Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27976715
TITLE
Heritability of the shape of subcortical brain structures in the general population.
ABSTRACT
NlmCategory: UNASSIGNED
The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus. In 3,686 unrelated individuals aged between 45 and 98 years, brain magnetic resonance imaging and genotyping was performed. The maximal heritability of shape varies from 32.7 to 53.3% across the subcortical structures. Genetic contributions to shape extend beyond influences on intracranial volume and the gross volume of the respective structure. The regional variance in heritability was related to the reliability of the measurements, but could not be accounted for by technical factors only. These findings could be replicated in an independent sample of 1,040 twins. Differences in genetic contributions within a single region reveal the value of refined brain maps to appreciate the genetic complexity of brain structures.
DATE PUBLISHED
2016 Dec 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/04/13
accepted 2016/10/28
entrez 2016/12/16 06:00
pubmed 2016/12/16 06:00
medline 2016/12/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Roshchupkin GV Roshchupkin Gennady V GV Department of Medical Informatics, Erasmus MC, Rotterdam 3015 CE, The Netherlands.
Gutman BA Gutman Boris A BA Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del ReyLos Angeles, California 90292, USA.
Vernooij MW Vernooij Meike W MW Department of Epidemiology, Erasmus MC, Rotterdam 3015 CE, The Netherlands.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del ReyLos Angeles, California 90292, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Hofman A Hofman Albert A Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland 4072, Australia.
van der Lee SJ van der Lee Sven J SJ Department of Epidemiology, Erasmus MC, Rotterdam 3015 CE, The Netherlands.
van Duijn CM van Duijn Cornelia M CM Translational Epidemiology, Faculty Science, Leiden University, Leiden, 2333 CC, The Netherlands.
de Zubicaray GI de Zubicaray Greig I GI Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
Uitterlinden AG Uitterlinden André G AG Department of Internal Medicine, Erasmus MC, Rotterdam 3015 CE, The Netherlands.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.
Niessen WJ Niessen Wiro J WJ Faculty of Applied Sciences, Delft University of Technology, Delft 2628 CJ, The Netherlands.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del ReyLos Angeles, California 90292, USA.
Ikram MA Ikram M Arfan MA Department of Neurology, Erasmus MC, Rotterdam 3015 CE, The Netherlands.
Adams HH Adams Hieab H H HH Department of Epidemiology, Erasmus MC, Rotterdam 3015 CE, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE:
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2016
MONTH: Dec
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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