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| PMID |
|
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| TITLE |
|
| Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. |
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| ABSTRACT |
|
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NlmCategory: UNASSIGNED |
| The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values <5 × 10(-5), Bonferroni-corrected P<0.05) for nine SNP alleles at three independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; Poverall: 2.47 × 10(-06)/Pfemales: 3.45 × 10(-07)/Pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean controls. We observed no evidence for associations for the look-up of BMI-related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by females. In addition, the detected altered hypothalamic expression patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation.Molecular Psychiatry advance online publication, 17 May 2016; doi:10.1038/mp.2016.71. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2015/08/28 |
| revised |
2016/02/22 |
| accepted |
2016/03/17 |
| entrez |
2016/05/18 06:00 |
| pubmed |
2016/05/18 06:00 |
| medline |
2016/05/18 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hinney A |
|
Hinney |
A |
A |
|
Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. |
| Kesselmeier M |
|
Kesselmeier |
M |
M |
|
Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. |
| Jall S |
|
Jall |
S |
S |
|
Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany. |
| Volckmar AL |
|
Volckmar |
A-L |
AL |
|
Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. |
| Föcker M |
|
Föcker |
M |
M |
|
Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. |
| Antel J |
|
Antel |
J |
J |
|
Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. |
|
GCAN |
|
|
|
|
|
|
WTCCC3 |
|
|
|
|
|
| Heid IM |
|
Heid |
I M |
IM |
|
Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. |
| Winkler TW |
|
Winkler |
T W |
TW |
|
Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. |
|
GIANT |
|
|
|
|
|
| Grant SF |
|
Grant |
S F A |
SF |
|
The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. |
|
EGG |
|
|
|
|
|
| Guo Y |
|
Guo |
Y |
Y |
|
The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. |
| Bergen AW |
|
Bergen |
A W |
AW |
|
BioRealm, LLC, Culver City, CA, USA. |
| Kaye W |
|
Kaye |
W |
W |
|
Department of Psychiatry, University of California, San Diego, San Diego, CA, USA. |
| Berrettini W |
|
Berrettini |
W |
W |
|
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. |
| Hakonarson H |
|
Hakonarson |
H |
H |
|
The Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
|
Price Foundation Collaborative Group |
|
|
|
|
|
|
Children’s Hospital of Philadelphia/Price Foundation |
|
|
|
|
|
| Herpertz-Dahlmann B |
|
Herpertz-Dahlmann |
B |
B |
|
Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of the RWTH Aachen, Aachen, Germany. |
| de Zwaan M |
|
de Zwaan |
M |
M |
|
Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany. |
| Herzog W |
|
Herzog |
W |
W |
|
Department of Internal Medicine II, General Internal and Psychosomatic Medicine, University of Heidelberg, Heidelberg, Germany. |
| Ehrlich S |
|
Ehrlich |
S |
S |
|
Translational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU-Dresden, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. |
| Zipfel S |
|
Zipfel |
S |
S |
|
Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital, Tübingen, Germany. |
