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PMID |
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TITLE |
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Genetic variants linked to education predict longevity. |
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ABSTRACT |
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NlmCategory: UNASSIGNED |
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pubmed |
2016/11/02 06:00 |
medline |
2016/11/02 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Marioni RE |
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Ritchie SJ |
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Joshi PK |
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Hagenaars SP |
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Okbay A |
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Fischer K |
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Adams MJ |
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Hill WD |
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Davies G |
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Social Science Genetic Association Consortium |
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Nagy R |
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Amador C |
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Lall K |
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Metspalu A |
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Liewald DC |
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Campbell A |
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Wilson JF |
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Hayward C |
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Esko T |
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Porteous DJ |
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Gale CR |
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Deary IJ |
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INVESTIGATORS |
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LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
Okbay |
Aysu |
A |
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Beauchamp |
Jonathan P |
JP |
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Fontana |
Mark A |
MA |
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Lee |
James J |
JJ |
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Pers |
Tune H |
TH |
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Rietveld |
Cornelius A |
CA |
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Turley |
Patrick |
P |
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Chen |
Guo-Bo |
GB |
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Emilsson |
Valur |
V |
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Meddens |
S Fleur W |
SF |
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Oskarsson |
Sven |
S |
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Pickrell |
Joseph K |
JK |
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Thom |
Kevin |
K |
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Timshel |
Pascal |
P |
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de Vlaming |
Ronald |
R |
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Abdellaoui |
Abdel |
A |
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Ahluwalia |
Tarunveer S |
TS |
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Bacelis |
Jonas |
J |
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Baumbach |
Clemens |
C |
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Bjornsdottir |
Gyda |
G |
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Brandsma |
Johannes H |
JH |
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Concas |
Maria Pina |
MP |
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Derringer |
Jaime |
J |
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Furlotte |
Nicholas A |
NA |
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Galesloot |
Tessel E |
TE |
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Girotto |
Giorgia |
G |
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Gupta |
Richa |
R |
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Hall |
Leanne M |
LM |
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Harris |
Sarah E |
SE |
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Hofer |
Edith |
E |
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Horikoshi |
Momoko |
M |
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Huffman |
Jennifer E |
JE |
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Kaasik |
Kadri |
K |
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Kalafati |
Ioanna P |
IP |
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Karlsson |
Robert |
R |
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Kong |
Augustine |
A |
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Lahti |
Jari |
J |
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van der Lee |
Sven J |
SJ |
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de Leeuw |
Christiaan |
C |
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Lind |
Penelope A |
PA |
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Lindgren |
Karl-Oskar |
KO |
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Liu |
Tian |
T |
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Mangino |
Massimo |
M |
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Marten |
Jonathan |
J |
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Mihailov |
Evelin |
E |
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Miller |
Michael B |
MB |
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van der Most |
Peter J |
PJ |
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Oldmeadow |
Christopher |
C |
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Payton |
Antony |
A |
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Pervjakova |
Natalia |
N |
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Peyrot |
Wouter J |
WJ |
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Qian |
Yong |
Y |
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Raitakari |
Olli |
O |
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Rueedi |
Rico |
R |
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Salvi |
Erika |
E |
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Schmidt |
Börge |
B |
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Schraut |
Katharina E |
KE |
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Shi |
Jianxin |
J |
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Smith |
Albert V |
AV |
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Poot |
Raymond A |
RA |
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St Pourcain |
Beate |
B |
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Teumer |
Alexander |
A |
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Thorleifsson |
Gudmar |
G |
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Verweij |
Niek |
N |
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Vuckovic |
Dragana |
D |
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Wellmann |
Juergen |
J |
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Westra |
Harm-Jan |
HJ |
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Yang |
Jingyun |
J |
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Zhao |
Wei |
W |
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Zhu |
Zhihong |
Z |
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Alizadeh |
