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| PMID |
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| TITLE |
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| Genetic variants linked to education predict longevity. |
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| ABSTRACT |
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NlmCategory: UNASSIGNED |
| Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2016/11/02 06:00 |
| medline |
2016/11/02 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Marioni RE |
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| Ritchie SJ |
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| Joshi PK |
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| Hagenaars SP |
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| Okbay A |
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| Fischer K |
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| Adams MJ |
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| Hill WD |
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| Davies G |
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| Social Science Genetic Association Consortium |
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| Nagy R |
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| Amador C |
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| Lall K |
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| Metspalu A |
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| Liewald DC |
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| Campbell A |
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| Wilson JF |
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| Hayward C |
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| Esko T |
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| Porteous DJ |
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| Gale CR |
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| Deary IJ |
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| INVESTIGATORS |
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| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Okbay |
Aysu |
A |
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| Beauchamp |
Jonathan P |
JP |
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| Fontana |
Mark A |
MA |
|
| Lee |
James J |
JJ |
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| Pers |
Tune H |
TH |
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| Rietveld |
Cornelius A |
CA |
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| Turley |
Patrick |
P |
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| Chen |
Guo-Bo |
GB |
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| Emilsson |
Valur |
V |
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| Meddens |
S Fleur W |
SF |
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| Oskarsson |
Sven |
S |
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| Pickrell |
Joseph K |
JK |
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| Thom |
Kevin |
K |
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| Timshel |
Pascal |
P |
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| de Vlaming |
Ronald |
R |
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| Abdellaoui |
Abdel |
A |
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| Ahluwalia |
Tarunveer S |
TS |
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| Bacelis |
Jonas |
J |
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| Baumbach |
Clemens |
C |
|
| Bjornsdottir |
Gyda |
G |
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| Brandsma |
Johannes H |
JH |
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| Concas |
Maria Pina |
MP |
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| Derringer |
Jaime |
J |
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| Furlotte |
Nicholas A |
NA |
|
| Galesloot |
Tessel E |
TE |
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| Girotto |
Giorgia |
G |
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| Gupta |
Richa |
R |
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| Hall |
Leanne M |
LM |
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| Harris |
Sarah E |
SE |
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| Hofer |
Edith |
E |
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| Horikoshi |
Momoko |
M |
|
| Huffman |
Jennifer E |
JE |
|
| Kaasik |
Kadri |
K |
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| Kalafati |
Ioanna P |
IP |
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| Karlsson |
Robert |
R |
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| Kong |
Augustine |
A |
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| Lahti |
Jari |
J |
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| van der Lee |
Sven J |
SJ |
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| de Leeuw |
Christiaan |
C |
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| Lind |
Penelope A |
PA |
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| Lindgren |
Karl-Oskar |
KO |
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| Liu |
Tian |
T |
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| Mangino |
Massimo |
M |
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| Marten |
Jonathan |
J |
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| Mihailov |
Evelin |
E |
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| Miller |
Michael B |
MB |
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| van der Most |
Peter J |
PJ |
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| Oldmeadow |
Christopher |
C |
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| Payton |
Antony |
A |
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| Pervjakova |
Natalia |
N |
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| Peyrot |
Wouter J |
WJ |
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| Qian |
Yong |
Y |
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| Raitakari |
Olli |
O |
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| Rueedi |
Rico |
R |
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| Salvi |
Erika |
E |
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| Schmidt |
Börge |
B |
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| Schraut |
Katharina E |
KE |
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| Shi |
Jianxin |
J |
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| Smith |
Albert V |
AV |
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| Poot |
Raymond A |
RA |
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| St Pourcain |
Beate |
B |
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| Teumer |
Alexander |
A |
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| Thorleifsson |
Gudmar |
G |
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| Verweij |
Niek |
N |
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| Vuckovic |
Dragana |
D |
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| Wellmann |
Juergen |
J |
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| Westra |
Harm-Jan |
HJ |
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| Yang |
Jingyun |
J |
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| Zhao |
Wei |
W |
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| Zhu |
Zhihong |
Z |
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| Alizadeh |
Behrooz Z |
BZ |
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| Amin |
Najaf |
N |
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| Bakshi |
