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| PMID |
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| TITLE |
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| Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group. |
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| ABSTRACT |
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| The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N=451) vs healthy controls (N=1996) or MDD patients with no suicidal symptoms (N=650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P=4.12 × 10(-3)) or a 2.87% smaller volume compared with controls (Cohen's d=-0.284). In addition, we observed a nonsignificant trend in which MDD cases with suicidal symptoms had smaller subcortical volumes and larger ventricular volumes compared with controls. Finally, no significant differences (P=0.28-0.97) were found between MDD patients with and those without suicidal symptoms for any of the brain volume measures. This is by far the largest neuroimaging meta-analysis of suicidal behaviour in MDD to date. Our results did not replicate previous reports of association between subcortical brain structure and suicidality and highlight the need for collecting better-powered imaging samples and using improved suicidality assessment instruments. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2015/07/24 |
| revised |
2017/02/25 |
| accepted |
2017/02/28 |
| entrez |
2017/05/03 06:00 |
| pubmed |
2017/05/04 06:00 |
| medline |
2017/05/04 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Rentería ME |
|
Rentería |
M E |
ME |
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Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
| Schmaal L |
|
Schmaal |
L |
L |
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Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. |
| Hibar DP |
|
Hibar |
D P |
DP |
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Imaging Genetics Center, Department of Neurology, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. |
| Couvy-Duchesne B |
|
Couvy-Duchesne |
B |
B |
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Center for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia. |
| Strike LT |
|
Strike |
L T |
LT |
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Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia. |
| Mills NT |
|
Mills |
N T |
NT |
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Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia. |
| de Zubicaray GI |
|
de Zubicaray |
G I |
GI |
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Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. |
| McMahon KL |
|
McMahon |
K L |
KL |
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Center for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia. |
| Medland SE |
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Medland |
S E |
SE |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Gillespie NA |
|
Gillespie |
N A |
NA |
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Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. |
| Hatton SN |
|
Hatton |
S N |
SN |
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Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia. |
| Lagopoulos J |
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Lagopoulos |
J |
J |
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Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia. |
| Veltman DJ |
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Veltman |
D J |
DJ |
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Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. |
| van der Wee N |
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van der Wee |
N |
N |
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Leiden Institute for Brain and Cognition, Leiden, The Netherlands. |
| van Erp TGM |
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van Erp |
T G M |
TGM |
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Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA. |
| Wittfeld K |
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Wittfeld |
K |
K |
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German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany. |
| Grabe HJ |
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Grabe |
H J |
HJ |
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Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. |
| Block A |
|
Block |
A |
A |
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Sociology of Health and Physical Activity, Department of Health Science, University of Potsdam, Potsdam, Germany. |
| Hegenscheid K |
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Hegenscheid |
K |
K |
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Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany. |
| Völzke H |
|
Völzke |
H |
H |
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Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Veer IM |
|
Veer |
I M |
IM |
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Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany. |
| Walter H |
|
Walter |
H |
H |
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Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany. |
| Schnell K |
|
Schnell |
K |
K |
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Department of General Psychiatry, University Hospital Heidelberg, Heidelberg, Germany. |
| Schramm E |
|
Schramm |
E |
E |
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Psychiatric University Clinic, Basel, Switzerland. |
| Normann C |
|
Normann |
C |
C |
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Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany. |
| Schoepf D |
|
Schoepf |
D |
D |
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Department of Psychiatry, University of Bonn, Bonn, Germany. |
| Konrad C |
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Konrad |
C |
C |
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Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany. |
| Zurowski B |
|
Zurowski |
B |
B |
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Center for Integrative Psychiatry, University of Lübeck, Lübeck, Germany. |
| Godlewska BR |
|
Godlewska |
B R |
BR |
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University Department of Psychiatry, Warneford Hospital, Oxford, UK. |
| Cowen PJ |
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Cowen |
P J |
PJ |
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University Department of Psychiatry, Warneford Hospital, Oxford, UK. |
| Penninx BWJH |
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Penninx |
B W J H |
BWJH |
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Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. |
| Jahanshad N |
|
Jahanshad |
N |
N |
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Imaging Genetics Center, Department of Neurology, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. |
| Thompson PM |
|
Thompson |
P M |
PM |
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Imaging Genetics Center, Department of Neurology, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. |
| Wright MJ |
|
Wright |
M J |
MJ |
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Center for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia. |
| Martin NG |
|
Martin |
N G |
NG |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Christensen H |
|
Christensen |
H |
H |
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Black Dog Institute, Prince of Wales Hospital and School of Medicine, University of New South Wales, Randwick, NSW, Australia. |
| Hickie IB |
|
Hickie |
I B |
IB |
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Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 7 |
| ISSUE: 5 |
| TITLE: Translational psychiatry |
| ISOABBREVIATION: Transl Psychiatry |
| YEAR: 2017 |
| MONTH: May |
| DAY: 02 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2158-3188 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Transl Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 2158-3188 |
| NLMUNIQUEID: 101562664 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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