Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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28436984
TITLE
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
ABSTRACT
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10 ) for age at menarche, a milestone in female pubertal development. In Icelandic data, these signals explain ∼7.4% of the population variance in age at menarche, corresponding to ∼25% of the estimated heritability. We implicate ∼250 genes via coding variation or associated expression, demonstrating significant enrichment in neural tissues. Rare variants near the imprinted genes MKRN3 and DLK1 were identified, exhibiting large effects when paternally inherited. Mendelian randomization analyses suggest causal inverse associations, independent of body mass index (BMI), between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. In aggregate, our findings highlight the complexity of the genetic regulation of puberty timing and support causal links with cancer susceptibility.
DATE PUBLISHED
2017 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/09/20
accepted 2017/03/17
pubmed 2017/04/25 06:00
medline 2017/09/13 06:00
entrez 2017/04/25 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Day FR Day Felix R FR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Helgason H Helgason Hannes H School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, Massachusetts, USA.
Finucane H Finucane Hilary H Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Sulem P Sulem Patrick P deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Ruth KS Ruth Katherine S KS Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Whalen S Whalen Sean S Gladstone Institutes, San Francisco, California, USA.
Sarkar AK Sarkar Abhishek K AK Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Albrecht E Albrecht Eva E Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Altmaier E Altmaier Elisabeth E Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Amini M Amini Marzyeh M Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Barbieri CM Barbieri Caterina M CM Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
Boutin T Boutin Thibaud T Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Campbell A Campbell Archie A Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Demerath E Demerath Ellen E Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Giri A Giri Ayush A Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.
He C He Chunyan C Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA.
Hottenga JJ Hottenga Jouke J JJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kolcic I Kolcic Ivana I Faculty of Medicine, University of Split, Split, Croatia.
Loh PR Loh Po-Ru PR Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Lunetta KL Lunetta Kathryn L KL NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Mangino M Mangino Massimo M National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.
Marco B Marco Brumat B Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy.
McMahon G McMahon George G School of Social and Community Medicine, University of Bristol, Bristol, UK.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Noordam R Noordam Raymond R Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics, CNR, Naples, Italy.
Paternoster L Paternoster Lavinia L MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Perjakova N Perjakova Natalia N Estonian Genome Center, University of Tartu, Tartu, Estonia.
Porcu E Porcu Eleonora E Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Rose LM Rose Lynda M LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Schraut KE Schraut Katharina E KE Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Segrè AV Segrè Ayellet V AV Cancer Program, Broad Institute, Cambridge, Massachusetts, USA.
Smith AV Smith Albert V AV Icelandic Heart Association, Kopavogur, Iceland.
Stolk L Stolk Lisette L Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Andrulis IL Andrulis Irene L IL Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Bandinelli S Bandinelli Stefania S Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy.
Beckmann MW Beckmann Matthias W MW Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Benitez J Benitez Javier J Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
Bergmann S Bergmann Sven S Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Bochud M Bochud Murielle M Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
Boerwinkle E Boerwinkle Eric E Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Bojesen SE Bojesen Stig E SE Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bolla MK Bolla Manjeet K MK Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Brand JS Brand Judith S JS Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Brauch H Brauch Hiltrud H German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brenner H Brenner Hermann H Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Broer L Broer Linda L Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.
Brüning T Brüning Thomas T Institute for Prevention and Occupational Medicine of German Social Accident Insurance, Institute of Ruhr University Bochum (IPA), Bochum, Germany.
Buring JE Buring Julie E JE Harvard Medical School, Boston, Massachusetts, USA.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Catamo E Catamo Eulalia E Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
Chanock S Chanock Stephen S Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Chenevix-Trench G Chenevix-Trench Georgia G Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Corre T Corre Tanguy T Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
Couch FJ Couch Fergus J FJ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Cousminer DL Cousminer Diana L DL Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Cox A Cox Angela A Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Crisponi L Crisponi Laura L Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Czene K Czene Kamila K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Davey Smith G Davey Smith George G MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
de Geus EJCN de Geus Eco J C N EJCN Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
de Mutsert R de Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
De Vivo I De Vivo Immaculata I Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Dennis J Dennis Joe J Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Devilee P Devilee Peter P Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Dos-Santos-Silva I Dos-Santos-Silva Isabel I Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Eriksson JG Eriksson Johan G JG Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
Fasching PA Fasching Peter A PA David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angles, California, USA.
Fernández-Rhodes L Fernández-Rhodes Lindsay L Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Ferrucci L Ferrucci Luigi L Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
Flesch-Janys D Flesch-Janys Dieter D Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Franke L Franke Lude L Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Gabrielson M Gabrielson Marike M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Gandin I Gandin Ilaria I Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy.
