Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28463239
TITLE
Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group.
ABSTRACT
The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N=451) vs healthy controls (N=1996) or MDD patients with no suicidal symptoms (N=650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P=4.12 × 10(-3)) or a 2.87% smaller volume compared with controls (Cohen's d=-0.284). In addition, we observed a nonsignificant trend in which MDD cases with suicidal symptoms had smaller subcortical volumes and larger ventricular volumes compared with controls. Finally, no significant differences (P=0.28-0.97) were found between MDD patients with and those without suicidal symptoms for any of the brain volume measures. This is by far the largest neuroimaging meta-analysis of suicidal behaviour in MDD to date. Our results did not replicate previous reports of association between subcortical brain structure and suicidality and highlight the need for collecting better-powered imaging samples and using improved suicidality assessment instruments.
DATE PUBLISHED
2017 May 02
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/07/24
revised 2017/02/25
accepted 2017/02/28
entrez 2017/05/03 06:00
pubmed 2017/05/04 06:00
medline 2017/05/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Rentería ME Rentería M E ME Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Schmaal L Schmaal L L Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Hibar DP Hibar D P DP Imaging Genetics Center, Department of Neurology, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Couvy-Duchesne B Couvy-Duchesne B B Center for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia.
Strike LT Strike L T LT Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
Mills NT Mills N T NT Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
de Zubicaray GI de Zubicaray G I GI Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
McMahon KL McMahon K L KL Center for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia.
Medland SE Medland S E SE Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Gillespie NA Gillespie N A NA Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Hatton SN Hatton S N SN Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Lagopoulos J Lagopoulos J J Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Veltman DJ Veltman D J DJ Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
van der Wee N van der Wee N N Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
van Erp TGM van Erp T G M TGM Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Wittfeld K Wittfeld K K German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.
Grabe HJ Grabe H J HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Block A Block A A Sociology of Health and Physical Activity, Department of Health Science, University of Potsdam, Potsdam, Germany.
Hegenscheid K Hegenscheid K K Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Völzke H Völzke H H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Veer IM Veer I M IM Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Walter H Walter H H Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Schnell K Schnell K K Department of General Psychiatry, University Hospital Heidelberg, Heidelberg, Germany.
Schramm E Schramm E E Psychiatric University Clinic, Basel, Switzerland.
Normann C Normann C C Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany.
Schoepf D Schoepf D D Department of Psychiatry, University of Bonn, Bonn, Germany.
Konrad C Konrad C C Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Zurowski B Zurowski B B Center for Integrative Psychiatry, University of Lübeck, Lübeck, Germany.
Godlewska BR Godlewska B R BR University Department of Psychiatry, Warneford Hospital, Oxford, UK.
Cowen PJ Cowen P J PJ University Department of Psychiatry, Warneford Hospital, Oxford, UK.
Penninx BWJH Penninx B W J H BWJH Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Jahanshad N Jahanshad N N Imaging Genetics Center, Department of Neurology, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Thompson PM Thompson P M PM Imaging Genetics Center, Department of Neurology, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Wright MJ Wright M J MJ Center for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia.
Martin NG Martin N G NG Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Christensen H Christensen H H Black Dog Institute, Prince of Wales Hospital and School of Medicine, University of New South Wales, Randwick, NSW, Australia.
Hickie IB Hickie I B IB Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE: 5
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2017
MONTH: May
DAY: 02
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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