| Egberts KM |
|
Egberts |
K M |
KM |
|
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany. |
| Adan R |
|
Adan |
R |
R |
|
Altrecht Eating Disorders Rintveld, Zeist, The Netherlands. |
| Brandys M |
|
Brandys |
M |
M |
|
Altrecht Eating Disorders Rintveld, Zeist, The Netherlands. |
| van Elburg A |
|
van Elburg |
A |
A |
|
Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. |
| Boraska Perica V |
|
Boraska Perica |
V |
V |
|
University of Split School of Medicine, Split, Croatia. |
| Franklin CS |
|
Franklin |
C S |
CS |
|
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. |
| Tschöp MH |
|
Tschöp |
M H |
MH |
|
Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany. |
| Zeggini E |
|
Zeggini |
E |
E |
|
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. |
| Bulik CM |
|
Bulik |
C M |
CM |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Collier D |
|
Collier |
D |
D |
|
Eli Lilly and Company Ltd, Surrey, UK. |
| Scherag A |
|
Scherag |
A |
A |
|
Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. |
| Müller TD |
|
Müller |
T D |
TD |
|
Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany. |
| Hebebrand J |
|
Hebebrand |
J |
J |
|
Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Perica |
Vesna Boraska |
VB |
|
| Franklin |
Christopher S |
CS |
|
| Floyd |
James A B |
JA |
|
| Thornton |
Laura M |
LM |
|
| Huckins |
Laura M |
LM |
|
| Southam |
Lorraine |
L |
|
| Rayner |
N William |
NW |
|
| Tachmazidou |
Ioanna |
I |
|
| Klump |
Kelly L |
KL |
|
| Treasure |
Janet |
J |
|
| Lewis |
Cathryn M |
CM |
|
| Schmidt |
Ulrike |
U |
|
| Tozzi |
Federica |
F |
|
| Iezebrink |
Kirsty |
K |
|
| Hebebrand |
Johannes |
J |
|
| Gorwood |
Philip |
P |
|
| Adan |
Roger A H |
RA |
|
| Kas |
Martien J H |
MJ |
|
| Favaro |
Angela |
A |
|
| Santonastaso |
Paolo |
P |
|
| Fernández-Aranda |
Fernando |
F |
|
| Gratacos |
Monica |
M |
|
| Rybakowski |
Filip |
F |
|
| Dmitrzak-Weglarz |
Monika |
M |
|
| Kaprio |
Jaakko |
J |
|
| Keski-Rahkonen |
Anna |
A |
|
| Raevuori-Helkamaa |
Anu |
A |
|
| Van Furth |
Eric F |
EF |
|
| Slof-Op't Landt |
Margarita C T |
MC |
|
| Hudson |
James I |
JI |
|
| Reichborn-Kjennerud |
Ted |
T |
|
| Knudsen |
Gun Peggy S |
GP |
|
| Monteleone |
Palmiero |
P |
|
| Kaplan |
Allan S |
AS |
|
| Karwautz |
Andreas |
A |
|
| Hakonarson |
Hakon |
H |
|
| Berrettini |
Wade H |
WH |
|
| Guo |
Yiran |
Y |
|
| Li |
Dong |
D |
|
| Schork |
Nicholas J |
NJ |
|
| Komaki |
Gen |
G |
|
| Ando |
Tetsuya |
T |
|
| Inoko |
Hidetoshi |
H |
|
| Esko |
Tõnu |
T |
|
| Fischer |
Krista |
K |
|
| Männik |
Katrin |
K |
|
| Metspalu |
Andres |
A |
|
| Baker |
Jessica H |
JH |
|
| Cone |
Roger D |
RD |
|
| Dackor |
Jennifer |
J |
|
| DeSocio |
Janiece E |
JE |
|
| Hilliard |
Christopher E |
CE |
|
| O'Toole |
Julie K |
JK |
|
| Pantel |
Jacques |
J |
|
| Szatkiewicz |
Jin P |
JP |
|
| Taico |
Chrysecolla |
C |
|
| Zerwas |
Stephanie |
S |
|
| Trace |
Sara E |
SE |
|
| Davis |
Oliver S P |
OS |
|
| Helder |
Sietske |
S |
|
| Bühren |
Katharina |
K |
|
| Burghardt |
Roland |
R |
|
| de Zwaan |
Martina |
M |
|
| Egberts |
Karin |
K |
|
| Ehrlich |
Stefan |
S |
|
| Herpertz-Dahlmann |
Beate |
B |
|
| Herzog |
Wolfgang |
W |
|
| Imgart |
Hartmut |
H |
|
| Scherag |
André |
A |
|
| Scherag |
Susann |
S |
|
| Zipfel |
Stephan |
S |
|
| Boni |
Claudette |
C |
|
| Ramoz |
Nicolas |
N |
|
| Versini |
Audrey |
A |
|
| Brandys |
Marek K |
MK |
|
