Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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27798627
TITLE
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
ABSTRACT
The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
DATE PUBLISHED
2016 12
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/06/12
accepted 2016/09/22
pubmed 2016/11/01 06:00
medline 2017/09/08 06:00
entrez 2016/11/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Barban N Barban Nicola N Department of Sociology and Nuffield College, University of Oxford, Oxford, UK.
Jansen R Jansen Rick R Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
de Vlaming R de Vlaming Ronald R Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
Vaez A Vaez Ahmad A Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Mandemakers JJ Mandemakers Jornt J JJ Sociology of Consumption and Households, Wageningen University Research, Wageningen, the Netherlands.
Tropf FC Tropf Felix C FC Department of Sociology and Nuffield College, University of Oxford, Oxford, UK.
Shen X Shen Xia X Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Wilson JF Wilson James F JF Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Chasman DI Chasman Daniel I DI Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Tragante V Tragante Vinicius V Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.
van der Laan SW van der Laan Sander W SW Laboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.
Perry JR Perry John R B JR MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Kong A Kong Augustine A deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
BIOS Consortium
Ahluwalia TS Ahluwalia Tarunveer S TS COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Albrecht E Albrecht Eva E Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Yerges-Armstrong L Yerges-Armstrong Laura L Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Atzmon G Atzmon Gil G Department of Natural Science, University of Haifa, Haifa, Israel.
Auro K Auro Kirsi K Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.
Ayers K Ayers Kristin K Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
Bakshi A Bakshi Andrew A Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Ben-Avraham D Ben-Avraham Danny D Department of Genetics, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Berger K Berger Klaus K Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Bergman A Bergman Aviv A Departments of Systems and Computational Biology, of Pathology and of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.
Bertram L Bertram Lars L School of Public Health, Faculty of Medicine, Imperial College, London, UK.
Bielak LF Bielak Lawrence F LF Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Bjornsdottir G Bjornsdottir Gyda G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Bonder MJ Bonder Marc Jan MJ Department of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Broer L Broer Linda L Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Bui M Bui Minh M Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Barbieri C Barbieri Caterina C Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.
Cavadino A Cavadino Alana A Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventative Medicine, Queen Mary University of London, London, UK.
Chavarro JE Chavarro Jorge E JE Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Turman C Turman Constance C Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Concas MP Concas Maria Pina MP Institute of Genetic and Biomedical Research, National Research Council, UOS of Sassari, Sassari, Italy.
Cordell HJ Cordell Heather J HJ Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
Davies G Davies Gail G Department of Psychology, University of Edinburgh, Edinburgh, UK.
Eibich P Eibich Peter P Health Economics Research Centre, University of Oxford, Oxford, UK.
Eriksson N Eriksson Nicholas N 23andMe, Inc., Mountain View, California, USA.
Esko T Esko Tõnu T Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Eriksson J Eriksson Joel J Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Falahi F Falahi Fahimeh F Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Felix JF Felix Janine F JF Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Fontana MA Fontana Mark Alan MA Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Franke L Franke Lude L Department of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Gandin I Gandin Ilaria I Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Gaskins AJ Gaskins Audrey J AJ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Gieger C Gieger Christian C Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Gunderson EP Gunderson Erica P EP Cardiovascular and Metabolic Conditions Section, Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Guo X Guo Xiuqing X Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Hayward C Hayward Caroline C MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
He C He Chunyan C Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA.
Hofer E Hofer Edith E Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Huang H Huang Hongyan H Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Kanoni S Kanoni Stavroula S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kiechl S Kiechl Stefan S Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Kifley A Kifley Annette A Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Kluttig A Kluttig Alexander A Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Kraft P Kraft Peter P Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Lagou V Lagou Vasiliki V Translational Immunology Laboratory, VIB, Leuven, Belgium.
Lecoeur C Lecoeur Cecile C University of Lille, CNRS, Institut Pasteur of Lille, Lille, France.
Lahti J Lahti Jari J Folkhälsan Research Centre, Helsinki, Finland.
Li-Gao R Li-Gao Ruifang R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Lind PA Lind Penelope A PA Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Herston Brisbane, Queensland, Australia.