Giles GG Giles Graham G GG Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Grallert H Grallert Harald H German Center for Diabetes Research, Neuherberg, Germany.
Gudbjartsson DF Gudbjartsson Daniel F DF School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Guénel P Guénel Pascal P Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
Hall P Hall Per P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hallberg E Hallberg Emily E Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Hamann U Hamann Ute U Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, Maryland, USA.
Hartman CA Hartman Catharina A CA Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Heiss G Heiss Gerardo G Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Hooning MJ Hooning Maartje J MJ Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Hu F Hu Frank F Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Hunter DJ Hunter David J DJ Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Im HK Im Hae Kyung HK Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Järvelin MR Järvelin Marjo-Riitta MR Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Karasik D Karasik David D Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts, USA.
Kellis M Kellis Manolis M Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kutalik Z Kutalik Zoltan Z Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
LaChance G LaChance Genevieve G Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Lambrechts D Lambrechts Diether D Vesalius Research Center (VRC), VIB, Leuven, Belgium.
Langenberg C Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Launer LJ Launer Lenore J LJ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, Maryland, USA.
Laven JSE Laven Joop S E JSE Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands.
Lenarduzzi S Lenarduzzi Stefania S Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
Li J Li Jingmei J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Lind PA Lind Penelope A PA QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Lindstrom S Lindstrom Sara S Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Liu Y Liu YongMei Y Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Mägi R Mägi Reedik R Estonian Genome Center, University of Tartu, Tartu, Estonia.
Mannermaa A Mannermaa Arto A Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Mbarek H Mbarek Hamdi H Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
McCarthy MI McCarthy Mark I MI Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Meisinger C Meisinger Christa C Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany.
Meitinger T Meitinger Thomas T Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Menni C Menni Cristina C Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu, Estonia.
Michailidou K Michailidou Kyriaki K Department of Electron Microscopy/Molecular Pathology, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, Estonia.
Milne RL Milne Roger L RL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Mulligan AM Mulligan Anna M AM Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.
Nalls MA Nalls Mike A MA Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.
Navarro P Navarro Pau P Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Nevanlinna H Nevanlinna Heli H Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Nyholt DR Nyholt Dale R DR Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
O'Mara TA O'Mara Tracy A TA Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Padmanabhan S Padmanabhan Sandosh S British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Palotie A Palotie Aarno A Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Pedersen N Pedersen Nancy N Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Peters A Peters Annette A German Center for Diabetes Research, Neuherberg, Germany.
Peto J Peto Julian J Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Pharoah PDP Pharoah Paul D P PDP Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Pouta A Pouta Anneli A National Institute for Health and Welfare, Helsinki, Finland.
Radice P Radice Paolo P Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Rahman I Rahman Iffat I Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Ring SM Ring Susan M SM MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Robino A Robino Antonietta A Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
Rosendaal FR Rosendaal Frits R FR Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Rueedi R Rueedi Rico R Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Ruggiero D Ruggiero Daniela D Institute of Genetics and Biophysics, CNR, Naples, Italy.
Sala CF Sala Cinzia F CF Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
Schmidt MK Schmidt Marjanka K MK Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Scott RA Scott Robert A RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Shah M Shah Mitul M Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Sorice R Sorice Rossella R Institute of Genetics and Biophysics, CNR, Naples, Italy.
Southey MC Southey Melissa C MC Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
Sovio U Sovio Ulla U Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK.
Stampfer M Stampfer Meir M Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Steri M Steri Maristella M Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Strauch K Strauch Konstantin K Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
Tanaka T Tanaka Toshiko T Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
Tikkanen E Tikkanen Emmi E Department of Public Health, University of Helsinki, Helsinki, Finland.
Timpson NJ Timpson Nicholas J NJ MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Traglia M Traglia Michela M Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
Truong T Truong Thérèse T Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
Tyrer JP Tyrer Jonathan P JP Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Uitterlinden AG Uitterlinden André G AG Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Edwards DRV Edwards Digna R Velez DRV Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Vitart V Vitart Veronique V Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Völker U Völker Uwe U Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Vollenweider P Vollenweider Peter P University Hospital of Lausanne, Lausanne, Switzerland.
Wang Q Wang Qin Q Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Widen E Widen Elisabeth E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
van Dijk KW van Dijk Ko Willems KW Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Winqvist R Winqvist Robert R Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland.
