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PMID |
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TITLE |
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Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994. |
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ABSTRACT |
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Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2016/08/04 |
accepted |
2016/11/21 |
entrez |
2016/12/15 06:00 |
pubmed |
2016/12/15 06:00 |
medline |
2017/11/07 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Jelenkovic A |
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Jelenkovic |
Aline |
A |
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Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain. |
Hur YM |
|
Hur |
Yoon-Mi |
YM |
|
Department of Education, Mokpo National University, Jeonnam, South Korea. |
Sund R |
|
Sund |
Reijo |
R |
|
Department of Social Research, University of Helsinki, Helsinki, Finland. |
Yokoyama Y |
|
Yokoyama |
Yoshie |
Y |
|
Department of Public Health Nursing, Osaka City University, Osaka, Japan. |
Siribaddana SH |
|
Siribaddana |
Sisira H |
SH |
|
Faculty of Medicine & Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka. |
Hotopf M |
|
Hotopf |
Matthew |
M |
|
NIHR Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, United Kingdom. |
Sumathipala A |
|
Sumathipala |
Athula |
A |
|
Research Institute for Primary Care and Health Sciences, School for Primary Care Research, Faculty of Health, Keele University, Staffordshire, United Kingdom. |
Rijsdijk F |
|
Rijsdijk |
Fruhling |
F |
|
MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. |
Tan Q |
|
Tan |
Qihua |
Q |
|
Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark. |
Zhang D |
|
Zhang |
Dongfeng |
D |
|
Department of Public Health, Qingdao University Medical College, Qingdao, China. |
Pang Z |
|
Pang |
Zengchang |
Z |
|
Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China. |
Aaltonen S |
|
Aaltonen |
Sari |
S |
|
Department of Public Health, University of Helsinki, Helsinki, Finland. |
Heikkilä K |
|
Heikkilä |
Kauko |
K |
|
Department of Public Health, University of Helsinki, Helsinki, Finland. |
Öncel SY |
|
Öncel |
Sevgi Y |
SY |
|
Department of Statistics, Faculty of Arts and Sciences, Kirikkale University, Kirikkale, Turkey. |
Aliev F |
|
Aliev |
Fazil |
F |
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Department of African American Studies, Virginia Commonwealth University, Richmond, United States. |
Rebato E |
|
Rebato |
Esther |
E |
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Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain. |
Tarnoki AD |
|
Tarnoki |
Adam D |
AD |
|
Hungarian Twin Registry, Budapest, Hungary. |
Tarnoki DL |
|
Tarnoki |
David L |
DL |
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Hungarian Twin Registry, Budapest, Hungary. |
Christensen K |
|
Christensen |
Kaare |
K |
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Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. |
Skytthe A |
|
Skytthe |
Axel |
A |
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Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark, Odense, Denmark. |
Kyvik KO |
|
Kyvik |
Kirsten O |
KO |
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Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark. |
Silberg JL |
|
Silberg |
Judy L |
JL |
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Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States. |
Eaves LJ |
|
Eaves |
Lindon J |
LJ |
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Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States. |
Maes HH |
|
Maes |
Hermine H |
HH |
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Department of Human and Molecular Genetics, Psychiatry & Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States. |
Cutler TL |
|
Cutler |
Tessa L |
TL |
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The Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Australia. |
Hopper JL |
|
Hopper |
John L |
JL |
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Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea. |
Ordoñana JR |
|
Ordoñana |
Juan R |
JR |
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IMIB-Arrixaca, Murcia, Spain. |
Sánchez-Romera JF |
|
Sánchez-Romera |
Juan F |
JF |
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Department of Developmental and Educational Psychology, University of Murcia, Murcia, Spain. |
Colodro-Conde L |
|
Colodro-Conde |
Lucia |
L |
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QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Cozen W |
|
Cozen |
Wendy |
W |
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USC Norris Comprehensive Cancer Center, Los Angeles, United States. |
Hwang AE |
|
Hwang |
Amie E |
AE |
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Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, United States. |
Mack TM |
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Mack |
Thomas M |
TM |
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USC Norris Comprehensive Cancer Center, Los Angeles, United States. |
Sung J |
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Sung |
Joohon |
J |
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Institute of Health and Environment, Seoul National University, Seoul, South-Korea. |
Song YM |
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Song |
Yun-Mi |
YM |
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Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South-Korea. |
Yang S |
|
Yang |
Sarah |
S |
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Institute of Health and Environment, Seoul National University, Seoul, South-Korea. |
Lee K |
|
Lee |
Kayoung |
K |
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Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. |
Franz CE |
