Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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28448500
TITLE
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
ABSTRACT
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
DATE PUBLISHED
2017 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/08/17
accepted 2016/12/07
entrez 2017/04/28 06:00
pubmed 2017/04/28 06:00
medline 2017/04/28 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Graff M Graff Mariaelisa M Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Scott RA Scott Robert A RA MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Justice AE Justice Anne E AE Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Young KL Young Kristin L KL Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Feitosa MF Feitosa Mary F MF Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Barata L Barata Llilda L Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Winkler TW Winkler Thomas W TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Chu AY Chu Audrey Y AY Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Mahajan A Mahajan Anubha A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Hadley D Hadley David D Division of Population Health Sciences and Education, St. George's, University of London, London, United Kingdom.
Xue L Xue Luting L Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Workalemahu T Workalemahu Tsegaselassie T Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Heard-Costa NL Heard-Costa Nancy L NL Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
den Hoed M den Hoed Marcel M Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Ahluwalia TS Ahluwalia Tarunveer S TS Steno Diabetes Center, Gentofte, Denmark.
Qi Q Qi Qibin Q Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Ngwa JS Ngwa Julius S JS Howard University, Department of Internal Medicine, Washington DC, United States of America.
Renström F Renström Frida F Department of Biobank Research, Umeå University, Umeå, Sweden.
Quaye L Quaye Lydia L Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Eicher JD Eicher John D JD Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
Hayes JE Hayes James E JE Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Cornelis M Cornelis Marilyn M Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Kutalik Z Kutalik Zoltan Z Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Lim E Lim Elise E Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Luan J Luan Jian'an J MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Huffman JE Huffman Jennifer E JE MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Zhang W Zhang Weihua W Department of Cardiology, Ealing Hospital HNS Trust, Middlesex, United Kingdom.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Griffin PJ Griffin Paula J PJ Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Haller T Haller Toomas T Estonian Genome Center, University of Tartu, Tartu, Estonia.
Ahmad S Ahmad Shafqat S Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Marques-Vidal PM Marques-Vidal Pedro M PM Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Bien S Bien Stephanie S Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Yengo L Yengo Loic L University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
Teumer A Teumer Alexander A DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Smith AV Smith Albert Vernon AV Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Kumari M Kumari Meena M ISER, University of Essex, Colchester, Essex, United Kingdom.
Harder MN Harder Marie Neergaard MN Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Justesen JM Justesen Johanne Marie JM Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kleber ME Kleber Marcus E ME Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany.
Hollensted M Hollensted Mette M Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lohman K Lohman Kurt K Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Rivera NV Rivera Natalia V NV Karolinska Institutet, Respiratory Unit, Department of Medicine Solna, Stockholm, Sweden.
Whitfield JB Whitfield John B JB Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Zhao JH Zhao Jing Hua JH MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Stringham HM Stringham Heather M HM Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
Huppertz C Huppertz Charlotte C Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands.
Willemsen G Willemsen Gonneke G EMGO+ Institute, Vrije Universiteit & VU University Medical Center, Amsterdam, The Netherlands.
Peyrot WJ Peyrot Wouter J WJ Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
Wu Y Wu Ying Y Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Kristiansson K Kristiansson Kati K Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Demirkan A Demirkan Ayse A Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Fornage M Fornage Myriam M Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Hassinen M Hassinen Maija M Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Bielak LF Bielak Lawrence F LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Cadby G Cadby Gemma G Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia.
Tanaka T Tanaka Toshiko T Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.
Mägi R Mägi Reedik R Estonian Genome Center, University of Tartu, Tartu, Estonia.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jackson AU Jackson Anne U AU Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Bragg-Gresham JL Bragg-Gresham Jennifer L JL Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Vitart V Vitart Veronique V MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Marten J Marten Jonathan J MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Navarro P Navarro Pau P MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Bellis C Bellis Claire C Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Pasko D Pasko Dorota D Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
Johansson Å Johansson Åsa Å Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Snitker S Snitker Søren S Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Cheng YC Cheng Yu-Ching YC Veterans Affairs Maryland Health Care System, University of Maryland, Baltimore, Maryland, United States of America.
