Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27413137
TITLE
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking.
OBJECTIVES NlmCategory: OBJECTIVE
We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments.
DESIGN NlmCategory: METHODS
Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling.
RESULTS NlmCategory: RESULTS
The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy, but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions.
CONCLUSIONS NlmCategory: CONCLUSIONS
Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.
2016 American Society for Nutrition.
DATE PUBLISHED
2016 Jul 13
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/01/19
accepted 2016/05/20
entrez 2016/07/15 06:00
pubmed 2016/07/15 06:00
medline 2016/07/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Silventoinen K Silventoinen Karri K Departments of Social Research and Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan; karri.silventoinen@helsinki.fi.
Jelenkovic A Jelenkovic Aline A Departments of Social Research and Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain;
Sund R Sund Reijo R Departments of Social Research and.
Hur YM Hur Yoon-Mi YM Department of Education, Mokpo National University, Jeonnam, South Korea;
Yokoyama Y Yokoyama Yoshie Y Department of Public Health Nursing, Osaka City University, Osaka, Japan;
Honda C Honda Chika C Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan;
Hjelmborg JV Hjelmborg Jacob vB JV The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and.
Möller S Möller Sören S The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and.
Ooki S Ooki Syuichi S Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan;
Aaltonen S Aaltonen Sari S Departments of Social Research and Public Health, University of Helsinki, Helsinki, Finland;
Ji F Ji Fuling F Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China;
Ning F Ning Feng F Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China;
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China;
Rebato E Rebato Esther E Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain;
Busjahn A Busjahn Andreas A HealthTwiSt GmbH, Berlin, Germany;
Kandler C Kandler Christian C Department of Psychology, Bielefeld University, Bielefeld, Germany;
Saudino KJ Saudino Kimberly J KJ Department of Psychological and Brain Sciences, Boston University, Boston, MA;
Jang KL Jang Kerry L KL Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada;
Cozen W Cozen Wendy W Department of Preventive Medicine, Keck School of Medicine of USC, and USC Norris Comprehensive Cancer Center, Los Angeles, CA;
Hwang AE Hwang Amie E AE Department of Preventive Medicine, Keck School of Medicine of USC, and.
Mack TM Mack Thomas M TM Department of Preventive Medicine, Keck School of Medicine of USC, and USC Norris Comprehensive Cancer Center, Los Angeles, CA;
Gao W Gao Wenjing W Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China;
Yu C Yu Canqing C Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China;
Li L Li Liming L Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China;
Corley RP Corley Robin P RP Institute for Behavioral Genetics, Boulder, CO;
Huibregtse BM Huibregtse Brooke M BM Institute for Behavioral Genetics, Boulder, CO;
Christensen K Christensen Kaare K The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and Departments of Clinical Biochemistry and Pharmacology Clinical Genetics.
Skytthe A Skytthe Axel A The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics and Biodemography, and.
Kyvik KO Kyvik Kirsten O KO Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Odense Patient data Explorative Network, and.
Derom CA Derom Catherine A CA Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium; Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium;
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium;
Loos RJ Loos Ruth Jf RJ The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY;
Heikkilä K Heikkilä Kauko K Public Health, University of Helsinki, Helsinki, Finland;
Wardle J Wardle Jane J Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom;
Llewellyn CH Llewellyn Clare H CH Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom;
Fisher A Fisher Abigail A Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom;
McAdams TA McAdams Tom A TA Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom; MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, and.
Eley TC Eley Thalia C TC MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, and.
Gregory AM Gregory Alice M AM Department of Psychology, Goldsmiths, University of London, London, United Kingdom;
He M He Mingguang M State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia;
Ding X Ding Xiaohu X State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China;
Bjerregaard-Andersen M Bjerregaard-Andersen Morten M Departments of Endocrinology and Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau; Research Center for Vitamins and Vaccines, Statens Serum Institute, Copenhagen, Denmark;
Beck-Nielsen H Beck-Nielsen Henning H Departments of Endocrinology and.
Sodemann M Sodemann Morten M Departments of Endocrinology and Infectious Diseases, Odense University Hospital, Odense, Denmark;
Tarnoki AD Tarnoki Adam D AD Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary; Hungarian Twin Registry, Budapest, Hungary;
Tarnoki DL Tarnoki David L DL Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary; Hungarian Twin Registry, Budapest, Hungary;
Stazi MA Stazi Maria A MA Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy;
Fagnani C Fagnani Corrado C Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy;
D'Ippolito C D'Ippolito Cristina C Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy;
Knafo-Noam A Knafo-Noam Ariel A The Hebrew University of Jerusalem, Jerusalem, Israel;
Mankuta D Mankuta David D Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel;
Abramson L Abramson Lior L The Hebrew University of Jerusalem, Jerusalem, Israel;
Burt SA Burt S Alexandra SA Michigan State University, East Lansing, MI;
Klump KL Klump Kelly L KL Michigan State University, East Lansing, MI;
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics.
