Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
27263615
TITLE
Familial Aggregation of Migraine and Depression: Insights From a Large Australian Twin Sample.
ABSTRACT
OBJECTIVES NlmCategory: OBJECTIVE
This research examined the familial aggregation of migraine, depression, and their co-occurrence.
METHODS NlmCategory: METHODS
Diagnoses of migraine and depression were determined in a sample of 5,319 Australian twins. Migraine was diagnosed by either self-report, the ID migraine™ Screener, or International Headache Society (IHS) criteria. Depression was defined by fulfilling either major depressive disorder (MDD) or minor depressive disorder (MiDD) based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria. The relative risks (RR) for migraine and depression were estimated in co-twins of twin probands reporting migraine or depression to evaluate their familial aggregation and co-occurrence.
RESULTS NlmCategory: RESULTS
An increased RR of both migraine and depression in co-twins of probands with the same trait was observed, with significantly higher estimates within monozygotic (MZ) twin pairs compared to dizygotic (DZ) twin pairs. For cross-trait analysis, the RR for migraine in co-twins of probands reporting depression was 1.36 (95% CI: 1.24-1.48) in MZ pairs and 1.04 (95% CI: 0.95-1.14) in DZ pairs; and the RR for depression in co-twins of probands reporting migraine was 1.26 (95% CI: 1.14-1.38) in MZ pairs and 1.02 (95% CI: 0.94-1.11) in DZ pairs. The RR for strict IHS migraine in co-twins of probands reporting MDD was 2.23 (95% CI: 1.81-2.75) in MZ pairs and 1.55 (95% CI: 1.34-1.79) in DZ pairs; and the RR for MDD in co-twins of probands reporting IHS migraine was 1.35 (95% CI: 1.13-1.62) in MZ pairs and 1.06 (95% CI: 0.93-1.22) in DZ pairs.
CONCLUSIONS NlmCategory: CONCLUSIONS
We observed significant evidence for a genetic contribution to familial aggregation of migraine and depression. Our findings suggest a bi-directional association between migraine and depression, with an increased risk for depression in relatives of probands reporting migraine, and vice versa. However, the observed risk for migraine in relatives of probands reporting depression was considerably higher than the reverse. These results add further support to previous studies suggesting that patients with comorbid migraine and depression are genetically more similar to patients with only depression than patients with only migraine.
DATE PUBLISHED
2016 Jun 6
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2016/06/07 06:00
pubmed 2016/06/07 06:00
medline 2016/06/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Yang Y Yang Yuanhao Y Statistical and Genomic Epidemiology Laboratory,Institute of Health and Biomedical Innovation,Queensland University of Technology,Brisbane,Queensland,Australia.
Zhao H Zhao Huiying H Statistical and Genomic Epidemiology Laboratory,Institute of Health and Biomedical Innovation,Queensland University of Technology,Brisbane,Queensland,Australia.
Heath AC Heath Andrew C AC Department of Psychiatry,Washington University School of Medicine,St. Louis,MO,USA.
Madden PA Madden Pamela A F PA Department of Psychiatry,Washington University School of Medicine,St. Louis,MO,USA.
Martin NG Martin Nicholas G NG Genetic Epidemiology Laboratory,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Nyholt DR Nyholt Dale R DR Statistical and Genomic Epidemiology Laboratory,Institute of Health and Biomedical Innovation,Queensland University of Technology,Brisbane,Queensland,Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2016
MONTH: Jun
DAY: 6
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
bi-directional association
depression
familial aggregation
migraine
relative risk
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's