Eriksson J Eriksson Joel J Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lim U Lim Unhee U Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
Aadahl M Aadahl Mette M Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Adair LS Adair Linda S LS Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Amin N Amin Najaf N Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Balkau B Balkau Beverley B INSERM U-1018, CESP, Renal and Cardiovascular Epidemiology, UVSQ-UPS, Villejuif, France.
Auvinen J Auvinen Juha J Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
Beilby J Beilby John J School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia.
Bergman RN Bergman Richard N RN Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Bergmann S Bergmann Sven S Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Bertoni AG Bertoni Alain G AG Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Blangero J Blangero John J Texas Biomedical Research Institute, San Antonio, Texas, United States of America.
Bonnefond A Bonnefond Amélie A University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
Bonnycastle LL Bonnycastle Lori L LL Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Borja JB Borja Judith B JB Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines.
Brage S Brage Søren S MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Busonero F Busonero Fabio F Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Buyske S Buyske Steve S Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
Chines PS Chines Peter S PS Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Collins FS Collins Francis S FS Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Corre T Corre Tanguy T Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Smith GD Smith George Davey GD MRC Integrative Epidemiology Unit & School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Delgado GE Delgado Graciela E GE Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Dueker N Dueker Nicole N University of Maryland School of Medicine, Department of Epidemiology & Public Health, Baltimore, Maryland, United States of America.
Dörr M Dörr Marcus M Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Ebeling T Ebeling Tapani T Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.
Eiriksdottir G Eiriksdottir Gudny G Icelandic Heart Association, Kopavogur, Iceland.
Esko T Esko Tõnu T Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.
Fu M Fu Mao M Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Færch K Færch Kristine K Steno Diabetes Center, Gentofte, Denmark.
Gieger C Gieger Christian C Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Gläser S Gläser Sven S Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Gong J Gong Jian J Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Gordon-Larsen P Gordon-Larsen Penny P Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Grallert H Grallert Harald H German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Grammer TB Grammer Tanja B TB Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Grarup N Grarup Niels N Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
van Grootheest G van Grootheest Gerard G Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
Harald K Harald Kennet K National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Hastie ND Hastie Nicholas D ND MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Havulinna AS Havulinna Aki S AS National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Hernandez D Hernandez Dena D Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America.
Hindorff L Hindorff Lucia L Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Hocking LJ Hocking Lynne J LJ Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Holmens OL Holmens Oddgeir L OL St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway.
Holzapfel C Holzapfel Christina C Institute for Nutritional Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Hottenga JJ Hottenga Jouke Jan JJ NCA Institute, VU University & VU Medical Center, Amsterdam, The Netherlands.
Huang J Huang Jie J Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
Huang T Huang Tao T Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Hui J Hui Jennie J School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia.
Huth C Huth Cornelia C German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Hutri-Kähönen N Hutri-Kähönen Nina N Department of Pediatrics, University of Tampere School of Medicine, Tampere, Finland.
James AL James Alan L AL School of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia, Australia.
Jansson JO Jansson John-Olov JO Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jhun MA Jhun Min A MA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Juonala M Juonala Markus M Division of Medicine, Turku University Hospital, Turku, Finland.
Kinnunen L Kinnunen Leena L National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Koistinen HA Koistinen Heikki A HA Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Kolcic I Kolcic Ivana I Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Komulainen P Komulainen Pirjo P Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Kuusisto J Kuusisto Johanna J Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Kvaløy K Kvaløy Kirsti K HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Kähönen M Kähönen Mika M Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland.
Lakka TA Lakka Timo A TA Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio Campus, Finland.
Launer LJ Launer Lenore J LJ Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Lehne B Lehne Benjamin B Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Lindgren CM Lindgren Cecilia M CM The Big Data Institute, University of Oxford, Oxford, United Kingdom.
Lorentzon M Lorentzon Mattias M Geriatric Medicine, Sahlgrenska University Hospital, Mölndal, Sweden.
Luben R Luben Robert R Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Marre M Marre Michel M Department of Endocrinology, Diabetology, Nutrition, and Metabolic Diseases, Bichat Claude Bernard Hospital, Paris, France.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
Monda KL Monda Keri L KL Center for Observational Research, Amgen Inc., Thousand Oaks, California, United States of America.
