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PMID |
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TITLE |
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The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries. |
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ABSTRACT |
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Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2016/02/10 |
accepted |
2016/08/23 |
pubmed |
2016/09/04 06:00 |
medline |
2017/05/10 06:00 |
entrez |
2016/09/04 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Maciejewski DF |
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Maciejewski |
Dominique F |
DF |
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Department of Clinical Developmental Psychology and EMGO Institute for Health and Care Research, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands. |
Renteria ME |
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Renteria |
Miguel E |
ME |
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Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
Abdellaoui A |
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Abdellaoui |
Abdel |
A |
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Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. |
Medland SE |
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Medland |
Sarah E |
SE |
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Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
Few LR |
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Few |
Lauren R |
LR |
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Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA. |
Gordon SD |
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Gordon |
Scott D |
SD |
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Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
Madden PA |
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Madden |
Pamela A F |
PA |
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Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA. |
Montgomery G |
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Montgomery |
Grant |
G |
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Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
Trull TJ |
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Trull |
Timothy J |
TJ |
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Department of Psychological Sciences, University of Missouri, Columbia, MO, 65211, USA. |
Heath AC |
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Heath |
Andrew C |
AC |
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Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA. |
Statham DJ |
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Statham |
Dixie J |
DJ |
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Faculty of Arts and Social Sciences, University of Sunshine Coast, Sippy Downs, QLD, 4556, Australia. |
Martin NG |
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Martin |
Nicholas G |
NG |
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Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. |
Zietsch BP |
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Zietsch |
Brendan P |
BP |
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School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia. |
Verweij KJ |
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Verweij |
Karin J H |
KJ |
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School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia. karin.verweij@vu.nl. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 47 |
ISSUE: 1 |
TITLE: Behavior genetics |
ISOABBREVIATION: Behav Genet |
YEAR: 2017 |
MONTH: Jan |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1573-3297 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Behav Genet |
COUNTRY: United States |
ISSNLINKING: 0001-8244 |
NLMUNIQUEID: 0251711 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Twin Study |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
R01 AA007535 |
NIAAA NIH HHS |
United States |
R01 AA014041 |
NIAAA NIH HHS |
United States |
K05 AA017688 |
NIAAA NIH HHS |
United States |
P50 AA011998 |
NIAAA NIH HHS |
United States |
R01 AA007728 |
NIAAA NIH HHS |
United States |
R01 DA023668 |
NIDA NIH HHS |
United States |
K21 DA000272 |
NIDA NIH HHS |
United States |
R01 AA013326 |
NIAAA NIH HHS |
United States |
R56 DA012854 |
NIDA NIH HHS |
United States |
R01 AA013321 |
NIAAA NIH HHS |
United States |
R01 DA018267 |
NIDA NIH HHS |
United States |
T32 DA007261 |
NIDA NIH HHS |
United States |
R01 DA012854 |
NIDA NIH HHS |
United States |
R01 AA010249 |
NIAAA NIH HHS |
United States |
K08 DA019951 |
NIDA NIH HHS |
United States |
R37 AA007728 |
NIAAA NIH HHS |
United States |
R01 DA018660 |
NIDA NIH HHS |
United States |
R01 AA013320 |
NIAAA NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
Depression |
Genetics |
Polygenic risk |
Self-injury |
Suicidal ideation |
Suicide attempts |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
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Aged |
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Aged, 80 and over |
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Depression |
genetics |
Female |
genetics |
Genetic Association Studies |
genetics |
Genetic Predisposition to Disease |
genetics |
Humans |
genetics |
Male |
genetics |
Middle Aged |
genetics |
Multifactorial Inheritance |
genetics |
Risk Factors |
genetics |
Self-Injurious Behavior |
genetics |
Suicidal Ideation |
genetics |
Young Adult |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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