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PMID |
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TITLE |
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KLB is associated with alcohol drinking, and its gene product ß-Klotho is necessary for FGF21 regulation of alcohol preference. |
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ABSTRACT |
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NlmCategory: UNASSIGNED |
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10(-12)). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pmc-release |
2017/06/13 |
pubmed |
2016/12/03 06:00 |
medline |
2016/12/03 06:00 |
entrez |
2016/12/03 06:00 |
|
AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Schumann G |
|
Schumann |
Gunter |
G |
|
Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk. |
Liu C |
|
Liu |
Chunyu |
C |
|
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118. |
O'Reilly P |
|
O'Reilly |
Paul |
P |
|
Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom. |
Gao H |
|
Gao |
He |
H |
|
Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom. |
Song P |
|
Song |
Parkyong |
P |
|
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390. |
Xu B |
|
Xu |
Bing |
B |
|
Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom. |
Ruggeri B |
|
Ruggeri |
Barbara |
B |
|
Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom. |
Amin N |
|
Amin |
Najaf |
N |
|
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Jia T |
|
Jia |
Tianye |
T |
|
Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom. |
Preis S |
|
Preis |
Sarah |
S |
|
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118. |
Segura Lepe M |
|
Segura Lepe |
Marcelo |
M |
|
Section of Bioinformatics, Bayer Pharma AG, 13342 Berlin, Germany. |
Akira S |
|
Akira |
Shizuo |
S |
|
Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan. |
Barbieri C |
|
Barbieri |
Caterina |
C |
|
Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy. |
Baumeister S |
|
Baumeister |
Sebastian |
S |
|
Department of Epidemiology and Preventive Medicine, University of Regensburg, 93053 Regensburg, Germany. |
Cauchi S |
|
Cauchi |
Stephane |
S |
|
CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France. |
Clarke TK |
|
Clarke |
Toni-Kim |
TK |
|
Divison of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, United Kingdom. |
Enroth S |
|
Enroth |
Stefan |
S |
|
Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden. |
Fischer K |
|
Fischer |
Krista |
K |
|
Estonian Genome Center, University of Tartu, 51010 Tartu, Estonia. |
Hällfors J |
|
Hällfors |
Jenni |
J |
|
Institute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland. |
Harris SE |
|
Harris |
Sarah E |
SE |
|
Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. |
Hieber S |
|
Hieber |
Saskia |
S |
|
Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany. |
Hofer E |
|
Hofer |
Edith |
E |
|
Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, 8036 Graz, Austria. |
Hottenga JJ |
|
Hottenga |
Jouke-Jan |
JJ |
|
Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands. |
Johansson Å |
|
Johansson |
Åsa |
Å |
|
Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden. |
Joshi PK |
|
Joshi |
Peter K |
PK |
|
Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom. |
Kaartinen N |
|
Kaartinen |
Niina |
N |
|
National Institute for Health and Welfare, 00271 Helsinki, Finland. |
Laitinen J |
|
Laitinen |
Jaana |
J |
|
Quantified Employee-Unit, Finnish Institute of Occupational Health, 00250 Helsinki, Finland. |
Lemaitre R |
|
Lemaitre |
Rozenn |
R |
|
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101. |
Loukola A |
|
Loukola |
Anu |
A |
|
Department of Public Health, University of Helsinki, 00014 Helsinki, Finland. |
Luan J |
|
Luan |
Jian'an |
J |
|
Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom. |
Lyytikäinen LP |
|
Lyytikäinen |
Leo-Pekka |
LP |
|
Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland. |
Mangino M |
|
Mangino |
Massimo |
M |
|
National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London SE1 9RT, United Kingdom. |
Manichaikul A |
|
Manichaikul |
Ani |
A |
|
Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22903. |
Mbarek H |
|
Mbarek |
Hamdi |
H |
|
Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands. |
Milaneschi Y |
|
Milaneschi |
Yuri |
Y |
|
Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands. |
Moayyeri A |
|
Moayyeri |
Alireza |
A |
|
Farr Institute of Health Informatics Research, University College London Institute of Health Informatics, London NW1 2DA, United Kingdom. |
Mukamal K |
|
Mukamal |
Kenneth |
K |
|
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215. |
Nelson C |
|
Nelson |
Christopher |
C |
|
National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, United Kingdom. |
Nettleton J |
|
Nettleton |
Jennifer |
J |
|
Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston, TX 77225. |
Partinen E |
|
Partinen |
Eemil |
E |
|
Faculty of Medicine, University of Tartu, 50411 Tartu, Estonia. |
Rawal R |
|
Rawal |
Rajesh |
R |
|
Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany. |
Robino A |
|
Robino |
Antonietta |
A |
|
Institute for Maternal and Child Health-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, 34137 Trieste, Italy. |
Rose L |
|
Rose |
Lynda |
L |
|
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215. |
Sala C |
|
Sala |
Cinzia |
C |
|
Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy. |
Satoh T |
|
Satoh |
Takashi |
T |
|
Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan. |
Schmidt R |
|
Schmidt |
Reinhold |
R |
|
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria. |
Schraut K |
|
Schraut |
Katharina |
K |
|
Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom. |
Scott R |
|
Scott |
Robert |
R |
|
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom. |
Smith AV |
|
Smith |
Albert Vernon |
AV |
|
Research Institute, Icelandic Heart Association, 201 Kopavogur, Iceland. |
Starr JM |
|
Starr |
John M |
JM |
|
Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom. |
Teumer A |
|
Teumer |
Alexander |
A |
|
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany. |
Trompet S |
|
Trompet |
Stella |
S |
|
Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. |
Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Venturini C |
|
Venturini |
Cristina |
C |
|
Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom. |
Vergnaud AC |
|
Vergnaud |
Anne-Claire |
AC |
|
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom. |
Verweij N |
|
Verweij |
Niek |
N |
|
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands. |
Vitart V |
|
Vitart |
Veronique |
V |
|
Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. |
Vuckovic D |
|
Vuckovic |
Dragana |
D |
|
Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy. |
Wedenoja J |
|
Wedenoja |
Juho |
J |
|
Department of Public Health, University of Helsinki, 00014 Helsinki, Finland. |
Yengo L |
|
Yengo |
Loic |
L |
|
CNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France. |
Yu B |
|
Yu |
Bing |
B |
|
Division of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX 77225. |
Zhang W |
|
Zhang |
Weihua |
W |
|
Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom. |
Zhao JH |
|
Zhao |
Jing Hua |
JH |
|
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom. |
Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands. |
Chambers J |
|
Chambers |
John |
J |
|
Imperial College Healthcare National Health Service Trust, London W12 0HS, United Kingdom. |
Chasman DI |
|
Chasman |
Daniel I |
DI |
|
Harvard Medical School, Boston, MA 02115. |
Daniela T |
|
Daniela |
Toniolo |
T |
|
Division of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy. |
de Geus E |
|
de Geus |
Eco |
E |
|
Department of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands. |
Deary I |
|
Deary |
Ian |
I |
|
Psychology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom. |
Eriksson JG |
|
Eriksson |
Johan G |
JG |
|
Vasa Central Hospital, 65130 Vasa, Finland. |
Esko T |
|
Esko |
Tõnu |
T |
|
Estonian Genome Center, University of Tartu, 51010 Tartu, Estonia. |
Eulenburg V |
|
Eulenburg |
Volker |
V |
|
Institute for Biochemistry and Molecular Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany. |
Franco OH |
|
Franco |
Oscar H |
OH |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Froguel P |
|
Froguel |
Philippe |
P |
|
Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0HR, United Kingdom. |
Gieger C |
|
Gieger |
Christian |
C |
|
Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany. |
Grabe HJ |
|
Grabe |
Hans J |
HJ |
|
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany. |
Gudnason V |
|
Gudnason |
Vilmundur |
V |
|
Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland. |
Gyllensten U |
|
Gyllensten |
Ulf |
U |
|
Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden. |
Harris TB |
|
Harris |
Tamara B |
TB |
|
National Institute on Aging, NIH, Bethesda, MD 20892. |
Hartikainen AL |
|
Hartikainen |
Anna-Liisa |
AL |
|
Unit of Primary Care, Oulu University Hospital, 90220 Oulu, Finland. |
Heath AC |
|
Heath |
Andrew C |
AC |
|
Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO 63110. |
Hocking L |
|
Hocking |
Lynne |
L |
|
Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom. |
Hofman A |
|
Hofman |
Albert |
A |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Huth C |
|
Huth |
Cornelia |
C |
|
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, D-85764 Neuherberg, Germany. |
Jarvelin MR |
|
Jarvelin |
Marjo-Riitta |
MR |
|
Biocenter Oulu, University of Oulu, Oulu FI-90014, Finland. |
Jukema JW |
|
Jukema |
J Wouter |
JW |
|
Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. |
Kaprio J |
|
Kaprio |
Jaakko |
J |
|
Department of Public Health, University of Helsinki, 00014 Helsinki, Finland. |
Kooner JS |
|
Kooner |
Jaspal S |
JS |
|
Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom. |
Kutalik Z |
|
Kutalik |
Zoltan |
Z |
|
Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudoise, 1010 Lausanne, Switzerland. |
Lahti J |
|
Lahti |
Jari |
J |
|
Institute of Behavioural Sciences, University of Helsinki, 00014 Helsinki, Finland. |
