Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28146470
TITLE
Rare and low-frequency coding variants alter human adult height.
ABSTRACT
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
DATE PUBLISHED
2017 Feb 09
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/07/11
accepted 2016/12/04
pmc-release 2017/08/01
pubmed 2017/02/02 06:00
medline 2017/02/02 06:00
entrez 2017/02/02 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Marouli E Marouli Eirini E William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Graff M Graff Mariaelisa M Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Medina-Gomez C Medina-Gomez Carolina C Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Lo KS Lo Ken Sin KS Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
Wood AR Wood Andrew R AR Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Kjaer TR Kjaer Troels R TR Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark.
Fine RS Fine Rebecca S RS Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Lu Y Lu Yingchang Y The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.
Schurmann C Schurmann Claudia C The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.
Highland HM Highland Heather M HM Human Genetics Center, The University of Texas School of Public Health, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Rüeger S Rüeger Sina S Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
Thorleifsson G Thorleifsson Gudmar G deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.
Justice AE Justice Anne E AE Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Lamparter D Lamparter David D Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland.
Stirrups KE Stirrups Kathleen E KE Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.
Turcot V Turcot Valérie V Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
Young KL Young Kristin L KL Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Winkler TW Winkler Thomas W TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.
Esko T Esko Tõnu T Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Karaderi T Karaderi Tugce T Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Locke AE Locke Adam E AE McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, Missouri 63108, USA.
Masca NG Masca Nicholas G D NG NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Ng MC Ng Maggie C Y MC Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Mudgal P Mudgal Poorva P Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Rivas MA Rivas Manuel A MA Nuffield Department of Clinical Medicine, Oxford OX3 7BN, UK.
Vedantam S Vedantam Sailaja S Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Mahajan A Mahajan Anubha A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Guo X Guo Xiuqing X Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Abecasis G Abecasis Goncalo G Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Aben KK Aben Katja K KK Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Adair LS Adair Linda S LS Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Alam DS Alam Dewan S DS Centre for Control of Chronic Diseases (CCCD), Dhaka, 1212, Bangladesh.
Albrecht E Albrecht Eva E Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Allin KH Allin Kristine H KH The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Allison M Allison Matthew M Department of Family Medicine &Public Health, University of California, San Diego, La Jolla, California 92093, USA.
Amouyel P Amouyel Philippe P Universite de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, F-59019, France.
Appel EV Appel Emil V EV The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Arveiler D Arveiler Dominique D Department of Public Health, University Hospital of Strasbourg, Strasbourg, 67081, France.
Asselbergs FW Asselbergs Folkert W FW Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
Auer PL Auer Paul L PL Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA.
Balkau B Balkau Beverley B INSERM U1018, Centre de recherche en Épidemiologie et Sante des Populations (CESP), Villejuif, France.
Banas B Banas Bernhard B Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany.
Bang LE Bang Lia E LE Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
Benn M Benn Marianne M Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Bergmann S Bergmann Sven S Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland.
Bielak LF Bielak Lawrence F LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Blüher M Blüher Matthias M University of Leipzig, Department of Medicine, Leipzig, 04103, Germany.
Boeing H Boeing Heiner H Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
Boerwinkle E Boerwinkle Eric E Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Böger CA Böger Carsten A CA Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany.
Bonnycastle LL Bonnycastle Lori L LL Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Bork-Jensen J Bork-Jensen Jette J The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Bots ML Bots Michiel L ML Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Bottinger EP Bottinger Erwin P EP The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Bowden DW Bowden Donald W DW Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Brandslund I Brandslund Ivan I Institute of Regional Health Research, University of Southern Denmark, Odense, 5000, Denmark.
Breen G Breen Gerome G MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London &NIHR Biomedical Research Centre for Mental Health at the Maudsley, London, SE5 8AF, UK.
Brilliant MH Brilliant Murray H MH Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
Broer L Broer Linda L Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Burt AA Burt Amber A AA Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Butterworth AS Butterworth Adam S AS NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK.
Carey DJ Carey David J DJ The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.
Caulfield MJ Caulfield Mark J MJ NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK.
Chambers JC Chambers John C JC Imperial College Healthcare NHS Trust, London W12 0HS, UK.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, Massachusetts 02115, USA.
Chen YI Chen Yii-Der Ida YI Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Chowdhury R Chowdhury Rajiv R MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Christensen C Christensen Cramer C Medical Department, Lillebaelt Hospital, Vejle, 7100, Denmark.
Chu AY Chu Audrey Y AY NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Cocca M Cocca Massimiliano M Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, 34100, Italy.
