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PMID |
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TITLE |
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Sweet Taste Perception is Associated with Body Mass Index at the Phenotypic and Genotypic Level. |
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ABSTRACT |
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NlmCategory: UNASSIGNED |
Investigations on the relationship between sweet taste perception and body mass index (BMI) have been inconclusive. Here, we report a longitudinal analysis using a genetically informative sample of 1,576 adolescent Australian twins to explore the relationship between BMI and sweet taste. First, we estimated the phenotypic correlations between perception scores for four different sweet compounds (glucose, fructose, neohesperidine dihydrochalcone (NHDC), and aspartame) and BMI. Then, we computed the association between adolescent taste perception and BMI in early adulthood (reported 9 years later). Finally, we used twin modeling and polygenic risk prediction analysis to investigate the genetic overlap between BMI and sweet taste perception. Our findings revealed that BMI in early adulthood was significantly associated with each of the sweet perception scores, with the strongest correlation observed in aspartame with r = 0.09 (p = .007). However, only limited evidence of association was observed between sweet taste perception and BMI that was measured at the same time (in adolescence), with the strongest evidence of association observed for glucose with a correlation coefficient of r = 0.06 (p = .029) and for aspartame with r = 0.06 (p = .035). We found a significant (p < .05) genetic correlation between glucose and NHDC perception and BMI. Our analyses suggest that sweet taste perception in adolescence can be a potential indicator of BMI in early adulthood. This association is further supported by evidence of genetic overlap between the traits, suggesting that some BMI genes may be acting through biological pathways of taste perception. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
entrez |
2016/08/06 06:00 |
pubmed |
2016/08/06 06:00 |
medline |
2016/08/06 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Hwang LD |
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Hwang |
Liang-Dar |
LD |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
Cuellar-Partida G |
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Cuellar-Partida |
Gabriel |
G |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
Ong JS |
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Ong |
Jue-Sheng |
JS |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
Breslin PA |
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Breslin |
Paul A S |
PA |
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Monell Chemical Senses Center,Philadelphia,Pennsylvania,USA. |
Reed DR |
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Reed |
Danielle R |
DR |
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Monell Chemical Senses Center,Philadelphia,Pennsylvania,USA. |
MacGregor S |
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MacGregor |
Stuart |
S |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
Gharahkhani P |
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Gharahkhani |
Puya |
P |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
Martin NG |
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Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
Rentería ME |
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Rentería |
Miguel E |
ME |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: |
ISSUE: |
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
ISOABBREVIATION: Twin Res Hum Genet |
YEAR: 2016 |
MONTH: Aug |
DAY: 5 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1832-4274 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Twin Res Hum Genet |
COUNTRY: England |
ISSNLINKING: 1832-4274 |
NLMUNIQUEID: 101244624 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
JOURNAL ARTICLE |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
BMI |
genetic risk |
longitudinal analysis |
sweetness |
taste perception |
twin study |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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