|
|
| PMID |
|
|
| TITLE |
|
| Genetic variants linked to education predict longevity. |
|
| ABSTRACT |
|
|
|
| Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2016/11/02 06:00 |
| medline |
2018/03/30 06:00 |
| entrez |
2016/11/02 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Marioni RE |
|
Marioni |
Riccardo E |
RE |
|
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia. |
| Ritchie SJ |
|
Ritchie |
Stuart J |
SJ |
|
Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom. |
| Joshi PK |
|
Joshi |
Peter K |
PK |
|
Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH16 4UX, United Kingdom. |
| Hagenaars SP |
|
Hagenaars |
Saskia P |
SP |
|
Division of Psychiatry, University of Edinburgh, Edinburgh EH8 9YL, United Kingdom. |
| Okbay A |
|
Okbay |
Aysu |
A |
|
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam 3062 PA, The Netherlands. |
| Fischer K |
|
Fischer |
Krista |
K |
|
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. |
| Adams MJ |
|
Adams |
Mark J |
MJ |
|
Division of Psychiatry, University of Edinburgh, Edinburgh EH8 9YL, United Kingdom. |
| Hill WD |
|
Hill |
W David |
WD |
|
Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom. |
| Davies G |
|
Davies |
Gail |
G |
|
Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom. |
|
Social Science Genetic Association Consortium |
|
|
|
|
|
| Nagy R |
|
Nagy |
Reka |
R |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. |
| Amador C |
|
Amador |
Carmen |
C |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. |
| Läll K |
|
Läll |
Kristi |
K |
|
Institute of Mathematical Statistics, University of Tartu, Tartu 50409, Estonia. |
| Metspalu A |
|
Metspalu |
Andres |
A |
|
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. |
| Liewald DC |
|
Liewald |
David C |
DC |
|
Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom. |
| Campbell A |
|
Campbell |
Archie |
A |
|
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. |
| Wilson JF |
|
Wilson |
James F |
JF |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. |
| Hayward C |
|
Hayward |
Caroline |
C |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. |
| Esko T |
|
Esko |
Tõnu |
T |
|
Department of Endocrinology, Children's Hospital Boston, Boston, MA 02115. |
| Porteous DJ |
|
Porteous |
David J |
DJ |
|
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. |
| Gale CR |
|
Gale |
Catharine R |
CR |
|
Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO17 1BJ, United Kingdom. |
| Deary IJ |
|
Deary |
Ian J |
IJ |
|
Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Okbay |
Aysu |
A |
|
| Beauchamp |
Jonathan P |
JP |
|
| Fontana |
Mark A |
MA |
|
| Lee |
James J |
JJ |
|
| Pers |
Tune H |
TH |
|
| Rietveld |
Cornelius A |
CA |
|
| Turley |
Patrick |
P |
|
| Chen |
Guo-Bo |
GB |
|
| Emilsson |
Valur |
V |
|
| Meddens |
S Fleur W |
SF |
|
| Oskarsson |
Sven |
S |
|
| Pickrell |
Joseph K |
JK |
|
| Thom |
Kevin |
K |
|
| Timshel |
Pascal |
P |
|
| de Vlaming |
Ronald |
R |
|
| Abdellaoui |
Abdel |
A |
|
