Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27964777
TITLE
Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994.
ABSTRACT
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.
DATE PUBLISHED
2016 12 14
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/08/04
accepted 2016/11/21
entrez 2016/12/15 06:00
pubmed 2016/12/15 06:00
medline 2017/11/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jelenkovic A Jelenkovic Aline A Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain.
Hur YM Hur Yoon-Mi YM Department of Education, Mokpo National University, Jeonnam, South Korea.
Sund R Sund Reijo R Department of Social Research, University of Helsinki, Helsinki, Finland.
Yokoyama Y Yokoyama Yoshie Y Department of Public Health Nursing, Osaka City University, Osaka, Japan.
Siribaddana SH Siribaddana Sisira H SH Faculty of Medicine & Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
Hotopf M Hotopf Matthew M NIHR Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, United Kingdom.
Sumathipala A Sumathipala Athula A Research Institute for Primary Care and Health Sciences, School for Primary Care Research, Faculty of Health, Keele University, Staffordshire, United Kingdom.
Rijsdijk F Rijsdijk Fruhling F MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Tan Q Tan Qihua Q Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Zhang D Zhang Dongfeng D Department of Public Health, Qingdao University Medical College, Qingdao, China.
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Aaltonen S Aaltonen Sari S Department of Public Health, University of Helsinki, Helsinki, Finland.
Heikkilä K Heikkilä Kauko K Department of Public Health, University of Helsinki, Helsinki, Finland.
Öncel SY Öncel Sevgi Y SY Department of Statistics, Faculty of Arts and Sciences, Kirikkale University, Kirikkale, Turkey.
Aliev F Aliev Fazil F Department of African American Studies, Virginia Commonwealth University, Richmond, United States.
Rebato E Rebato Esther E Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain.
Tarnoki AD Tarnoki Adam D AD Hungarian Twin Registry, Budapest, Hungary.
Tarnoki DL Tarnoki David L DL Hungarian Twin Registry, Budapest, Hungary.
Christensen K Christensen Kaare K Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Skytthe A Skytthe Axel A Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark, Odense, Denmark.
Kyvik KO Kyvik Kirsten O KO Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States.
Eaves LJ Eaves Lindon J LJ Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States.
Maes HH Maes Hermine H HH Department of Human and Molecular Genetics, Psychiatry & Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States.
Cutler TL Cutler Tessa L TL The Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Australia.
Hopper JL Hopper John L JL Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea.
Ordoñana JR Ordoñana Juan R JR IMIB-Arrixaca, Murcia, Spain.
Sánchez-Romera JF Sánchez-Romera Juan F JF Department of Developmental and Educational Psychology, University of Murcia, Murcia, Spain.
Colodro-Conde L Colodro-Conde Lucia L QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Cozen W Cozen Wendy W USC Norris Comprehensive Cancer Center, Los Angeles, United States.
Hwang AE Hwang Amie E AE Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, United States.
Mack TM Mack Thomas M TM USC Norris Comprehensive Cancer Center, Los Angeles, United States.
Sung J Sung Joohon J Institute of Health and Environment, Seoul National University, Seoul, South-Korea.
Song YM Song Yun-Mi YM Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South-Korea.
Yang S Yang Sarah S Institute of Health and Environment, Seoul National University, Seoul, South-Korea.
Lee K Lee Kayoung K Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Franz CE Franz Carol E CE Department of Psychiatry, University of California, San Diego, San Diego, United States.
Kremen WS Kremen William S WS VA San Diego Center of Excellence for Stress and Mental Health, La Jolla, CA, United States.
Lyons MJ Lyons Michael J MJ Department of Psychology, Boston University, Boston, United States.
Busjahn A Busjahn Andreas A HealthTwiSt GmbH, Berlin, Germany.
Nelson TL Nelson Tracy L TL Department of Health and Exercise Sciences and Colorado School of Public Health, Colorado State University, Colorado, United States.
Whitfield KE Whitfield Keith E KE Psychology and Neuroscience, Duke University, Durham, United States.
Kandler C Kandler Christian C Department of Psychology, Bielefeld University, Bielefeld, Germany.
Jang KL Jang Kerry L KL Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Gatz M Gatz Margaret M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Butler DA Butler David A DA Health and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, United States.
Stazi MA Stazi Maria A MA Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Fagnani C Fagnani Corrado C Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
D'Ippolito C D'Ippolito Cristina C Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Duncan GE Duncan Glen E GE Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, United States.
Buchwald D Buchwald Dedra D Washington State Twin Registry, Washington State University, Seattle, United States.
Derom CA Derom Catherine A CA Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Loos RJ Loos Ruth Jf RJ The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Martin NG Martin Nicholas G NG Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Molecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jeong HU Jeong Hoe-Uk HU Department of Education, Mokpo National University, Jeonnam, South Korea.
