Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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27799538
TITLE
Genetic variants linked to education predict longevity.
ABSTRACT
NlmCategory: UNASSIGNED
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
DATE PUBLISHED
2016 Nov 22
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2016/11/02 06:00
medline 2016/11/02 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Marioni RE
Ritchie SJ
Joshi PK
Hagenaars SP
Okbay A
Fischer K
Adams MJ
Hill WD
Davies G
Social Science Genetic Association Consortium
Nagy R
Amador C
Lall K
Metspalu A
Liewald DC
Campbell A
Wilson JF
Hayward C
Esko T
Porteous DJ
Gale CR
Deary IJ
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Okbay Aysu A
Beauchamp Jonathan P JP
Fontana Mark A MA
Lee James J JJ
Pers Tune H TH
Rietveld Cornelius A CA
Turley Patrick P
Chen Guo-Bo GB
Emilsson Valur V
Meddens S Fleur W SF
Oskarsson Sven S
Pickrell Joseph K JK
Thom Kevin K
Timshel Pascal P
de Vlaming Ronald R
Abdellaoui Abdel A
Ahluwalia Tarunveer S TS
Bacelis Jonas J
Baumbach Clemens C
Bjornsdottir Gyda G
Brandsma Johannes H JH
Concas Maria Pina MP
Derringer Jaime J
Furlotte Nicholas A NA
Galesloot Tessel E TE
Girotto Giorgia G
Gupta Richa R
Hall Leanne M LM
Harris Sarah E SE
Hofer Edith E
Horikoshi Momoko M
Huffman Jennifer E JE
Kaasik Kadri K
Kalafati Ioanna P IP
Karlsson Robert R
Kong Augustine A
Lahti Jari J
van der Lee Sven J SJ
de Leeuw Christiaan C
Lind Penelope A PA
Lindgren Karl-Oskar KO
Liu Tian T
Mangino Massimo M
Marten Jonathan J
Mihailov Evelin E
Miller Michael B MB
van der Most Peter J PJ
Oldmeadow Christopher C
Payton Antony A
Pervjakova Natalia N
Peyrot Wouter J WJ
Qian Yong Y
Raitakari Olli O
Rueedi Rico R
Salvi Erika E
Schmidt Börge B
Schraut Katharina E KE
Shi Jianxin J
Smith Albert V AV
Poot Raymond A RA
St Pourcain Beate B
Teumer Alexander A
Thorleifsson Gudmar G
Verweij Niek N
Vuckovic Dragana D
Wellmann Juergen J
Westra Harm-Jan HJ
Yang Jingyun J
Zhao Wei W
Zhu Zhihong Z
Alizadeh Behrooz Z BZ
Amin Najaf N
Bakshi Andrew A
Baumeister Sebastian E SE
Biino Ginevra G
Bønnelykke Klaus K
Boyle Patricia A PA
Campbell Harry H
Cappuccio Francesco P FP
Davies Gail G
De Neve Jan-Emmanuel JE
Deloukas Panos P
Demuth Ilja I
Ding Jun J
Eibich Peter P
Eisele Lewin L
Eklund Niina N
Evans David M DM
Faul Jessica D JD
Feitosa Mary F MF
Forstner Andreas J AJ
Gandin Ilaria I
Gunnarsson Bjarni B
Halldórsson Bjarni V BV
Harris Tamara B TB
Heath Andrew C AC
Hocking Lynne J LJ
Holliday Elizabeth G EG
Homuth Georg G
Horan Michael A MA
Hottenga Jouke-Jan JJ
de Jager Philip L PL
Joshi Peter K PK
Jugessur Astanand A
Kaakinen Marika A MA
Kähönen Mika M
Kanoni Stavroula S
Keltigangas-Järvinen Liisa L
Kiemeney Lambertus A L M LA
Kolcic Ivana I
Koskinen Seppo S
Kraja Aldi T AT
Kroh Martin M
Kutalik Zoltan Z
Latvala Antti A
Launer Lenore J LJ
Lebreton Maël P MP
Levinson Douglas F DF
Lichtenstein Paul P
Lichtner Peter P
Liewald David C M DC
Loukola Anu A
Madden Pamela A PA
Mägi Reedik R
Mäki-Opas Tomi T