| Danner |
Unna N |
UN |
|
| de Kove |
Carolien |
C |
|
| Hendriks |
Judith |
J |
|
| Koeleman |
Bobby P C |
BP |
|
| Ophoff |
Roel A |
RA |
|
| Strengman |
Eric |
E |
|
| van Elburg |
Annemarie A |
AA |
|
| Bruson |
Alice |
A |
|
| Clementi |
Maurizio |
M |
|
| Degortes |
Daniela |
D |
|
| Forzan |
Monica |
M |
|
| Tenconi |
Elena |
E |
|
| Docampo |
Elisa |
E |
|
| Escaramí |
Geòrgia |
G |
|
| Jiménez-Murcia |
Susana |
S |
|
| Lissowska |
Jolanta |
J |
|
| Rajewski |
Andrzej |
A |
|
| Szeszenia-Dabrowska |
Neonila |
N |
|
| Slopien |
Agnieszka |
A |
|
| Hauser |
Joanna |
J |
|
| Karhunen |
Leila |
L |
|
| Meulenbelt |
Ingrid |
I |
|
| Slagboom |
P Eline |
PE |
|
| Tortorella |
Alfonso |
A |
|
| Maj |
Mario |
M |
|
| Dedoussis |
George |
G |
|
| Dikeos |
Dimitris |
D |
|
| Gonidakis |
Fragiskos |
F |
|
| Tziouvas |
Konstantinos |
K |
|
| Tsitsika |
Artemis |
A |
|
| Papezova |
Hana |
H |
|
| Slachtova |
Lenka |
L |
|
| Martaskova |
Debora |
D |
|
| Kennedy |
James L |
JL |
|
| Levitan |
Robert D |
RD |
|
| Yilmaz |
Zeynep |
Z |
|
| Huemer |
Julia |
J |
|
| Koubek |
Doris |
D |
|
| Merl |
Elisabeth |
E |
|
| Wagner |
Gudrun |
G |
|
| Lichtenstein |
Paul |
P |
|
| Breen |
Gerome |
G |
|
| Cohen-Woods |
Sarah |
S |
|
| Farmer |
Anne |
A |
|
| McGuffin |
Peter |
P |
|
| Cichon |
Sven |
S |
|
| Giegling |
Ina |
I |
|
| Herms |
Stefan |
S |
|
| Rujescu |
Dan |
D |
|
| Schreiber |
Stefan |
S |
|
| Wichmann |
H-Erich |
HE |
|
| Dina |
Christian |
C |
|
| Sladek |
Rob |
R |
|
| Gambaro |
Giovanni |
G |
|
| Soranzo |
Nicole |
N |
|
| Julia |
Antonio |
A |
|
| Marsal |
Sara |
S |
|
| Rabionet |
Raquel |
R |
|
| Gaborieau |
Valerie |
V |
|
| Dick |
Danielle M |
DM |
|
| Palotie |
Aarno |
A |
|
| Ripatti |
Samuli |
S |
|
| Widén |
Elisabeth |
E |
|
| Andreassen |
Ole A |
OA |
|
| Espeseth |
Thomas |
T |
|
| Lundervold |
Astri |
A |
|
| Reinvang |
Ivar |
I |
|
| Steen |
Vidar M |
VM |
|
| Hellard |
Stephanie Le |
SL |
|
| Mattingsdal |
Morten |
M |
|
| Ntalla |
Ioanna |
I |
|
| Bencko |
Vladimir |
V |
|
| Foretova |
Lenka |
L |
|
| Janout |
Vladimir |
V |
|
| Navratilova |
Marie |
M |
|
| Gallinger |
Steven |
S |
|
| Pinto |
Dalila |
D |
|
| Scherer |
Stephen W |
SW |
|
| Aschauer |
Harald |
H |
|
| Carlberg |
Laura |
L |
|
| Schosser |
Alexandra |
A |
|
| Alfredsson |
Lars |
L |
|
| Ding |
Bo |
B |
|
| Klareskog |
Lars |
L |
|
| Padyukov |
Leonid |
L |
|
| Finan |
Chris |
C |
|
| Kalsi |
Gursharan |
G |
|
| Roberts |
Marion |
M |
|
| Logan |
Darren W |
DW |
|
| Peltonen |
Leena |
L |
|
| Ritchie |
Graham R S |
GR |
|
| Barrett |
Jeff C |
JC |
|
| Estivill |
Xavier |
X |
|
| Hinney |
Anke |
A |
|
| Sullivan |
Patrick F |
PF |
|
| Collier |
David A |
DA |
|
| Zeggini |
Eleftheria |
E |
|
| Bulik |
Cynthia M |
CM |
|
| Anderson |
Carl A |
CA |
|
| Barrett |
Jeffrey C |
JC |
|
| Floyd |
James A B |
JA |
|
| Franklin |
Christopher S |
CS |
|
| McGinnis |
Ralph |
R |
|
| Soranzo |
Nicole |
N |
|
| Zeggini |
Eleftheria |
E |
|
| Sambrook |
Jennifer |
J |
|
| Stephens |
Jonathan |
J |
|
| Ouwehand |
Willem H |
WH |
|
| McArdle |
Wendy L |
WL |
|
| Ring |
Susan M |
SM |
|
| Strachan |
David P |
DP |
|
| Alexander |
Graeme |
G |
|
| Bulik |
Cynthia M |
CM |
|
| Collier |
David A |
DA |
|
| Conlon |
Peter J |
PJ |
|
| Dominiczak |
Anna |
A |
|
| Duncanson |
Audrey |
A |
|
| Hill |
Adrian |
A |
|
| Langford |
Cordelia |
C |
|
| Lord |
Graham |
G |
|
| Maxwell |
Alexander P |
AP |
|
| Morgan |