| Ahluwalia |
Tarunveer S |
TS |
|
| Bacelis |
Jonas |
J |
|
| Baumbach |
Clemens |
C |
|
| Bjornsdottir |
Gyda |
G |
|
| Brandsma |
Johannes H |
JH |
|
| Concas |
Maria Pina |
MP |
|
| Derringer |
Jaime |
J |
|
| Furlotte |
Nicholas A |
NA |
|
| Galesloot |
Tessel E |
TE |
|
| Girotto |
Giorgia |
G |
|
| Gupta |
Richa |
R |
|
| Hall |
Leanne M |
LM |
|
| Harris |
Sarah E |
SE |
|
| Hofer |
Edith |
E |
|
| Horikoshi |
Momoko |
M |
|
| Huffman |
Jennifer E |
JE |
|
| Kaasik |
Kadri |
K |
|
| Kalafati |
Ioanna P |
IP |
|
| Karlsson |
Robert |
R |
|
| Kong |
Augustine |
A |
|
| Lahti |
Jari |
J |
|
| van der Lee |
Sven J |
SJ |
|
| de Leeuw |
Christiaan |
C |
|
| Lind |
Penelope A |
PA |
|
| Lindgren |
Karl-Oskar |
KO |
|
| Liu |
Tian |
T |
|
| Mangino |
Massimo |
M |
|
| Marten |
Jonathan |
J |
|
| Mihailov |
Evelin |
E |
|
| Miller |
Michael B |
MB |
|
| van der Most |
Peter J |
PJ |
|
| Oldmeadow |
Christopher |
C |
|
| Payton |
Antony |
A |
|
| Pervjakova |
Natalia |
N |
|
| Peyrot |
Wouter J |
WJ |
|
| Qian |
Yong |
Y |
|
| Raitakari |
Olli |
O |
|
| Rueedi |
Rico |
R |
|
| Salvi |
Erika |
E |
|
| Schmidt |
Börge |
B |
|
| Schraut |
Katharina E |
KE |
|
| Shi |
Jianxin |
J |
|
| Smith |
Albert V |
AV |
|
| Poot |
Raymond A |
RA |
|
| St Pourcain |
Beate |
B |
|
| Teumer |
Alexander |
A |
|
| Thorleifsson |
Gudmar |
G |
|
| Verweij |
Niek |
N |
|
| Vuckovic |
Dragana |
D |
|
| Wellmann |
Juergen |
J |
|
| Westra |
Harm-Jan |
HJ |
|
| Yang |
Jingyun |
J |
|
| Zhao |
Wei |
W |
|
| Zhu |
Zhihong |
Z |
|
| Alizadeh |
Behrooz Z |
BZ |
|
| Amin |
Najaf |
N |
|
| Bakshi |
Andrew |
A |
|
| Baumeister |
Sebastian E |
SE |
|
| Biino |
Ginevra |
G |
|
| Bønnelykke |
Klaus |
K |
|
| Boyle |
Patricia A |
PA |
|
| Campbell |
Harry |
H |
|
| Cappuccio |
Francesco P |
FP |
|
| Davies |
Gail |
G |
|
| De Neve |
Jan-Emmanuel |
JE |
|
| Deloukas |
Panos |
P |
|
| Demuth |
Ilja |
I |
|
| Ding |
Jun |
J |
|
| Eibich |
Peter |
P |
|
| Eisele |
Lewin |
L |
|
| Eklund |
Niina |
N |
|
| Evans |
David M |
DM |
|
| Faul |
Jessica D |
JD |
|
| Feitosa |
Mary F |
MF |
|
| Forstner |
Andreas J |
AJ |
|
| Gandin |
Ilaria |
I |
|
| Gunnarsson |
Bjarni |
B |
|
| Halldórsson |
Bjarni V |
BV |
|
| Harris |
Tamara B |
TB |
|
| Heath |
Andrew C |
AC |
|
| Hocking |
Lynne J |
LJ |
|
| Holliday |
Elizabeth G |
EG |
|
| Homuth |
Georg |
G |
|
| Horan |
Michael A |
MA |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| de Jager |
Philip L |
PL |
|
| Joshi |
Peter K |
PK |
|
| Jugessur |
Astanand |
A |
|
| Kaakinen |
Marika A |
MA |
|
| Kähönen |
Mika |
M |
|
| Kanoni |
Stavroula |
S |
|
| Keltigangas-Järvinen |
Liisa |
L |
|
| Kiemeney |
Lambertus A L M |
LA |
|
| Kolcic |
Ivana |
I |
|
| Koskinen |
Seppo |
S |
|
| Kraja |
Aldi T |
AT |
|
| Kroh |
Martin |
M |
|
| Kutalik |
Zoltan |
Z |
|
| Latvala |
Antti |
A |
|
| Launer |
Lenore J |
LJ |
|
| Lebreton |
Maël P |
MP |
|
| Levinson |
Douglas F |
DF |
|
| Lichtenstein |
Paul |
P |
|
| Lichtner |
Peter |
P |
|
| Liewald |
David C M |
DC |
|