Langenberg C |
|
Langenberg |
Claudia |
C |
|
Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom. |
Lehtimäki T |
|
Lehtimäki |
Terho |
T |
|
Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland. |
Liu Y |
|
Liu |
Yongmei |
Y |
|
Wake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157. |
Madden PA |
|
Madden |
Pamela A F |
PA |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110. |
Martin N |
|
Martin |
Nicholas |
N |
|
Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia. |
Morrison A |
|
Morrison |
Alanna |
A |
|
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225. |
Penninx B |
|
Penninx |
Brenda |
B |
|
Department of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands. |
Pirastu N |
|
Pirastu |
Nicola |
N |
|
Department of Medical Sciences, University of Trieste, 34149 Trieste, Italy. |
Psaty B |
|
Psaty |
Bruce |
B |
|
Group Health Cooperative, Group Health Research Institute, Seattle, WA 98101. |
Raitakari O |
|
Raitakari |
Olli |
O |
|
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland. |
Ridker P |
|
Ridker |
Paul |
P |
|
Harvard Medical School, Boston, MA 02115. |
Rose R |
|
Rose |
Richard |
R |
|
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405. |
Rotter JI |
|
Rotter |
Jerome I |
JI |
|
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90509. |
Samani NJ |
|
Samani |
Nilesh J |
NJ |
|
National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, United Kingdom. |
Schmidt H |
|
Schmidt |
Helena |
H |
|
Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz, Austria. |
Spector TD |
|
Spector |
Tim D |
TD |
|
Department of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom. |
Stott D |
|
Stott |
David |
D |
|
Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G31 2ER, United Kingdom. |
Strachan D |
|
Strachan |
David |
D |
|
Population Health Research Institute, St. George's, University of London, London SW17 0RE, United Kingdom. |
Tzoulaki I |
|
Tzoulaki |
Ioanna |
I |
|
Department of Hygiene and Epidemiology, University of Ioannina Medical School, 45110 Ioannina, Greece. |
van der Harst P |
|
van der Harst |
Pim |
P |
|
Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of The Netherlands-Netherlands Heart Institute, 3511GC Utrecht, The Netherlands. |
van Duijn CM |
|
van Duijn |
Cornelia M |
CM |
|
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Marques-Vidal P |
|
Marques-Vidal |
Pedro |
P |
|
Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland. |
Vollenweider P |
|
Vollenweider |
Peter |
P |
|
Department of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland. |
Wareham NJ |
|
Wareham |
Nicholas J |
NJ |
|
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom. |
Whitfield JB |
|
Whitfield |
John B |
JB |
|
Genetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia. |
Wilson J |
|
Wilson |
James |
J |
|
Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. |
Wolffenbuttel B |
|
Wolffenbuttel |
Bruce |
B |
|
Department of Endocrinology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands. |
Bakalkin G |
|
Bakalkin |
Georgy |
G |
|
Division of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences, Uppsala University, 751 24 Uppsala, Sweden. |
Evangelou E |
|
Evangelou |
Evangelos |
E |
|
Department of Hygiene and Epidemiology, University of Ioannina Medical School, 45110 Ioannina, Greece. |
Liu Y |
|
Liu |
Yun |
Y |
|
Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, 200032 Shanghai, People's Republic of China. |
Rice KM |
|
Rice |
Kenneth M |
KM |
|
Department of Biostatistics, University of Washington, Seattle, WA 98195. |
Desrivières S |
|
Desrivières |
Sylvane |
S |
|
Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom. |
Kliewer SA |
|
Kliewer |
Steven A |
SA |
|
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390. |
Mangelsdorf DJ |
|
Mangelsdorf |
David J |
DJ |
|
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390. |
Müller CP |
|
Müller |
Christian P |
CP |
|
Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany. |
Levy D |
|
Levy |
Daniel |
D |
|
The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD 20824. |
Elliott P |
|
Elliott |
Paul |
P |
|
Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London W2 1PG, United Kingdom. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 113 |
ISSUE: 50 |
TITLE: Proceedings of the National Academy of Sciences of the United States of America |
ISOABBREVIATION: Proc. Natl. Acad. Sci. U.S.A. |
YEAR: 2016 |
MONTH: Dec |
DAY: 13 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1091-6490 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Proc Natl Acad Sci U S A |
COUNTRY: United States |
ISSNLINKING: 0027-8424 |
NLMUNIQUEID: 7505876 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
P30 DK063491 |
NIDDK NIH HHS |
United States |
UL1 TR000124 |
NCATS NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
FGF21 |
alcohol consumption |
human |
mouse model |
ß-Klotho |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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