|
Franz |
Carol E |
CE |
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Department of Psychiatry, University of California, San Diego, San Diego, United States. |
Kremen WS |
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Kremen |
William S |
WS |
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VA San Diego Center of Excellence for Stress and Mental Health, La Jolla, CA, United States. |
Lyons MJ |
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Lyons |
Michael J |
MJ |
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Department of Psychology, Boston University, Boston, United States. |
Busjahn A |
|
Busjahn |
Andreas |
A |
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HealthTwiSt GmbH, Berlin, Germany. |
Nelson TL |
|
Nelson |
Tracy L |
TL |
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Department of Health and Exercise Sciences and Colorado School of Public Health, Colorado State University, Colorado, United States. |
Whitfield KE |
|
Whitfield |
Keith E |
KE |
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Psychology and Neuroscience, Duke University, Durham, United States. |
Kandler C |
|
Kandler |
Christian |
C |
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Department of Psychology, Bielefeld University, Bielefeld, Germany. |
Jang KL |
|
Jang |
Kerry L |
KL |
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Department of Psychiatry, University of British Columbia, Vancouver, Canada. |
Gatz M |
|
Gatz |
Margaret |
M |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Butler DA |
|
Butler |
David A |
DA |
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Health and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, United States. |
Stazi MA |
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Stazi |
Maria A |
MA |
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Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy. |
Fagnani C |
|
Fagnani |
Corrado |
C |
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Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy. |
D'Ippolito C |
|
D'Ippolito |
Cristina |
C |
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Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy. |
Duncan GE |
|
Duncan |
Glen E |
GE |
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Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, United States. |
Buchwald D |
|
Buchwald |
Dedra |
D |
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Washington State Twin Registry, Washington State University, Seattle, United States. |
Derom CA |
|
Derom |
Catherine A |
CA |
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Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium. |
Vlietinck RF |
|
Vlietinck |
Robert F |
RF |
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Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium. |
Loos RJ |
|
Loos |
Ruth Jf |
RJ |
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The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, United States. |
Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Medland SE |
|
Medland |
Sarah E |
SE |
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Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
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Molecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Jeong HU |
|
Jeong |
Hoe-Uk |
HU |
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Department of Education, Mokpo National University, Jeonnam, South Korea. |
Swan GE |
|
Swan |
Gary E |
GE |
|
Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, United States. |
Krasnow R |
|
Krasnow |
Ruth |
R |
|
Center for Health Sciences, SRI International, Menlo Park, United States. |
Magnusson PK |
|
Magnusson |
Patrik Ke |
PK |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Pedersen NL |
|
Pedersen |
Nancy L |
NL |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Dahl-Aslan AK |
|
Dahl-Aslan |
Anna K |
AK |
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Institute of Gerontology and Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden. |
McAdams TA |
|
McAdams |
Tom A |
TA |
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MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. |
Eley TC |
|
Eley |
Thalia C |
TC |
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MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. |
Gregory AM |
|
Gregory |
Alice M |
AM |
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Department of Psychology, Goldsmiths, University of London, London, United Kingdom. |
Tynelius P |
|
Tynelius |
Per |
P |
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Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. |
Baker LA |
|
Baker |
Laura A |
LA |
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Department of Psychology, University of Southern California, Los Angeles, United States. |
Tuvblad C |
|
Tuvblad |
Catherine |
C |
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School of Law, Psychology and Social Work, Örebro University, Örebro, Sweden. |
Bayasgalan G |
|
Bayasgalan |
Gombojav |
G |
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Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia. |
Narandalai D |
|
Narandalai |
Danshiitsoodol |
D |
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Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. |
Lichtenstein P |
|
Lichtenstein |
Paul |
P |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Spector TD |
|
Spector |
Timothy D |
TD |
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Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom. |
Mangino M |
|
Mangino |
Massimo |
M |
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Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom. |
Lachance G |
|
Lachance |
Genevieve |
G |
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Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom. |