Liu T Liu Tian T Center for Lifespan Psychology, Max Planck Institute for Human Development and Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Makalic E Makalic Enes E Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Mamasoula C Mamasoula Crysovalanto C Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.
Matteson L Matteson Lindsay L Minnesota Center for Twin and Family Research, Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Mbarek H Mbarek Hamdi H EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
McArdle PF McArdle Patrick F PF Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
McMahon G McMahon George G School of Social and Community Medicine, University of Bristol, Bristol, UK.
Meddens SF Meddens S Fleur W SF Complex Trait Genetics, VU University, Amsterdam, the Netherlands.
Mihailov E Mihailov Evelin E Estonian Genome Center, University of Tartu, Tartu, Estonia.
Miller M Miller Mike M Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Missmer SA Missmer Stacey A SA Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Monnereau C Monnereau Claire C Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Myhre R Myhre Ronny R Department of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.
Nalls MA Nalls Mike A MA Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy.
Kalafati IP Kalafati Ioanna Panagiota IP Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Porcu E Porcu Eleonora E Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.
Prokopenko I Prokopenko Inga I Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Rajan KB Rajan Kumar B KB Rush University Medical Center, Chicago, Illinois, USA.
Rich-Edwards J Rich-Edwards Janet J Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Rietveld CA Rietveld Cornelius A CA Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
Robino A Robino Antonietta A Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Rose LM Rose Lynda M LM Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Rueedi R Rueedi Rico R Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Ryan KA Ryan Kathleen A KA Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Saba Y Saba Yasaman Y Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria.
Schmidt D Schmidt Daniel D Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Smith JA Smith Jennifer A JA Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Stolk L Stolk Lisette L Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Streeten E Streeten Elizabeth E Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Tönjes A Tönjes Anke A Department of Medicine, University of Leipzig, Leipzig, Germany.
Thorleifsson G Thorleifsson Gudmar G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Ulivi S Ulivi Sheila S Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Wedenoja J Wedenoja Juho J Department of Public Health, University of Helsinki, Helsinki, Finland.
Wellmann J Wellmann Juergen J Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Willeit P Willeit Peter P Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Yao J Yao Jie J Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Yengo L Yengo Loic L Centre for Neurogenetics and Statistical Genomics, University of Queensland, Brisbane, Queensland, Australia.
Zhao JH Zhao Jing Hua JH MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Zhao W Zhao Wei W Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Zhernakova DV Zhernakova Daria V DV Department of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Amin N Amin Najaf N Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Andrews H Andrews Howard H Data Coordinating Center, New York State Psychiatric Institute, New York, New York, USA.
Balkau B Balkau Beverley B University of Lille, CNRS, Institut Pasteur of Lille, Lille, France.
Barzilai N Barzilai Nir N Department of Medicine, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Bergmann S Bergmann Sven S Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Biino G Biino Ginevra G Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Bisgaard H Bisgaard Hans H COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Bønnelykke K Bønnelykke Klaus K COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Boomsma DI Boomsma Dorret I DI EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Buring JE Buring Julie E JE Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Cappellani S Cappellani Stefania S Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Ciullo M Ciullo Marina M IRCCS Neuromed, Pozzilli, Isernia, Italy.
Cox SR Cox Simon R SR Department of Psychology, University of Edinburgh, Edinburgh, UK.
Cucca F Cucca Francesco F Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.
Toniolo D Toniolo Daniela D Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.
Davey-Smith G Davey-Smith George G MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Deary IJ Deary Ian J IJ Department of Psychology, University of Edinburgh, Edinburgh, UK.
Dedoussis G Dedoussis George G Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Deloukas P Deloukas Panos P Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
van Duijn CM van Duijn Cornelia M CM Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
de Geus EJ de Geus Eco J C EJ EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Eriksson JG Eriksson Johan G JG Vasa Central Hospital, Vasa, Finland.
Evans DA Evans Denis A DA Rush University Medical Center, Chicago, Illinois, USA.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Sala CF Sala Cinzia Felicita CF Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.
Froguel P Froguel Philippe P University of Lille, CNRS, Institut Pasteur of Lille, Lille, France.
