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PMID |
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TITLE |
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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. |
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ABSTRACT |
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Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2015/02/09 |
accepted |
2016/02/10 |
entrez |
2016/03/30 06:00 |
pubmed |
2016/03/30 06:00 |
medline |
2016/03/30 06:00 |
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AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Fan Q |
|
Fan |
Qiao |
Q |
|
Duke-NUS Medical School, Singapore 169857, Singapore. |
Verhoeven VJ |
|
Verhoeven |
Virginie J M |
VJ |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Wojciechowski R |
|
Wojciechowski |
Robert |
R |
|
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 20205, USA. |
Barathi VA |
|
Barathi |
Veluchamy A |
VA |
|
Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore. |
Hysi PG |
|
Hysi |
Pirro G |
PG |
|
Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London SE1 7EH, UK. |
Guggenheim JA |
|
Guggenheim |
Jeremy A |
JA |
|
School of Optometry and Vision Sciences, Cardiff University, Cardiff CF24 4HQ, UK. |
Höhn R |
|
Höhn |
René |
R |
|
Department of Ophthalmology, Inselspital, University Hospital Bern, CH-3010 Bern, Switzerland. |
Vitart V |
|
Vitart |
Veronique |
V |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland. |
Khawaja AP |
|
Khawaja |
Anthony P |
AP |
|
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SR, UK. |
Yamashiro K |
|
Yamashiro |
Kenji |
K |
|
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan. |
Hosseini SM |
|
Hosseini |
S Mohsen |
SM |
|
Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto, Toronto Ontario, Canada M5G 1X8. |
Lehtimäki T |
|
Lehtimäki |
Terho |
T |
|
Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33520, Finland. |
Lu Y |
|
Lu |
Yi |
Y |
|
Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia. |
Haller T |
|
Haller |
Toomas |
T |
|
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. |
Xie J |
|
Xie |
Jing |
J |
|
Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia. |
Delcourt C |
|
Delcourt |
Cécile |
C |
|
INSERM, U1219-Bordeaux Population Health Research Center, Bordeaux 33000, France. |
Pirastu M |
|
Pirastu |
Mario |
M |
|
Institute of Population Genetics, National Research Council, Sassari 07100, Italy. |
Wedenoja J |
|
Wedenoja |
Juho |
J |
|
Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland. |
Gharahkhani P |
|
Gharahkhani |
Puya |
P |
|
Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia. |
Venturini C |
|
Venturini |
Cristina |
C |
|
UCL Institute of Ophthalmology, London SE1 7EH, UK. |
Miyake M |
|
Miyake |
Masahiro |
M |
|
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan. |
Hewitt AW |
|
Hewitt |
Alex W |
AW |
|
Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania 7000, Australia. |
Guo X |
|
Guo |
Xiaobo |
X |
|
Department of Statistical Science, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China. |
Mazur J |
|
Mazur |
Johanna |
J |
|
Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, 55131 Mainz, Germany. |
Huffman JE |
|
Huffman |
Jenifer E |
JE |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland. |
Williams KM |
|
Williams |
Katie M |
KM |
|
Department of Ophthalmology, King's College London, London SE1 7EH, UK. |
Polasek O |
|
Polasek |
Ozren |
O |
|
Faculty of Medicine, University of Split, Split 21000, Croatia. |
Campbell H |
|
Campbell |
Harry |
H |
|
Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland. |
Rudan I |
|
Rudan |
Igor |
I |
|
Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland. |
Vatavuk Z |
|
Vatavuk |
Zoran |
Z |
|
Department of Ophthalmology, Sisters of Mercy University Hospital, Zagreb 10000, Croatia. |
Wilson JF |
|
Wilson |
James F |
JF |
|
Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland. |
Joshi PK |
|
Joshi |
Peter K |
PK |
|
Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland. |
McMahon G |
|
McMahon |
George |
G |
|
School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK. |
St Pourcain B |
|
St Pourcain |
Beate |
B |
|
Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525 XD Nijmegen, The Netherlands. |
Evans DM |
|
Evans |
David M |
DM |
|
University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia. |
Simpson CL |
|
Simpson |
Claire L |
CL |
|
Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA. |
Schwantes-An TH |
|
Schwantes-An |
Tae-Hwi |
TH |
|
Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA. |
Igo RP |
|
Igo |
Robert P |
RP |
|
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA. |
Mirshahi A |
|
Mirshahi |
Alireza |
A |
|
Dardenne Eye Hospital, Bonn-Bad Godesberg, 53177 Bonn, Germany. |
Cougnard-Gregoire A |
|
Cougnard-Gregoire |
Audrey |
A |
|
INSERM, U1219-Bordeaux Population Health Research Center, Bordeaux 33000, France. |
Bellenguez C |
|
Bellenguez |
Céline |
C |
|
Université Lille 2, Lille 59000, France. |
Blettner M |
|
Blettner |
Maria |
M |
|
Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, 55131 Mainz, Germany. |
Raitakari O |
|
Raitakari |
Olli |
O |
|
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20520, Finland. |
Kähönen M |
|
Kähönen |
Mika |
M |
|
Department of Clinical Physiology, Tampere University Hospital and School of Medicine, University of Tampere, Tampere 33520, Finland. |
Seppala I |
|
Seppala |
Ilkka |
I |
|
Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere 33520, Finland. |
Zeller T |
|
Zeller |
Tanja |
T |
|
Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany. |
Meitinger T |
|
Meitinger |
Thomas |
T |
|
Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany. |
|
Consortium for Refractive Error and Myopia (CREAM) |
|
|
|
|
|
Ried JS |
|
Ried |
Janina S |
JS |
|
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany. |
Gieger C |
|
Gieger |
Christian |
C |
|
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany. |
Portas L |
|
Portas |
Laura |
L |
|
Institute of Population Genetics, National Research Council, Sassari 07100, Italy. |
van Leeuwen EM |
|
van Leeuwen |
Elisabeth M |
EM |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Amin N |
|
Amin |
Najaf |
N |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, 2518 AD Hague, The Netherlands. |
Rivadeneira F |
|
Rivadeneira |
Fernando |
F |
|
Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, 2518 AD Hague, The Netherlands. |
Hofman A |
|
Hofman |
Albert |
A |
|
Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, 2518 AD Hague, The Netherlands. |
Vingerling JR |
|
Vingerling |
Johannes R |
JR |
|
Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Wang YX |
|
Wang |
Ya Xing |
YX |
|
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100044, China. |
Wang X |
|
Wang |
Xu |
X |
|
Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore. |
Tai-Hui Boh E |
|
Tai-Hui Boh |
Eileen |
E |
|
Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore. |
Ikram MK |
|
Ikram |
M Kamran |
MK |
|
Duke-NUS Medical School, Singapore 169857, Singapore. |
Sabanayagam C |
|
Sabanayagam |
Charumathi |
C |
|
Duke-NUS Medical School, Singapore 169857, Singapore. |
Gupta P |
|
Gupta |
Preeti |
P |
|
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore. |
Tan V |
|
Tan |
Vincent |
V |
|
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore. |
Zhou L |
|
Zhou |
Lei |
L |
|
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore. |
Ho CE |
|
Ho |
Candice E H |
CE |
|
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore. |
Lim W |
|
Lim |
Wan'e |
W |
|
Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore. |
Beuerman RW |
|
Beuerman |
Roger W |
RW |
|
Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore. |
Siantar R |
|
Siantar |
Rosalynn |
R |
|