Collins FS Collins Francis S FS Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Cook JP Cook James P JP Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
Corley J Corley Janie J Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Galbany JC Galbany Jordi Corominas JC Department of Human Genetics, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Cox AJ Cox Amanda J AJ Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia.
Cuellar-Partida G Cuellar-Partida Gabriel G QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Danesh J Danesh John J British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Davies G Davies Gail G Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
de Bakker PI de Bakker Paul I W PI Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
de Borst GJ de Borst Gert J GJ Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
de Denus S de Denus Simon S Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
de Groot MC de Groot Mark C H MC Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology &Clinical Pharmacology, Utrecht University, Utrecht, 3508 TB, The Netherlands.
de Mutsert R de Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Deary IJ Deary Ian J IJ Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Dedoussis G Dedoussis George G Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.
Demerath EW Demerath Ellen W EW Division of Epidemiology &Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA.
den Hollander AI den Hollander Anneke I AI Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Dennis JG Dennis Joe G JG Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Di Angelantonio E Di Angelantonio Emanuele E NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK.
Drenos F Drenos Fotios F MRC Integrative Epidemiology Unit, School of Social &Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Du M Du Mengmeng M Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, New York 10017, USA.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Ebeling T Ebeling Tapani T Research Unit of Internal Medicine, University of Oulu, Oulu, FI-90014, Finland.
Edwards TL Edwards Todd L TL Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
Ellinor PT Ellinor Patrick T PT Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.
Elliott P Elliott Paul P Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
Evangelou E Evangelou Evangelos E Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Farmaki AE Farmaki Aliki-Eleni AE Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA.
Feitosa MF Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA.
Feng S Feng Shuang S Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Ferrannini E Ferrannini Ele E Department of Clinical &Experimental Medicine, University of Pisa, Pisa, Italy.
Ferrario MM Ferrario Marco M MM Research Center on Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, 21100, Italy.
Ferrieres J Ferrieres Jean J Toulouse University School of Medicine, Toulouse, TSA 50032 31059, France.
Florez JC Florez Jose C JC Department of Medicine, Harvard University Medical School, Boston, Massachusetts 02115, USA.
Ford I Ford Ian I University of Glasgow, Glasgow G12 8QQ, UK.
Fornage M Fornage Myriam M Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Franks PW Franks Paul W PW Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, 901 87, Sweden.
Frikke-Schmidt R Frikke-Schmidt Ruth R Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
Galesloot TE Galesloot Tessel E TE Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Gan W Gan Wei W Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Gandin I Gandin Ilaria I Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
Gasparini P Gasparini Paolo P Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar.
Giedraitis V Giedraitis Vilmantas V Geriatrics, Department of Public Health, Uppsala University, Uppsala, 751 85, Sweden.
Giri A Giri Ayush A Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
Girotto G Girotto Giorgia G Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Gordon-Larsen P Gordon-Larsen Penny P Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Gorski M Gorski Mathias M Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany.
Grarup N Grarup Niels N The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Grove ML Grove Megan L ML School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Gudnason V Gudnason Vilmundur V Icelandic Heart Association, Kopavogur, 201, Iceland.
Gustafsson S Gustafsson Stefan S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden.
Hansen T Hansen Torben T The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Harris KM Harris Kathleen Mullan KM Department of Sociology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA.
Hattersley AT Hattersley Andrew T AT University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Hayward C Hayward Caroline C MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
He L He Liang L Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.
Heid IM Heid Iris M IM Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Heikkilä K Heikkilä Kauko K Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Helgeland Ø Helgeland Øyvind KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway.
Hernesniemi J Hernesniemi Jussi J Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland.
Hewitt AW Hewitt Alex W AW Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, 7000, Australia.
Hocking LJ Hocking Lynne J LJ Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Hollensted M Hollensted Mette M The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Holmen OL Holmen Oddgeir L OL K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, Norway.
Hovingh GK Hovingh G Kees GK AMC, Department of Vascular Medicine, Amsterdam, 1105 AZ, The Netherlands.
Howson JM Howson Joanna M M JM MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Hoyng CB Hoyng Carel B CB Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Huang PL Huang Paul L PL Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Hveem K Hveem Kristian K HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, 7600, Norway.
Ikram MA Ikram M Arfan MA Department of Radiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Ingelsson E Ingelsson Erik E Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
Jackson AU Jackson Anne U AU Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Jansson JH Jansson Jan-Håkan JH Research Unit Skellefteå, Skellefteå, SE-93141, Sweden.
Jarvik GP Jarvik Gail P GP Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
Jensen GB Jensen Gorm B GB The Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, 2000, Denmark.