Linda |
L |
|
| Peltonen |
Leena |
L |
|
| Sandford |
Richard N |
RN |
|
| Sheerin |
Neil |
N |
|
| Vannberg |
Frederik O |
FO |
|
| Blackburn |
Hannah |
H |
|
| Chen |
Wei-Min |
WM |
|
| Edkins |
Sarah |
S |
|
| Gillman |
Mathew |
M |
|
| Gray |
Emma |
E |
|
| Hunt |
Sarah E |
SE |
|
| Nengut-Gumuscu |
Suna |
S |
|
| Potter |
Simon |
S |
|
| Rich |
Stephen S |
SS |
|
| Simpkin |
Douglas |
D |
|
| Whittaker |
Pamela |
P |
|
| de Bakker |
P |
P |
|
| Bültmann |
U |
U |
|
| Geleijnse |
M |
M |
|
| Harst |
P V |
PV |
|
| Koppelman |
G |
G |
|
| Rosmalen |
J G |
JG |
|
| van Rossum |
L |
L |
|
| Smidt |
H |
H |
|
| Swertz |
M A |
MA |
|
| Stolk |
R P |
RP |
|
| Alizadeh |
B |
B |
|
| de Boer |
R |
R |
|
| Boezen |
H M |
HM |
|
| Bruinenberg |
M |
M |
|
| Franke |
L |
L |
|
| van der Harst |
P |
P |
|
| Hillege |
H |
H |
|
| van der Klauw |
M |
M |
|
| Navis |
G |
G |
|
| Ormel |
J |
J |
|
| Postma |
D |
D |
|
| Rosmalen |
J |
J |
|
| Slaets |
J |
J |
|
| Snieder |
H |
H |
|
| Stolk |
R |
R |
|
| Wolffenbuttel |
B |
B |
|
| Wijmenga |
C |
C |
|
| Berg |
J |
J |
|
| Blackwood |
D |
D |
|
| Campbell |
H |
H |
|
| Cavanagh |
J |
J |
|
| Connell |
J |
J |
|
| Connor |
M |
M |
|
| Cunningham-Burley |
S |
S |
|
| Deary |
I |
I |
|
| Dominiczak |
A |
A |
|
| Ellis |
P |
P |
|
| FitzPatrick |
B |
B |
|
| Ford |
I |
I |
|
| Gertz |
R |
R |
|
| Grau |
A |
A |
|
| Haddow |
G |
G |
|
| Jackson |
C |
C |
|
| Kerr |
S |
S |
|
| Lindsay |
R |
R |
|
| McGilchrist |
M |
M |
|
| McIntyre |
D |
D |
|
| Morris |
A |
A |
|
| Morton |
R |
R |
|
| Muir |
W |
W |
|
| Murray |
G |
G |
|
| Palmer |
C |
C |
|
| Pell |
J |
J |
|
| Philp |
A |
A |
|
| Porteous |
D |
D |
|
| Porteous |
M |
M |
|
| Procter |
R |
R |
|
| Ralston |
S |
S |
|
| Reid |
D |
D |
|
| Sinnott |
R |
R |
|
| Smith |
B |
B |
|
| Clair |
D S |
DS |
|
| Sullivan |
F |
F |
|
| Sweetland |
M |
M |
|
| Ure |
J |
J |
|
| Watt |
G |
G |
|
| Wolf |
R |
R |
|
| Wright |
A |
A |
|
| Berndt |
S I |
SI |
|
| Gustafsson |
S |
S |
|
| Mägi |
R |
R |
|
| Ganna |
A |
A |
|
| Wheeler |
E |
E |
|
| Feitosa |
M F |
MF |
|
| Justice |
A E |
AE |
|
| Monda |
K L |
KL |
|
| Croteau-Chonka |
D C |
DC |
|
| Day |
F R |
FR |
|
| Esko |
T |
T |
|
| Fall |
T |
T |
|
| Ferreira |
T |
T |
|
| Gentilini |
D |
D |
|
| Jackson |
A U |
AU |
|
| Luan |
J |
J |
|
| Randall |
J C |
JC |
|
| Vedantam |
S |
S |
|
| Willer |
C J |
CJ |
|
| Winkler |
T W |
TW |
|
| Wood |
A R |
AR |
|
| Workalemahu |
T |
T |
|
| Hu |
Y J |
YJ |
|
| Lee |
S H |
SH |
|
| Liang |
L |
L |
|
| Lin |
D Y |
DY |
|
| Min |
J L |
JL |
|
| Neale |
B M |
BM |
|
| Thorleifsson |
G |
G |
|
| Yang |
J |
J |
|
| Albrecht |
E |
E |
|
| Amin |
N |
N |
|
| Bragg-Gresham |
J L |
JL |
|
| Cadby |
G |
G |
|
| den Heijer |
M |
M |
|
| Eklund |
N |
N |
|
| Fischer |
K |
K |
|
| Goel |
A |
A |
|
| Hottenga |
J J |
JJ |
|
| Huffman |
J E |
JE |
|
| Jarick |
I |
I |
|
| Johansson |
A |
A |
|
| Johnson |
T |
T |
|
| Kanoni |
S |
S |
|
| Kleber |
M E |
ME |
|
| König |
I R |
IR |
|
| Kristiansson |
K |
K |
|
| Kutalik |
Z |
Z |
|
| Lamina |
C |
C |
|
| Lecoeur |
C |
C |
|
| Li |
G |
G |
|
| Mangino |
M |
M |
|
| McArdle |
W L |
WL |
|
| Medina-Gomez |
C |
C |
|
| Müller-Nurasyid |
M |
M |
|
| Ngwa |
J S |
JS |
|
| Nolte |
I M |
IM |
|
| Paternoster |
L |
L |
|
| Pechlivanis |
S |
S |
|
| Perola |
M |
M |
|
| Peters |
M J |
MJ |
|
| Preuss |
M |
M |
|
| Rose |
L M |
LM |
|
| Shi |
J |
J |
|
| Shungin |
D |
D |
|
| Smith |