Behrooz Z |
BZ |
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Amin |
Najaf |
N |
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Bakshi |
Andrew |
A |
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Baumeister |
Sebastian E |
SE |
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Biino |
Ginevra |
G |
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Bønnelykke |
Klaus |
K |
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Boyle |
Patricia A |
PA |
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Campbell |
Harry |
H |
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Cappuccio |
Francesco P |
FP |
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Davies |
Gail |
G |
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De Neve |
Jan-Emmanuel |
JE |
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Deloukas |
Panos |
P |
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Demuth |
Ilja |
I |
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Ding |
Jun |
J |
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Eibich |
Peter |
P |
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Eisele |
Lewin |
L |
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Eklund |
Niina |
N |
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Evans |
David M |
DM |
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Faul |
Jessica D |
JD |
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Feitosa |
Mary F |
MF |
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Forstner |
Andreas J |
AJ |
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Gandin |
Ilaria |
I |
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Gunnarsson |
Bjarni |
B |
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Halldórsson |
Bjarni V |
BV |
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Harris |
Tamara B |
TB |
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Heath |
Andrew C |
AC |
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Hocking |
Lynne J |
LJ |
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Holliday |
Elizabeth G |
EG |
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Homuth |
Georg |
G |
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Horan |
Michael A |
MA |
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Hottenga |
Jouke-Jan |
JJ |
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de Jager |
Philip L |
PL |
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Joshi |
Peter K |
PK |
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Jugessur |
Astanand |
A |
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Kaakinen |
Marika A |
MA |
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Kähönen |
Mika |
M |
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Kanoni |
Stavroula |
S |
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Keltigangas-Järvinen |
Liisa |
L |
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Kiemeney |
Lambertus A L M |
LA |
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Kolcic |
Ivana |
I |
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Koskinen |
Seppo |
S |
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Kraja |
Aldi T |
AT |
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Kroh |
Martin |
M |
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Kutalik |
Zoltan |
Z |
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Latvala |
Antti |
A |
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Launer |
Lenore J |
LJ |
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Lebreton |
Maël P |
MP |
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Levinson |
Douglas F |
DF |
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Lichtenstein |
Paul |
P |
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Lichtner |
Peter |
P |
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Liewald |
David C M |
DC |
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Loukola |
Anu |
A |
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Madden |
Pamela A |
PA |
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Mägi |
Reedik |
R |
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Mäki-Opas |
Tomi |
T |
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Marioni |
Riccardo E |
RE |
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Marques-Vidal |
Pedro |
P |
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Meddens |
Gerardus A |
GA |
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McMahon |
George |
G |
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Meisinger |
Christa |
C |
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Meitinger |
Thomas |
T |
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Milaneschi |
Yusplitri |
Y |
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Milani |
Lili |
L |
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Montgomery |
Grant W |
GW |
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Myhre |
Ronny |
R |
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Nelson |
Christopher P |
CP |
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Nyholt |
Dale R |
DR |
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Ollier |
William E R |
WE |
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Palotie |
Aarno |
A |
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Paternoster |
Lavinia |
L |
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Pedersen |
Nancy L |
NL |
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Petrovic |
Katja E |
KE |
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Porteous |
David J |
DJ |
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Räikkönen |
Katri |
K |
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Ring |
Susan M |
SM |
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Robino |
Antonietta |
A |
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Rostapshova |
Olga |
O |
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Rudan |
Igor |
I |
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Rustichini |
Aldo |
A |
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Salomaa |
Veikko |
V |
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Sanders |
Alan R |
AR |
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Sarin |
Antti-Pekka |
AP |
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Schmidt |
Helena |
H |
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Scott |
Rodney J |
RJ |
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Smith |
Blair H |
BH |
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Smith |
Jennifer A |
JA |
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Staessen |
Jan A |
JA |
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Steinhagen-Thiessen |
Elisabeth |
E |
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Strauch |
Konstantin |
K |
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Terracciano |
Antonio |
A |
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Tobin |
Martin D |
MD |
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Ulivi |
Sheila |
S |
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Vaccargiu |
Simona |
S |
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Quaye |
Lydia |
L |
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van Rooij |
Frank J A |
FJ |
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Venturini |
Cristina |
C |
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Vinkhuyzen |
Anna A E |
AA |
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Völker |