Marioni Riccardo E RE
Marques-Vidal Pedro P
Meddens Gerardus A GA
McMahon George G
Meisinger Christa C
Meitinger Thomas T
Milaneschi Yusplitri Y
Milani Lili L
Montgomery Grant W GW
Myhre Ronny R
Nelson Christopher P CP
Nyholt Dale R DR
Ollier William E R WE
Palotie Aarno A
Paternoster Lavinia L
Pedersen Nancy L NL
Petrovic Katja E KE
Porteous David J DJ
Räikkönen Katri K
Ring Susan M SM
Robino Antonietta A
Rostapshova Olga O
Rudan Igor I
Rustichini Aldo A
Salomaa Veikko V
Sanders Alan R AR
Sarin Antti-Pekka AP
Schmidt Helena H
Scott Rodney J RJ
Smith Blair H BH
Smith Jennifer A JA
Staessen Jan A JA
Steinhagen-Thiessen Elisabeth E
Strauch Konstantin K
Terracciano Antonio A
Tobin Martin D MD
Ulivi Sheila S
Vaccargiu Simona S
Quaye Lydia L
van Rooij Frank J A FJ
Venturini Cristina C
Vinkhuyzen Anna A E AA
Völker Uwe U
Völzke Henry H
Vonk Judith M JM
Vozzi Diego D
Waage Johannes J
Ware Erin B EB
Willemsen Gonneke G
Attia John R JR
Bennett David A DA
Berger Klaus K
Bertram Lars L
Bisgaard Hans H
Boomsma Dorret I DI
Borecki Ingrid B IB
Bultmann Ute U
Chabris Christopher F CF
Cucca Francesco F
Cusi Daniele D
Deary Ian J IJ
Dedoussis George V GV
van Duijn Cornelia M CM
Eriksson Johan G JG
Franke Barbara B
Franke Lude L
Gasparini Paolo P
Gejman Pablo V PV
Gieger Christian C
Grabe Hans-Jörgen HJ
Gratten Jacob J
Groenen Patrick J F PJ
Gudnason Vilmundur V
van der Harst Pim P
Hayward Caroline C
Hinds David A DA
Hoffmann Wolfgang W
Hypponen Elina E
Iacono William G WG
Jacobsson Bo B
Järvelin Marjo-Riitta MR
Jöckel Karl-Heinz KH
Kaprio Jaakko J
Kardia Sharon L R SL
Lehtimäki Terho T
Lehrer Steven F SF
Magnusson Patrik K E PK
Martin Nicholas G NG
McGue Matt M
Metspalu Andres A
Pendleton Neil N
Penninx Brenda W J H BW
Perola Markus M
Pirastu Nicola N
Pirastu Mario M
Polasek Ozren O
Posthuma Danielle D
Power Christine C
Province Michael A MA
Samani Nilesh J NJ
Schlessinger David D
Schmidt Reinhold R
Sørensen Thorkild I A TI
Spector Tim D TD
Stefansson Kari K
Thorsteinsdottir Unnur U
Thurik A Roy AR
Timpson Nicholas J NJ
Tiemeier Henning H
Tung Joyce Y JY
Uitterlinden André G AG
Vitart Veronique V
Vollenweider Peter P
Weir David R DR
Wilson James F JF
Wright Alan F AF
Conley Dalton C DC
Krueger Robert F RF
Smith George Davey GD
Hofman Albert A
Laibson David I DI
Medland Sarah E SE
Meyer Michelle N MN
Yang Jian J
Johannesson Magnus M
Visscher Peter M PM
Esko Tõnu T
Koellinger Philipp D PD
Cesarini David D
Benjamin Daniel J DJ
JOURNAL
VOLUME:
ISSUE:
TITLE: Proceedings of the National Academy of Sciences of the United States of America
ISOABBREVIATION: Proc. Natl. Acad. Sci. U.S.A.
YEAR: 2016
MONTH: Oct
DAY: 31
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1091-6490
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Proc Natl Acad Sci U S A
COUNTRY: United States
ISSNLINKING: 0027-8424
NLMUNIQUEID: 7505876
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
education
genetics
longevity
polygenic score
prediction
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's