A V |
AV |
|
| Strawbridge |
R J |
RJ |
|
| Surakka |
I |
I |
|
| Teumer |
A |
A |
|
| Trip |
M D |
MD |
|
| Tyrer |
J |
J |
|
| Van Vliet-Ostaptchouk |
J V |
JV |
|
| Vandenput |
L |
L |
|
| Waite |
L L |
LL |
|
| Zhao |
J H |
JH |
|
| Absher |
D |
D |
|
| Asselbergs |
F W |
FW |
|
| Atalay |
M |
M |
|
| Attwood |
A P |
AP |
|
| Balmforth |
A J |
AJ |
|
| Basart |
H |
H |
|
| Beilby |
J |
J |
|
| Bonnycastle |
L L |
LL |
|
| Brambilla |
P |
P |
|
| Bruinenberg |
M |
M |
|
| Campbell |
H |
H |
|
| Chasman |
D I |
DI |
|
| Chines |
P S |
PS |
|
| Collins |
F S |
FS |
|
| Connell |
J M |
JM |
|
| Cookson |
W |
W |
|
| de Faire |
U |
U |
|
| de Vegt |
F |
F |
|
| Dei |
M |
M |
|
| Dimitriou |
M |
M |
|
| Edkins |
S |
S |
|
| Estrada |
K |
K |
|
| Evans |
D M |
DM |
|
| Farrall |
M |
M |
|
| Ferrario |
M M |
MM |
|
| Ferrières |
J |
J |
|
| Franke |
L |
L |
|
| Frau |
F |
F |
|
| Gejman |
P V |
PV |
|
| Grallert |
H |
H |
|
| Grönberg |
H |
H |
|
| Gudnason |
V |
V |
|
| Hall |
A S |
AS |
|
| Hall |
P |
P |
|
| Hartikainen |
A L |
AL |
|
| Hayward |
C |
C |
|
| Heard-Costa |
N L |
NL |
|
| Heath |
A C |
AC |
|
| Hebebrand |
J |
J |
|
| Homuth |
G |
G |
|
| Hu |
F B |
FB |
|
| Hunt |
S E |
SE |
|
| Hyppönen |
E |
E |
|
| Iribarren |
C |
C |
|
| Jacobs |
K B |
KB |
|
| Jansson |
J O |
JO |
|
| Jula |
A |
A |
|
| Kähönen |
M |
M |
|
| Kathiresan |
S |
S |
|
| Kee |
F |
F |
|
| Khaw |
K T |
KT |
|
| Kivimaki |
M |
M |
|
| Koenig |
W |
W |
|
| Kraja |
A T |
AT |
|
| Kumari |
M |
M |
|
| Kuulasmaa |
K |
K |
|
| Kuusisto |
J |
J |
|
| Laitinen |
J H |
JH |
|
| Lakka |
T A |
TA |
|
| Langenberg |
C |
C |
|
| Launer |
L J |
LJ |
|
| Lind |
L |
L |
|
| Lindström |
J |
J |
|
| Liu |
J |
J |
|
| Liuzzi |
A |
A |
|
| Lokki |
M L |
ML |
|
| Lorentzon |
M |
M |
|
| Madden |
P A |
PA |
|
| Magnusson |
P K |
PK |
|
| Manunta |
P |
P |
|
| Marek |
D |
D |
|
| März |
W |
W |
|
| Mateo Leach |
I |
I |
|
| McKnight |
B |
B |
|
| Medland |
S E |
SE |
|
| Mihailov |
E |
E |
|
| Milani |
L |
L |
|
| Montgomery |
G W |
GW |
|
| Mooser |
V |
V |
|
| Mühleisen |
T W |
TW |
|
| Munroe |
P B |
PB |
|
| Musk |
A W |
AW |
|
| Narisu |
N |
N |
|
| Navis |
G |
G |
|
| Nicholson |
G |
G |
|
| Nohr |
E A |
EA |
|
| Ong |
K K |
KK |
|
| Oostra |
B A |
BA |
|
| Palmer |
C N |
CN |
|
| Palotie |
A |
A |
|
| Peden |
J F |
JF |
|
| Pedersen |
N |
N |
|
| Peters |
A |
A |
|
| Polasek |
O |
O |
|
| Pouta |
A |
A |
|
| Pramstaller |
P P |
PP |
|
| Prokopenko |
I |
I |
|
| Pütter |
C |
C |
|
| Radhakrishnan |
A |
A |
|
| Raitakari |
O |
O |
|
| Rendon |
A |
A |
|
| Rivadeneira |
F |
F |
|
| Rudan |
I |
I |
|
| Saaristo |
T E |
TE |
|
| Sambrook |
J G |
JG |
|
| Sanders |
A R |
AR |
|
| Sanna |
S |
S |
|
| Saramies |
J |
J |
|
| Schipf |
S |
S |
|
| Schreiber |
S |
S |
|
| Schunkert |
H |
H |
|
| Shin |
S Y |
SY |
|
| Signorini |
S |
S |
|
| Sinisalo |
J |
J |
|
| Skrobek |
B |
B |
|
| Soranzo |
N |
N |
|
| Stancakova |
A |
A |
|
| Stark |
K |
K |
|
| Stephens |
J C |
JC |
|
| Stirrups |
K |
K |
|
| Stolk |
R P |
RP |
|
| Stumvoll |
M |
M |
|
| Swift |
A J |
AJ |
|
| Theodoraki |
E V |
EV |
|
| Thorand |
B |
B |
|
| Tregouet |
D A |
DA |
|
| Tremoli |
E |
E |
|
| Van der Klauw |
M M |
MM |
|
| van Meurs |
J B |
JB |
|
| Vermeulen |
S H |
SH |
|
| Viikari |
J |
J |
|
| Virtamo |
J |
J |
|
| Vitart |
V |
V |
|
| Waeber |
G |
G |
|
| Wang |
Z |
Z |
|
| Widen |
E |
E |
|
| Wild |
S H |
SH |
|
| Willemsen |
G |
G |
|
