|
PMID |
|
|
TITLE |
|
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. |
|
ABSTRACT |
|
|
|
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10 ) for age at menarche, a milestone in female pubertal development. In Icelandic data, these signals explain ∼7.4% of the population variance in age at menarche, corresponding to ∼25% of the estimated heritability. We implicate ∼250 genes via coding variation or associated expression, demonstrating significant enrichment in neural tissues. Rare variants near the imprinted genes MKRN3 and DLK1 were identified, exhibiting large effects when paternally inherited. Mendelian randomization analyses suggest causal inverse associations, independent of body mass index (BMI), between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. In aggregate, our findings highlight the complexity of the genetic regulation of puberty timing and support causal links with cancer susceptibility. |
|
DATE PUBLISHED |
|
|
HISTORY |
|
PUBSTATUS |
PUBSTATUSDATE |
received |
2016/09/20 |
accepted |
2017/03/17 |
pubmed |
2017/04/25 06:00 |
medline |
2017/09/13 06:00 |
entrez |
2017/04/25 06:00 |
|
AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Day FR |
|
Day |
Felix R |
FR |
|
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. |
Thompson DJ |
|
Thompson |
Deborah J |
DJ |
|
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. |
Helgason H |
|
Helgason |
Hannes |
H |
|
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. |
Chasman DI |
|
Chasman |
Daniel I |
DI |
|
Harvard Medical School, Boston, Massachusetts, USA. |
Finucane H |
|
Finucane |
Hilary |
H |
|
Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. |
Sulem P |
|
Sulem |
Patrick |
P |
|
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. |
Ruth KS |
|
Ruth |
Katherine S |
KS |
|
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. |
Whalen S |
|
Whalen |
Sean |
S |
|
Gladstone Institutes, San Francisco, California, USA. |
Sarkar AK |
|
Sarkar |
Abhishek K |
AK |
|
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. |
Albrecht E |
|
Albrecht |
Eva |
E |
|
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. |
Altmaier E |
|
Altmaier |
Elisabeth |
E |
|
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. |
Amini M |
|
Amini |
Marzyeh |
M |
|
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Barbieri CM |
|
Barbieri |
Caterina M |
CM |
|
Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy. |
Boutin T |
|
Boutin |
Thibaud |
T |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Campbell A |
|
Campbell |
Archie |
A |
|
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Demerath E |
|
Demerath |
Ellen |
E |
|
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA. |
Giri A |
|
Giri |
Ayush |
A |
|
Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA. |
He C |
|
He |
Chunyan |
C |
|
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA. |
Hottenga JJ |
|
Hottenga |
Jouke J |
JJ |
|
Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands. |
Karlsson R |
|
Karlsson |
Robert |
R |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Kolcic I |
|
Kolcic |
Ivana |
I |
|
Faculty of Medicine, University of Split, Split, Croatia. |
Loh PR |
|
Loh |
Po-Ru |
PR |
|
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. |
Lunetta KL |
|
Lunetta |
Kathryn L |
KL |
|
NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA. |
Mangino M |
|
Mangino |
Massimo |
M |
|
National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK. |
Marco B |
|
Marco |
Brumat |
B |
|
Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy. |
McMahon G |
|
McMahon |
George |
G |
|
School of Social and Community Medicine, University of Bristol, Bristol, UK. |
Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Nolte IM |
|
Nolte |
Ilja M |
IM |
|
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Noordam R |
|
Noordam |
Raymond |
R |
|
Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands. |
Nutile T |
|
Nutile |
Teresa |
T |
|
Institute of Genetics and Biophysics, CNR, Naples, Italy. |
Paternoster L |
|
Paternoster |
Lavinia |
L |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Perjakova N |
|
Perjakova |
Natalia |
N |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Porcu E |
|
Porcu |
Eleonora |
E |
|
Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy. |
Rose LM |
|
Rose |
Lynda M |
LM |
|
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. |
Schraut KE |
|
Schraut |
Katharina E |
KE |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Segrè AV |
|
Segrè |
Ayellet V |
AV |
|
Cancer Program, Broad Institute, Cambridge, Massachusetts, USA. |
Smith AV |
|
Smith |
Albert V |
AV |
|
Icelandic Heart Association, Kopavogur, Iceland. |
Stolk L |
|
Stolk |
Lisette |
L |
|
Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. |
Teumer A |
|
Teumer |
Alexander |
A |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
Andrulis IL |
|
Andrulis |
Irene L |
IL |
|
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. |
