Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28272467
TITLE
Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.
ABSTRACT
Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10(-8), METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.
DATE PUBLISHED
2017 Mar 08
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/10/27
accepted 2017/01/23
entrez 2017/03/09 06:00
pubmed 2017/03/09 06:00
medline 2017/03/09 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Heilmann-Heimbach S Heilmann-Heimbach Stefanie S Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany.
Herold C Herold Christine C German Center for Neurodegenerative Disorders, 53175 Bonn, Germany.
Hochfeld LM Hochfeld Lara M LM Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany.
Hillmer AM Hillmer Axel M AM TRON-Translational Oncology at the University Medical Center of Johannes Gutenberg University, TRON gGmbH, 55131 Mainz, Germany.
Nyholt DR Nyholt Dale R DR Institute of Health and Biomedical Innovation, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia.
Hecker J Hecker Julian J Institute of Genomic Mathematics, University of Bonn, 53127 Bonn, Germany.
Javed A Javed Asif A Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore.
Chew EG Chew Elaine G Y EG Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore.
Pechlivanis S Pechlivanis Sonali S Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, 45122 Essen, Germany.
Drichel D Drichel Dmitriy D Cologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Heng XT Heng Xiu Ting XT Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore.
Del Rosario RC Del Rosario Ricardo C-H RC Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
Fier HL Fier Heide L HL Department of Biostatistics, Harvard School T.H. Chan of Public Health, Boston, Massachusetts 02115, USA.
Paus R Paus Ralf R Dermatology Research Centre, Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PL, UK.
Rueedi R Rueedi Rico R Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Galesloot TE Galesloot Tessel E TE Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Moebus S Moebus Susanne S Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, 45122 Essen, Germany.
Anhalt T Anhalt Thomas T Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany.
Prabhakar S Prabhakar Shyam S Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
Li R Li Rui R Centre for Clinical Epidemiology, Departments of Medicine, Genetics and Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2 Canada.
Kanoni S Kanoni Stavroula S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Papanikolaou G Papanikolaou George G School of Health Sciences and Education, Department of Nutrition and Dietetics, Harokopio University, Attica, 17671 Kallithea, Greece.
Kutalik Z Kutalik Zoltán Z Institute of Social and Preventive Medicine, University Hospital of Lausanne, 1010 Lausanne, Switzerland.
Deloukas P Deloukas Panos P Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Philpott MP Philpott Michael P MP Centre for Cell Biology and Cutaneous Research Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Waeber G Waeber Gérard G Department of Internal Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Spector TD Spector Tim D TD Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Vollenweider P Vollenweider Peter P Department of Internal Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Kiemeney LA Kiemeney Lambertus A L M LA Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Dedoussis G Dedoussis George G School of Health Sciences and Education, Department of Nutrition and Dietetics, Harokopio University, Attica, 17671 Kallithea, Greece.
Richards JB Richards J Brent JB Department of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Nothnagel M Nothnagel Michael M Cologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Becker T Becker Tim T Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, 17475 Greifswald, Germany.
Hinds DA Hinds David A DA 23andMe Inc., Mountain View, California 94040, USA.
Nöthen MM Nöthen Markus M MM Department of Genomics, Life &Brain Center, University of Bonn, 53127 Bonn, Germany.
INVESTIGATORS
JOURNAL
VOLUME: 8
ISSUE:
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2017
MONTH: Mar
DAY: 08
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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