Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27537477
TITLE
Age at first use and later substance use disorder: Shared genetic and environmental pathways for nicotine, alcohol, and cannabis.
ABSTRACT
NlmCategory: UNASSIGNED
Behavioral genetic studies have provided insights into why early substance use initiation is associated with increased risk for disorder. Few genetically informative studies, however, have operationalized initiation as the timing of first use and simultaneously modeled the timing of initiation and problematic use of multiple substances. Such research can help capture the risk associated with early initiation and determine the extent to which genetic and environmental risk generalizes across substances. This study utilized a behavior genetic approach to examine the relation between the age of substance use initiation and symptoms of substance use disorder. Participants were 7,285 monozygotic and dizygotic twins (40% male, mean age at interview = 30.6 years) from the Australian Twin Registry who reported on their ages of tobacco, alcohol, and cannabis initiation and symptoms of Diagnostic and Statistical Manual of Mental Disorders (4th ed., DSM-IV) nicotine dependence, alcohol use disorder, and cannabis use disorder. Biometric modeling was conducted to (a) determine the structure of genetic and environmental influences on initiation and disorder and (b) examine their genetic and environmental overlap. The latent structure of initiation differed across men and women. The familial covariance between initiation and disorder was genetic among men and genetic and environmental among women, suggesting that the relation between first substance use and disorder is partly explained by a shared liability. After accounting for familial overlap, significant unique environmental correlations were observed, indicating that the age of initiation of multiple drugs may directly increase risk for substance-related problems. Results support the utility of conceptualizing initiation in terms of age and of adopting a multivariate approach. (PsycINFO Database Record
(c) 2016 APA, all rights reserved).
DATE PUBLISHED
2016 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pmc-release 2017/10/01
pubmed 2016/08/19 06:00
medline 2016/08/19 06:00
entrez 2016/08/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Richmond-Rakerd LS Richmond-Rakerd Leah S LS Department of Psychological Sciences.
Slutske WS Slutske Wendy S WS Department of Psychological Sciences.
Lynskey MT Lynskey Michael T MT Institute of Psychiatry, Psychology & Neuroscience, King's College London.
Agrawal A Agrawal Arpana A Alcoholism Research Center.
Madden PA Madden Pamela A F PA Alcoholism Research Center.
Bucholz KK Bucholz Kathleen K KK Alcoholism Research Center.
Heath AC Heath Andrew C AC Alcoholism Research Center.
Statham DJ Statham Dixie J DJ School of Social Sciences, University of the Sunshine Coast.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute.
INVESTIGATORS
JOURNAL
VOLUME: 125
ISSUE: 7
TITLE: Journal of abnormal psychology
ISOABBREVIATION: J Abnorm Psychol
YEAR: 2016
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1939-1846
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Abnorm Psychol
COUNTRY: United States
ISSNLINKING: 0021-843X
NLMUNIQUEID: 0034461
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
K02 DA032573 NIDA NIH HHS United States
R21 AA021235 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
R01 DA018267 NIDA NIH HHS United States
F31 AA023419 NIAAA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
GENERAL NOTE
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