Montgomery GW Montgomery Grant W GW Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
De Moor MHM De Moor Marleen H M MHM Section of Clinical Child and Family Studies, Department of Educational and Family Studies, Vrije Universiteit, Amsterdam, The Netherlands.
Mulas A Mulas Antonella A Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.
Müller-Nurasyid M Müller-Nurasyid Martina M DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Musk AW Musk A W AW Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Männikkö R Männikkö Reija R Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Männistö S Männistö Satu S National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Narisu N Narisu Narisu N Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Nauck M Nauck Matthias M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Nettleton JA Nettleton Jennifer A JA Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Olden M Olden Matthias M Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Ong KK Ong Ken K KK MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Padmanabhan S Padmanabhan Sandosh S Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Paternoster L Paternoster Lavinia L MRC Integrative Epidemiology Unit & School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Perez J Perez Jeremiah J Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Perola M Perola Markus M University of Tartu, Estonian Genome Centre, Tartu, Estonia.
Peters A Peters Annette A DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Peters U Peters Ulrike U Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Peyser PA Peyser Patricia A PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Prokopenko I Prokopenko Inga I Genomics of Common Disease, Imperial College London, London, United Kingdom.
Puolijoki H Puolijoki Hannu H South Ostrobothnia Central Hospital, Seinäjoki, Finland.
Raitakari OT Raitakari Olli T OT Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Rankinen T Rankinen Tuomo T Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Rasmussen-Torvik LJ Rasmussen-Torvik Laura J LJ Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Rawal R Rawal Rajesh R Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, Massachusetts, United States of America.
Rose LM Rose Lynda M LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
Sarti C Sarti Cinzia C Social Services and Health Care Department, City of Helsinki, Helsinki, Finland.
Sarzynski MA Sarzynski Mark A MA Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Savonen K Savonen Kai K Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Scott WR Scott William R WR Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Sanna S Sanna Serena S Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
Shuldiner AR Shuldiner Alan R AR Veterans Affairs Maryland Health Care System, University of Maryland, Baltimore, Maryland, United States of America.
Sidney S Sidney Steve S Division of Research, Kaiser Permanente Northern California, Oakland, California, United States of America.
Silbernagel G Silbernagel Günther G Division of Angiology, Department of Internal Medicine, Medical University Graz, Austria.
Smith BH Smith Blair H BH School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland.
Smith JA Smith Jennifer A JA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Stančáková A Stančáková Alena A Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Sternfeld B Sternfeld Barbara B Division of Research, Kaiser Permanente Northern California, Oakland, California, United States of America.
Swift AJ Swift Amy J AJ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Tammelin T Tammelin Tuija T LIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland.
Tan ST Tan Sian-Tsung ST National Heart and Lung Institute, Imperial College London, United Kingdom.
Thorand B Thorand Barbara B German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Thuillier D Thuillier Dorothée D University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
Vandenput L Vandenput Liesbeth L Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Vestergaard H Vestergaard Henrik H Steno Diabetes Center, Gentofte, Denmark.
van Vliet-Ostaptchouk JV van Vliet-Ostaptchouk Jana V JV Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Vohl MC Vohl Marie-Claude MC School of Nutrition, Laval University, Quebec, Canada.
Völker U Völker Uwe U Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.
Waeber G Waeber Gérard G Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Walker M Walker Mark M Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Wild S Wild Sarah S Centre for Population Health Sciences, Usher Institute for Population Health Sciences and Informatics, Teviot Place, Edinburgh, Scotland.
Wong A Wong Andrew A MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Wright AF Wright Alan F AF MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Zillikens MC Zillikens M Carola MC Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Zubair N Zubair Niha N Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Haiman CA Haiman Christopher A CA Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Lemarchand L Lemarchand Loic L Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
Gyllensten U Gyllensten Ulf U Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Ohlsson C Ohlsson Claes C Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hofman A Hofman Albert A Netherlands Consortium for Healthy Aging, Leiden University Medical Center, Leiden, The Netherlands.
Rivadeneira F Rivadeneira Fernando F Netherlands Consortium for Healthy Aging, Leiden University Medical Center, Leiden, The Netherlands.
