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PMID |
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TITLE |
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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. |
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ABSTRACT |
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Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2015/12/11 |
accepted |
2016/03/24 |
entrez |
2016/04/19 06:00 |
pubmed |
2016/04/19 06:00 |
medline |
2017/06/29 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Okbay A |
|
Okbay |
Aysu |
A |
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Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands. |
Baselmans BM |
|
Baselmans |
Bart M L |
BM |
|
EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands. |
De Neve JE |
|
De Neve |
Jan-Emmanuel |
JE |
|
Saïd Business School, University of Oxford, Oxford, UK. |
Turley P |
|
Turley |
Patrick |
P |
|
Department of Economics, Harvard University, Cambridge, Massachusetts, USA. |
Nivard MG |
|
Nivard |
Michel G |
MG |
|
Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands. |
Fontana MA |
|
Fontana |
Mark Alan |
MA |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA. |
Meddens SF |
|
Meddens |
S Fleur W |
SF |
|
Amsterdam Business School, University of Amsterdam, Amsterdam, the Netherlands. |
Linnér RK |
|
Linnér |
Richard Karlsson |
RK |
|
Amsterdam Business School, University of Amsterdam, Amsterdam, the Netherlands. |
Rietveld CA |
|
Rietveld |
Cornelius A |
CA |
|
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands. |
Derringer J |
|
Derringer |
Jaime |
J |
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Department of Psychology, University of Illinois, Champaign, Illinois, USA. |
Gratten J |
|
Gratten |
Jacob |
J |
|
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Lee JJ |
|
Lee |
James J |
JJ |
|
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA. |
Liu JZ |
|
Liu |
Jimmy Z |
JZ |
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New York Genome Center, New York, New York, USA. |
de Vlaming R |
|
de Vlaming |
Ronald |
R |
|
Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands. |
Ahluwalia TS |
|
Ahluwalia |
Tarunveer S |
TS |
|
Steno Diabetes Center, Gentofte, Denmark. |
Buchwald J |
|
Buchwald |
Jadwiga |
J |
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Department of Public Health, University of Helsinki, Helsinki, Finland. |
Cavadino A |
|
Cavadino |
Alana |
A |
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South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. |
Frazier-Wood AC |
|
Frazier-Wood |
Alexis C |
AC |
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USDA-ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA. |
Furlotte NA |
|
Furlotte |
Nicholas A |
NA |
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23andMe, Inc., Mountain View, California, USA. |
Garfield V |
|
Garfield |
Victoria |
V |
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Department of Epidemiology and Public Health, University College London, London, UK. |
Geisel MH |
|
Geisel |
Marie Henrike |
MH |
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Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany. |
Gonzalez JR |
|
Gonzalez |
Juan R |
JR |
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CIBER Epidemiología y Salud Pública, Barcelona, Spain. |
Haitjema S |
|
Haitjema |
Saskia |
S |
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Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands. |
Karlsson R |
|
Karlsson |
Robert |
R |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
van der Laan SW |
|
van der Laan |
Sander W |
SW |
|
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands. |
Ladwig KH |
|
Ladwig |
Karl-Heinz |
KH |
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Department of Psychosomatic Medicine and Psychotherapy, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. |
Lahti J |
|
Lahti |
Jari |
J |
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Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland. |
van der Lee SJ |
|
van der Lee |
Sven J |
SJ |
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Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
Lind PA |
|
Lind |
Penelope A |
PA |
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Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Liu T |
|
Liu |
Tian |
T |
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Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, Germany. |
Matteson L |
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Matteson |
Lindsay |
L |
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Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA. |
Mihailov E |
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Mihailov |
Evelin |
E |
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Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Miller MB |
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Miller |
Michael B |
MB |
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Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA. |
Minica CC |
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Minica |
Camelia C |
CC |
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Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands. |
Nolte IM |
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Nolte |
Ilja M |
IM |
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Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Mook-Kanamori D |
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Mook-Kanamori |
Dennis |
D |
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BESC, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. |
van der Most PJ |
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van der Most |
Peter J |
PJ |
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Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Oldmeadow C |
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Oldmeadow |
Christopher |
C |
