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| PMID |
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| TITLE |
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| Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. |
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| ABSTRACT |
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| Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10(-8), METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2016/10/27 |
| accepted |
2017/01/23 |
| entrez |
2017/03/09 06:00 |
| pubmed |
2017/03/09 06:00 |
| medline |
2017/03/09 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Heilmann-Heimbach S |
|
Heilmann-Heimbach |
Stefanie |
S |
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Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany. |
| Herold C |
|
Herold |
Christine |
C |
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German Center for Neurodegenerative Disorders, 53175 Bonn, Germany. |
| Hochfeld LM |
|
Hochfeld |
Lara M |
LM |
|
Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany. |
| Hillmer AM |
|
Hillmer |
Axel M |
AM |
|
TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University, TRON gGmbH, 55131 Mainz, Germany. |
| Nyholt DR |
|
Nyholt |
Dale R |
DR |
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Institute of Health and Biomedical Innovation, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia. |
| Hecker J |
|
Hecker |
Julian |
J |
|
Institute of Genomic Mathematics, University of Bonn, 53127 Bonn, Germany. |
| Javed A |
|
Javed |
Asif |
A |
|
Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore. |
| Chew EG |
|
Chew |
Elaine G Y |
EG |
|
Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore. |
| Pechlivanis S |
|
Pechlivanis |
Sonali |
S |
|
Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, 45122 Essen, Germany. |
| Drichel D |
|
Drichel |
Dmitriy |
D |
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Cologne Center for Genomics, University of Cologne, 50931 Cologne, Germany. |
| Heng XT |
|
Heng |
Xiu Ting |
XT |
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Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore. |
| Del Rosario RC |
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Del Rosario |
Ricardo C-H |
RC |
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Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore. |
| Fier HL |
|
Fier |
Heide L |
HL |
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Department of Biostatistics, Harvard School T.H. Chan of Public Health, Boston, Massachusetts 02115, USA. |
| Paus R |
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Paus |
Ralf |
R |
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Dermatology Research Centre, Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PL, UK. |
| Rueedi R |
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Rueedi |
Rico |
R |
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Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland. |
| Galesloot TE |
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Galesloot |
Tessel E |
TE |
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Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands. |
| Moebus S |
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Moebus |
Susanne |
S |
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Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, 45122 Essen, Germany. |
| Anhalt T |
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Anhalt |
Thomas |
T |
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Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany. |
| Prabhakar S |
|
Prabhakar |
Shyam |
S |
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Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore. |
| Li R |
|
Li |
Rui |
R |
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Centre for Clinical Epidemiology, Departments of Medicine, Genetics and Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2 Canada. |
| Kanoni S |
|
Kanoni |
Stavroula |
S |
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William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. |
| Papanikolaou G |
|
Papanikolaou |
George |
G |
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School of Health Sciences and Education, Department of Nutrition and Dietetics, Harokopio University, Attica, 17671 Kallithea, Greece. |
| Kutalik Z |
|
Kutalik |
Zoltán |
Z |
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Institute of Social and Preventive Medicine, University Hospital of Lausanne, 1010 Lausanne, Switzerland. |
| Deloukas P |
|
Deloukas |
Panos |
P |
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Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia. |
| Philpott MP |
|
Philpott |
Michael P |
MP |
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Centre for Cell Biology and Cutaneous Research Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK. |
| Waeber G |
|
Waeber |
Gérard |
G |
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Department of Internal Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland. |
| Spector TD |
|
Spector |
Tim D |
TD |
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Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK. |
| Vollenweider P |
|
Vollenweider |
Peter |
P |
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Department of Internal Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland. |
| Kiemeney LA |
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Kiemeney |
Lambertus A L M |
LA |
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Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands. |
| Dedoussis G |
|
Dedoussis |
George |
G |
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School of Health Sciences and Education, Department of Nutrition and Dietetics, Harokopio University, Attica, 17671 Kallithea, Greece. |
| Richards JB |
|
Richards |
J Brent |
JB |
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Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK. |
| Nothnagel M |
|
Nothnagel |
Michael |
M |
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Cologne Center for Genomics, University of Cologne, 50931 Cologne, Germany. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
| Becker T |
|
Becker |
Tim |
T |
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Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, 17475 Greifswald, Germany. |
| Hinds DA |
|
Hinds |
David A |
DA |
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23andMe Inc., Mountain View, California 94040, USA. |
| Nöthen MM |
|
Nöthen |
Markus M |
MM |
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Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 8 |
| ISSUE: |
| TITLE: Nature communications |
| ISOABBREVIATION: Nat Commun |
| YEAR: 2017 |
| MONTH: Mar |
| DAY: 08 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2041-1723 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Nat Commun |
| COUNTRY: England |
| ISSNLINKING: 2041-1723 |
| NLMUNIQUEID: 101528555 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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