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| PMID |
|
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| TITLE |
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| The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries. |
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| ABSTRACT |
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| Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2016/02/10 |
| accepted |
2016/08/23 |
| pubmed |
2016/09/04 06:00 |
| medline |
2017/05/10 06:00 |
| entrez |
2016/09/04 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Maciejewski DF |
|
Maciejewski |
Dominique F |
DF |
|
Department of Clinical Developmental Psychology and EMGO Institute for Health and Care Research, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands. |
| Renteria ME |
|
Renteria |
Miguel E |
ME |
|
Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
| Abdellaoui A |
|
Abdellaoui |
Abdel |
A |
|
Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
| Few LR |
|
Few |
Lauren R |
LR |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA. |
| Gordon SD |
|
Gordon |
Scott D |
SD |
|
Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA. |
| Montgomery G |
|
Montgomery |
Grant |
G |
|
Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
| Trull TJ |
|
Trull |
Timothy J |
TJ |
|
Department of Psychological Sciences, University of Missouri, Columbia, MO, 65211, USA. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA. |
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
Faculty of Arts and Social Sciences, University of Sunshine Coast, Sippy Downs, QLD, 4556, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
| Zietsch BP |
|
Zietsch |
Brendan P |
BP |
|
School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia. |
| Verweij KJ |
|
Verweij |
Karin J H |
KJ |
|
School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia. karin.verweij@vu.nl. |
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 47 |
| ISSUE: 1 |
| TITLE: Behavior genetics |
| ISOABBREVIATION: Behav Genet |
| YEAR: 2017 |
| MONTH: Jan |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-3297 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Behav Genet |
| COUNTRY: United States |
| ISSNLINKING: 0001-8244 |
| NLMUNIQUEID: 0251711 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA014041 |
NIAAA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| P50 AA011998 |
NIAAA NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| R01 DA023668 |
NIDA NIH HHS |
United States |
| K21 DA000272 |
NIDA NIH HHS |
United States |
| R01 AA013326 |
NIAAA NIH HHS |
United States |
| R56 DA012854 |
NIDA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| R01 DA018267 |
NIDA NIH HHS |
United States |
| T32 DA007261 |
NIDA NIH HHS |
United States |
| R01 DA012854 |
NIDA NIH HHS |
United States |
| R01 AA010249 |
NIAAA NIH HHS |
United States |
| K08 DA019951 |
NIDA NIH HHS |
United States |
| R37 AA007728 |
NIAAA NIH HHS |
United States |
| R01 DA018660 |
NIDA NIH HHS |
United States |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
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| KEYWORDS |
|
| KEYWORD |
| Depression |
| Genetics |
| Polygenic risk |
| Self-injury |
| Suicidal ideation |
| Suicide attempts |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Depression |
genetics |
| Female |
genetics |
| Genetic Association Studies |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Multifactorial Inheritance |
genetics |
| Risk Factors |
genetics |
| Self-Injurious Behavior |
genetics |
| Suicidal Ideation |
genetics |
| Young Adult |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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