Bartels M |
|
Bartels |
Meike |
M |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. |
van Beijsterveldt TC |
|
van Beijsterveldt |
Toos Cem |
TC |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. |
Willemsen G |
|
Willemsen |
Gonneke |
G |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. |
Burt SA |
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Burt |
S Alexandra |
SA |
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Michigan State University, East Lansing, Michigan, United States. |
Klump KL |
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Klump |
Kelly L |
KL |
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Michigan State University, East Lansing, Michigan, United States. |
Harris JR |
|
Harris |
Jennifer R |
JR |
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Norwegian Institute of Public Health, Oslo, Norway. |
Brandt I |
|
Brandt |
Ingunn |
I |
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Norwegian Institute of Public Health, Oslo, Norway. |
Nilsen TS |
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Nilsen |
Thomas Sevenius |
TS |
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Norwegian Institute of Public Health, Oslo, Norway. |
Krueger RF |
|
Krueger |
Robert F |
RF |
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Department of Psychology, University of Minnesota, Minneapolis, United States. |
McGue M |
|
McGue |
Matt |
M |
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Department of Psychology, University of Minnesota, Minneapolis, United States. |
Pahlen S |
|
Pahlen |
Shandell |
S |
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Department of Psychology, University of Minnesota, Minneapolis, United States. |
Corley RP |
|
Corley |
Robin P |
RP |
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Institute for Behavioral Genetics, University of Colorado, Boulder, United States. |
Hjelmborg JV |
|
Hjelmborg |
Jacob V B |
JV |
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Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark, Odense, Denmark. |
Goldberg JH |
|
Goldberg |
Jack H |
JH |
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Department of Epidemiology, School of Public Health, University of Washington, Seattle, United States. |
Iwatani Y |
|
Iwatani |
Yoshinori |
Y |
|
Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
Watanabe M |
|
Watanabe |
Mikio |
M |
|
Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
Honda C |
|
Honda |
Chika |
C |
|
Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
Inui F |
|
Inui |
Fujio |
F |
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Faculty of Health Science, Kio University, Nara, Japan. |
Rasmussen F |
|
Rasmussen |
Finn |
F |
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Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. |
Huibregtse BM |
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Huibregtse |
Brooke M |
BM |
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Institute for Behavioral Genetics, University of Colorado, Boulder, United States. |
Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands. |
Sørensen TI |
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Sørensen |
Thorkild I A |
TI |
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Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark. |
Kaprio J |
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Kaprio |
Jaakko |
J |
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Institute for Molecular Medicine FIMM, Helsinki, Finland. |
Silventoinen K |
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Silventoinen |
Karri |
K |
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Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 5 |
ISSUE: |
TITLE: eLife |
ISOABBREVIATION: Elife |
YEAR: 2016 |
MONTH: 12 |
DAY: 14 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2050-084X |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Elife |
COUNTRY: England |
ISSNLINKING: 2050-084X |
NLMUNIQUEID: 101579614 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, Non-U.S. Gov't |
Research Support, N.I.H., Extramural |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
R21 MH070542 |
NIMH NIH HHS |
United States |
R01 MH081813 |
NIMH NIH HHS |
United States |
T32 DA017637 |
NIDA NIH HHS |
United States |
R01 AG022982 |
NIA NIH HHS |
United States |
R01 MH092377 |
NIMH NIH HHS |
United States |
R01 AG018386 |
NIA NIH HHS |
United States |
R01 ES015150 |
NIEHS NIH HHS |
United States |
R01 HD066040 |
NICHD NIH HHS |
United States |
R01 AA009203 |
NIAAA NIH HHS |
United States |
R01 AG018384 |
NIA NIH HHS |
United States |
R21 AG039572 |
NIA NIH HHS |
United States |
230374 |
European Research Council |
International |
RC2 HL103416 |
NHLBI NIH HHS |
United States |
R01 HD010333 |
NICHD NIH HHS |
United States |
P01 AG008761 |
NIA NIH HHS |
United States |
K05 AA000145 |
NIAAA NIH HHS |
United States |
P30 AG017265 |
NIA NIH HHS |
United States |
R01 AA012502 |
NIAAA NIH HHS |
United States |
R03 MH063851 |
NIMH NIH HHS |
United States |
R01 MH058354 |
NIMH NIH HHS |
United States |
P60 DA011015 |
NIDA NIH HHS |
United States |
R01 AG022381 |
NIA NIH HHS |
United States |
R37 AA012502 |
NIAAA NIH HHS |
United States |
R01 AG050595 |
NIA NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
CODATwins project |
birth cohorts |
height |
heritability |
human |
human biology |
medicine |
twins |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
|
Aged |
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Aged, 80 and over |
|
Body Height |
genetics |
Cohort Studies |
genetics |
Environmental Exposure |
genetics |
Female |
genetics |
Global Health |
genetics |
Humans |
genetics |
Male |
genetics |
Middle Aged |
genetics |
Twins |
genetics |
Young Adult |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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