Andrew |
A |
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| Baumeister |
Sebastian E |
SE |
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| Biino |
Ginevra |
G |
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| Bønnelykke |
Klaus |
K |
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| Boyle |
Patricia A |
PA |
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| Campbell |
Harry |
H |
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| Cappuccio |
Francesco P |
FP |
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| Davies |
Gail |
G |
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| De Neve |
Jan-Emmanuel |
JE |
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| Deloukas |
Panos |
P |
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| Demuth |
Ilja |
I |
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| Ding |
Jun |
J |
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| Eibich |
Peter |
P |
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| Eisele |
Lewin |
L |
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| Eklund |
Niina |
N |
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| Evans |
David M |
DM |
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| Faul |
Jessica D |
JD |
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| Feitosa |
Mary F |
MF |
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| Forstner |
Andreas J |
AJ |
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| Gandin |
Ilaria |
I |
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| Gunnarsson |
Bjarni |
B |
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| Halldórsson |
Bjarni V |
BV |
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| Harris |
Tamara B |
TB |
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| Heath |
Andrew C |
AC |
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| Hocking |
Lynne J |
LJ |
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| Holliday |
Elizabeth G |
EG |
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| Homuth |
Georg |
G |
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| Horan |
Michael A |
MA |
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| Hottenga |
Jouke-Jan |
JJ |
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| de Jager |
Philip L |
PL |
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| Joshi |
Peter K |
PK |
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| Jugessur |
Astanand |
A |
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| Kaakinen |
Marika A |
MA |
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| Kähönen |
Mika |
M |
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| Kanoni |
Stavroula |
S |
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| Keltigangas-Järvinen |
Liisa |
L |
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| Kiemeney |
Lambertus A L M |
LA |
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| Kolcic |
Ivana |
I |
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| Koskinen |
Seppo |
S |
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| Kraja |
Aldi T |
AT |
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| Kroh |
Martin |
M |
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| Kutalik |
Zoltan |
Z |
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| Latvala |
Antti |
A |
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| Launer |
Lenore J |
LJ |
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| Lebreton |
Maël P |
MP |
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| Levinson |
Douglas F |
DF |
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| Lichtenstein |
Paul |
P |
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| Lichtner |
Peter |
P |
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| Liewald |
David C M |
DC |
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| Loukola |
Anu |
A |
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| Madden |
Pamela A |
PA |
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| Mägi |
Reedik |
R |
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| Mäki-Opas |
Tomi |
T |
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| Marioni |
Riccardo E |
RE |
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| Marques-Vidal |
Pedro |
P |
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| Meddens |
Gerardus A |
GA |
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| McMahon |
George |
G |
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| Meisinger |
Christa |
C |
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| Meitinger |
Thomas |
T |
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| Milaneschi |
Yusplitri |
Y |
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| Milani |
Lili |
L |
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| Montgomery |
Grant W |
GW |
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| Myhre |
Ronny |
R |
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| Nelson |
Christopher P |
CP |
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| Nyholt |
Dale R |
DR |
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| Ollier |
William E R |
WE |
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| Palotie |
Aarno |
A |
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| Paternoster |
Lavinia |
L |
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| Pedersen |
Nancy L |
NL |
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| Petrovic |
Katja E |
KE |
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| Porteous |
David J |
DJ |
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| Räikkönen |
Katri |
K |
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| Ring |
Susan M |
SM |
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| Robino |
Antonietta |
A |
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| Rostapshova |
Olga |
O |
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| Rudan |
Igor |
I |
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| Rustichini |
Aldo |
A |
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| Salomaa |
Veikko |
V |
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| Sanders |
Alan R |
AR |
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| Sarin |
Antti-Pekka |
AP |
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| Schmidt |
Helena |
H |
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| Scott |
Rodney J |
RJ |
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| Smith |
Blair H |
BH |
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| Smith |
Jennifer A |
JA |
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| Staessen |
Jan A |
JA |
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| Steinhagen-Thiessen |
Elisabeth |
E |
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| Strauch |
Konstantin |
K |
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| Terracciano |
Antonio |
A |
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| Tobin |
Martin D |
MD |
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| Ulivi |
Sheila |
S |
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| Vaccargiu |
Simona |
S |
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| Quaye |
Lydia |
L |
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| van Rooij |
Frank J A |
FJ |
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| Venturini |
Cristina |
C |
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| Vinkhuyzen |
Anna A E |
AA |
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| Völker |
Uwe |
U |