Eaves LJ Eaves Lindon J LJ Department of Human and Molecular Genetics.
Maes HH Maes Hermine H HH Department of Human and Molecular Genetics, Massey Cancer Center, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA;
Krueger RF Krueger Robert F RF Department of Psychology, University of Minnesota, Minneapolis, MN; Departments of.
McGue M McGue Matt M Department of Psychology, University of Minnesota, Minneapolis, MN; Departments of.
Pahlen S Pahlen Shandell S Department of Psychology, University of Minnesota, Minneapolis, MN; Departments of.
Gatz M Gatz Margaret M Department of Psychology, University of Southern California, Los Angeles, CA; Medical Epidemiology and Biostatistics and.
Butler DA Butler David A DA Institute of Medicine, National Academy of Sciences Washington, DC;
Bartels M Bartels Meike M Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands;
van Beijsterveldt TC van Beijsterveldt Toos Cem TC Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands;
Craig JM Craig Jeffrey M JM Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia;
Saffery R Saffery Richard R Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia;
Freitas DL Freitas Duarte L DL Department of Physical Education and Sport, University of Madeira, Funchal, Portugal;
Maia JA Maia José Antonio JA Centre of Research, Education, Innovation and Intervention in Sport, Faculty of Sport, Porto, University of Porto, Portugal;
Dubois L Dubois Lise L School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada;
Boivin M Boivin Michel M École de psychologie, Université Laval, Québec, Canada; Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Russian Federation;
Brendgen M Brendgen Mara M Département de psychologie, Université du Québec à Montréal, Montréal, Québec, Canada;
Dionne G Dionne Ginette G École de psychologie, Université Laval, Québec, Canada;
Vitaro F Vitaro Frank F École de psychoéducation, Université de Montréal, Montréal, Québec, Canada;
Martin NG Martin Nicholas G NG Genetic Epidemiology Department and.
Medland SE Medland Sarah E SE Genetic Epidemiology Department and.
Montgomery GW Montgomery Grant W GW Molecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia;
Chong Y Chong Youngsook Y Department of Psychology, Pusan National University, Busan, South Korea;
Swan GE Swan Gary E GE Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA;
Krasnow R Krasnow Ruth R Center for Health Sciences, SRI International, Menlo Park, CA;
Magnusson PK Magnusson Patrik Ke PK Medical Epidemiology and Biostatistics and.
Pedersen NL Pedersen Nancy L NL Medical Epidemiology and Biostatistics and.
Tynelius P Tynelius Per P Public Health Sciences, Karolinska Institutet, Stockholm, Sweden;
Lichtenstein P Lichtenstein Paul P Medical Epidemiology and Biostatistics and.
Haworth CM Haworth Claire Ma CM MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom;
Plomin R Plomin Robert R MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, and.
Bayasgalan G Bayasgalan Gombojav G Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia;
Narandalai D Narandalai Danshiitsoodol D Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;
Harden KP Harden K Paige KP Department of Psychology, University of Texas at Austin, Austin, TX;
Tucker-Drob EM Tucker-Drob Elliot M EM Department of Psychology, University of Texas at Austin, Austin, TX;
Öncel SY Öncel Sevgi Y SY Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey;
Aliev F Aliev Fazil F Department of Human and Molecular Genetics, Departments of Psychiatry and Psychology.
Spector T Spector Timothy T Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom;
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom;
Lachance G Lachance Genevieve G Department of Twin Research and Genetic Epidemiology, King's College, London, United Kingdom;
Baker LA Baker Laura A LA Department of Psychology, University of Southern California, Los Angeles, CA;
Tuvblad C Tuvblad Catherine C Department of Psychology, University of Southern California, Los Angeles, CA; Örebro University, School of Law, Psychology and Social Work, Örebro, Sweden;
Duncan GE Duncan Glen E GE College of Medicine, Washington State University - Health Sciences Spokane, Spokane, WA;
Buchwald D Buchwald Dedra D Washington State Twin Registry, Washington State University, Seattle, WA;
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands;
Rasmussen F Rasmussen Finn F Public Health Sciences, Karolinska Institutet, Stockholm, Sweden;
Goldberg JH Goldberg Jack H JH Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA;
Sørensen TI Sørensen Thorkild Ia TI MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Novo Nordisk Foundation Center for Basic Metabolic Research (Section on Metabolic Genetics) and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen,Denmark; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Copenhagen, The Capital Region, Denmark;
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands;
Kaprio J Kaprio Jaakko J Public Health, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland; and Institute for Molecular Medicine FIMM, Helsinki, Finland.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: The American journal of clinical nutrition
ISOABBREVIATION: Am. J. Clin. Nutr.
YEAR: 2016
MONTH: Jul
DAY: 13
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1938-3207
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Clin Nutr
COUNTRY: United States
ISSNLINKING: 0002-9165
NLMUNIQUEID: 0376027
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
BMI
children
genetics
international comparisons
twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's