Gasparini P Gasparini Paolo P Division of Experimental Genetics, Sidra, Doha, Qatar.
Girotto G Girotto Giorgia G Division of Experimental Genetics, Sidra, Doha, Qatar.
Grabe HJ Grabe Hans-Jörgen HJ Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
Greiser KH Greiser Karin Halina KH Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Groenen PJ Groenen Patrick J F PJ Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
de Haan HG de Haan Hugoline G HG Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Haerting J Haerting Johannes J Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
Heath AC Heath Andrew C AC Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Heikkilä K Heikkilä Kauko K Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.
Hofman A Hofman Albert A Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Holliday EG Holliday Elizabeth G EG Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Hopper J Hopper John J Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Hyppönen E Hyppönen Elina E South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Jacobsson B Jacobsson Bo B Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Jaddoe VW Jaddoe Vincent W V VW Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Johannesson M Johannesson Magnus M Department of Economics, Stockholm School of Economics, Stockholm, Sweden.
Jugessur A Jugessur Astanand A Department of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.
Kähönen M Kähönen Mika M Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
Kajantie E Kajantie Eero E Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Kardia SL Kardia Sharon L R SL Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Keavney B Keavney Bernard B Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK.
Kolcic I Kolcic Ivana I Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Koponen P Koponen Päivikki P Health Monitoring Unit, National Institute for Health and Welfare, Helsinki, Finland.
Kovacs P Kovacs Peter P IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Kronenberg F Kronenberg Florian F Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
Kutalik Z Kutalik Zoltan Z Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
La Bianca M La Bianca Martina M Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Lachance G Lachance Genevieve G Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Iacono WG Iacono William G WG Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Lai S Lai Sandra S Istituto di Ricerca Genetica e Biomedica, CMR, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
Liewald DC Liewald David C DC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
LifeLines Cohort Study
Lindgren CM Lindgren Cecilia M CM Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.
Liu Y Liu Yongmei Y Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Luben R Luben Robert R Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.
Lucht M Lucht Michael M Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Luoto R Luoto Riitta R UKK Institute for Health Promotion,Tampere, Finland.
Magnus P Magnus Per P Department of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.
Magnusson PK Magnusson Patrik K E PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Martin NG Martin Nicholas G NG Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Herston Brisbane, Queensland, Australia.
McGue M McGue Matt M Danish Aging Research Center and Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
McQuillan R McQuillan Ruth R Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Medland SE Medland Sarah E SE Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Herston Brisbane, Queensland, Australia.
Meisinger C Meisinger Christa C MONICA/KORA Myocardial Infarction Registry, Central Hospital of Augsburg, Augsburg, Germany.
Mellström D Mellström Dan D Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Metspalu A Metspalu Andres A Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Traglia M Traglia Michela M Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, Estonia.
Mitchell P Mitchell Paul P Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Montgomery GW Montgomery Grant W GW Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Mook-Kanamori D Mook-Kanamori Dennis D Department of BESC, Epidemiology Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
de Mutsert R de Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Nohr EA Nohr Ellen A EA Research Unit for Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Ohlsson C Ohlsson Claes C Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Olsen J Olsen Jørn J Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
Ong KK Ong Ken K KK MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Paternoster L Paternoster Lavinia L MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Pattie A Pattie Alison A Department of Psychology, University of Edinburgh, Edinburgh, UK.
Penninx BW Penninx Brenda W J H BW EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Perola M Perola Markus M Estonian Genome Center, University of Tartu, Tartu, Estonia.
Peyser PA Peyser Patricia A PA Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Pirastu M Pirastu Mario M Institute of Genetic and Biomedical Research, National Research Council, UOS of Sassari, Sassari, Italy.
Polasek O Polasek Ozren O Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Power C Power Chris C Population, Policy and Practice, UCL Institute of Child Health, London, UK.
Kaprio J Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, Finland.
Raffel LJ Raffel Leslie J LJ Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Räikkönen K Räikkönen Katri K Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
Raitakari O Raitakari Olli O Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Ridker PM Ridker Paul M PM Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ring SM Ring Susan M SM MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Roll K Roll Kathryn K Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Ruggiero D Ruggiero Daniela D Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy.