Bandinelli S |
|
Bandinelli |
Stefania |
S |
|
Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy. |
Beckmann MW |
|
Beckmann |
Matthias W |
MW |
|
Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany. |
Benitez J |
|
Benitez |
Javier |
J |
|
Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain. |
Bergmann S |
|
Bergmann |
Sven |
S |
|
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. |
Bochud M |
|
Bochud |
Murielle |
M |
|
Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland. |
Boerwinkle E |
|
Boerwinkle |
Eric |
E |
|
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA. |
Bojesen SE |
|
Bojesen |
Stig E |
SE |
|
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. |
Bolla MK |
|
Bolla |
Manjeet K |
MK |
|
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. |
Brand JS |
|
Brand |
Judith S |
JS |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Brauch H |
|
Brauch |
Hiltrud |
H |
|
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. |
Brenner H |
|
Brenner |
Hermann |
H |
|
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany. |
Broer L |
|
Broer |
Linda |
L |
|
Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. |
Brüning T |
|
Brüning |
Thomas |
T |
|
Institute for Prevention and Occupational Medicine of German Social Accident Insurance, Institute of Ruhr University Bochum (IPA), Bochum, Germany. |
Buring JE |
|
Buring |
Julie E |
JE |
|
Harvard Medical School, Boston, Massachusetts, USA. |
Campbell H |
|
Campbell |
Harry |
H |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Catamo E |
|
Catamo |
Eulalia |
E |
|
Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy. |
Chanock S |
|
Chanock |
Stephen |
S |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. |
Chenevix-Trench G |
|
Chenevix-Trench |
Georgia |
G |
|
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Corre T |
|
Corre |
Tanguy |
T |
|
Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland. |
Couch FJ |
|
Couch |
Fergus J |
FJ |
|
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. |
Cousminer DL |
|
Cousminer |
Diana L |
DL |
|
Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA. |
Cox A |
|
Cox |
Angela |
A |
|
Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK. |
Crisponi L |
|
Crisponi |
Laura |
L |
|
Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy. |
Czene K |
|
Czene |
Kamila |
K |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Davey Smith G |
|
Davey Smith |
George |
G |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
de Geus EJCN |
|
de Geus |
Eco J C N |
EJCN |
|
Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands. |
de Mutsert R |
|
de Mutsert |
Renée |
R |
|
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. |
De Vivo I |
|
De Vivo |
Immaculata |
I |
|
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. |
Dennis J |
|
Dennis |
Joe |
J |
|
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. |
Devilee P |
|
Devilee |
Peter |
P |
|
Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. |
Dos-Santos-Silva I |
|
Dos-Santos-Silva |
Isabel |
I |
|
Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK. |
Dunning AM |
|
Dunning |
Alison M |
AM |
|
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. |
Eriksson JG |
|
Eriksson |
Johan G |
JG |
|
Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. |
Fasching PA |
|
Fasching |
Peter A |
PA |
|
David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angles, California, USA. |
Fernández-Rhodes L |
|
Fernández-Rhodes |
Lindsay |
L |
|
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA. |
Ferrucci L |
|
Ferrucci |
Luigi |
L |
|
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA. |
Flesch-Janys D |
|
Flesch-Janys |
Dieter |
D |
|
Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany. |
Franke L |
|
Franke |
Lude |
L |
|
Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands. |
Gabrielson M |
|
Gabrielson |
Marike |
M |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Gandin I |
|
Gandin |
Ilaria |
I |
|
Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy. |
Giles GG |
|
Giles |
Graham G |
GG |
|
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. |
Grallert H |
|
Grallert |
Harald |
H |
|
German Center for Diabetes Research, Neuherberg, Germany. |
Gudbjartsson DF |
|
Gudbjartsson |
Daniel F |
DF |
|
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. |
Guénel P |
|
Guénel |
Pascal |
P |
|
Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France. |
Hall P |
|
Hall |
Per |
P |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Hallberg E |
|
Hallberg |
Emily |
E |
|
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. |
Hamann U |
|
Hamann |
Ute |
U |
|
Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. |
Harris TB |
|
Harris |
Tamara B |
TB |
|
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, Maryland, USA. |
Hartman CA |
|
Hartman |
Catharina A |
CA |
|
Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Heiss G |