Jhun MA Jhun Min A MA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Jia Y Jia Yucheng Y Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Jiang X Jiang Xuejuan X USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA.
Johansson S Johansson Stefan S Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5021, Norway.
Jørgensen ME Jørgensen Marit E ME Steno Diabetes Center, Gentofte, 2820, Denmark.
Jørgensen T Jørgensen Torben T Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark.
Jousilahti P Jousilahti Pekka P National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Jukema JW Jukema J Wouter JW The Interuniversity Cardiology Institute of the Netherlands, Utrecht, 2333, The Netherlands.
Kahali B Kahali Bratati B Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Kahn RS Kahn René S RS Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.
Kähönen M Kähönen Mika M Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, 33014, Finland.
Kamstrup PR Kamstrup Pia R PR Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
Kanoni S Kanoni Stavroula S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Kaprio J Kaprio Jaakko J National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Karaleftheri M Karaleftheri Maria M Echinos Medical Centre, Echinos, Greece.
Kardia SL Kardia Sharon L R SL Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Karpe F Karpe Fredrik F Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.
Kee F Kee Frank F UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast BT12 6BJ, UK.
Keeman R Keeman Renske R Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands.
Kiemeney LA Kiemeney Lambertus A LA Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Kitajima H Kitajima Hidetoshi H Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Kluivers KB Kluivers Kirsten B KB Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Kocher T Kocher Thomas T Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, 17475, Germany.
Komulainen P Komulainen Pirjo P Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Kontto J Kontto Jukka J National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Kooner JS Kooner Jaspal S JS National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.
Kooperberg C Kooperberg Charles C Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Kovacs P Kovacs Peter P IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.
Kriebel J Kriebel Jennifer J Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
Kuivaniemi H Kuivaniemi Helena H Department of Psychiatry, and Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, 7505, South Africa.
Küry S Küry Sébastien S CHU Nantes, Service de Génétique Médicale, Nantes, 44093, France.
Kuusisto J Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
La Bianca M La Bianca Martina M Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
Laakso M Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
Lakka TA Lakka Timo A TA Institute of Biomedicine &Physiology, University of Eastern Finland, Kuopio, 70210, Finland.
Lange EM Lange Ethan M EM Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Lange LA Lange Leslie A LA Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Langefeld CD Langefeld Carl D CD Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Langenberg C Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Larson EB Larson Eric B EB Department of Health Services, University of Washington, Seattle, Washington 98101, USA.
Lee IT Lee I-Te IT School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland.
Lewis CE Lewis Cora E CE Division of Preventive Medicine University of Alabama at Birmingham, Birmingham, Alabama 35205, USA.
Li H Li Huaixing H Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Li J Li Jin J Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
Li-Gao R Li-Gao Ruifang R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Lin H Lin Honghuang H Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Lin LA Lin Li-An LA Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Lin X Lin Xu X Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Lind L Lind Lars L Uppsala University, Uppsala, 75185, Sweden.
Lindström J Lindström Jaana J National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Linneberg A Linneberg Allan A Department of Experimental Medicine, Rigshospitalet, Copenhagen, DK-2200, Denmark.
Liu Y Liu Yeheng Y Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Liu Y Liu Yongmei Y Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Lophatananon A Lophatananon Artitaya A Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Lubitz SA Lubitz Steven A SA Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland.
Mackey DA Mackey David A DA Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, 6009, Australia.
Madden PA Madden Pamela A F PA Department of Psychiatry, Washington University, Saint Louis, Missouri 63110, USA.
Manning AK Manning Alisa K AK Department of Medicine, Harvard University Medical School, Boston, Massachusetts 02115, USA.
Männistö S Männistö Satu S National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Marenne G Marenne Gaëlle G Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Marten J Marten Jonathan J MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Mazul AL Mazul Angela L AL Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Meidtner K Meidtner Karina K Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Mitchell P Mitchell Paul P Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, 2022, Australia.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Mook-Kanamori DO Mook-Kanamori Dennis O DO Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Morgan A Morgan Anna A Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
Morris AD Morris Andrew D AD Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
Morris AP Morris Andrew P AP Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
Müller-Nurasyid M Müller-Nurasyid Martina M DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, 80802, Germany.
Munroe PB Munroe Patricia B PB NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK.
Nalls MA Nalls Mike A MA Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
Nauck M Nauck Matthias M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
Nelson CP Nelson Christopher P CP NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Neville M Neville Matt M Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.
Nielsen SF Nielsen Sune F SF Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Nikus K Nikus Kjell K Department of Cardiology, Heart Center, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, 33521, Finland.
Njølstad PR Njølstad Pål R PR KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway.