National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Singapore. |
Tai ES |
|
Tai |
E-Shyong |
ES |
|
Department of Medicine, National University of Singapore, Singapore 119228, Singapore. |
Vithana E |
|
Vithana |
Eranga |
E |
|
Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore. |
Mihailov E |
|
Mihailov |
Evelin |
E |
|
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. |
Khor CC |
|
Khor |
Chiea-Chuen |
CC |
|
Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore. |
Hayward C |
|
Hayward |
Caroline |
C |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland. |
Luben RN |
|
Luben |
Robert N |
RN |
|
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SR, UK. |
Foster PJ |
|
Foster |
Paul J |
PJ |
|
NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London EC1V 2PD, UK. |
Klein BE |
|
Klein |
Barbara E K |
BE |
|
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA. |
Klein R |
|
Klein |
Ronald |
R |
|
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA. |
Wong HS |
|
Wong |
Hoi-Suen |
HS |
|
Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto, Toronto Ontario, Canada M5G 1X8. |
Mitchell P |
|
Mitchell |
Paul |
P |
|
Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia. |
Metspalu A |
|
Metspalu |
Andres |
A |
|
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. |
Aung T |
|
Aung |
Tin |
T |
|
Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore. |
Young TL |
|
Young |
Terri L |
TL |
|
Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA. |
He M |
|
He |
Mingguang |
M |
|
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China. |
Pärssinen O |
|
Pärssinen |
Olavi |
O |
|
Gerontology Research Center and Department of Health Sciences, University of Jyväskylä, Jyväskylä 40014, Finland. |
van Duijn CM |
|
van Duijn |
Cornelia M |
CM |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Jin Wang J |
|
Jin Wang |
Jie |
J |
|
Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia. |
Williams C |
|
Williams |
Cathy |
C |
|
School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK. |
Jonas JB |
|
Jonas |
Jost B |
JB |
|
Medical Faculty Mannheim, Department of Ophthalmology, Ruprecht-Karls-University Heidelberg, 69115 Mannheim, Germany. |
Teo YY |
|
Teo |
Yik-Ying |
YY |
|
Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546, Singapore. |
Mackey DA |
|
Mackey |
David A |
DA |
|
Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia 6009, Australia. |
Oexle K |
|
Oexle |
Konrad |
K |
|
Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany. |
Yoshimura N |
|
Yoshimura |
Nagahisa |
N |
|
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan. |
Paterson AD |
|
Paterson |
Andrew D |
AD |
|
Program in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of Toronto, Toronto Ontario, Canada M5G 1X8. |
Pfeiffer N |
|
Pfeiffer |
Norbert |
N |
|
Department of Ophthalmology, University Medical Center Mainz, 55131 Mainz, Germany. |
Wong TY |
|
Wong |
Tien-Yin |
TY |
|
Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore. |
Baird PN |
|
Baird |
Paul N |
PN |
|
Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia. |
Stambolian D |
|
Stambolian |
Dwight |
D |
|
Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. |
Wilson JE |
|
Wilson |
Joan E Bailey |
JE |
|
Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA. |
Cheng CY |
|
Cheng |
Ching-Yu |
CY |
|
Department of Ophthalmology, National University Health Systems, National University of Singapore Singapore 119228, Singapore. |
Hammond CJ |
|
Hammond |
Christopher J |
CJ |
|
Department of Ophthalmology, King's College London, London SE1 7EH, UK. |
Klaver CC |
|
Klaver |
Caroline C W |
CC |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Saw SM |
|
Saw |
Seang-Mei |
SM |
|
Saw Swee Hock School of Public Health, National University of Singapore and National University Health Systems, Singapore 117549, Singapore. |
Rahi JS |
|
Rahi |
Jugnoo S |
JS |
|
|
Korobelnik JF |
|
Korobelnik |
Jean-François |
JF |
|