|
Heiss |
Gerardo |
G |
|
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA. |
Hooning MJ |
|
Hooning |
Maartje J |
MJ |
|
Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. |
Hopper JL |
|
Hopper |
John L |
JL |
|
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. |
Hu F |
|
Hu |
Frank |
F |
|
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. |
Hunter DJ |
|
Hunter |
David J |
DJ |
|
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. |
Ikram MA |
|
Ikram |
M Arfan |
MA |
|
Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. |
Im HK |
|
Im |
Hae Kyung |
HK |
|
Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA. |
Järvelin MR |
|
Järvelin |
Marjo-Riitta |
MR |
|
Unit of Primary Care, Oulu University Hospital, Oulu, Finland. |
Joshi PK |
|
Joshi |
Peter K |
PK |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Karasik D |
|
Karasik |
David |
D |
|
Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts, USA. |
Kellis M |
|
Kellis |
Manolis |
M |
|
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. |
Kutalik Z |
|
Kutalik |
Zoltan |
Z |
|
Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland. |
LaChance G |
|
LaChance |
Genevieve |
G |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
Lambrechts D |
|
Lambrechts |
Diether |
D |
|
Vesalius Research Center (VRC), VIB, Leuven, Belgium. |
Langenberg C |
|
Langenberg |
Claudia |
C |
|
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. |
Launer LJ |
|
Launer |
Lenore J |
LJ |
|
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, Maryland, USA. |
Laven JSE |
|
Laven |
Joop S E |
JSE |
|
Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands. |
Lenarduzzi S |
|
Lenarduzzi |
Stefania |
S |
|
Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy. |
Li J |
|
Li |
Jingmei |
J |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Lind PA |
|
Lind |
Penelope A |
PA |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Lindstrom S |
|
Lindstrom |
Sara |
S |
|
Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA. |
Liu Y |
|
Liu |
YongMei |
Y |
|
Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. |
Luan J |
|
Luan |
Jian'an |
J |
|
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. |
Mägi R |
|
Mägi |
Reedik |
R |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Mannermaa A |
|
Mannermaa |
Arto |
A |
|
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland. |
Mbarek H |
|
Mbarek |
Hamdi |
H |
|
Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands. |
McCarthy MI |
|
McCarthy |
Mark I |
MI |
|
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. |
Meisinger C |
|
Meisinger |
Christa |
C |
|
Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany. |
Meitinger T |
|
Meitinger |
Thomas |
T |
|
Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. |
Menni C |
|
Menni |
Cristina |
C |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
Metspalu A |
|
Metspalu |
Andres |
A |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Michailidou K |
|
Michailidou |
Kyriaki |
K |
|
Department of Electron Microscopy/Molecular Pathology, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus. |
Milani L |
|
Milani |
Lili |
L |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Milne RL |
|
Milne |
Roger L |
RL |
|
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
Mulligan AM |
|
Mulligan |
Anna M |
AM |
|
Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada. |
Nalls MA |
|
Nalls |
Mike A |
MA |
|
Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA. |
Navarro P |
|
Navarro |
Pau |
P |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Nevanlinna H |
|
Nevanlinna |
Heli |
H |
|
Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. |
Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. |
Oldehinkel AJ |
|
Oldehinkel |
Albertine J |
AJ |
|
Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
O'Mara TA |
|
O'Mara |
Tracy A |
TA |
|
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Padmanabhan S |
|
Padmanabhan |
Sandosh |
S |
|
British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. |
Palotie A |
|
Palotie |
Aarno |
A |
|
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. |
Pedersen N |
|
Pedersen |
Nancy |
N |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Peters A |
|
Peters |
Annette |
A |
|
German Center for Diabetes Research, Neuherberg, Germany. |
Peto J |
|
Peto |
Julian |
J |
|
Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK. |
Pharoah PDP |
|
Pharoah |
Paul D P |
PDP |
|
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. |
Pouta A |
|
Pouta |
Anneli |
A |
|
National Institute for Health and Welfare, Helsinki, Finland. |
Radice P |
|
Radice |
Paolo |
P |
|
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy. |
Rahman I |
|
Rahman |
Iffat |
I |
|
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. |
Ring SM |
|
Ring |
Susan M |
SM |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Robino A |
|
Robino |
Antonietta |
A |
|
Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy. |
Rosendaal FR |
|
Rosendaal |
Frits R |
FR |
|
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. |
Rudan I |
|
Rudan |
Igor |
I |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Rueedi R |
|
Rueedi |
Rico |
R |
|
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. |
Ruggiero D |
|
Ruggiero |
Daniela |
D |
|
Institute of Genetics and Biophysics, CNR, Naples, Italy. |
Sala CF |
|
Sala |
Cinzia F |
CF |
|
Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy. |
Schmidt MK |
|
Schmidt |
Marjanka K |
MK |
|
Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. |
Scott RA |
|
Scott |
Robert A |
RA |
|
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. |
Shah M |
|
Shah |
Mitul |
M |
|
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. |
Sorice R |
|
Sorice |
Rossella |
R |
|
Institute of Genetics and Biophysics, CNR, Naples, Italy. |
Southey MC |
|
Southey |
Melissa C |
MC |
|
Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia. |
Sovio U |
|
Sovio |
Ulla |
U |
|
Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK. |
Stampfer M |
|
Stampfer |
Meir |
M |
|
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. |
Steri M |
|
Steri |
Maristella |
M |
|
Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy. |
Strauch K |
|
Strauch |
Konstantin |
K |
|
Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. |
Tanaka T |
|
Tanaka |
Toshiko |
T |
|
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA. |
Tikkanen E |
|
Tikkanen |
Emmi |
E |
|
Department of Public Health, University of Helsinki, Helsinki, Finland. |
Timpson NJ |
|
Timpson |
Nicholas J |
NJ |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Traglia M |
|
Traglia |
Michela |
M |
|
Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy. |
Truong T |
|
Truong |
Thérèse |
T |
|
Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France. |
Tyrer JP |
|
Tyrer |
Jonathan P |
JP |
|
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. |
Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. |
Edwards DRV |
|
Edwards |
Digna R Velez |
DRV |
|
Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. |
Vitart V |
|
Vitart |
Veronique |
V |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Völker U |
|
Völker |
Uwe |
U |
|
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. |
Vollenweider P |
|
Vollenweider |
Peter |
P |
|
University Hospital of Lausanne, Lausanne, Switzerland. |
Wang Q |
|
Wang |
Qin |
Q |
|
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. |
Widen E |
|
Widen |
Elisabeth |
E |
|
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. |
van Dijk KW |
|
van Dijk |
Ko Willems |
KW |
|
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands. |
Willemsen G |
|
Willemsen |
Gonneke |
G |
|
Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands. |
Winqvist R |
|
Winqvist |
Robert |
R |
|
Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland. |
Wolffenbuttel BHR |
|
Wolffenbuttel |
Bruce H R |
BHR |
|
Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands. |
Zhao JH |
|
Zhao |
Jing Hua |
JH |
|
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. |
Zoledziewska M |
|
Zoledziewska |
Magdalena |
M |
|
Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy. |
Zygmunt M |
|
Zygmunt |
Marek |
M |
|
Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany. |
Alizadeh BZ |
|
Alizadeh |
Behrooz Z |
BZ |
|
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands. |
Ciullo M |
|
Ciullo |
Marina |
M |
|
Institute of Genetics and Biophysics, CNR, Naples, Italy. |
Cucca F |
|
Cucca |
Francesco |
F |
|
Department of Biomedical Sciences, University of Sassari, Sassari, Italy. |
Esko T |
|
Esko |
Tõnu |
T |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Franceschini N |
|
Franceschini |
Nora |
N |
|
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA. |
Gieger C |
|
Gieger |
Christian |
C |
|
German Center for Diabetes Research, Neuherberg, Germany. |
Gudnason V |
|
Gudnason |
Vilmundur |
V |
|
Icelandic Heart Association, Kopavogur, Iceland. |
Hayward C |
|
Hayward |
Caroline |
C |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Kraft P |
|
Kraft |
Peter |
P |
|
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. |
Lawlor DA |
|
Lawlor |
Debbie A |
DA |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Magnusson PKE |
|
Magnusson |
Patrik K E |
PKE |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Mook-Kanamori DO |
|
Mook-Kanamori |
Dennis O |
DO |
|
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. |
Nohr EA |
|
Nohr |
Ellen A |
EA |
|
Research Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. |
Polasek O |
|
Polasek |
Ozren |
O |
|
Faculty of Medicine, University of Split, Split, Croatia. |
Porteous D |
|
Porteous |
David |
D |
|
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Price AL |
|
Price |
Alkes L |
AL |
|
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. |
Ridker PM |
|
Ridker |
Paul M |
PM |
|
