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| PMID |
|
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| TITLE |
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| Cannabis and Depression: A Twin Model Approach to Co-morbidity. |
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| ABSTRACT |
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| Cannabis use disorder (CUD) co-occurs with major depressive disorder (MDD) more frequently than would be expected by chance. However, studies to date have not produced a clear understanding of the mechanisms underlying this co-morbidity. Genetically informative studies can add valuable insight to this problem, as they allow the evaluation of competing models of co-morbidity. This study uses data from the Australian Twin Registry to compare 13 co-morbidity twin models initially proposed by Neale and Kendler (Am J Hum Genet 57:935-953, 1995). The analysis sample comprised 2410 male and female monozygotic and dizygotic twins (average age 32) who were assessed on CUD and MDD using the SSAGA-OZ interview. Data were analyzed in OpenMx. Of the 13 different co-morbidity models, two fit equally well: CUD causes MDD and Random Multiformity of CUD. Both fit substantially better than the Correlated Liabilities model. Although the current study cannot differentiate between them statistically, these models, in combination, suggest that CUD risk factors may causally influence the risk to develop MDD, but only when risk for CUD is high. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2016/11/23 |
| accepted |
2017/04/13 |
| entrez |
2017/05/04 06:00 |
| pubmed |
2017/05/04 06:00 |
| medline |
2017/05/04 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Smolkina M |
|
Smolkina |
M |
M |
|
National Addiction Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, Addiction Sciences Building, 4 Windsor Walk, SE5 8BB, London, UK. milana.smolkina@kcl.ac.uk. |
| Morley KI |
|
Morley |
K I |
KI |
|
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia. |
| Rijsdijk F |
|
Rijsdijk |
F |
F |
|
Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK. |
| Agrawal A |
|
Agrawal |
A |
A |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Bergin JE |
|
Bergin |
J E |
JE |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. |
| Nelson EC |
|
Nelson |
E C |
EC |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Statham D |
|
Statham |
D |
D |
|
Faculty of Arts, Business and Law, School of Social Sciences, University of the Sunshine Coast, Sippy Downs, QLD, Australia. |
| Martin NG |
|
Martin |
N G |
NG |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Lynskey MT |
|
Lynskey |
M T |
MT |
|
National Addiction Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, Addiction Sciences Building, 4 Windsor Walk, SE5 8BB, London, UK. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Behavior genetics |
| ISOABBREVIATION: Behav. Genet. |
| YEAR: 2017 |
| MONTH: May |
| DAY: 02 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-3297 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Behav Genet |
| COUNTRY: United States |
| ISSNLINKING: 0001-8244 |
| NLMUNIQUEID: 0251711 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Cannabis use disorder |
| Co-morbidity |
| Genetics |
| Major depressive disorder |
| Twin model |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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