|
|
| PMID |
|
|
| TITLE |
|
| Heritability of the shape of subcortical brain structures in the general population. |
|
| ABSTRACT |
|
|
NlmCategory: UNASSIGNED |
| The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus. In 3,686 unrelated individuals aged between 45 and 98 years, brain magnetic resonance imaging and genotyping was performed. The maximal heritability of shape varies from 32.7 to 53.3% across the subcortical structures. Genetic contributions to shape extend beyond influences on intracranial volume and the gross volume of the respective structure. The regional variance in heritability was related to the reliability of the measurements, but could not be accounted for by technical factors only. These findings could be replicated in an independent sample of 1,040 twins. Differences in genetic contributions within a single region reveal the value of refined brain maps to appreciate the genetic complexity of brain structures. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2016/04/13 |
| accepted |
2016/10/28 |
| entrez |
2016/12/16 06:00 |
| pubmed |
2016/12/16 06:00 |
| medline |
2016/12/16 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Roshchupkin GV |
|
Roshchupkin |
Gennady V |
GV |
|
Department of Medical Informatics, Erasmus MC, Rotterdam 3015 CE, The Netherlands. |
| Gutman BA |
|
Gutman |
Boris A |
BA |
|
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del ReyLos Angeles, California 90292, USA. |
| Vernooij MW |
|
Vernooij |
Meike W |
MW |
|
Department of Epidemiology, Erasmus MC, Rotterdam 3015 CE, The Netherlands. |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
|
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del ReyLos Angeles, California 90292, USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
| Hofman A |
|
Hofman |
Albert |
A |
|
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland 4072, Australia. |
| van der Lee SJ |
|
van der Lee |
Sven J |
SJ |
|
Department of Epidemiology, Erasmus MC, Rotterdam 3015 CE, The Netherlands. |
| van Duijn CM |
|
van Duijn |
Cornelia M |
CM |
|
Translational Epidemiology, Faculty Science, Leiden University, Leiden, 2333 CC, The Netherlands. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia. |
| Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Department of Internal Medicine, Erasmus MC, Rotterdam 3015 CE, The Netherlands. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia. |
| Niessen WJ |
|
Niessen |
Wiro J |
WJ |
|
Faculty of Applied Sciences, Delft University of Technology, Delft 2628 CJ, The Netherlands. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del ReyLos Angeles, California 90292, USA. |
| Ikram MA |
|
Ikram |
M Arfan |
MA |
|
Department of Neurology, Erasmus MC, Rotterdam 3015 CE, The Netherlands. |
| Adams HH |
|
Adams |
Hieab H H |
HH |
|
Department of Epidemiology, Erasmus MC, Rotterdam 3015 CE, The Netherlands. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 7 |
| ISSUE: |
| TITLE: Nature communications |
| ISOABBREVIATION: Nat Commun |
| YEAR: 2016 |
| MONTH: Dec |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2041-1723 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Nat Commun |
| COUNTRY: England |
| ISSNLINKING: 2041-1723 |
| NLMUNIQUEID: 101528555 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