| Winkelmann |
B R |
BR |
|
| Witteman |
J C |
JC |
|
| Wolffenbuttel |
B H |
BH |
|
| Wong |
A |
A |
|
| Wright |
A F |
AF |
|
| Zillikens |
M |
M |
|
| Amouyel |
P |
P |
|
| Boehm |
B O |
BO |
|
| Boerwinkle |
E |
E |
|
| Boomsma |
D I |
DI |
|
| Caulfield |
M J |
MJ |
|
| Chanock |
S J |
SJ |
|
| Cupples |
L |
L |
|
| Cusi |
D |
D |
|
| Dedoussis |
G V |
GV |
|
| Erdmann |
J |
J |
|
| Eriksson |
J G |
JG |
|
| Franks |
P W |
PW |
|
| Froguel |
P |
P |
|
| Gieger |
C |
C |
|
| Gyllensten |
U |
U |
|
| Hamsten |
A |
A |
|
| Harris |
T B |
TB |
|
| Hengstenberg |
C |
C |
|
| Hicks |
A A |
AA |
|
| Hingorani |
A |
A |
|
| Hinney |
A |
A |
|
| Hofman |
A |
A |
|
| Hovingh |
K G |
KG |
|
| Hveem |
K |
K |
|
| Illig |
T |
T |
|
| Jarvelin |
M R |
MR |
|
| Jöckel |
K H |
KH |
|
| Keinanen-Kiukaanniemi |
S M |
SM |
|
| Kiemeney |
L A |
LA |
|
| Kuh |
D |
D |
|
| Laakso |
M |
M |
|
| Lehtimäki |
T |
T |
|
| Levinson |
D F |
DF |
|
| Martin |
N G |
NG |
|
| Metspalu |
A |
A |
|
| Morris |
A D |
AD |
|
| Nieminen |
M S |
MS |
|
| Njølstad |
I |
I |
|
| Ohlsson |
C |
C |
|
| Oldehinkel |
A J |
AJ |
|
| Ouwehand |
W H |
WH |
|
| Palmer |
L J |
LJ |
|
| Penninx |
B |
B |
|
| Power |
C |
C |
|
| Province |
M A |
MA |
|
| Psaty |
B M |
BM |
|
| Qi |
L |
L |
|
| Rauramaa |
R |
R |
|
| Ridker |
P M |
PM |
|
| Ripatti |
S |
S |
|
| Salomaa |
V |
V |
|
| Samani |
N J |
NJ |
|
| Snieder |
H |
H |
|
| Sørensen |
T I |
TI |
|
| Spector |
T D |
TD |
|
| Stefansson |
K |
K |
|
| Tönjes |
A |
A |
|
| Tuomilehto |
J |
J |
|
| Uitterlinden |
A G |
AG |
|
| Uusitupa |
M |
M |
|
| van der Harst |
P |
P |
|
| Vollenweider |
P |
P |
|
| Wallaschofski |
H |
H |
|
| Wareham |
N J |
NJ |
|
| Watkins |
H |
H |
|
| Wichmann |
H- |
H |
|
| Wilson |
J F |
JF |
|
| Abecasis |
G R |
GR |
|
| Assimes |
T L |
TL |
|
| Barroso |
I |
I |
|
| Boehnke |
M |
M |
|
| Borecki |
I B |
IB |
|
| Deloukas |
P |
P |
|
| Fox |
C S |
CS |
|
| Frayling |
T |
T |
|
| Groop |
L C |
LC |
|
| Haritunian |
T |
T |
|
| Heid |
I M |
IM |
|
| Hunter |
D |
D |
|
| Kaplan |
R C |
RC |
|
| Karpe |
F |
F |
|
| Moffatt |
M |
M |
|
| Mohlke |
K L |
KL |
|
| O'Connell |
J R |
JR |
|
| Pawitan |
Y |
Y |
|
| Schadt |
E E |
EE |
|
| Schlessinger |
D |
D |
|
| Steinthorsdottir |
V |
V |
|
| Strachan |
D P |
DP |
|
| Thorsteinsdottir |
U |
U |
|
| van Duijn |
C M |
CM |
|
| Visscher |
P M |
PM |
|
| Di Blasio |
A M |
AM |
|
| Hirschhorn |
J N |
JN |
|
| Lindgren |
C M |
CM |
|
| Morris |
A P |
AP |
|
| Meyre |
D |
D |
|
| Scherag |
A |
A |
|
| McCarthy |
M I |
MI |
|
| Speliotes |
E K |
EK |
|
| North |
K E |
KE |
|
| Loos |
R J |
RJ |
|
| Adair |
L S |
LS |
|
| Ang |
W |
W |
|
| Atalay |
M |
M |
|
| van Beijsterveldt |
T |
T |
|
| Bergen |
N |
N |
|
| Benke |
K |
K |
|
| Berry |
D J |
DJ |
|
| Boomsma |
D I |
DI |
|
| Bradfield |
J P |
JP |
|
| Charoen |
P |
P |
|
| Coin |
L |
L |
|
| Cooper |
C |
C |
|
| Cousminer |
D L |
DL |
|
| Das |
S |
S |
|
| Davis |
O S |
OS |
|
| Dedoussis |
G V |
GV |
|
| Elliott |
P |
P |
|
| Estivill |
X |
X |
|
| Evans |
D M |
DM |
|
| Feenstra |
B |
B |
|
| Flexeder |
C |
C |
|
| Frayling |
T |
T |
|
| Freathy |
R M |
RM |
|
| Gaillard |
R |
R |
|
| Geller |
F |
F |
|
| Gillman |
M |
M |
|
| Grant |
S F |
SF |
|
| Groen-Blokhuis |
M |
M |
|
| Goh |
L K |
LK |
|
| Guxens |
M |
M |
|
| Hakonarson |
H |
H |
|
| Hattersley |
A T |
AT |
|
| Haworth |
C M |
CM |
|
| Hadley |
D |
D |
|
| Hebebrand |
J |
J |
|
| Heinrich |
J |
J |