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Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia. |
Qian Y |
|
Qian |
Yong |
Y |
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Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA. |
Raitakari O |
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Raitakari |
Olli |
O |
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Department of Clinical Physiology, Turku University Hospital, Turku, Finland. |
Rawal R |
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Rawal |
Rajesh |
R |
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Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. |
Realo A |
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Realo |
Anu |
A |
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Department of Psychology, University of Warwick, Coventry, UK. |
Rueedi R |
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Rueedi |
Rico |
R |
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Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
Schmidt B |
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Schmidt |
Börge |
B |
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Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany. |
Smith AV |
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Smith |
Albert V |
AV |
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Faculty of Medicine, University of Iceland, Reykjavik, Iceland. |
Stergiakouli E |
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Stergiakouli |
Evie |
E |
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MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Tanaka T |
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Tanaka |
Toshiko |
T |
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National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA. |
Taylor K |
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Taylor |
Kent |
K |
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Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA, Torrence, California, USA. |
Thorleifsson G |
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Thorleifsson |
Gudmar |
G |
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Wedenoja J |
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Wedenoja |
Juho |
J |
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Department of Public Health, University of Helsinki, Helsinki, Finland. |
Wellmann J |
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Wellmann |
Juergen |
J |
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Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. |
Westra HJ |
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Westra |
Harm-Jan |
HJ |
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Division of Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. |
Willems SM |
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Willems |
Sara M |
SM |
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Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
Zhao W |
|
Zhao |
Wei |
W |
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Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA. |
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LifeLines Cohort Study |
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Amin N |
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Amin |
Najaf |
N |
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Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
Bakshi A |
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Bakshi |
Andrew |
A |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Bergmann S |
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Bergmann |
Sven |
S |
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Bjornsdottir G |
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Bjornsdottir |
Gyda |
G |
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Boyle PA |
|
Boyle |
Patricia A |
PA |
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Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA. |
Cherney S |
|
Cherney |
Samantha |
S |
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RAND Corporation, Santa Monica, California, USA. |
Cox SR |
|
Cox |
Simon R |
SR |
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Department of Psychology, University of Edinburgh, Edinburgh, UK. |
Davies G |
|
Davies |
Gail |
G |
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Department of Psychology, University of Edinburgh, Edinburgh, UK. |
Davis OS |
|
Davis |
Oliver S P |
OS |
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MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Ding J |
|
Ding |
Jun |
J |
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Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA. |
Direk N |
|
Direk |
Nese |
N |
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Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
Eibich P |
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Eibich |
Peter |
P |
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Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK. |
Emeny RT |
|
Emeny |
Rebecca T |
RT |
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Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA. |
Fatemifar G |
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Fatemifar |
Ghazaleh |
G |
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Farr Institute of Health Informatics, University College London, London, UK. |
Faul JD |
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Faul |
Jessica D |
JD |
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Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA. |
Ferrucci L |
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Ferrucci |
Luigi |
L |
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National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA. |
Forstner AJ |
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Forstner |
Andreas J |
AJ |