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| Völzke |
Henry |
H |
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| Vonk |
Judith M |
JM |
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| Vozzi |
Diego |
D |
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| Waage |
Johannes |
J |
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| Ware |
Erin B |
EB |
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| Willemsen |
Gonneke |
G |
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| Attia |
John R |
JR |
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| Bennett |
David A |
DA |
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| Berger |
Klaus |
K |
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| Bertram |
Lars |
L |
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| Bisgaard |
Hans |
H |
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| Boomsma |
Dorret I |
DI |
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| Borecki |
Ingrid B |
IB |
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| Bultmann |
Ute |
U |
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| Chabris |
Christopher F |
CF |
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| Cucca |
Francesco |
F |
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| Cusi |
Daniele |
D |
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| Deary |
Ian J |
IJ |
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| Dedoussis |
George V |
GV |
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| van Duijn |
Cornelia M |
CM |
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| Eriksson |
Johan G |
JG |
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| Franke |
Barbara |
B |
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| Franke |
Lude |
L |
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| Gasparini |
Paolo |
P |
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| Gejman |
Pablo V |
PV |
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| Gieger |
Christian |
C |
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| Grabe |
Hans-Jörgen |
HJ |
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| Gratten |
Jacob |
J |
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| Groenen |
Patrick J F |
PJ |
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| Gudnason |
Vilmundur |
V |
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| van der Harst |
Pim |
P |
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| Hayward |
Caroline |
C |
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| Hinds |
David A |
DA |
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| Hoffmann |
Wolfgang |
W |
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| Hypponen |
Elina |
E |
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| Iacono |
William G |
WG |
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| Jacobsson |
Bo |
B |
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| Järvelin |
Marjo-Riitta |
MR |
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| Jöckel |
Karl-Heinz |
KH |
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| Kaprio |
Jaakko |
J |
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| Kardia |
Sharon L R |
SL |
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| Lehtimäki |
Terho |
T |
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| Lehrer |
Steven F |
SF |
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| Magnusson |
Patrik K E |
PK |
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| Martin |
Nicholas G |
NG |
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| McGue |
Matt |
M |
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| Metspalu |
Andres |
A |
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| Pendleton |
Neil |
N |
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| Penninx |
Brenda W J H |
BW |
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| Perola |
Markus |
M |
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| Pirastu |
Nicola |
N |
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| Pirastu |
Mario |
M |
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| Polasek |
Ozren |
O |
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| Posthuma |
Danielle |
D |
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| Power |
Christine |
C |
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| Province |
Michael A |
MA |
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| Samani |
Nilesh J |
NJ |
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| Schlessinger |
David |
D |
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| Schmidt |
Reinhold |
R |
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| Sørensen |
Thorkild I A |
TI |
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| Spector |
Tim D |
TD |
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| Stefansson |
Kari |
K |
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| Thorsteinsdottir |
Unnur |
U |
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| Thurik |
A Roy |
AR |
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| Timpson |
Nicholas J |
NJ |
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| Tiemeier |
Henning |
H |
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| Tung |
Joyce Y |
JY |
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| Uitterlinden |
André G |
AG |
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| Vitart |
Veronique |
V |
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| Vollenweider |
Peter |
P |
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| Weir |
David R |
DR |
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| Wilson |
James F |
JF |
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| Wright |
Alan F |
AF |
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| Conley |
Dalton C |
DC |
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| Krueger |
Robert F |
RF |
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| Smith |
George Davey |
GD |
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| Hofman |
Albert |
A |
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| Laibson |
David I |
DI |
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| Medland |
Sarah E |
SE |
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| Meyer |
Michelle N |
MN |
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| Yang |
Jian |
J |
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| Johannesson |
Magnus |
M |
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| Visscher |
Peter M |
PM |
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| Esko |
Tõnu |
T |
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| Koellinger |
Philipp D |
PD |
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| Cesarini |
David |
D |
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| Benjamin |
Daniel J |
DJ |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Proceedings of the National Academy of Sciences of the United States of America |
| ISOABBREVIATION: Proc. Natl. Acad. Sci. U.S.A. |
| YEAR: 2016 |
| MONTH: Oct |
| DAY: 31 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1091-6490 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Proc Natl Acad Sci U S A |
| COUNTRY: United States |
| ISSNLINKING: 0027-8424 |
| NLMUNIQUEID: 7505876 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| education |
| genetics |
| longevity |
| polygenic score |
| prediction |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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