|
| Hinney |
A |
A |
|
| Hirschhorn |
J N |
JN |
|
| Hocher |
B |
B |
|
| Holloway |
J W |
JW |
|
| Holst |
C |
C |
|
| Hottenga |
J J |
JJ |
|
| Horikoshi |
M |
M |
|
| Huikari |
V |
V |
|
| Hypponen |
E |
E |
|
| Iñiguez |
C |
C |
|
| Jaddoe |
V W |
VW |
|
| Jarvelin |
M R |
MR |
|
| Kaakinen |
M |
M |
|
| Kilpeläinen |
T O |
TO |
|
| Kirin |
M |
M |
|
| Kowgier |
M |
M |
|
| Lakka |
H M |
HM |
|
| Lakka |
T A |
TA |
|
| Lange |
L A |
LA |
|
| Lawlor |
D A |
DA |
|
| Lehtimäki |
T |
T |
|
| Lewin |
A |
A |
|
| Lindgren |
C |
C |
|
| Lindi |
V |
V |
|
| Maggi |
R |
R |
|
| Marsh |
J |
J |
|
| McCarthy |
M I |
MI |
|
| Melbye |
M |
M |
|
| Middeldorp |
C |
C |
|
| Millwood |
I |
I |
|
| Mohlke |
K L |
KL |
|
| Mook-Kanamori |
D O |
DO |
|
| Murray |
J C |
JC |
|
| Nivard |
M |
M |
|
| Nohr |
E A |
EA |
|
| Ntalla |
I |
I |
|
| Oken |
E |
E |
|
| Ong |
K K |
KK |
|
| O'Reilly |
P F |
PF |
|
| Palmer |
L J |
LJ |
|
| Panoutsopoulou |
K |
K |
|
| Pararajasingham |
J |
J |
|
| Pearson |
E R |
ER |
|
| Pennell |
C E |
CE |
|
| Power |
C |
C |
|
| Price |
T S |
TS |
|
| Prokopenko |
I |
I |
|
| Raitakari |
O T |
OT |
|
| Rodriguez |
A |
A |
|
| Salem |
R M |
RM |
|
| Saw |
S M |
SM |
|
| Scherag |
A |
A |
|
| Sebert |
S |
S |
|
| Siitonen |
N |
N |
|
| Simell |
O |
O |
|
| Sørensen |
T I |
TI |
|
| Sovio |
U |
U |
|
| Pourcain |
B S |
BS |
|
| Strachan |
D P |
DP |
|
| Sunyer |
J |
J |
|
| Taal |
H R |
HR |
|
| Teo |
Y Y |
YY |
|
| Thiering |
E |
E |
|
| Tiesler |
C |
C |
|
| Timpson |
N J |
NJ |
|
| Uitterlinden |
A G |
AG |
|
| Valcárcel |
B |
B |
|
| Warrington |
N M |
NM |
|
| White |
S |
S |
|
| Widén |
E |
E |
|
| Willemsen |
G |
G |
|
| Wilson |
J F |
JF |
|
| Yaghootkar |
H |
H |
|
| Zeggini |
E |
E |
|
| Elks |
C E |
CE |
|
| Perry |
J R |
JR |
|
| Sulem |
P |
P |
|
| Chasman |
D I |
DI |
|
| Franceschini |
N |
N |
|
| He |
C |
C |
|
| Lunetta |
K L |
KL |
|
| Visser |
J A |
JA |
|
| Byrne |
E M |
EM |
|
| Cousminer |
D L |
DL |
|
| Gudbjartsson |
D F |
DF |
|
| Esko |
T |
T |
|
| Feenstra |
B |
B |
|
| Hottenga |
J J |
JJ |
|
| Koller |
D L |
DL |
|
| Kutalik |
Z |
Z |
|
| Lin |
P |
P |
|
| Mangino |
M |
M |
|
| Marongiu |
M |
M |
|
| McArdle |
P F |
PF |
|
| Smith |
A V |
AV |
|
| Stolk |
L |
L |
|
| van Wingerden |
S H |
SH |
|
| Zhao |
J H |
JH |
|
| Albrecht |
E |
E |
|
| Corre |
T |
T |
|
| Ingelsson |
E |
E |
|
| Hayward |
C |
C |
|
| Magnusson |
P K |
PK |
|
| Smith |
E N |
EN |
|
| Ulivi |
S |
S |
|
| Warrington |
M |
M |
|
| Zgaga |
L |
L |
|
| Alavere |
H |
H |
|
| Amin |
N |
N |
|
| Aspelund |
T |
T |
|
| Bandinelli |
S |
S |
|
| Barroso |
I |
I |
|
| Berenson |
G S |
GS |
|
| Bergmann |
S |
S |
|
| Blackburn |
H |
H |
|
| Boerwinkle |
E |
E |
|
| Buring |
J E |
JE |
|
| Busonero |
F |
F |
|
| Campbell |
H |
H |
|
| Chanock |
S J |
SJ |
|
| Chen |
W |
W |
|
| Cornelis |
M C |
MC |
|
| Couper |
D |
D |
|
| Coviello |
A D |
AD |
|
| d'Adamo |
P |
P |
|
| de Faire |
U |
U |
|
| de Geus |
E J |
EJ |
|
| Deloukas |
P |
P |
|
| Döring |
A |
A |
|
| Davey Smith |
G |
G |
|
| Easton |
D F |
DF |
|
| Eiriksdottir |
G |
G |
|
| Emilsson |
V |
V |
|
| Eriksson |
J |
J |
|
| Ferrucci |
L |
L |
|
| Folsom |
A R |
AR |
|
| Foroud |
T |
T |
|
| Garcia |
M |
M |
|
| Gasparini |
P |
P |
|
| Geller |
F |
F |
|
| Gieger |
C |
C |
|
| Gudnason |
V |
V |
|
| Hall |
P |
P |
|
| Hankinson |
S E |
SE |
|
| Ferreli |
L |
L |
|
| Heath |
A C |
AC |
|
| Hernandez |
D G |
DG |
|