Uwe |
U |
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Völzke |
Henry |
H |
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Vonk |
Judith M |
JM |
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Vozzi |
Diego |
D |
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Waage |
Johannes |
J |
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Ware |
Erin B |
EB |
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Willemsen |
Gonneke |
G |
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Attia |
John R |
JR |
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Bennett |
David A |
DA |
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Berger |
Klaus |
K |
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Bertram |
Lars |
L |
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Bisgaard |
Hans |
H |
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Boomsma |
Dorret I |
DI |
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Borecki |
Ingrid B |
IB |
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Bultmann |
Ute |
U |
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Chabris |
Christopher F |
CF |
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Cucca |
Francesco |
F |
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Cusi |
Daniele |
D |
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Deary |
Ian J |
IJ |
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Dedoussis |
George V |
GV |
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van Duijn |
Cornelia M |
CM |
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Eriksson |
Johan G |
JG |
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Franke |
Barbara |
B |
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Franke |
Lude |
L |
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Gasparini |
Paolo |
P |
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Gejman |
Pablo V |
PV |
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Gieger |
Christian |
C |
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Grabe |
Hans-Jörgen |
HJ |
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Gratten |
Jacob |
J |
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Groenen |
Patrick J F |
PJ |
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Gudnason |
Vilmundur |
V |
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van der Harst |
Pim |
P |
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Hayward |
Caroline |
C |
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Hinds |
David A |
DA |
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Hoffmann |
Wolfgang |
W |
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Hypponen |
Elina |
E |
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Iacono |
William G |
WG |
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Jacobsson |
Bo |
B |
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Järvelin |
Marjo-Riitta |
MR |
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Jöckel |
Karl-Heinz |
KH |
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Kaprio |
Jaakko |
J |
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Kardia |
Sharon L R |
SL |
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Lehtimäki |
Terho |
T |
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Lehrer |
Steven F |
SF |
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Magnusson |
Patrik K E |
PK |
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Martin |
Nicholas G |
NG |
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McGue |
Matt |
M |
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Metspalu |
Andres |
A |
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Pendleton |
Neil |
N |
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Penninx |
Brenda W J H |
BW |
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Perola |
Markus |
M |
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Pirastu |
Nicola |
N |
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Pirastu |
Mario |
M |
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Polasek |
Ozren |
O |
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Posthuma |
Danielle |
D |
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Power |
Christine |
C |
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Province |
Michael A |
MA |
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Samani |
Nilesh J |
NJ |
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Schlessinger |
David |
D |
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Schmidt |
Reinhold |
R |
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Sørensen |
Thorkild I A |
TI |
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Spector |
Tim D |
TD |
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Stefansson |
Kari |
K |
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Thorsteinsdottir |
Unnur |
U |
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Thurik |
A Roy |
AR |
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Timpson |
Nicholas J |
NJ |
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Tiemeier |
Henning |
H |
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Tung |
Joyce Y |
JY |
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Uitterlinden |
André G |
AG |
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Vitart |
Veronique |
V |
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Vollenweider |
Peter |
P |
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Weir |
David R |
DR |
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Wilson |
James F |
JF |
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Wright |
Alan F |
AF |
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Conley |
Dalton C |
DC |
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Krueger |
Robert F |
RF |
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Smith |
George Davey |
GD |
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Hofman |
Albert |
A |
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Laibson |
David I |
DI |
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Medland |
Sarah E |
SE |
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Meyer |
Michelle N |
MN |
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Yang |
Jian |
J |
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Johannesson |
Magnus |
M |
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Visscher |
Peter M |
PM |
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Esko |
Tõnu |
T |
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Koellinger |
Philipp D |
PD |
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Cesarini |
David |
D |
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Benjamin |
Daniel J |
DJ |
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JOURNAL |
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VOLUME: |
ISSUE: |
TITLE: Proceedings of the National Academy of Sciences of the United States of America |
ISOABBREVIATION: Proc. Natl. Acad. Sci. U.S.A. |
YEAR: 2016 |
MONTH: Oct |
DAY: 31 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1091-6490 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Proc Natl Acad Sci U S A |
COUNTRY: United States |
ISSNLINKING: 0027-8424 |
NLMUNIQUEID: 7505876 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
education |
genetics |
longevity |
polygenic score |
prediction |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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