Nordestgaard BG Nordestgaard Børge G BG Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Ntalla I Ntalla Ioanna I William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
O'Connel JR O'Connel Jeffrey R JR Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Oksa H Oksa Heikki H Department of Medicine, Tampere University Hospital, Tampere, 33521, Finland.
Loohuis LM Loohuis Loes M Olde LM Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA.
Ophoff RA Ophoff Roel A RA Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA.
Owen KR Owen Katharine R KR Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.
Packard CJ Packard Chris J CJ University of Glasgow, Glasgow G12 8QQ, UK.
Padmanabhan S Padmanabhan Sandosh S University of Glasgow, Glasgow G12 8QQ, UK.
Palmer CN Palmer Colin N A CN Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Pasterkamp G Pasterkamp Gerard G Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Patel AP Patel Aniruddh P AP Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Pattie A Pattie Alison A Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Pedersen O Pedersen Oluf O The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Peissig PL Peissig Peggy L PL Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
Peloso GM Peloso Gina M GM Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.
Pennell CE Pennell Craig E CE School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia.
Perola M Perola Markus M University of Tartu, Estonian Genome Center, Tartu, Estonia, Tartu, 51010, Estonia.
Perry JA Perry James A JA Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Perry JR Perry John R B JR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Person TN Person Thomas N TN Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
Pirie A Pirie Ailith A Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Polasek O Polasek Ozren O School of Medicine, University of Split, Split, 21000, Croatia.
Posthuma D Posthuma Danielle D Neuroscience Campus Amsterdam, Department Clinical Genetics, VU Medical Center, Amsterdam, 1081 HV, The Netherlands.
Raitakari OT Raitakari Olli T OT Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Rasheed A Rasheed Asif A Centre for Non-Communicable Diseases, Karachi, Pakistan.
Rauramaa R Rauramaa Rainer R Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70210, Finland.
Reilly DF Reilly Dermot F DF MRL, Merck &Co., Inc., Genetics and Pharmacogenomics, Boston, Massachusetts 02115, USA.
Reiner AP Reiner Alex P AP Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA.
Renström F Renström Frida F Department of Biobank Research, Umeå University, Umeå, SE-90187, Sweden.
Ridker PM Ridker Paul M PM Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Rioux JD Rioux John D JD Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Robertson N Robertson Neil N Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
Robino A Robino Antonietta A Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
Rolandsson O Rolandsson Olov O Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, 90185, Sweden.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
Ruth KS Ruth Katherine S KS Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Saleheen D Saleheen Danish D Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Salomaa V Salomaa Veikko V National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Samani NJ Samani Nilesh J NJ NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Sandow K Sandow Kevin K Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Sapkota Y Sapkota Yadav Y QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Sattar N Sattar Naveed N University of Glasgow, Glasgow G12 8QQ, UK.
Schmidt MK Schmidt Marjanka K MK Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands.
Schreiner PJ Schreiner Pamela J PJ Division of Epidemiology &Community Health University of Minnesota, Minneapolis, Minnesota 55454, USA.
Schulze MB Schulze Matthias B MB Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
Scott RA Scott Robert A RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Segura-Lepe MP Segura-Lepe Marcelo P MP Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.
Shah S Shah Svati S Duke University, Durham, North Carolina 27703, USA.
Sim X Sim Xueling X Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Sivapalaratnam S Sivapalaratnam Suthesh S Department of Vascular Medicine, AMC, Amsterdam, 1105 AZ, The Netherlands.
Small KS Small Kerrin S KS Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK.
Smith AV Smith Albert Vernon AV Icelandic Heart Association, Kopavogur, 201, Iceland.
Smith JA Smith Jennifer A JA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Southam L Southam Lorraine L Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Spector TD Spector Timothy D TD Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK.
Speliotes EK Speliotes Elizabeth K EK Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Starr JM Starr John M JM Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Steinthorsdottir V Steinthorsdottir Valgerdur V deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.
Stringham HM Stringham Heather M HM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Stumvoll M Stumvoll Michael M University of Leipzig, Department of Medicine, Leipzig, 04103, Germany.
Surendran P Surendran Praveen P MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
't Hart LM 't Hart Leen M LM Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.
Tansey KE Tansey Katherine E KE MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Tardif JC Tardif Jean-Claude JC Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Taylor KD Taylor Kent D KD Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Thorsteinsdottir U Thorsteinsdottir Unnur U Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Thuesen BH Thuesen Betina H BH Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark.
Tönjes A Tönjes Anke A Center for Pediatric Research, Department for Women's and Child Health, University of Leipzig, Leipzig, 04103, Germany.
Tromp G Tromp Gerard G Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, 7505, South Africa.