| Loukola |
Anu |
A |
|
| Madden |
Pamela A |
PA |
|
| Mägi |
Reedik |
R |
|
| Mäki-Opas |
Tomi |
T |
|
| Marioni |
Riccardo E |
RE |
|
| Marques-Vidal |
Pedro |
P |
|
| Meddens |
Gerardus A |
GA |
|
| McMahon |
George |
G |
|
| Meisinger |
Christa |
C |
|
| Meitinger |
Thomas |
T |
|
| Milaneschi |
Yusplitri |
Y |
|
| Milani |
Lili |
L |
|
| Montgomery |
Grant W |
GW |
|
| Myhre |
Ronny |
R |
|
| Nelson |
Christopher P |
CP |
|
| Nyholt |
Dale R |
DR |
|
| Ollier |
William E R |
WE |
|
| Palotie |
Aarno |
A |
|
| Paternoster |
Lavinia |
L |
|
| Pedersen |
Nancy L |
NL |
|
| Petrovic |
Katja E |
KE |
|
| Porteous |
David J |
DJ |
|
| Räikkönen |
Katri |
K |
|
| Ring |
Susan M |
SM |
|
| Robino |
Antonietta |
A |
|
| Rostapshova |
Olga |
O |
|
| Rudan |
Igor |
I |
|
| Rustichini |
Aldo |
A |
|
| Salomaa |
Veikko |
V |
|
| Sanders |
Alan R |
AR |
|
| Sarin |
Antti-Pekka |
AP |
|
| Schmidt |
Helena |
H |
|
| Scott |
Rodney J |
RJ |
|
| Smith |
Blair H |
BH |
|
| Smith |
Jennifer A |
JA |
|
| Staessen |
Jan A |
JA |
|
| Steinhagen-Thiessen |
Elisabeth |
E |
|
| Strauch |
Konstantin |
K |
|
| Terracciano |
Antonio |
A |
|
| Tobin |
Martin D |
MD |
|
| Ulivi |
Sheila |
S |
|
| Vaccargiu |
Simona |
S |
|
| Quaye |
Lydia |
L |
|
| van Rooij |
Frank J A |
FJ |
|
| Venturini |
Cristina |
C |
|
| Vinkhuyzen |
Anna A E |
AA |
|
| Völker |
Uwe |
U |
|
| Völzke |
Henry |
H |
|
| Vonk |
Judith M |
JM |
|
| Vozzi |
Diego |
D |
|
| Waage |
Johannes |
J |
|
| Ware |
Erin B |
EB |
|
| Willemsen |
Gonneke |
G |
|
| Attia |
John R |
JR |
|
| Bennett |
David A |
DA |
|
| Berger |
Klaus |
K |
|
| Bertram |
Lars |
L |
|
| Bisgaard |
Hans |
H |
|
| Boomsma |
Dorret I |
DI |
|
| Borecki |
Ingrid B |
IB |
|
| Bultmann |
Ute |
U |
|
| Chabris |
Christopher F |
CF |
|
| Cucca |
Francesco |
F |
|
| Cusi |
Daniele |
D |
|
| Deary |
Ian J |
IJ |
|
| Dedoussis |
George V |
GV |
|
| van Duijn |
Cornelia M |
CM |
|
| Eriksson |
Johan G |
JG |
|
| Franke |
Barbara |
B |
|
| Franke |
Lude |
L |
|
| Gasparini |
Paolo |
P |
|
| Gejman |
Pablo V |
PV |
|
| Gieger |
Christian |
C |
|
| Grabe |
Hans-Jörgen |
HJ |
|
| Gratten |
Jacob |
J |
|
| Groenen |
Patrick J F |
PJ |
|
| Gudnason |
Vilmundur |
V |
|
| van der Harst |
Pim |
P |
|
| Hayward |
Caroline |
C |
|
| Hinds |
David A |
DA |
|
| Hoffmann |
Wolfgang |
W |
|
| Hypponen |
Elina |
E |
|
| Iacono |
William G |
WG |
|
| Jacobsson |
Bo |
B |
|
| Järvelin |
Marjo-Riitta |
MR |
|
| Jöckel |
Karl-Heinz |
KH |
|
| Kaprio |
Jaakko |
J |
|
| Kardia |
Sharon L R |
SL |
|
| Lehtimäki |
Terho |
T |
|
| Lehrer |
Steven F |
SF |
|
| Magnusson |
Patrik K E |
PK |
|
| Martin |
Nicholas G |
NG |
|
| McGue |
Matt |
M |
|
| Metspalu |
Andres |
A |
|
| Pendleton |
Neil |
N |
|
| Penninx |
Brenda W J H |
BW |
|
| Perola |
Markus |
M |
|
| Pirastu |
Nicola |
N |
|
| Pirastu |
Mario |
M |
|
| Polasek |
Ozren |
O |
|
| Posthuma |
Danielle |
D |
|
| Power |
Christine |
C |
|
| Province |
Michael A |
MA |
|
| Samani |
Nilesh J |
NJ |
|
| Schlessinger |
David |
D |
|