Uitterlinden AG Uitterlinden André G AG Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Pérusse L Pérusse Louis L Department of Kinesiology, Laval University, Quebec, Canada.
Wilson JF Wilson James F JF Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Polasek O Polasek Ozren O Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Cucca F Cucca Francesco F Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.
Hveem K Hveem Kristian K HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Hartman CA Hartman Catharina A CA Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Tönjes A Tönjes Anke A University of Leipzig, Medical Department, Leipzig, Germany.
Bandinelli S Bandinelli Stefania S Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.
Palmer LJ Palmer Lyle J LJ School of Public Health, University of Adelaide, Adelaide, South Australia, Australia.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Rauramaa R Rauramaa Rainer R Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Sørensen TIA Sørensen Thorkild I A TIA Department of Clinical Epidemiology, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.
Tuomilehto J Tuomilehto Jaakko J Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
Salomaa V Salomaa Veikko V National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
de Geus EJC de Geus Eco J C EJC EMGO+ Institute, Vrije Universiteit & VU University Medical Center, Amsterdam, The Netherlands.
Boomsma DI Boomsma Dorret I DI NCA Institute, VU University & VU Medical Center, Amsterdam, The Netherlands.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
Mangino M Mangino Massimo M National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, United Kingdom.
Laakso M Laakso Markku M Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Bouchard C Bouchard Claude C Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Kuh D Kuh Diana D MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Liu Y Liu Yongmei Y Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Linneberg A Linneberg Allan A Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
März W März Winfried W Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Strauch K Strauch Konstantin K Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
Kivimäki M Kivimäki Mika M Department of Epidemiology and Public Health, University College London, London, United Kingdom.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, Maryland, United States of America.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Völzke H Völzke Henry H DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Qi L Qi Lu L Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Järvelin MR Järvelin Marjo-Riitta MR MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom.
Chambers JC Chambers John C JC Imperial College Healthcare NHS Trust, London, United Kingdom.
Kooner JS Kooner Jaspal S JS Imperial College Healthcare NHS Trust, London, United Kingdom.
Froguel P Froguel Philippe P Hammersmith Hospital, London, United Kingdom.
Kooperberg C Kooperberg Charles C Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Vollenweider P Vollenweider Peter P Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Hallmans G Hallmans Göran G Department of Biobank Research, Umeå University, Umeå, Sweden.
Hansen T Hansen Torben T Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pedersen O Pedersen Oluf O Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu, Estonia.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Langenberg C Langenberg Claudia C MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.
Porteous DJ Porteous David J DJ Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Boerwinkle E Boerwinkle Eric E Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, Massachusetts, United States of America.
CHARGE Consortium
EPIC-InterAct Consortium
PAGE Consortium
Abecasis GR Abecasis Gonçalo R GR Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Barroso I Barroso Inês I The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.
McCarthy MI McCarthy Mark I MI Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom.
Frayling TM Frayling Timothy M TM Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
O'Connell JR O'Connell Jeffrey R JR Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
van Duijn CM van Duijn Cornelia M CM Center of Medical Systems Biology, Leiden, The Netherlands.
Boehnke M Boehnke Michael M Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Heid IM Heid Iris M IM Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Strachan DP Strachan David P DP Population Health Research Institute, St. George's University of London, London, United Kingdom.
Fox CS Fox Caroline S CS Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
Liu CT Liu Ching-Ti CT Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Hirschhorn JN Hirschhorn Joel N JN Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America.
Klein RJ Klein Robert J RJ Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Johnson AD Johnson Andrew D AD Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
Borecki IB Borecki Ingrid B IB Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Franks PW Franks Paul W PW Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.
North KE North Kari E KE Carolina Center for Genome Sciences, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Cupples LA Cupples L Adrienne LA Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Loos RJF Loos Ruth J F RJF The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Kilpeläinen TO Kilpeläinen Tuomas O TO The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
INVESTIGATORS
JOURNAL
VOLUME: 13
ISSUE: 4
TITLE: PLoS genetics
ISOABBREVIATION: PLoS Genet.
YEAR: 2017
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1553-7404
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS Genet
COUNTRY: United States
ISSNLINKING: 1553-7390
NLMUNIQUEID: 101239074
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