Wolffenbuttel BHR Wolffenbuttel Bruce H R BHR Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Zhao JH Zhao Jing Hua JH MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Zoledziewska M Zoledziewska Magdalena M Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Zygmunt M Zygmunt Marek M Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany.
Alizadeh BZ Alizadeh Behrooz Z BZ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Ciullo M Ciullo Marina M Institute of Genetics and Biophysics, CNR, Naples, Italy.
Cucca F Cucca Francesco F Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Esko T Esko Tõnu T Estonian Genome Center, University of Tartu, Tartu, Estonia.
Franceschini N Franceschini Nora N Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Gieger C Gieger Christian C German Center for Diabetes Research, Neuherberg, Germany.
Gudnason V Gudnason Vilmundur V Icelandic Heart Association, Kopavogur, Iceland.
Hayward C Hayward Caroline C Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Kraft P Kraft Peter P Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
Lawlor DA Lawlor Debbie A DA MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Mook-Kanamori DO Mook-Kanamori Dennis O DO Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
Nohr EA Nohr Ellen A EA Research Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Polasek O Polasek Ozren O Faculty of Medicine, University of Split, Split, Croatia.
Porteous D Porteous David D Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Price AL Price Alkes L AL Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, Massachusetts, USA.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Stöckl D Stöckl Doris D Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig Maximilians University, Munich, Germany.
Toniolo D Toniolo Daniela D Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
Ulivi S Ulivi Sheila S Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
Visser JA Visser Jenny A JA Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Wilson JF Wilson James F JF Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
LifeLines Cohort Study
InterAct Consortium
kConFab/AOCS Investigators
Endometrial Cancer Association Consortium
Ovarian Cancer Association Consortium
PRACTICAL consortium
Spurdle AB Spurdle Amanda B AB Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Thorsteindottir U Thorsteindottir Unnur U Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Pollard KS Pollard Katherine S KS Division of Biostatistics, Institute for Human Genetics, and Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, California, USA.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Tung JY Tung Joyce Y JY 23andMe, Inc., Mountain View, California, USA.
Chang-Claude J Chang-Claude Jenny J University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hinds D Hinds David D 23andMe, Inc., Mountain View, California, USA.
Murray A Murray Anna A Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Murabito JM Murabito Joanne M JM Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts, USA.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Ong KK Ong Ken K KK Department of Paediatrics, University of Cambridge, Cambridge, UK.
Perry JRB Perry John R B JRB MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
INVESTIGATORS
JOURNAL
VOLUME: 49
ISSUE: 6
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2017
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
CommentIn Nat Rev Endocrinol. 2017 Jul;13(7):377 28497815
GRANTS
GRANTID AGENCY COUNTRY
SP/07/008/24066 British Heart Foundation United Kingdom
MC_UU_12015/2 Medical Research Council United Kingdom
14136 Cancer Research UK United Kingdom
G0401527 Medical Research Council United Kingdom
MC_UU_12013/1 Medical Research Council United Kingdom
UM1 CA182913 NCI NIH HHS United States
MC_UU_12013/5 Medical Research Council United Kingdom
Z01 AG006000-01 Intramural NIH HHS United States
10124 Cancer Research UK United Kingdom
MR/N003284/1 Medical Research Council United Kingdom
MC_UU_12013/3 Medical Research Council United Kingdom
G1000143 Medical Research Council United Kingdom
MR/J012165/1 Medical Research Council United Kingdom
MC_EX_MR/L100002/1 Medical Research Council United Kingdom
R56 AG029451 NIA NIH HHS United States
G1001357 Medical Research Council United Kingdom
MC_UU_12015/1 Medical Research Council United Kingdom
P2C HD050924 NICHD NIH HHS United States
T32 HL007055 NHLBI NIH HHS United States
R01 CA192393 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Age Factors
Body Mass Index
Calcium-Binding Proteins
Databases, Genetic
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomic Imprinting
Humans
Intercellular Signaling Peptides and Proteins genetics
Male genetics
Membrane Proteins genetics
Menarche genetics
Neoplasms genetics
Polymorphism, Single Nucleotide genetics
Puberty genetics
Quantitative Trait Loci genetics
Ribonucleoproteins genetics
Risk Factors genetics
Ubiquitin-Protein Ligases genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Calcium-Binding Proteins
0 DLK1 protein, human
0 Intercellular Signaling Peptides and Proteins
0 Membrane Proteins
0 Ribonucleoproteins
EC 2.3.2.27 MKRN3 protein, human
EC 2.3.2.27 Ubiquitin-Protein Ligases
OTHER ID's
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Last Modified: Oct 15 2007