| Schmidt |
Reinhold |
R |
|
| Sørensen |
Thorkild I A |
TI |
|
| Spector |
Tim D |
TD |
|
| Stefansson |
Kari |
K |
|
| Thorsteinsdottir |
Unnur |
U |
|
| Thurik |
A Roy |
AR |
|
| Timpson |
Nicholas J |
NJ |
|
| Tiemeier |
Henning |
H |
|
| Tung |
Joyce Y |
JY |
|
| Uitterlinden |
André G |
AG |
|
| Vitart |
Veronique |
V |
|
| Vollenweider |
Peter |
P |
|
| Weir |
David R |
DR |
|
| Wilson |
James F |
JF |
|
| Wright |
Alan F |
AF |
|
| Conley |
Dalton C |
DC |
|
| Krueger |
Robert F |
RF |
|
| Smith |
George Davey |
GD |
|
| Hofman |
Albert |
A |
|
| Laibson |
David I |
DI |
|
| Medland |
Sarah E |
SE |
|
| Meyer |
Michelle N |
MN |
|
| Yang |
Jian |
J |
|
| Johannesson |
Magnus |
M |
|
| Visscher |
Peter M |
PM |
|
| Esko |
Tõnu |
T |
|
| Koellinger |
Philipp D |
PD |
|
| Cesarini |
David |
D |
|
| Benjamin |
Daniel J |
DJ |
|
|
| JOURNAL |
|
| VOLUME: 113 |
| ISSUE: 47 |
| TITLE: Proceedings of the National Academy of Sciences of the United States of America |
| ISOABBREVIATION: Proc Natl Acad Sci U S A |
| YEAR: 2016 |
| MONTH: 11 |
| DAY: 22 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1091-6490 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Proc Natl Acad Sci U S A |
| COUNTRY: United States |
| ISSNLINKING: 0027-8424 |
| NLMUNIQUEID: 7505876 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13269-13271 |
27837022 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| MC_UP_A620_1015 |
Medical Research Council |
United Kingdom |
| RF1 AG015819 |
NIA NIH HHS |
United States |
| MC_U147585827 |
Medical Research Council |
United Kingdom |
| U01 AG009740 |
NIA NIH HHS |
United States |
| MC_U147574232 |
Medical Research Council |
United Kingdom |
| MC_QA137853 |
Medical Research Council |
United Kingdom |
| MC_UU_12011/2 |
Medical Research Council |
United Kingdom |
|
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| MC_U147585819 |
Medical Research Council |
United Kingdom |
| MR/K026992/1 |
Medical Research Council |
United Kingdom |
| MC_UP_A620_1014 |
Medical Research Council |
United Kingdom |
| P30 AG010161 |
NIA NIH HHS |
United States |
| CZD/16/6/4 |
Chief Scientist Office |
United Kingdom |
| MC_PC_U127561128 |
Medical Research Council |
United Kingdom |
| MC_UU_12011/1 |
Medical Research Council |
United Kingdom |
| G0400491 |
Medical Research Council |
United Kingdom |
| MC_U147585824 |
Medical Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| education |
| genetics |
| longevity |
| polygenic score |
| prediction |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Aged |
|
| Aged, 80 and over |
|
| Cohort Studies |
|
| Databases, Genetic |
|
| Educational Status |
|
| Estonia |
|
| Female |
|
| Genetic Association Studies |
methods |
| Genetic Variation |
methods |
| Humans |
methods |
| Longevity |
methods |
| Male |
methods |
| Middle Aged |
methods |
| Multifactorial Inheritance |
methods |
| Parents |
methods |
| Scotland |
methods |
| United Kingdom |
methods |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