Trompet S Trompet Stella S Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Tsafantakis E Tsafantakis Emmanouil E Anogia Medical Centre, Anogia, Greece.
Tuomilehto J Tuomilehto Jaakko J Diabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Tybjaerg-Hansen A Tybjaerg-Hansen Anne A Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
Tyrer JP Tyrer Jonathan P JP Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Uher R Uher Rudolf R Department of Psychiatry, Dalhousie University, Halifax B3H 4R2, Canada.
Uitterlinden AG Uitterlinden André G AG Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Ulivi S Ulivi Sheila S Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
van der Laan SW van der Laan Sander W SW Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Van Der Leij AR Van Der Leij Andries R AR University of Amsterdam, Department of Brain &Cognition, Amsterdam, 1018 WS, The Netherlands.
van Duijn CM van Duijn Cornelia M CM Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
van Schoor NM van Schoor Natasja M NM Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands.
van Setten J van Setten Jessica J Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Varbo A Varbo Anette A Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Varga TV Varga Tibor V TV Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.
Varma R Varma Rohit R USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA.
Edwards DR Edwards Digna R Velez DR Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
Vermeulen SH Vermeulen Sita H SH Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Vestergaard H Vestergaard Henrik H The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Vitart V Vitart Veronique V MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Vogt TF Vogt Thomas F TF MRL, Merck &Co., Inc., Cardiometabolic Disease, Kenilworth, New Jersey 07033, USA.
Vozzi D Vozzi Diego D Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar.
Walker M Walker Mark M Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle NE2 4HH, UK.
Wang F Wang Feijie F Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Wang CA Wang Carol A CA School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia.
Wang S Wang Shuai S Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Wang Y Wang Yiqin Y Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Warren HR Warren Helen R HR NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK.
Wessel J Wessel Jennifer J Departments of Epidemiology &Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health &School of Medicine, Indiana University, Indiana 46202, USA.
Willems SM Willems Sara M SM MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Wilson JG Wilson James G JG Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Witte DR Witte Daniel R DR Department of Public Health, Aarhus University, Aarhus, 8000, Denmark.
Woods MO Woods Michael O MO Memorial University, Faculty of Medicine, Discipline of Genetics, St. John's, Newfoundland A1B 3V6, Canada.
Wu Y Wu Ying Y Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Yaghootkar H Yaghootkar Hanieh H Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Yao J Yao Jie J Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Yao P Yao Pang P Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Yerges-Armstrong LM Yerges-Armstrong Laura M LM GlaxoSmithKlein, King of Prussia, Pennsylvania 19406, USA.
Young R Young Robin R University of Glasgow, Glasgow G12 8QQ, UK.
Zeggini E Zeggini Eleftheria E Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Zhan X Zhan Xiaowei X Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Zhang W Zhang Weihua W Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.
Zhao JH Zhao Jing Hua JH MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Zhao W Zhao Wei W Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Zheng H Zheng He H Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
Zhou W Zhou Wei W Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
EPIC-InterAct Consortium
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ExomeBP Consortium
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Global Lipids Genetics Consortium
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Rotter JI Rotter Jerome I JI Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Boehnke M Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Kathiresan S Kathiresan Sekar S Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
McCarthy MI McCarthy Mark I MI Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK.
Willer CJ Willer Cristen J CJ Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Borecki IB Borecki Ingrid B IB Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA.
Liu DJ Liu Dajiang J DJ Department of Public Health Sciences, Institute for Personalized Medicine, the Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.
North KE North Kari E KE Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, North Carolina 27514, USA.
Heard-Costa NL Heard-Costa Nancy L NL Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Pers TH Pers Tune H TH Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2200, Denmark.
Lindgren CM Lindgren Cecilia M CM Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford OX3 7BN, UK.
Oxvig C Oxvig Claus C Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark.
Kutalik Z Kutalik Zoltán Z Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
Rivadeneira F Rivadeneira Fernando F Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
Loos RJ Loos Ruth J F RJ The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.
Frayling TM Frayling Timothy M TM Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Hirschhorn JN Hirschhorn Joel N JN Departments of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Deloukas P Deloukas Panos P Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Lettre G Lettre Guillaume G Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
INVESTIGATORS
JOURNAL
VOLUME: 542
ISSUE: 7640
TITLE: Nature
ISOABBREVIATION: Nature
YEAR: 2017
MONTH: Feb
DAY: 09
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-4687
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nature
COUNTRY: England
ISSNLINKING: 0028-0836
NLMUNIQUEID: 0410462
PUBLICATION TYPE
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REFTYPE REFSOURCE REFPMID NOTE
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