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Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. |
Gieger C |
|
Gieger |
Christian |
C |
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Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. |
Gupta R |
|
Gupta |
Richa |
R |
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Department of Public Health, University of Helsinki, Helsinki, Finland. |
Harris TB |
|
Harris |
Tamara B |
TB |
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Laboratory of Epidemiology, Demography, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA. |
Harris JM |
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Harris |
Juliette M |
JM |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
Holliday EG |
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Holliday |
Elizabeth G |
EG |
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Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia. |
Hottenga JJ |
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Hottenga |
Jouke-Jan |
JJ |
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EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands. |
De Jager PL |
|
De Jager |
Philip L |
PL |
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Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. |
Kaakinen MA |
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Kaakinen |
Marika A |
MA |
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Center for Life Course Health Research, University of Oulu and Oulu University Hospital, Oulu, Finland. |
Kajantie E |
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Kajantie |
Eero |
E |
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National Institute for Health and Welfare, Helsinki, Finland. |
Karhunen V |
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Karhunen |
Ville |
V |
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Center for Life Course Health Research, University of Oulu and Oulu University Hospital, Oulu, Finland. |
Kolcic I |
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Kolcic |
Ivana |
I |
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Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia. |
Kumari M |
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Kumari |
Meena |
M |
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Institute for Social and Economic Research, University of Essex, Wivenhoe Park, UK. |
Launer LJ |
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Launer |
Lenore J |
LJ |
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Neuroepidemiology Section, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA. |
Franke L |
|
Franke |
Lude |
L |
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Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. |
Li-Gao R |
|
Li-Gao |
Ruifang |
R |
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Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. |
Liewald DC |
|
Liewald |
David C |
DC |
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Koini M |
|
Koini |
Marisa |
M |
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Department of Neurology, General Hospital and Medical University Graz, Graz, Austria. |
Loukola A |
|
Loukola |
Anu |
A |
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Department of Public Health, University of Helsinki, Helsinki, Finland. |
Marques-Vidal P |
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Marques-Vidal |
Pedro |
P |
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Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
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Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Mosing MA |
|
Mosing |
Miriam A |
MA |
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Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. |
Paternoster L |
|
Paternoster |
Lavinia |
L |
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MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Pattie A |
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Pattie |
Alison |
A |
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Department of Psychology, University of Edinburgh, Edinburgh, UK. |
Petrovic KE |
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Petrovic |
Katja E |
KE |
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Department of Neurology, General Hospital and Medical University Graz, Graz, Austria. |
Pulkki-Råback L |
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Pulkki-Råback |
Laura |
L |
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Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland. |
Quaye L |
|
Quaye |
Lydia |
L |
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Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
Räikkönen K |
|
Räikkönen |
Katri |
K |
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Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland. |
Rudan I |
|
Rudan |
Igor |
I |
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Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. |
Scott RJ |
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Scott |
Rodney J |
RJ |
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Information-Based Medicine Stream, Hunter Medical Research Institute, New Lambton, New South Wales, Australia. |
Smith JA |
|
Smith |
Jennifer A |
JA |
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Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA. |
Sutin AR |
|
Sutin |
Angelina R |
AR |
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Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, Florida, USA. |
Trzaskowski M |
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Trzaskowski |
Maciej |
M |
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Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia. |
Vinkhuyzen AE |
|
Vinkhuyzen |
Anna E |
AE |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Yu L |
|
Yu |
Lei |
L |
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Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA. |
Zabaneh D |
|
Zabaneh |
Delilah |