Rujescu D Rujescu Dan D Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Salomaa V Salomaa Veikko V Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Schlessinger D Schlessinger David D Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.
Schmidt H Schmidt Helena H Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Schupf N Schupf Nicole N Departments of Epidemiology and Psychiatry, Columbia University Medical Center, New York, New York, USA.
Smit J Smit Johannes J EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Sorice R Sorice Rossella R IRCCS Neuromed, Pozzilli, Isernia, Italy.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Starr JM Starr John M JM Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Stöckl D Stöckl Doris D Departments of Epidemiology and Psychiatry, Columbia University Medical Center, New York, New York, USA.
Strauch K Strauch Konstantin K Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig Maximilians Universität, Munich, Germany.
Stumvoll M Stumvoll Michael M IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Swertz MA Swertz Morris A MA Department of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Thorsteinsdottir U Thorsteinsdottir Unnur U Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Thurik AR Thurik A Roy AR Montpellier Business School, Montpellier, France.
Timpson NJ Timpson Nicholas J NJ MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Tung JY Tung Joyce Y JY 23andMe, Inc., Mountain View, California, USA.
Uitterlinden AG Uitterlinden André G AG Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Vaccargiu S Vaccargiu Simona S Institute of Genetic and Biomedical Research, National Research Council, UOS of Sassari, Sassari, Italy.
Viikari J Viikari Jorma J Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland.
Vitart V Vitart Veronique V MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Vollenweider P Vollenweider Peter P Department of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Vuckovic D Vuckovic Dragana D Division of Experimental Genetics, Sidra, Doha, Qatar.
Waage J Waage Johannes J COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Wagner GG Wagner Gert G GG German Socio-Economic Panel Study (SOEP), Max Planck Institute for Human Development and Berlin University of Technology (TUB), Berlin, Germany.
Wang JJ Wang Jie Jin JJ Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Willemsen G Willemsen Gonneke G EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
Willeit J Willeit Johann J Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Wright AF Wright Alan F AF MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Zondervan KT Zondervan Krina T KT Endometriosis CaRe Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Krueger RF Krueger Robert F RF Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Lee JJ Lee James J JJ Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Benjamin DJ Benjamin Daniel J DJ National Bureau of Economic Research, Cambridge, Massachusetts, USA.
Cesarini D Cesarini David D Research Institute for Industrial Economics, Stockholm, Sweden.
Koellinger PD Koellinger Philipp D PD Complex Trait Genetics, VU University, Amsterdam, the Netherlands.
den Hoed M den Hoed Marcel M Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Mills MC Mills Melinda C MC Department of Sociology and Nuffield College, University of Oxford, Oxford, UK.
INVESTIGATORS
JOURNAL
VOLUME: 48
ISSUE: 12
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2016
MONTH: 12
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
G1001799 Medical Research Council United Kingdom
RG/15/12/31616 British Heart Foundation United Kingdom
R01 AG051635 NIA NIH HHS United States
MC_UU_12013/3 Medical Research Council United Kingdom
SDR 10-012 HSRD VA United States
Z99 AG999999 Intramural NIH HHS United States
U01 AG016976 NIA NIH HHS United States
MR/J012165/1 Medical Research Council United Kingdom
UL1 TR000124 NCATS NIH HHS United States
MR/K026992/1 Medical Research Council United Kingdom
MC_PC_U127561128 Medical Research Council United Kingdom
P30 AG038072 NIA NIH HHS United States
P01 AG005842 NIA NIH HHS United States
UL1 TR001881 NCATS NIH HHS United States
Wellcome Trust United Kingdom
P30 AG012810 NIA NIH HHS United States
R01 AG042568 NIA NIH HHS United States
T32 AG000186 NIA NIH HHS United States
615603 European Research Council International
G9815508 Medical Research Council United Kingdom
647648 European Research Council International
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Birth Order
Female
Fertility genetics
Genome-Wide Association Study genetics
Humans genetics
Maternal Age genetics
Parity genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
Pregnancy genetics
Quantitative Trait Loci genetics
Reproduction genetics
Reproductive Behavior physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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