Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27006297
TITLE
Heritability and genetic correlation between the cerebral cortex and associated white matter connections.
ABSTRACT
NlmCategory: UNASSIGNED
The aim of this study is to investigate the genetic influence on the cerebral cortex, based on the analyses of heritability and genetic correlation between grey matter (GM) thickness, derived from structural MR images (sMRI), and associated white matter (WM) connections obtained from diffusion MRI (dMRI). We measured on sMRI the cortical thickness (CT) from a large twin imaging cohort using a surface-based approach (N = 308, average age 22.8 ± 2.3 SD). An ACE model was employed to compute the heritability of CT. WM connections were estimated based on probabilistic tractography using fiber orientation distributions (FOD) from dMRI. We then fitted the ACE model to estimate the heritability of CT and FOD peak measures along WM fiber tracts. The WM fiber tracts where genetic influence was detected were mapped onto the cortical surface. Bivariate genetic modeling was performed to estimate the cross-trait genetic correlation between the CT and the FOD-based connectivity of the tracts associated with the cortical regions. We found some cortical regions displaying heritable and genetically correlated GM thickness and WM connectivity, forming networks under stronger genetic influence. Significant heritability and genetic correlations between the CT and WM connectivity were found in regions including the right postcentral gyrus, left posterior cingulate gyrus, right middle temporal gyri, suggesting common genetic factors influencing both GM and WM. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.
(c) 2016 Wiley Periodicals, Inc.
DATE PUBLISHED
2016 Mar 23
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/06/29
revised 2016/02/22
accepted 2016/02/25
entrez 2016/03/24 06:00
pubmed 2016/03/24 06:00
medline 2016/03/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Shen KK
Dore V
Rose S
Fripp J
McMahon KL
de Zubicaray GI
Martin NG
Thompson PM
Wright MJ
Salvado O
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Human brain mapping
ISOABBREVIATION: Hum Brain Mapp
YEAR: 2016
MONTH: Mar
DAY: 23
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1097-0193
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Brain Mapp
COUNTRY: United States
ISSNLINKING: 1065-9471
NLMUNIQUEID: 9419065
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
cerebral cortex
diffusion MRI
genetic correlation
grey matter
heritability
structural MRI
white matter
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's