D |
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Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia. |
Attia JR |
|
Attia |
John R |
JR |
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Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia. |
Bennett DA |
|
Bennett |
David A |
DA |
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Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA. |
Berger K |
|
Berger |
Klaus |
K |
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Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. |
Bertram L |
|
Bertram |
Lars |
L |
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Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, Imperial College London, London, UK. |
Boomsma DI |
|
Boomsma |
Dorret I |
DI |
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Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. |
Snieder H |
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Snieder |
Harold |
H |
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Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Chang SC |
|
Chang |
Shun-Chiao |
SC |
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Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. |
Cucca F |
|
Cucca |
Francesco |
F |
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Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cittadella Universitarià di Monserrato, Monserrato, Italy. |
Deary IJ |
|
Deary |
Ian J |
IJ |
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Department of Psychology, University of Edinburgh, Edinburgh, UK. |
van Duijn CM |
|
van Duijn |
Cornelia M |
CM |
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Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. |
Eriksson JG |
|
Eriksson |
Johan G |
JG |
|
Unit of General Practice, University Central Hospital, Helsinki, Finland. |
Bültmann U |
|
Bültmann |
Ute |
U |
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Department of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
de Geus EJ |
|
de Geus |
Eco J C |
EJ |
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Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. |
Groenen PJ |
|
Groenen |
Patrick J F |
PJ |
|
Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands. |
Gudnason V |
|
Gudnason |
Vilmundur |
V |
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Faculty of Medicine, University of Iceland, Reykjavik, Iceland. |
Hansen T |
|
Hansen |
Torben |
T |
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Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark. |
Hartman CA |
|
Hartman |
Catharine A |
CA |
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Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Haworth CM |
|
Haworth |
Claire M A |
CM |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Hayward C |
|
Hayward |
Caroline |
C |
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MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. |
Heath AC |
|
Heath |
Andrew C |
AC |
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Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. |
Hinds DA |
|
Hinds |
David A |
DA |
|
23andMe, Inc., Mountain View, California, USA. |
Hyppönen E |
|
Hyppönen |
Elina |
E |
|
Population, Policy and Practice, UCL Institute of Child Health, London, UK. |
Iacono WG |
|
Iacono |
William G |
WG |
|
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA. |
Järvelin MR |
|
Järvelin |
Marjo-Riitta |
MR |
|
Unit of Primary Care, Oulu University Hospital, Oulu, Finland. |
Jöckel KH |
|
Jöckel |
Karl-Heinz |
KH |
|
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany. |
Kaprio J |
|
Kaprio |
Jaakko |
J |
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Department for Health, THL (National Institute for Health and Welfare), Helsinki, Finland. |
Kardia SL |
|
Kardia |
Sharon L R |
SL |
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Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA. |
Keltikangas-Järvinen L |
|
Keltikangas-Järvinen |
Liisa |
L |
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Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland. |
Kraft P |
|
Kraft |
Peter |
P |
|
Department of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. |
Kubzansky LD |
|
Kubzansky |
Laura D |
LD |
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Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. |
Lehtimäki T |
|
Lehtimäki |
Terho |
T |
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Department of Clinical Chemistry, University of Tampere, School of Medicine, Tampere, Finland. |
Magnusson PK |
|
Magnusson |
Patrik K E |
PK |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
McGue M |
|
McGue |
Matt |
M |
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Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA. |
Metspalu A |
|
Metspalu |
Andres |
A |
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Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. |
Mills M |
|
Mills |
Melinda |
M |
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Department of Sociology, University of Oxford, Oxford, UK. |
de Mutsert R |
|
de Mutsert |
Renée |
R |
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Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. |
Oldehinkel AJ |
|
Oldehinkel |
Albertine J |
AJ |
|
Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands. |
Pasterkamp G |
|
Pasterkamp |
Gerard |
G |
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Laboratory of Clinical Chemistry and Hematology, Division of Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands. |
Pedersen NL |
|
Pedersen |
Nancy L |
NL |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Plomin R |
|
Plomin |
Robert |
R |
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Social, Genetic and Developmental Psychiatry Centre, King's College London, De Crespigny Park, UK. |
Polasek O |
|
Polasek |
Ozren |
O |
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Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia. |
Power C |
|
Power |
Christine |
