HG Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Strike LT Strike Lachlan T LT Queensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia.
Swagerman SC Swagerman Suzanne C SC Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Thalamuthu A Thalamuthu Anbupalam A Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, Australia.
Wen W Wen Wei W Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, Australia.
Gilmore JH Gilmore John H JH Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina.
Gogtay N Gogtay Nitin N National Institute of Mental Health, Bethesda, Maryland.
Kahn RS Kahn René S RS Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Sachdev PS Sachdev Perminder S PS Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, Australia.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, University of Queensland, St. Lucia, QLD, Australia.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Kremen WS Kremen William S WS Department of Psychiatry, University of California, San Diego, California.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, California.
Hulshoff Pol HE Hulshoff Pol Hilleke E HE Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Human brain mapping
ISOABBREVIATION: Hum Brain Mapp
YEAR: 2017
MONTH: Jun
DAY: 05
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1097-0193
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Brain Mapp
COUNTRY: United States
ISSNLINKING: 1065-9471
NLMUNIQUEID: 9419065
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
ENIGMA plasticity working group
heritability
individual brain plasticity
longitudinal magnetic resonance imaging
twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's