Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
27590903
TITLE
The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries.
ABSTRACT
Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI.
DATE PUBLISHED
2017 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/02/10
accepted 2016/08/23
pubmed 2016/09/04 06:00
medline 2017/05/10 06:00
entrez 2016/09/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Maciejewski DF Maciejewski Dominique F DF Department of Clinical Developmental Psychology and EMGO Institute for Health and Care Research, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands.
Renteria ME Renteria Miguel E ME Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Abdellaoui A Abdellaoui Abdel A Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Medland SE Medland Sarah E SE Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Few LR Few Lauren R LR Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
Gordon SD Gordon Scott D SD Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Madden PA Madden Pamela A F PA Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
Montgomery G Montgomery Grant G Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Trull TJ Trull Timothy J TJ Department of Psychological Sciences, University of Missouri, Columbia, MO, 65211, USA.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
Statham DJ Statham Dixie J DJ Faculty of Arts and Social Sciences, University of Sunshine Coast, Sippy Downs, QLD, 4556, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Zietsch BP Zietsch Brendan P BP School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia.
Verweij KJ Verweij Karin J H KJ School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia. karin.verweij@vu.nl.
INVESTIGATORS
JOURNAL
VOLUME: 47
ISSUE: 1
TITLE: Behavior genetics
ISOABBREVIATION: Behav Genet
YEAR: 2017
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 AA007535 NIAAA NIH HHS United States
R01 AA014041 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
K21 DA000272 NIDA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
R56 DA012854 NIDA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA018267 NIDA NIH HHS United States
T32 DA007261 NIDA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R01 DA018660 NIDA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Depression
Genetics
Polygenic risk
Self-injury
Suicidal ideation
Suicide attempts
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Depression genetics
Female genetics
Genetic Association Studies genetics
Genetic Predisposition to Disease genetics
Humans genetics
Male genetics
Middle Aged genetics
Multifactorial Inheritance genetics
Risk Factors genetics
Self-Injurious Behavior genetics
Suicidal Ideation genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's