C |
|
Population, Policy and Practice, UCL Institute of Child Health, London, UK. |
Rich SS |
|
Rich |
Stephen S |
SS |
|
Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA. |
Rosendaal FR |
|
Rosendaal |
Frits R |
FR |
|
Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. |
den Ruijter HM |
|
den Ruijter |
Hester M |
HM |
|
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands. |
Schlessinger D |
|
Schlessinger |
David |
D |
|
Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA. |
Schmidt H |
|
Schmidt |
Helena |
H |
|
Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, General Hospital and Medical University Graz, Graz, Austria. |
Svento R |
|
Svento |
Rauli |
R |
|
Department of Economics, Oulu Business School, Oulu, Finland. |
Schmidt R |
|
Schmidt |
Reinhold |
R |
|
Department of Neurology, General Hospital and Medical University Graz, Graz, Austria. |
Alizadeh BZ |
|
Alizadeh |
Behrooz Z |
BZ |
|
Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. |
Sørensen TI |
|
Sørensen |
Thorkild I A |
TI |
|
Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Capital Region, Frederiksberg, Denmark. |
Spector TD |
|
Spector |
Tim D |
TD |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
Starr JM |
|
Starr |
John M |
JM |
|
|
Stefansson K |
|
Stefansson |
Kari |
K |
|
|
Steptoe A |
|
Steptoe |
Andrew |
A |
|
Department of Epidemiology and Public Health, University College London, London, UK. |
Terracciano A |
|
Terracciano |
Antonio |
A |
|
Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, Florida, USA. |
Thorsteinsdottir U |
|
Thorsteinsdottir |
Unnur |
U |
|
|
Thurik AR |
|
Thurik |
A Roy |
AR |
|
Panteia, Zoetermeer, the Netherlands. |
Timpson NJ |
|
Timpson |
Nicholas J |
NJ |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Tiemeier H |
|
Tiemeier |
Henning |
H |
|
Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands. |
Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. |
Vollenweider P |
|
Vollenweider |
Peter |
P |
|
Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland. |
Wagner GG |
|
Wagner |
Gert G |
GG |
|
School of Economics and Management, Berlin University of Technology, Berlin, Germany. |
Weir DR |
|
Weir |
David R |
DR |
|
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA. |
Yang J |
|
Yang |
Jian |
J |
|
University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. |
Conley DC |
|
Conley |
Dalton C |
DC |
|
Department of Sociology, Princeton University, Princeton, New Jersey, USA. |
Smith GD |
|
Smith |
George Davey |
GD |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. |
Hofman A |
|
Hofman |
Albert |
A |
|
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. |
Johannesson M |
|
Johannesson |
Magnus |
M |
|
Department of Economics, Stockholm School of Economics, Stockholm, Sweden. |
Laibson DI |
|
Laibson |
David I |
DI |
|
Department of Economics, Harvard University, Cambridge, Massachusetts, USA. |
Medland SE |
|
Medland |
Sarah E |
SE |
|
Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Meyer MN |
|
Meyer |
Michelle N |
MN |
|
Icahn School of Medicine at Mount Sinai, New York, New York, USA. |
Pickrell JK |
|
Pickrell |
Joseph K |
JK |
|
Department of Biological Sciences, Columbia University, New York, New York, USA. |
Esko T |
|
Esko |
Tõnu |
T |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Krueger RF |
|
Krueger |
Robert F |
RF |
|
Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA. |
Beauchamp JP |
|
Beauchamp |
Jonathan P |
JP |
|
Department of Economics, Harvard University, Cambridge, Massachusetts, USA. |
Koellinger PD |
|
Koellinger |
Philipp D |
PD |
|
Amsterdam Business School, University of Amsterdam, Amsterdam, the Netherlands. |
Benjamin DJ |
|
Benjamin |
Daniel J |
DJ |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA. |
Bartels M |
|
Bartels |
Meike |
M |
|
Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. |
Cesarini D |
|
Cesarini |
David |
D |
|
Research Institute for Industrial Economics, Stockholm, Sweden. |
|
INVESTIGATORS |
|
|
JOURNAL |
|
VOLUME: 48 |
ISSUE: 6 |
TITLE: Nature genetics |
ISOABBREVIATION: Nat Genet |
YEAR: 2016 |
MONTH: 06 |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1718 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
|
COMMENTS AND CORRECTIONS |
|
REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
ErratumIn |
Nat Genet. 2016 Jul 27;48(8):970 |
27463399 |
|
ErratumIn |
Nat Genet. 2016 Nov 29;48(12 ):1591 |
27898078 |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
R01 DA036216 |
NIDA NIH HHS |
United States |
G1001799 |
Medical Research Council |
United Kingdom |
RF1 AG015819 |
NIA NIH HHS |
United States |
U01 AG009740 |
NIA NIH HHS |
United States |
MC_UU_12013/3 |
Medical Research Council |
United Kingdom |
MC_QA137853 |
Medical Research Council |
United Kingdom |
R01 AG017917 |
NIA NIH HHS |
United States |
MR/J012165/1 |
Medical Research Council |
United Kingdom |
R03 AG051960 |
NIA NIH HHS |
United States |
UL1 TR000124 |
NCATS NIH HHS |
United States |
MR/K026992/1 |
Medical Research Council |
United Kingdom |
MR/N01104X/1 |
Medical Research Council |
United Kingdom |
P30 DK063491 |
NIDDK NIH HHS |
United States |
P2C HD047879 |
NICHD NIH HHS |
United States |
MC_PC_15018 |
Medical Research Council |
United Kingdom |
P30 AG010161 |
NIA NIH HHS |
United States |
MC_UU_12013/1 |
Medical Research Council |
United Kingdom |
MC_PC_U127561128 |
Medical Research Council |
United Kingdom |
P01 AG005842 |
NIA NIH HHS |
United States |
R37 DA005147 |
NIDA NIH HHS |
United States |
P30 AG012810 |
NIA NIH HHS |
United States |
R01 AG042568 |
NIA NIH HHS |
United States |
T32 AG000186 |
NIA NIH HHS |
United States |
647648 |
European Research Council |
International |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Anxiety Disorders |
genetics |
Bayes Theorem |
genetics |
Depression |
genetics |
Genome-Wide Association Study |
genetics |
Humans |
genetics |
Neuroticism |
genetics |
Phenotype |
genetics |
Polymorphism, Single Nucleotide |
genetics |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
|
OTHER ID's |
|
|
|