| Hofman |
A |
A |
|
| Hu |
F B |
FB |
|
| Illig |
T |
T |
|
| Järvelin |
M R |
MR |
|
| Johnson |
A D |
AD |
|
| Karasik |
D |
D |
|
| Khaw |
K T |
KT |
|
| Kiel |
D P |
DP |
|
| Kilpeläinen |
T O |
TO |
|
| Kolcic |
I |
I |
|
| Kraft |
P |
P |
|
| Launer |
L J |
LJ |
|
| Laven |
J S |
JS |
|
| Li |
S |
S |
|
| Liu |
J |
J |
|
| Levy |
D |
D |
|
| Martin |
N G |
NG |
|
| McArdle |
W L |
WL |
|
| Melbye |
M |
M |
|
| Mooser |
V |
V |
|
| Murray |
J C |
JC |
|
| Murray |
S S |
SS |
|
| Nalls |
M A |
MA |
|
| Navarro |
P |
P |
|
| Nelis |
M |
M |
|
| Ness |
A R |
AR |
|
| Northstone |
K |
K |
|
| Oostra |
B A |
BA |
|
| Peacock |
M |
M |
|
| Palmer |
L J |
LJ |
|
| Palotie |
A |
A |
|
| Paré |
G |
G |
|
| Parker |
A N |
AN |
|
| Pedersen |
N L |
NL |
|
| Peltonen |
L |
L |
|
| Pennell |
C E |
CE |
|
| Pharoah |
P |
P |
|
| Polasek |
O |
O |
|
| Plump |
A S |
AS |
|
| Pouta |
A |
A |
|
| Porcu |
E |
E |
|
| Rafnar |
T |
T |
|
| Rice |
J P |
JP |
|
| Ring |
S M |
SM |
|
| Rivadeneira |
F |
F |
|
| Rudan |
I |
I |
|
| Sala |
C |
C |
|
| Salomaa |
V |
V |
|
| Sanna |
S |
S |
|
| Schlessinger |
D |
D |
|
| Schork |
N J |
NJ |
|
| Scuteri |
A |
A |
|
| Segrè |
A V |
AV |
|
| Shuldiner |
A R |
AR |
|
| Soranzo |
N |
N |
|
| Sovio |
U |
U |
|
| Srinivasan |
S R |
SR |
|
| Strachan |
D P |
DP |
|
| Tammesoo |
M L |
ML |
|
| Tikkanen |
E |
E |
|
| Toniolo |
D |
D |
|
| Tsui |
K |
K |
|
| Tryggvadottir |
L |
L |
|
| Tyrer |
J |
J |
|
| Uda |
M |
M |
|
| van Dam |
R M |
RM |
|
| van Meurs |
J B |
JB |
|
| Vollenweider |
P |
P |
|
| Waeber |
G |
G |
|
| Wareham |
N J |
NJ |
|
| Waterworth |
D M |
DM |
|
| Weedon |
M N |
MN |
|
| Wichmann |
H E |
HE |
|
| Willemsen |
G |
G |
|
| Wilson |
J F |
JF |
|
| Wright |
A F |
AF |
|
| Young |
L |
L |
|
| Zhai |
G |
G |
|
| Zhuang |
W V |
WV |
|
| Bierut |
L J |
LJ |
|
| Boyd |
H A |
HA |
|
| Crisponi |
L |
L |
|
| Demerath |
E W |
EW |
|
| van Duijn |
C M |
CM |
|
| Econs |
M J |
MJ |
|
| Harris |
T B |
TB |
|
| Hunter |
D J |
DJ |
|
| Loos |
R J |
RJ |
|
| Metspalu |
A |
A |
|
| Montgomery |
G W |
GW |
|
| Ridker |
P M |
PM |
|
| Spector |
T D |
TD |
|
| Streeten |
E A |
EA |
|
| Stefansson |
K |
K |
|
| Thorsteinsdottir |
U |
U |
|
| Uitterlinden |
A G |
AG |
|
| Widen |
E |
E |
|
| Murabito |
J M |
JM |
|
| Ong |
K K |
KK |
|
| Murray |
A |
A |
|
| Brandt |
Harry |
H |
|
| Crawford |
Steve |
S |
|
| Crow |
Scott |
S |
|
| Fichter |
Manfred M |
MM |
|
| Halmi |
Katherine A |
KA |
|
| Johnson |
Craig |
C |
|
| Kaplan |
Allan S |
AS |
|
| Via |
Maria La |
M |
|
| Mitchell |
James |
J |
|
| Strober |
Michael |
M |
|
| Rotondo |
Alessandro |
A |
|
| Treasure |
Janet |
J |
|
| Woodside |
D Blake |
DB |
|
| Bulik |
Cynthia M |
CM |
|
| Keel |
Pamela |
P |
|
| Klump |
Kelly L |
KL |
|
| Lilenfeld |
Lisa |
L |
|
| Thornton |
Laura M |
LM |
|
| Plotnicov |
Kathy |
K |
|
| Bergen |
Andrew W |
AW |
|
| Berrettini |
Wade |
W |
|
| Kaye |
Walter |
W |
|
| Magistretti |
Pierre |
P |
|
|
| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: Molecular psychiatry |
| ISOABBREVIATION: Mol. Psychiatry |
| YEAR: 2016 |
| MONTH: May |
| DAY: 17 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5578 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Mol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1359-4184 |
| NLMUNIQUEID: 9607835 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 DK075787 |
NIDDK NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