Harvard Medical School, Boston, Massachusetts, USA. |
Snieder H |
|
Snieder |
Harold |
H |
|
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Spector TD |
|
Spector |
Tim D |
TD |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
Stöckl D |
|
Stöckl |
Doris |
D |
|
Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig Maximilians University, Munich, Germany. |
Toniolo D |
|
Toniolo |
Daniela |
D |
|
Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy. |
Ulivi S |
|
Ulivi |
Sheila |
S |
|
Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy. |
Visser JA |
|
Visser |
Jenny A |
JA |
|
Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. |
Völzke H |
|
Völzke |
Henry |
H |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
Wareham NJ |
|
Wareham |
Nicholas J |
NJ |
|
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. |
Wilson JF |
|
Wilson |
James F |
JF |
|
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
|
LifeLines Cohort Study |
|
|
|
|
|
|
InterAct Consortium |
|
|
|
|
|
|
kConFab/AOCS Investigators |
|
|
|
|
|
|
Endometrial Cancer Association Consortium |
|
|
|
|
|
|
Ovarian Cancer Association Consortium |
|
|
|
|
|
|
PRACTICAL consortium |
|
|
|
|
|
Spurdle AB |
|
Spurdle |
Amanda B |
AB |
|
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Thorsteindottir U |
|
Thorsteindottir |
Unnur |
U |
|
Faculty of Medicine, University of Iceland, Reykjavik, Iceland. |
Pollard KS |
|
Pollard |
Katherine S |
KS |
|
Division of Biostatistics, Institute for Human Genetics, and Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, California, USA. |
Easton DF |
|
Easton |
Douglas F |
DF |
|
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. |
Tung JY |
|
Tung |
Joyce Y |
JY |
|
23andMe, Inc., Mountain View, California, USA. |
Chang-Claude J |
|
Chang-Claude |
Jenny |
J |
|
University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. |
Hinds D |
|
Hinds |
David |
D |
|
23andMe, Inc., Mountain View, California, USA. |
Murray A |
|
Murray |
Anna |
A |
|
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. |
Murabito JM |
|
Murabito |
Joanne M |
JM |
|
Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts, USA. |
Stefansson K |
|
Stefansson |
Kari |
K |
|
Faculty of Medicine, University of Iceland, Reykjavik, Iceland. |
Ong KK |
|
Ong |
Ken K |
KK |
|
Department of Paediatrics, University of Cambridge, Cambridge, UK. |
Perry JRB |
|
Perry |
John R B |
JRB |
|
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. |
|
INVESTIGATORS |
|
|
JOURNAL |
|
VOLUME: 49 |
ISSUE: 6 |
TITLE: Nature genetics |
ISOABBREVIATION: Nat Genet |
YEAR: 2017 |
MONTH: Jun |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1718 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
|
COMMENTS AND CORRECTIONS |
|
REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
CommentIn |
Nat Rev Endocrinol. 2017 Jul;13(7):377 |
28497815 |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
SP/07/008/24066 |
British Heart Foundation |
United Kingdom |
MC_UU_12015/2 |
Medical Research Council |
United Kingdom |
14136 |
Cancer Research UK |
United Kingdom |
G0401527 |
Medical Research Council |
United Kingdom |
MC_UU_12013/1 |
Medical Research Council |
United Kingdom |
UM1 CA182913 |
NCI NIH HHS |
United States |
MC_UU_12013/5 |
Medical Research Council |
United Kingdom |
Z01 AG006000-01 |
Intramural NIH HHS |
United States |
10124 |
Cancer Research UK |
United Kingdom |
MR/N003284/1 |
Medical Research Council |
United Kingdom |
MC_UU_12013/3 |
Medical Research Council |
United Kingdom |
G1000143 |
Medical Research Council |
United Kingdom |
MR/J012165/1 |
Medical Research Council |
United Kingdom |
MC_EX_MR/L100002/1 |
Medical Research Council |
United Kingdom |
R56 AG029451 |
NIA NIH HHS |
United States |
G1001357 |
Medical Research Council |
United Kingdom |
MC_UU_12015/1 |
Medical Research Council |
United Kingdom |
P2C HD050924 |
NICHD NIH HHS |
United States |
T32 HL007055 |
NHLBI NIH HHS |
United States |
R01 CA192393 |
NCI NIH HHS |
United States |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Adolescent |
|
Age Factors |
|
Body Mass Index |
|
Calcium-Binding Proteins |
|
Databases, Genetic |
|
Female |
|
Genetic Predisposition to Disease |
|
Genome-Wide Association Study |
|
Genomic Imprinting |
|
Humans |
|
Intercellular Signaling Peptides and Proteins |
genetics |
Male |
genetics |
Membrane Proteins |
genetics |
Menarche |
genetics |
Neoplasms |
genetics |
Polymorphism, Single Nucleotide |
genetics |
Puberty |
genetics |
Quantitative Trait Loci |
genetics |
Ribonucleoproteins |
genetics |
Risk Factors |
genetics |
Ubiquitin-Protein Ligases |
genetics |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
REGISTRYNUMBER |
NAMEOFSUBSTANCE |
0 |
Calcium-Binding Proteins |
0 |
DLK1 protein, human |
0 |
Intercellular Signaling Peptides and Proteins |
0 |
Membrane Proteins |
0 |
Ribonucleoproteins |
EC 2.3.2.27 |
MKRN3 protein, human |
EC 2.3.2.27 |
Ubiquitin-Protein Ligases |
|
OTHER ID's |
|
|
|