Swan GE Swan Gary E GE Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, United States.
Krasnow R Krasnow Ruth R Center for Health Sciences, SRI International, Menlo Park, United States.
Magnusson PK Magnusson Patrik Ke PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dahl-Aslan AK Dahl-Aslan Anna K AK Institute of Gerontology and Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.
McAdams TA McAdams Tom A TA MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Eley TC Eley Thalia C TC MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Gregory AM Gregory Alice M AM Department of Psychology, Goldsmiths, University of London, London, United Kingdom.
Tynelius P Tynelius Per P Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Baker LA Baker Laura A LA Department of Psychology, University of Southern California, Los Angeles, United States.
Tuvblad C Tuvblad Catherine C School of Law, Psychology and Social Work, Örebro University, Örebro, Sweden.
Bayasgalan G Bayasgalan Gombojav G Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Narandalai D Narandalai Danshiitsoodol D Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Lichtenstein P Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Spector TD Spector Timothy D TD Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom.
Lachance G Lachance Genevieve G Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom.
Bartels M Bartels Meike M Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
van Beijsterveldt TC van Beijsterveldt Toos Cem TC Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Burt SA Burt S Alexandra SA Michigan State University, East Lansing, Michigan, United States.
Klump KL Klump Kelly L KL Michigan State University, East Lansing, Michigan, United States.
Harris JR Harris Jennifer R JR Norwegian Institute of Public Health, Oslo, Norway.
Brandt I Brandt Ingunn I Norwegian Institute of Public Health, Oslo, Norway.
Nilsen TS Nilsen Thomas Sevenius TS Norwegian Institute of Public Health, Oslo, Norway.
Krueger RF Krueger Robert F RF Department of Psychology, University of Minnesota, Minneapolis, United States.
McGue M McGue Matt M Department of Psychology, University of Minnesota, Minneapolis, United States.
Pahlen S Pahlen Shandell S Department of Psychology, University of Minnesota, Minneapolis, United States.
Corley RP Corley Robin P RP Institute for Behavioral Genetics, University of Colorado, Boulder, United States.
Hjelmborg JV Hjelmborg Jacob V B JV Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark, Odense, Denmark.
Goldberg JH Goldberg Jack H JH Department of Epidemiology, School of Public Health, University of Washington, Seattle, United States.
Iwatani Y Iwatani Yoshinori Y Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Watanabe M Watanabe Mikio M Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Honda C Honda Chika C Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Inui F Inui Fujio F Faculty of Health Science, Kio University, Nara, Japan.
Rasmussen F Rasmussen Finn F Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Huibregtse BM Huibregtse Brooke M BM Institute for Behavioral Genetics, University of Colorado, Boulder, United States.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Sørensen TI Sørensen Thorkild I A TI Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine FIMM, Helsinki, Finland.
Silventoinen K Silventoinen Karri K Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
INVESTIGATORS
JOURNAL
VOLUME: 5
ISSUE:
TITLE: eLife
ISOABBREVIATION: Elife
YEAR: 2016
MONTH: 12
DAY: 14
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2050-084X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Elife
COUNTRY: England
ISSNLINKING: 2050-084X
NLMUNIQUEID: 101579614
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R21 MH070542 NIMH NIH HHS United States
R01 MH081813 NIMH NIH HHS United States
T32 DA017637 NIDA NIH HHS United States
R01 AG022982 NIA NIH HHS United States
R01 MH092377 NIMH NIH HHS United States
R01 AG018386 NIA NIH HHS United States
R01 ES015150 NIEHS NIH HHS United States
R01 HD066040 NICHD NIH HHS United States
R01 AA009203 NIAAA NIH HHS United States
R01 AG018384 NIA NIH HHS United States
R21 AG039572 NIA NIH HHS United States
230374 European Research Council International
RC2 HL103416 NHLBI NIH HHS United States
R01 HD010333 NICHD NIH HHS United States
P01 AG008761 NIA NIH HHS United States
K05 AA000145 NIAAA NIH HHS United States
P30 AG017265 NIA NIH HHS United States
R01 AA012502 NIAAA NIH HHS United States
R03 MH063851 NIMH NIH HHS United States
R01 MH058354 NIMH NIH HHS United States
P60 DA011015 NIDA NIH HHS United States
R01 AG022381 NIA NIH HHS United States
R37 AA012502 NIAAA NIH HHS United States
R01 AG050595 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
CODATwins project
birth cohorts
height
heritability
human
human biology
medicine
twins
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Body Height genetics
Cohort Studies genetics
Environmental Exposure genetics
Female genetics
Global Health genetics
Humans genetics
Male genetics
Middle Aged genetics
Twins genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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