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| PMID |
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| TITLE |
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| Heritability and genetic correlation between the cerebral cortex and associated white matter connections. |
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| ABSTRACT |
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NlmCategory: UNASSIGNED |
| The aim of this study is to investigate the genetic influence on the cerebral cortex, based on the analyses of heritability and genetic correlation between grey matter (GM) thickness, derived from structural MR images (sMRI), and associated white matter (WM) connections obtained from diffusion MRI (dMRI). We measured on sMRI the cortical thickness (CT) from a large twin imaging cohort using a surface-based approach (N = 308, average age 22.8 ± 2.3 SD). An ACE model was employed to compute the heritability of CT. WM connections were estimated based on probabilistic tractography using fiber orientation distributions (FOD) from dMRI. We then fitted the ACE model to estimate the heritability of CT and FOD peak measures along WM fiber tracts. The WM fiber tracts where genetic influence was detected were mapped onto the cortical surface. Bivariate genetic modeling was performed to estimate the cross-trait genetic correlation between the CT and the FOD-based connectivity of the tracts associated with the cortical regions. We found some cortical regions displaying heritable and genetically correlated GM thickness and WM connectivity, forming networks under stronger genetic influence. Significant heritability and genetic correlations between the CT and WM connectivity were found in regions including the right postcentral gyrus, left posterior cingulate gyrus, right middle temporal gyri, suggesting common genetic factors influencing both GM and WM. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc. |
| (c) 2016 Wiley Periodicals, Inc. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2015/06/29 |
| revised |
2016/02/22 |
| accepted |
2016/02/25 |
| entrez |
2016/03/24 06:00 |
| pubmed |
2016/03/24 06:00 |
| medline |
2016/03/24 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Shen KK |
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| Dore V |
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| Rose S |
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| Fripp J |
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| McMahon KL |
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| de Zubicaray GI |
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| Martin NG |
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| Thompson PM |
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| Wright MJ |
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| Salvado O |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Human brain mapping |
| ISOABBREVIATION: Hum Brain Mapp |
| YEAR: 2016 |
| MONTH: Mar |
| DAY: 23 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1097-0193 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Hum Brain Mapp |
| COUNTRY: United States |
| ISSNLINKING: 1065-9471 |
| NLMUNIQUEID: 9419065 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| cerebral cortex |
| diffusion MRI |
| genetic correlation |
| grey matter |
| heritability |
| structural MRI |
| white matter |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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