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| PMID |
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| TITLE |
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| From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process. |
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| ABSTRACT |
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NlmCategory: UNASSIGNED |
| The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the "starting" milestone decreased risk for a shorter time period between the starting and the "ending" milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2016/07/16 06:00 |
| pubmed |
2016/07/16 06:00 |
| medline |
2016/07/16 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Deutsch AR |
|
Deutsch |
Arielle R |
AR |
|
University of Missouri-Columbia. |
| Slutske WS |
|
Slutske |
Wendy S |
WS |
|
University of Missouri-Columbia. |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Washington University School of Medicine. |
| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
Washington University School of Medicine. |
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
Washington University School of Medicine. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Washington University School of Medicine. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Development and psychopathology |
| ISOABBREVIATION: Dev. Psychopathol. |
| YEAR: 2016 |
| MONTH: Jul |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1469-2198 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Dev Psychopathol |
| COUNTRY: |
| ISSNLINKING: 0954-5794 |
| NLMUNIQUEID: 8910645 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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