Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27137745
TITLE
Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group.
ABSTRACT
NlmCategory: UNASSIGNED
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.Molecular Psychiatry advance online publication, 3 May 2016; doi:10.1038/mp.2016.60.
DATE PUBLISHED
2016 May 3
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/01/20
revised 2016/02/25
accepted 2016/03/17
entrez 2016/05/04 06:00
pubmed 2016/05/04 06:00
medline 2016/05/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Schmaal L Schmaal L L Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Hibar DP Hibar D P DP Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Sämann PG Sämann P G PG Neuroimaging Core Unit, Max Planck Institute of Psychiatry, Munich, Germany.
Hall GB Hall G B GB Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
Baune BT Baune B T BT Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
Jahanshad N Jahanshad N N Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Cheung JW Cheung J W JW Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
van Erp TG van Erp T G M TG Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Bos D Bos D D Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Ikram MA Ikram M A MA Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Vernooij MW Vernooij M W MW Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Niessen WJ Niessen W J WJ Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.
Tiemeier H Tiemeier H H Department of Child and Adolescent Psychiatry, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
Hofman A Hofman A A Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Wittfeld K Wittfeld K K German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Germany.
Grabe HJ Grabe H J HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Janowitz D Janowitz D D Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Bülow R Bülow R R Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Selonke M Selonke M M Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Völzke H Völzke H H German Center for Diabetes Research (DZD), partner site Griefswald, Greifswald, Germany.
Grotegerd D Grotegerd D D Department of Psychiatry, University of Muenster, Muenster, Germany.
Dannlowski U Dannlowski U U Department of Psychiatry, University of Marburg, Marburg, Germany.
Arolt V Arolt V V Department of Psychiatry, University of Muenster, Muenster, Germany.
Opel N Opel N N Department of Psychiatry, University of Muenster, Muenster, Germany.
Heindel W Heindel W W Department of Clinical Radiology, University of Muenster, Muenster, Germany.
Kugel H Kugel H H Department of Clinical Radiology, University of Muenster, Muenster, Germany.
Hoehn D Hoehn D D Neuroimaging Core Unit, Max Planck Institute of Psychiatry, Munich, Germany.
Czisch M Czisch M M Neuroimaging Core Unit, Max Planck Institute of Psychiatry, Munich, Germany.
Couvy-Duchesne B Couvy-Duchesne B B Queensland Institute of Medical Research Berghofer, Brisbane, QLD, Australia.
Rentería ME Rentería M E ME Queensland Institute of Medical Research Berghofer, Brisbane, QLD, Australia.
Strike LT Strike L T LT Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Wright MJ Wright M J MJ Center for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Mills NT Mills N T NT Queensland Institute of Medical Research Berghofer, Brisbane, QLD, Australia.
de Zubicaray GI de Zubicaray G I GI Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
McMahon KL McMahon K L KL Center for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Medland SE Medland S E SE Queensland Institute of Medical Research Berghofer, Brisbane, QLD, Australia.
Martin NG Martin N G NG Queensland Institute of Medical Research Berghofer, Brisbane, QLD, Australia.
Gillespie NA Gillespie N A NA Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA.
Goya-Maldonado R Goya-Maldonado R R Centre for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Göttingen, Germany.
Gruber O Gruber O O Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
Krämer B Krämer B B Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
Hatton SN Hatton S N SN Clinical Research Unit, Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Lagopoulos J Lagopoulos J J Clinical Research Unit, Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Hickie IB Hickie I B IB Clinical Research Unit, Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Frodl T Frodl T T Department of Psychiatry and Institute of Neuroscience, Trinity College, Dublin, Ireland.
Carballedo A Carballedo A A Department of Psychiatry and Institute of Neuroscience, Trinity College, Dublin, Ireland.
Frey EM Frey E M EM Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
van Velzen LS van Velzen L S LS Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Penninx BW Penninx B W J H BW Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
van Tol MJ van Tol M-J MJ Neuroimaging Center, Section of Cognitive Neuropsychiatry, Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
van der Wee NJ van der Wee N J NJ Department of Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands.
Davey CG Davey C G CG Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
Harrison BJ Harrison B J BJ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
Mwangi B Mwangi B B UT Center of Excellence on Mood Disoders, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
Cao B Cao B B UT Center of Excellence on Mood Disoders, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
Soares JC Soares J C JC UT Center of Excellence on Mood Disoders, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
Veer IM Veer I M IM Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Walter H Walter H H Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Schoepf D Schoepf D D Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Zurowski B Zurowski B B Center for Integrative Psychiatry, University of Lübeck, Lübeck, Germany.
Konrad C Konrad C C Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum Rotenburg, Rotenburg, Germany.
Schramm E Schramm E E Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany.
Normann C Normann C C Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany.
Schnell K Schnell K K Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
Sacchet MD Sacchet M D MD Neurosciences Program and Department of Psychology, Stanford University, Stanford, CA, USA.
Gotlib IH Gotlib I H IH Neurosciences Program and Department of Psychology, Stanford University, Stanford, CA, USA.
MacQueen GM MacQueen G M GM Department of Psychiatry, University of Calgary, Calgary, AB, Canada.
Godlewska BR Godlewska B R BR University Department of Psychiatry, Warneford Hospital, Oxford, UK.
Nickson T Nickson T T Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
McIntosh AM McIntosh A M AM Centre for Cogntive Ageing and Cogntive Epidemiology, University of Edinburgh, Edinburg, UK.
Papmeyer M Papmeyer M M Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.
Whalley HC Whalley H C HC Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
Hall J Hall J J Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
Sussmann JE Sussmann J E JE Department of Psychiatry, NHS Borders, Melrose, UK.
Li M Li M M Leibniz Institute for Neurobiology, Magdeburg, Germany.
Walter M Walter M M Department of Psychiatry, University Tübingen, Tübingen, Germany.
Aftanas L Aftanas L L Department of Experimental and Clinical Neuroscience, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
Brack I Brack I I Department of Experimental and Clinical Neuroscience, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
Bokhan NA Bokhan N A NA Department of General Medicine, Siberian State Medical University, Tomsk, Russia.
Thompson PM Thompson P M PM Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Veltman DJ Veltman D J DJ Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2016
MONTH: May
DAY: 3
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
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JOURNAL ARTICLE
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