|
Kemp JP |
|
Kemp |
John P |
JP |
|
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Timpson NJ |
|
Timpson |
Nicholas J |
NJ |
|
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Smith GD |
|
Smith |
George Davey |
GD |
|
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Craig JE |
|
Craig |
Jamie E |
JE |
|
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Burdon KP |
|
Burdon |
Kathryn P |
KP |
|
|
Fogarty RD |
|
Fogarty |
Rhys D |
RD |
|
|
Iyengar SK |
|
Iyengar |
Sudha K |
SK |
|
|
Chew E |
|
Chew |
Emily |
E |
|
|
Janmahasatian S |
|
Janmahasatian |
Sarayut |
S |
|
|
Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
MacGregor S |
|
MacGregor |
Stuart |
S |
|
Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland 4029, Australia. |
Xu L |
|
Xu |
Liang |
L |
|
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100044, China. |
Schache M |
|
Schache |
Maria |
M |
|
Centre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria 3002, Australia. |
Nangia V |
|
Nangia |
Vinay |
V |
|
|
Panda-Jonas S |
|
Panda-Jonas |
Songhomitra |
S |
|
|
Wright AF |
|
Wright |
Alan F |
AF |
|
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland. |
Fondran JR |
|
Fondran |
Jeremy R |
JR |
|
|
Lass JH |
|
Lass |
Jonathan H |
JH |
|
|
Feng S |
|
Feng |
Sheng |
S |
|
|
Zhao JH |
|
Zhao |
Jing Hua |
JH |
|
|
Khaw KT |
|
Khaw |
Kay-Tee |
KT |
|
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 0SR, UK. |
Wareham NJ |
|
Wareham |
Nick J |
NJ |
|
|
Rantanen T |
|
Rantanen |
Taina |
T |
|
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Kaprio J |
|
Kaprio |
Jaakko |
J |
|
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Pang CP |
|
Pang |
Chi Pui |
CP |
|
|
Chen LJ |
|
Chen |
Li Jia |
LJ |
|
|
Tam PO |
|
Tam |
Pancy O |
PO |
|
|
Jhanji V |
|
Jhanji |
Vishal |
V |
|
|
Young AL |
|
Young |
Alvin L |
AL |
|
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Döring A |
|
Döring |
Angela |
A |
|
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Raffel LJ |
|
Raffel |
Leslie J |
LJ |
|
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Cotch MF |
|
Cotch |
Mary-Frances |
MF |
|
|
Li X |
|
Li |
Xiaohui |
X |
|
|
Yip SP |
|
Yip |
Shea Ping |
SP |
|
|
Yap MK |
|
Yap |
Maurice K H |
MK |
|
|
Biino G |
|
Biino |
Ginevra |
G |
|
|
Vaccargiu S |
|
Vaccargiu |
Simona |
S |
|
Institute of Population Genetics, National Research Council, Sassari 07100, Italy. |
Fossarello M |
|
Fossarello |
Maurizio |
M |
|
Institute of Population Genetics, National Research Council, Sassari 07100, Italy. |
Fleck B |
|
Fleck |
Brian |
B |
|
|
Yazar S |
|
Yazar |
Seyhan |
S |
|
Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia 6009, Australia. |
Tideman JW |
|
Tideman |
Jan Willem L |
JW |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Tedja M |
|
Tedja |
Milly |
M |
|
Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands. |
Deangelis MM |
|
Deangelis |
Margaret M |
MM |
|
|
Morrison M |
|
Morrison |
Margaux |
M |
|
|
Farrer L |
|
Farrer |
Lindsay |
L |
|
|
Zhou X |
|
Zhou |
Xiangtian |
X |
|
|
Chen W |
|
Chen |
Wei |
W |
|
|
Mizuki N |
|
Mizuki |
Nobuhisa |
N |
|
|
Meguro A |
|
Meguro |
Akira |
A |
|
|
Mäkelä KM |
|
Mäkelä |
Kari Matti |
KM |
|
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 7 |
ISSUE: |
TITLE: Nature communications |
ISOABBREVIATION: Nat Commun |
YEAR: 2016 |
MONTH: |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2041-1723 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Commun |
COUNTRY: England |
ISSNLINKING: 2041-1723 |
NLMUNIQUEID: 101528555 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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REFSOURCE |
REFPMID |
NOTE |
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Science. 2015 May 8;348(6235):666-9 |
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OTHERID |
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PMC4820539 |
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